AutismKB 2.0

Annotation Detail for HAL


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:HAL ( HIS,HSTD )
Gene Full Name: histidine ammonia-lyase
Band: 12q23.1
Quick LinksEntrez ID:3034; OMIM: 609457; Uniprot ID:HUTH_HUMAN; ENSEMBL ID: ENSG00000084110; HGNC ID: 4806
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-5030histidine degradation III
Pathway IDPathway Name
hsa00910Nitrogen metabolism
hsa01100Metabolic pathways
hsa00340Histidine metabolism
Pathway IDPathway Name
Metabolism of amino acids and derivatives
No data
No data
Pathway IDPathway Name
500960Histidine catabolism
Related Diseases/Disorders Top
Desease IDDesease Name
Inherited disorders of amino acid metabolism
H00171Histidinemia
Genetic disorders
No data
No data
No data
Desease Name
Histidinemia
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C014211 2,3,7,8-tetrachlorodibenzofuran 2,3,7,8-tetrachlorodibenzofuran affects the expression of HAL mRNAaffects expression 18343893
C014024 2,4,5,2',4',5'-hexachlorobiphenyl [3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of HAL mRNAaffects cotreatment|decreases expression 16984957
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of HAL mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in decreased expression of HAL mRNAdecreases expression 20406850
C023035 3,4,5,3',4'-pentachlorobiphenyl [3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of HAL mRNAaffects cotreatment|decreases expression 16984957
C026137 3-hydroxyacetanilide 3-hydroxyacetanilide results in decreased expression of HAL mRNAdecreases expression 18544908
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of HAL mRNAincreases expression 18648102
D000082 Acetaminophen [Dietary Carbohydrates co-treated with Acetaminophen] results in increased expression of HAL mRNAaffects cotreatment|increases expression 17093179
D000082 Acetaminophen Acetaminophen affects the expression of HAL mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in decreased expression of HAL mRNAdecreases expression 18544908
D000082 Acetaminophen Acetaminophen affects the expression of HAL proteinaffects expression 16687475
D000082 Acetaminophen Acetaminophen results in decreased expression of HAL mRNAdecreases expression 18346771
D019386 Alendronate Alendronate affects the expression of HAL mRNAaffects expression 16079270
D024502 alpha-Tocopherol alpha-Tocopherol results in increased expression of HAL mRNAincreases expression 16908007
D000638 Amiodarone Amiodarone affects the expression of HAL mRNAaffects expression 19483382
D000643 Ammonium Chloride Ammonium Chloride affects the expression of HAL mRNAaffects expression 16483693
D001553 Benzbromarone Benzbromarone affects the expression of HAL mRNAaffects expression 19483382
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of HAL mRNAaffects cotreatment|decreases expression 18164116
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of HAL mRNAdecreases expression 18346771
D002994 Clofibrate Clofibrate affects the expression of HAL mRNAaffects expression 19483382
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of HAL mRNAaffects cotreatment|affects expression 17602206
D003314 Corn Oil Corn Oil affects the expression of HAL mRNAaffects expression 16360708
C030123 coumarin coumarin results in decreased expression of HAL mRNAdecreases expression 18480146
D016572 Cyclosporine Cyclosporine results in decreased expression of HAL mRNAdecreases expression 20106945
D004040 Dietary Carbohydrates [Dietary Carbohydrates co-treated with Acetaminophen] results in increased expression of HAL mRNAaffects cotreatment|increases expression 17093179
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of HAL mRNAaffects cotreatment|decreases expression 18164116
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of HAL mRNAaffects cotreatment|affects expression 17602206
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of HAL mRNAdecreases expression 19638242
D002117 Calcitriol Calcitriol results in increased expression of HAL mRNAincreases expression 12798352
D004958 Estradiol Estradiol results in decreased expression of HAL mRNAdecreases expression 20106945
D000431 Ethanol [Fish Oils co-treated with Ethanol] results in increased expression of HAL mRNAaffects cotreatment|increases expression 17347304
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of HAL mRNAincreases expression 17555576
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HAL mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of HAL mRNAaffects expression 16079270
D005001 Ethionine Ethionine affects the expression of HAL mRNAaffects expression 19483382
D005395 Fish Oils [Fish Oils co-treated with Ethanol] results in increased expression of HAL mRNAaffects cotreatment|increases expression 17347304
C056933 fumonisin B1 fumonisin B1 results in decreased expression of HAL mRNAdecreases expression 16221962
D005912 Gliotoxin Gliotoxin results in decreased expression of HAL mRNAdecreases expression 18346771
C482199 lipopolysaccharide, E coli O55-B5 lipopolysaccharide, E coli O55-B5 results in decreased expression of HAL mRNAdecreases expression 18346771
D008730 Methoxsalen Methoxsalen results in decreased activity of HAL proteindecreases activity 20880231
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of HAL mRNAincreases expression 17616710
D009853 Omeprazole Omeprazole affects the expression of HAL mRNAaffects expression 19483382
D019308 Palmitic Acid Palmitic Acid results in increased expression of HAL mRNAincreases expression 17658692
C023036 perfluorooctanoic acid perfluorooctanoic acid affects the expression of HAL mRNAaffects expression 18281256
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of HAL mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of HAL mRNAdecreases expression 19482888
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of HAL mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of HAL mRNAdecreases expression 20059764
18445702
16221962
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in decreased expression of HAL mRNA]decreases expression|increases reaction 20059764
