AutismKB 2.0

Annotation Detail for HAGH


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Basic Information Top
Gene Symbol:HAGH ( GLO2,GLX2,GLXII,HAGH1 )
Gene Full Name: hydroxyacylglutathione hydrolase
Band: 16p13.3
Quick LinksEntrez ID:3029; OMIM: 138760; Uniprot ID:GLO2_HUMAN; ENSEMBL ID: ENSG00000063854; HGNC ID: 4805
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-5386methylglyoxal degradation I
Pathway IDPathway Name
hsa00620Pyruvate metabolism
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Related Diseases/Disorders Top
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Desease Name
Glyoxalase II deficiency
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of HAGH mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of HAGH proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of HAGH mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of HAGH mRNAdecreases expression 20106945
D002330 Carmustine Carmustine results in decreased expression of HAGH mRNAdecreases expression 15980968
D016572 Cyclosporine Cyclosporine results in decreased expression of HAGH mRNAdecreases expression 20106945
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of HAGH mRNAdecreases expression 19638242
C056933 fumonisin B1 fumonisin B1 results in decreased expression of HAGH mRNAdecreases expression 16221962
C006253 pirinixic acid pirinixic acid results in increased expression of HAGH mRNAincreases expression 16221962
D012643 Selenium Selenium results in increased expression of HAGH mRNAincreases expression 19244175
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of HAGH mRNAdecreases expression 18796159
C057693 troglitazone troglitazone results in decreased activity of HAGH proteindecreases activity 12572858
D014810 Vitamin E Vitamin E results in increased expression of HAGH mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9611752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.6818287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.2018653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0020127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 6.786695378
MESH:D000236 Adenoma Diethylnitrosamine 6.7810737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 17.9916434500 19061943 18056438 19052882 17620307 17162532
MESH:D018248 Adenoma, Liver Cell pirinixic acid 17.9916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 17.9916835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1819183758
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.0419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.0412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D001932 Brain Neoplasms Carmustine 4.4616187019
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8020146248 17474063
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.8017474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8020435547
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.0316050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.613084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.6121507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.6117162532 18785209 20007298 16288022 19107877 17055752 19383236 17761372 16698587 19171122 20524982 19052882 17428255 17173139 19394651 18210153 18494052 16569478 20432363 19919837 19519916 16807293 18691550 16328049 3581430 19539802 16681979 16878318 18056438 10672840 16540662 18393292 20935162 17138121 21159647 19208518 20084675 16502159 16779866 18788625 19335982 18506893 16830150 3084413 11831363 17978847 20512989 20727157 18978308 20514400 19822196 19701751 20101231 18971187 19418558 16935385 18665156 20214788 10737359
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0720419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4118850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 2.6310977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.7912371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.7917174075 7505956 21159647 2727394
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.5719052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.5716835633
MESH:D002779 Cholestasis Cyclosporine 7.9619486331
MESH:D002779 Cholestasis pirinixic acid 7.9619176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1312621046 15340226 16354765 8697196 15668235
MESH:D003092 Colitis Selenium 3.8817936198
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1317141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5020055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.5019769572
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4618249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 7.3620387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 7.3617107852
MESH:D003924 Diabetes Mellitus, Type 2 troglitazone 7.3616023994
MESH:D003925 Diabetic Angiopathies troglitazone 5.7212601628
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 15.5916227642 12540782 14725611 11529661 11834606 11743745 19085960 10774834 11421492 14550746 17522070 16393943 16109766 19923254 12958197 11739529 12705907 19370779 16177239 12594235 11287661 18713872 15968718 15619225 14986274 19420014 18071297 10663392 10915739 16485898 16081117 2444490 17906064 12392966 16781746 17562736 12153990 19164858 19739265 11461765 19416960
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 15.5919107877
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 15.5916221962
MESH:D056486 Drug-Induced Liver Injury Selenium 15.5915131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 15.5920420201
MESH:D056486 Drug-Induced Liver Injury troglitazone 15.5914986274
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:C538011 Eales disease Vitamin E 4.849068938
MESH:D004487 Edema pirinixic acid 6.8112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.8111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0418230668 15322242 16714409
MESH:D004612 Elliptocytosis, Hereditary marker/mechanism
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.109294722 10568697
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2516302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0216530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver Cyclosporine 13.5319224547
MESH:D005234 Fatty Liver Diethylnitrosamine 13.5320387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 13.5319236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005355 Fibrosis Cyclosporine 8.8312168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.8320067830
MESH:D005756 Gastritis Acetaminophen 3.8116983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.348708960
MESH:D005909 Glioblastoma Carmustine 3.9816187019
