AutismKB 2.0

Annotation Detail for HADHA


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:HADHA ( ECHA,GBP,HADH,LCEH,LCHAD,MGC1728,MTPA,TP-ALPHA )
Gene Full Name: hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
Band: 2p23.3
Quick LinksEntrez ID:3030; OMIM: 600890; Uniprot ID:ECHA_HUMAN; ENSEMBL ID: ENSG00000084754; HGNC ID: 4801
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
VALDEG-PWYvaline degradation I
ILEUDEG-PWYisoleucine degradation I
FAO-PWYfatty acid beta-oxidation I
Pathway IDPathway Name
hsa00410beta-Alanine metabolism
hsa00310Lysine degradation
hsa00380Tryptophan metabolism
hsa00280Valine, leucine and isoleucine degradation
hsa00640Propanoate metabolism
hsa01100Metabolic pathways
hsa00650Butanoate metabolism
hsa00062Fatty acid elongation in mitochondria
hsa01040Biosynthesis of unsaturated fatty acids
hsa00071Fatty acid metabolism
Pathway IDPathway Name
Metabolism of lipids and lipoproteins
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
No data
No data
Desease Name
Trifunctional protein deficiency
LCHAD deficiency
Fatty liver, acute, of pregnancy
HELLP syndrome, maternal, of pregnancy
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of HADHA mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of HADHA mRNAaffects expression 16483693
D001629 Bezafibrate Bezafibrate results in increased expression of HADHA mRNAincreases expression 17118139
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of HADHA mRNAaffects expression 15963342
C099555 CD 437 CD 437 results in decreased expression of HADHA mRNAdecreases expression 12958071
D016572 Cyclosporine Cyclosporine results in decreased expression of HADHA mRNAdecreases expression 20106945
D019259 Lamivudine [Zidovudine co-treated with Lamivudine] results in increased expression of HADHA mRNAaffects cotreatment|increases expression 18313992
D004041 Dietary Fats Dietary Fats results in increased expression of HADHA mRNAincreases expression 18042831
16357043
D004052 Diethylnitrosamine [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of HADHA mRNAaffects cotreatment|increases expression 16158176
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of HADHA mRNAincreases expression 16174780
D011345 Fenofibrate Fenofibrate results in increased expression of HADHA mRNAincreases expression 17118139
D011345 Fenofibrate Fenofibrate results in increased expression of HADHA mRNAincreases expression 16707586
D005419 Flavonoids Flavonoids results in increased expression of HADHA mRNAincreases expression 18035473
D015073 2-Acetylaminofluorene [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of HADHA mRNAaffects cotreatment|increases expression 16158176
D005485 Flutamide Flutamide results in decreased expression of HADHA mRNAdecreases expression 17702527
D005978 Glutathione Glutathione deficiency results in increased expression of HADHA mRNAincreases expression 15345336
C041786 palm oil palm oil results in increased expression of HADHA mRNAincreases expression 18042831
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of HADHA mRNAincreases expression 18467677
17681415
C023036 perfluorooctanoic acid PPARA protein promotes the reaction [perfluorooctanoic acid results in increased expression of HADHA mRNA]increases expression|increases reaction 18467677
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of HADHA mRNAincreases expression 16221955
D010634 Phenobarbital Phenobarbital results in increased expression of HADHA mRNAincreases expression 12082028
C006253 pirinixic acid pirinixic acid results in increased expression of HADHA mRNAincreases expression 17426115
18467677
16357043
17118139
18301758
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of HADHA mRNA]increases expression|increases reaction 18467677
C006253 pirinixic acid pirinixic acid results in increased expression of HADHA mRNAincreases expression 16707586
D012643 Selenium Selenium results in decreased expression of HADHA mRNAdecreases expression 19244175
D018038 Sodium Selenite Sodium Selenite results in increased expression of HADHA mRNAincreases expression 18175754
C004648 testosterone enanthate testosterone enanthate affects the expression of HADHA mRNAaffects expression 17440010
D013752 Tetracycline Tetracycline results in increased expression of HADHA mRNAincreases expression 16917069
D014303 Trinitrotoluene Trinitrotoluene affects the expression of HADHA mRNAaffects expression 21346803
D014810 Vitamin E Vitamin E results in decreased expression of HADHA mRNAdecreases expression 19244175