C006253 pirinixic acid pirinixic acid affects the expression of HAL mRNAaffects expression 19483382
C006253 pirinixic acid pirinixic acid results in decreased expression of HAL mRNAdecreases expression 17164430
D011441 Propylthiouracil Propylthiouracil affects the expression of HAL mRNAaffects expression 19483382
D020849 Raloxifene Raloxifene affects the expression of HAL mRNAaffects expression 16079270
C488333 Ro 65-7199 Ro 65-7199 results in decreased expression of HAL mRNAdecreases expression 14610520
C488334 Ro 66-0074 Ro 66-0074 affects the expression of HAL mRNAaffects expression 14610520
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of HAL mRNAdecreases expression 11489354
20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of HAL mRNAaffects expression 18343893
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HAL mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of HAL mRNAdecreases expression 16960034
11906171
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of HAL mRNAdecreases expression 16054898
16960034
18178546
D013853 Thioacetamide Thioacetamide affects the expression of HAL mRNAaffects expression 19483382
D014212 Tretinoin Tretinoin results in increased expression of HAL mRNAincreases expression 16604517
C034028 vanadyl sulfate vanadyl sulfate results in increased expression of HAL mRNAincreases expression 16330358
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 11.4517676605 18926900
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 11.456195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 11.4515322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 8.8518287403
MESH:D000138 Acidosis Ethanol 8.8511192467
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.4517505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.6718653653
MESH:D000230 Adenocarcinoma Estradiol 3.7311473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 3.7314692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 9.493712494
MESH:D000236 Adenoma beta-Naphthoflavone 9.4919389873
MESH:D000236 Adenoma Diethylnitrosamine 9.4910737359 6695378
MESH:D018248 Adenoma, Liver Cell 3,4,5,3',4'-pentachlorobiphenyl 27.5116628245
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 27.5119061943 17620307 16434500 19052882 18056438 17162532
MESH:D018248 Adenoma, Liver Cell Phenobarbital 27.5117620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 27.5116434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 27.5116835633
MESH:D000419 Albuminuria Raloxifene 4.1317308373 17451421
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 4.8215451039 15451040
MESH:D000505 Alopecia Tretinoin 3.2315955085
MESH:D000544 Alzheimer Disease Raloxifene 2.4215800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.5311748828
MESH:D000799 Angioedema Acetaminophen 3.3510982225
MESH:D000853 Anophthalmos Ethanol 4.3415513904
MESH:D001008 Anxiety Disorders Ethanol 3.6211141031
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.3820041841 18057881 18218290
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 2.9911256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.1615885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.1616412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.1416292516
MESH:D001249 Asthma Tretinoin 2.1816456186
MESH:D001281 Atrial Fibrillation Amiodarone 3.5418651412 19698954
MESH:D001321 Autistic Disorder Acetaminophen 1.4818445737
MESH:D001471 Barrett Esophagus Tretinoin 3.9416935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.521440618 11289319
MESH:D001778 Blood Coagulation Disorders Amiodarone 56.5519483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 56.5519483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 56.5519483382
MESH:D001778 Blood Coagulation Disorders Ethionine 56.5519483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 56.5519483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 56.5519483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 56.5519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 56.5512125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 56.5519483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 56.5516197459 16206674
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.2915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.4415746008
MESH:D001930 Brain Injuries Raloxifene 4.0016580743
MESH:D001943 Breast Neoplasms Calcitriol 2.6711237771
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.6717474063
MESH:D001943 Breast Neoplasms Estradiol 2.6717289903 16675129 12948864 14630087 18497071 19861407 17261762 17018787
MESH:D001943 Breast Neoplasms Raloxifene 2.6715758505 17242785 16912660 17049068 15572757 17952589 17893378 15775269 16837676 17595753 17261762 17440819
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.6720435547
MESH:D001943 Breast Neoplasms Tretinoin 2.6716166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.1016813970
MESH:D002056 Burns Ethanol 4.1816374292
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.9816111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.3118705752 15673190 16192424 16124888 10355542 16097048 16011737 15721981 16050911 15700767 16227642 3786805
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.4116835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.6616168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 26.8216705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 26.8216705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 26.823581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 26.823084413
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 26.821701930
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 26.8218788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 26.8220084675 16288022 16779866 17173139 19107877 18788625 18978308 18210153 19418558 19701751 18665156 19919837 20512989 18506893 17162532 3084413 16830150 17761372 18494052 16502159 16807293 19539802 17428255 17978847 16681979 20514400 16698587 19171122 19519916 20727157 18691550 18393292 20101231 17138121 18971187 16878318 19335982 19052882 10737359 16328049 20935162 19208518 3581430 17055752 21159647 10672840 20524982 16540662 18785209 20214788 19822196 16569478 19394651 16935385 20007298 19383236 18056438 20432363 11831363