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 11.3420471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.3411294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 11.3416080930
MESH:D006333 Heart Failure pirinixic acid 7.1120558911
MESH:D006333 Heart Failure Selenium 7.1117162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006529 Hepatomegaly fumonisin B1 15.1216221962
MESH:D006529 Hepatomegaly pirinixic acid 15.1216221962 19176532 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 15.1216120746 15340226 12621046
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7316863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.1114716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1816959395 8697196 18606429 15340226 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.7616870215
MESH:D006943 Hyperglycemia pirinixic acid 3.2620558911
MESH:D006973 Hypertension Cyclosporine 5.0410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0418850075 18670907
MESH:D007249 Inflammation Diethylnitrosamine 5.0318785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.0312878042 12200463
MESH:D007251 Influenza, Human Selenium 11.4116624496
MESH:D007251 Influenza, Human Vitamin E 11.4116624496
MESH:D007333 Insulin Resistance pirinixic acid 2.6816306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5815604871
MESH:D007674 Kidney Diseases Acetaminophen 10.2715629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 10.278314463 10903974 18776723
MESH:D007674 Kidney Diseases Vitamin E 10.2712488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.9716518626
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8012371664
MESH:D004915 Leukemia, Erythroblastic, Acute troglitazone 6.2816085563
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8718407596 18522880 19638242 18665156 20032147
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4515474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4512878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.4516169303
MESH:D008107 Liver Diseases Acetaminophen 3.9719784758 12587719 19460945 16610002 12969438 16611625 19014921 11587558
MESH:D008107 Liver Diseases Diethylnitrosamine 3.9717034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3116871587 17185352
MESH:D008113 Liver Neoplasms Aflatoxin B1 14.5418177683 2125692 15890375 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.5420195826 21137059
MESH:D008113 Liver Neoplasms Diethylnitrosamine 14.5421167192 2422723 20492335 21071580 20501860 19090486 16942905 19294768 20405173 19551842 18978307 19642983 19256749 2862719 20118626 20101389 19427195 21278145 19833225 19426721 19255062 20137499 9163691 19812893 20583210 12112319 15885732 18648771 10737359 19638242 19850985 19499222 21047994 18977376 20434301 20452335 19073162 19690152 19996281 18644402 12771043 18754104 19254457 15175105
MESH:D008113 Liver Neoplasms pirinixic acid 14.5415890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.5416984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 10.108603461
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.1019539802 17942915 18079962 18308698 18544905 21159647 18775883 18093689 16267830 17174075 19009564 19126423 19519916 18253720 2563599 18164116 9362446 19004024 17854601 16842330 3124819 18282651
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.1012151625
MESH:D008171 Lung Diseases Vitamin E 3.2316863852
MESH:D008175 Lung Neoplasms Aflatoxin B1 6.6814755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.6820464547 18520028 18569708 20869020 18816296 6695378 20135361 17053015 20064080
MESH:D008175 Lung Neoplasms Diethylnitrosamine 6.6821163286 6695378 20970405 20512841
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.6819555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 6.6811062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8115318939
MESH:D008545 Melanoma Carmustine 2.8712393984
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D008654 Mesothelioma Selenium 2.8215107826
MESH:D008661 Metabolism, Inborn Errors marker/mechanism
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9216801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2516381670
MESH:D009135 Muscular Diseases pirinixic acid 3.6116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1719151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0116411023
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.599029167 3581430
MESH:D009369 Neoplasms Benzo(a)pyrene 4.9511141357
MESH:D009369 Neoplasms pirinixic acid 4.9517405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3618481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3114600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.4118514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.4120387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2520387270
MESH:D009765 Obesity pirinixic acid 1.8320558911
MESH:D010146 Pain Acetaminophen 2.4616870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4516540662
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D010954 Plasmacytoma Selenium 5.0215087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011230 Precancerous Conditions Cyclosporine 9.1912371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.192563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3111399792 11118676 11896295 11222880
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1717292933
MESH:D011471 Prostatic Neoplasms Vitamin E 3.1715084515
MESH:D011565 Psoriasis Cyclosporine 2.2516882103
MESH:D011658 Pulmonary Fibrosis troglitazone 3.9218162602
MESH:D015427 Reperfusion Injury pirinixic acid 2.4219058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012871 Skin Diseases Vitamin E 2.4618709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.5919755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.5916192470
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.552093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.5518456281
MESH:D013274 Stomach Neoplasms troglitazone 3.5515930296
MESH:D020521 Stroke Vitamin E 3.5816517955
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.047505956
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2017053015
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D014605 Uveitis Cyclosporine 4.121336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
MESH:D014985 Xerophthalmia Cyclosporine 4.5817120751
Pathway ID Pathway Name
KEGG:00620 Pyruvate metabolism
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00143 - BSS Plus Dietary supplement;Micronutrient
DB03889 - S-(N-Hydroxy-N-Bromophenylcarbamoyl)Glutathione
DB04184 - Acetate Ion Indicators and Reagents
DB04399 - Cacodylate Ion Herbicides
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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