D015215 Zidovudine [Zidovudine co-treated with Lamivudine] results in increased expression of HADHA mRNAaffects cotreatment|increases expression 18313992
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.096195326
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 8.097525203
MESH:D000138 Acidosis Ammonium Chloride 3.3518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7317505938
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.629612607
MESH:D055371 Acute Lung Injury pirinixic acid 2.9218653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.7614692618
MESH:D000236 Adenoma 2-Acetylaminofluorene 6.6310737359
MESH:D000236 Adenoma Diethylnitrosamine 6.6310737359 6695378
MESH:D002759 Adenoma, Bile Duct 2-Acetylaminofluorene 5.806705139
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 16.1319052882 17162532 17620307 18056438 19061943 16434500
MESH:D018248 Adenoma, Liver Cell Phenobarbital 16.1317620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 16.1316434500
MESH:D001161 Arteriosclerosis Dietary Fats 9.2215238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.2211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5415885639
MESH:D001321 Autistic Disorder Glutathione 3.0316917939 19056591 19267885 18929414
MESH:D001778 Blood Coagulation Disorders pirinixic acid 2.9619483382
MESH:D001943 Breast Neoplasms Dietary Fats 2.2220435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2217474063
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 9.2416050911 15700767 16192424 15721981 18705752 16097048 3786805 16227642 16011737 16124888 15673190 10355542
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 9.2416050911
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 8.5116705839
MESH:D006528 Carcinoma, Hepatocellular 2-Acetylaminofluorene 8.5110737359 6705139 3084413 3581430 17761372
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 8.5118788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 8.5119519916 16569478 11831363 19208518 18971187 3084413 18691550 18210153 21159647 19701751 20084675 16878318 17162532 20214788 16807293 17055752 3581430 18506893 17761372 18393292 16779866 19052882 16681979 10672840 18665156 19171122 19394651 17138121 19383236 16935385 20524982 19539802 18978308 17978847 17428255 16288022 18056438 17173139 20512989 19919837 18494052 16328049 20007298 16830150 19418558 16502159 19335982 20514400 16698587 20727157 19107877 18788625 20935162 19822196 20432363 18785209 16540662 20101231 10737359
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 8.5117173139 1701930 20935162 6705139 20007298
MESH:D002294 Carcinoma, Squamous Cell Glutathione 3.3217015178
MESH:D002386 Cataract Trinitrotoluene 3.7515817613 14694615
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 10.336135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.3312371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 10.3317174075 2727394 21159647 7505956
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.044080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.5119052882
MESH:D002779 Cholestasis Cyclosporine 12.4519486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.4516919318 15861022 17333356 17110522 17681005 11677210 16105132
MESH:D002779 Cholestasis pirinixic acid 12.4519176532
MESH:D019457 Chromosome Breakage Sodium Selenite 4.5415894690
MESH:D003092 Colitis Selenium 3.5717936198
MESH:D000013 Congenital Abnormalities Trinitrotoluene 4.2215095906
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9019769572
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.5418551238
MESH:D003490 Cyanosis Trinitrotoluene 10.5418551238
MESH:D003550 Cystic Fibrosis Glutathione 4.3119747007
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3318249437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.6016285004
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.1420387270
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 17.7118551238 21346803
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 17.713786805 10915739 4309450 17522070 19336974 16177239 7120509 2869522 3732212 15968718 6884620 16227642 15998439 19085960 10092053 9327722 11566570 21278145 6623471 7440962 15027814 7179309
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 17.7119107877
MESH:D056486 Drug-Induced Liver Injury Selenium 17.7115131321
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 17.7115131321
MESH:D056486 Drug-Induced Liver Injury Tetracycline 17.7117522070
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 17.7121346803 18551238
MESH:D004362 Drug Toxicity Lamivudine 8.2815040536
MESH:D004362 Drug Toxicity Zidovudine 8.2815040536
MESH:D050171 Dyslipidemias Dietary Fats 8.4618367378
MESH:D050171 Dyslipidemias Fenofibrate 8.4616707586
MESH:D004421 Dystonia Phenobarbital 3.811851702
MESH:C538011 Eales disease Vitamin E 4.499068938
MESH:D004487 Edema perfluorooctanoic acid 6.3612083418 17259670
MESH:D004487 Edema pirinixic acid 6.3612083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.9912538720
MESH:D016889 Endometrial Neoplasms Fenofibrate 3.9616569247
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.903659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.663922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.7820417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.376401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.047750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.813659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9016302075
MESH:D005234 Fatty Liver Carbon Tetrachloride 40.0761145 15959796 19224547 12631006 16045604 12795759 16239168 17595544
MESH:D005234 Fatty Liver Cyclosporine 40.0719224547
MESH:D005234 Fatty Liver Dietary Fats 40.0717967931 19004024 19551842 18296743
MESH:D005234 Fatty Liver Diethylnitrosamine 40.0721071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 40.0715345470
MESH:D005234 Fatty Liver pirinixic acid 40.0720131406 19236843
MESH:D005234 Fatty Liver Tetracycline 40.0716917069 19224547
MESH:D005234 Fatty Liver Zidovudine 40.0718299183
MESH:D005355 Fibrosis Carbon Tetrachloride 13.5918705752
MESH:D005355 Fibrosis Cyclosporine 13.5912639820 12168785
MESH:D005355 Fibrosis Dietary Fats 13.5918296743
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.018708960
MESH:D006330 Heart Defects, Congenital Vitamin E 2.8816080930
MESH:D006333 Heart Failure pirinixic acid 6.5320558911
MESH:D006333 Heart Failure Selenium 6.5317162251
MESH:D006390 Hemangioendothelioma 2-Acetylaminofluorene 5.106705139
MESH:D006394 Hemangiosarcoma 2-Acetylaminofluorene 4.226705139
MESH:D006402 Hematologic Diseases Zidovudine 4.5212579204
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2115720958
MESH:D006505 Hepatitis Carbon Tetrachloride 3.3919900420 19110552
MESH:D006509 Hepatitis B Lamivudine 4.9117703166
MESH:D019694 Hepatitis B, Chronic Lamivudine 4.9115274664 16476009 15309715 15631357 12044531
MESH:D006529 Hepatomegaly perfluorooctanoic acid 19.053609246
MESH:D006529 Hepatomegaly Phenobarbital 19.0516109766
MESH:D006529 Hepatomegaly pirinixic acid 19.0519176532 16221962 18467677 19772884
MESH:D006529 Hepatomegaly Trinitrotoluene 19.0515817613
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6316490937 16863852
MESH:D015658 HIV Infections Lamivudine 6.7011141242 17530837 9296927 20032539
MESH:D015658 HIV Infections Zidovudine 6.7011141242 17358032 20032539 11363243 11698656
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.5317440010
MESH:D019584 Hot Flashes Vitamin E 3.7614716179
MESH:D006930 Hyperalgesia perfluorooctanoic acid 3.6912083418
MESH:D017588 Hyperandrogenism Flutamide 5.2515356085
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3216899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.4021332399
MESH:D006943 Hyperglycemia pirinixic acid 3.0020558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.4221332399
MESH:D006973 Hypertension Cyclosporine 2.0210903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8815338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6016569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.4317937319
MESH:D007248 Infertility, Male Trinitrotoluene 6.4312150543
MESH:D007249 Inflammation Dietary Fats 11.1220412841
MESH:D007249 Inflammation Diethylnitrosamine 11.1218785209
MESH:D007249 Inflammation Flavonoids 11.1217296493
MESH:D007249 Inflammation perfluorooctanoic acid 11.1212083418
MESH:D007251 Influenza, Human Selenium 10.2516624496
MESH:D007251 Influenza, Human Vitamin E 10.2516624496
MESH:D007333 Insulin Resistance Dietary Fats 11.5518457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 11.5516306350
MESH:D007333 Insulin Resistance Sodium Selenite 11.5514714311
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2315604871
MESH:D007674 Kidney Diseases Cyclosporine 5.6218776723 10903974 8314463
MESH:D007674 Kidney Diseases Vitamin E 5.6212488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.7016518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 11.4916705839
MESH:D007680 Kidney Neoplasms Cyclosporine 11.4912371664
MESH:D007680 Kidney Neoplasms Zidovudine 11.4912579204
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.2220370541
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 5.028812269
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 14.8111408273 16239168 16943688 17157831 16221502 21278145 11903743 17334410 17174718
MESH:D008103 Liver Cirrhosis Dietary Fats 14.8118296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 14.8118665156 18407596 19638242 20032147 18522880
MESH:D008103 Liver Cirrhosis Phenobarbital 14.8121047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 4.7918210741 16116963 17698563 18317297 17708605 18420326 12445418 12958196 12389079 12632512 18395914 10355542 15931870 17823541 17805973 16011737 17922224 15057751 16638106 18418968 18412020 17631135 15338365 18263696 14620537 18429990 17761835 14716496 12632514 16033810 18472332 15362042 17869086 12445421 15730626 12666154 17481882 15876570 14748882 13678700 15673190 16097048 16136751 15052691 18054572 12586293 18006644 17976157 18277467 16027843 15925388 18481824 16248980 15650968 18472094 14724832 16015684 18166357 12649538 12667390 12546737 15893842 12898905 15370692 17714472 18205269 18251166 18279442 15818738 17944888 12741479 18705752 17557913 15959796 18376398 17640975 16192424 17565644 17525996 17766677 17721639 20821823 17900296 15996030 11481614 18187930 18339082 18395095 18156304 14512876 14716833 12609069 15123356
MESH:D008106 Liver Cirrhosis, Experimental Fenofibrate 4.7915474484
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.7915474484
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 4.7916169303
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.2216246199 15830285 15720792 16964402 17285989
MESH:D008107 Liver Diseases Diethylnitrosamine 6.2217034775
MESH:D008107 Liver Diseases Phenobarbital 6.2219363144
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9615123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.5114706259 16899240
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 24.577678174
MESH:D008113 Liver Neoplasms 2-Acetylaminofluorene 24.5710672840 10737359 18001218 11376686 16273603 14678523
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 24.5719294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 24.5719254457 19996281 19499222 19255062 18754104 19294768 19638242 2422723 15175105 20583210 21278145 19090486 19426721 19073162 18644402 19812893 18977376 16942905 18648771 19833225 19690152 2862719 20452335 19642983 12112319 20405173 20101389 19850985 12771043 19427195 20137499 20434301 20501860 10737359 21167192 19256749 20118626 21071580 18978307 19551842 20492335 9163691 21047994 15885732
MESH:D008113 Liver Neoplasms Fenofibrate 24.5718978307
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 24.5714757943 18709148
MESH:D008113 Liver Neoplasms Phenobarbital 24.5719482888 19812893 8742319 19073162 21047994 15975961
MESH:D008113 Liver Neoplasms pirinixic acid 24.5720007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 21.702876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental 2-Acetylaminofluorene 21.706150874 534488 1399818
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 21.7012014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 21.702563599 18775883 21159647 18079962 17942915 19539802 18253720 19009564 18282651 16267830 19004024 19519916 17854601 18308698 3124819 18544905 19126423 17174075 18164116 9362446 16842330 18093689
MESH:D008114 Liver Neoplasms, Experimental Fenofibrate 21.7018775883 18253720
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 21.702563599 17172636 18308698 1399818 6150874
OMIM:609016 LONG-CHAIN 3-HYDROXYACYL-CoA DEHYDROGENASE DEFICIENCY marker/mechanism
MESH:D008171 Lung Diseases Vitamin E 3.0416863852
MESH:D008175 Lung Neoplasms 2-Acetylaminofluorene 4.7311376686
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.7320970405 20512841 21163286 6695378
MESH:D008175 Lung Neoplasms Vitamin E 4.7311062179
MESH:D008175 Lung Neoplasms Zidovudine 4.7318800350
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 3.8614737004
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.6315318939
MESH:D008654 Mesothelioma Selenium 2.7115107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5816801185
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.6317358032
MESH:D009135 Muscular Diseases Bezafibrate 10.0416239165
MESH:D009135 Muscular Diseases pirinixic acid 10.0416239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.0619151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.7916411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.2617484760
MESH:D009336 Necrosis 2,6-dinitrotoluene 9.9818551238 7678174
MESH:D009336 Necrosis Trinitrotoluene 9.9818551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.483581430 9029167
MESH:D009369 Neoplasms pirinixic acid 1.8517405874
MESH:D009395 Nephritis, Interstitial Tetracycline 4.579884423
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2317954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1119348381 18481113
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.1720387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9020387270
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 4.759802331
MESH:D009765 Obesity Dietary Fats 4.2521332399 11836018 17217161 20132043 16723640 18674790 18457598 19632207 20518802
MESH:D009765 Obesity pirinixic acid 4.2520558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.6116049721
MESH:D009784 Occupational Diseases Trinitrotoluene 8.6112819281 17852074 14694615
MESH:D010018 Osteomalacia Phenobarbital 4.1517016548
MESH:D010051 Ovarian Neoplasms CD 437 3.2517474084
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.0116540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.0116965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4911578682
MESH:D010391 Pemphigoid, Bullous Tetracycline 5.2211026799
MESH:D010954 Plasmacytoma Selenium 4.6815087411
MESH:D011085 Polycystic Ovary Syndrome Flutamide 4.8215356085
MESH:D011230 Precancerous Conditions Cyclosporine 14.2512371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 14.252563599
MESH:D011230 Precancerous Conditions Phenobarbital 14.252563599
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 4.1917132714
MESH:D017096 Prion Diseases Tetracycline 5.2010903871
MESH:D011471 Prostatic Neoplasms Flutamide 2.823169114
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.8218760546
MESH:D011471 Prostatic Neoplasms Vitamin E 2.8215084515
MESH:D011537 Pruritus Ethinyl Estradiol 3.1016919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 4.2812752131
MESH:D011565 Psoriasis Cyclosporine 2.1616882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.2919058328
MESH:D012206 Rhabdomyolysis Lamivudine 5.329296927
MESH:D012640 Seizures 2,6-dinitrotoluene 9.1118551238
MESH:D012640 Seizures Phenobarbital 9.113137016 11442880 16876388 4039156
MESH:D012640 Seizures Trinitrotoluene 9.1118551238
MESH:D003294 Seizures, Febrile Phenobarbital 4.616407741
MESH:D012871 Skin Diseases Vitamin E 2.3918709164
MESH:D013088 Spermatocele Ethinyl Estradiol 3.7316709447
MESH:D013163 Splenomegaly Trinitrotoluene 4.9915817613
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.6218456281
MESH:D013274 Stomach Neoplasms Zidovudine 2.6217696246
MESH:D020521 Stroke Vitamin E 3.3616517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9815669648
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 6.667505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 6.661399818
OMIM:609015 TRIFUNCTIONAL PROTEIN DEFICIENCY marker/mechanism
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.0816049721
MESH:D001749 Urinary Bladder Neoplasms 2-Acetylaminofluorene 8.081399818 15289314 15867355
MESH:D001749 Urinary Bladder Neoplasms CD 437 8.0816720286
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.1110091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1014692618
MESH:D014605 Uveitis Cyclosporine 3.771336536
MESH:D014625 Vaginal Neoplasms Zidovudine 4.5512579204
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3514671159 15869587
MESH:D015430 Weight Gain Dietary Fats 3.5616723640
MESH:D014985 Xerophthalmia Cyclosporine 4.2317120751
Pathway ID Pathway Name
KEGG:00410 beta-Alanine metabolism
KEGG:01040 Biosynthesis of unsaturated fatty acids
KEGG:00650 Butanoate metabolism
KEGG:00062 Fatty acid elongation in mitochondria
KEGG:00071 Fatty acid metabolism
KEGG:00310 Lysine degradation
KEGG:01100 Metabolic pathways
REACT:22258 Metabolism of lipids and lipoproteins
KEGG:00640 Propanoate metabolism
KEGG:00380 Tryptophan metabolism
KEGG:00280 Valine, leucine and isoleucine degradation
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00157 - NADH Dietary supplement;Micronutrient
No data
No data
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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