MESH:D006528 Carcinoma, Hepatocellular Estradiol 26.8216924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 26.8215289165 15763234 18788625
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 26.8220935162 17173139 20007298 1701930 6705139
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 26.8217997003
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 26.821917145
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.437296757
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 4.2311237771
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.2316051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 3.6517572228
MESH:D006332 Cardiomegaly Ethanol 5.9019332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 5.9018850075 18670907 16120746
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.7115710769 19225199
MESH:D002318 Cardiovascular Diseases Raloxifene 3.1115775269
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.6018974383
MESH:D002386 Cataract Acetaminophen 6.2310977129
MESH:D002386 Cataract Tretinoin 6.2317460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 21.916135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 21.917505956
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 21.911399818
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 21.9112371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 21.9117174075 21159647 7505956 2727394
MESH:D002471 Cell Transformation, Neoplastic Estradiol 21.9118566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.784080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.1016129372
MESH:D002637 Chest Pain Omeprazole 4.6115447763
MESH:D018281 Cholangiocarcinoma 3,4,5,3',4'-pentachlorobiphenyl 19.7416628245
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 19.7419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 19.7416835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 19.7418291259
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 16.229022650 19486331
MESH:D002779 Cholestasis Cyclosporine 16.2219486331
MESH:D002779 Cholestasis Ethinyl Estradiol 16.2216105132 17110522 16919318 15861022 17681005 11677210 17333356
MESH:D002779 Cholestasis pirinixic acid 16.2219176532
MESH:D002822 Choriocarcinoma Tretinoin 4.6616461808
MESH:D002971 Cleft Lip Ethanol 3.3215513904
MESH:D002972 Cleft Palate Ethanol 8.5315513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 8.5315668235 15340226 12621046 8697196 16354765
MESH:D002972 Cleft Palate Tretinoin 8.539407595
MESH:D003072 Cognition Disorders Raloxifene 4.1415800139
MESH:D003092 Colitis Tretinoin 3.2317035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.6517141729 14669216
MESH:D019465 Craniofacial Abnormalities 3,4,5,3',4'-pentachlorobiphenyl 4.9217686920
MESH:D019465 Craniofacial Abnormalities Ethanol 4.9215451039 10194807 19302082 15513904 11198716 11873399 15451040
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 4.9220055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 4.929211117 16925845 9142499 17551590 8800419 10589399 9224671 9664655 9125849 14991402
MESH:D003490 Cyanosis 2,4-dinitrotoluene 9.3118551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 9.3118551238
MESH:D003865 Depressive Disorder, Major Raloxifene 3.7517474826
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.368156756 2524372 18759878 11298694 12868966 8970840 11906362 14531868
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.1818249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.043621924 2952479
MESH:D003921 Diabetes Mellitus, Experimental vanadyl sulfate 3.9816684804
MESH:D003924 Diabetes Mellitus, Type 2 alpha-Tocopherol 9.1316506275
MESH:D003924 Diabetes Mellitus, Type 2 coumarin 9.1319647726
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 9.1320387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 9.1317107852
MESH:D003928 Diabetic Nephropathies Estradiol 7.6519279558
MESH:D003928 Diabetic Nephropathies Raloxifene 7.6517308373 17451421 15920148
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 33.1518551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 33.1518551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 33.1518289764 11289319 18692083 6482804 9328219 1440618 9022650 7440962 16192314 18648102 6679447 9653073 8291058
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 33.1519420014 14986274 12540782 16781746 17562736 11287661 19923254 16177239 2444490 19739265 15619225 11421492 19370779 16393943 10774834 12705907 11739529 18071297 19164858 11461765 11743745 11834606 12594235 15968718 12392966 17522070 16485898 16109766 14550746 16227642 11529661 19085960 10663392 16081117 18713872 19416960 17906064 14725611 12153990 12958197 10915739
MESH:D056486 Drug-Induced Liver Injury Amiodarone 33.1518218290 15265979
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 33.1517522070 7179309 10915739 10092053 16177239 6884620 9327722 19336974 2869522 3786805 21278145 3732212 19085960 7120509 15968718 15027814 7440962 11566570 16227642 4309450 15998439 6623471
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 33.1519107877
MESH:D056486 Drug-Induced Liver Injury Ethanol 33.1511566570
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 33.1516221962
MESH:D056486 Drug-Induced Liver Injury Gliotoxin 33.1519739265
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 33.1520420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 33.1512963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.6019426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.4011462148
MESH:D004381 Duodenal Ulcer Omeprazole 3.8715991576 21218061 17151854 16613094
MESH:D050171 Dyslipidemias Clofibrate 3.7116707586
MESH:D004421 Dystonia Phenobarbital 3.551851702
MESH:D004485 Eczema Methoxsalen 5.5616259964
MESH:D004487 Edema perfluorooctanoic acid 12.9212083418 17259670
MESH:D004487 Edema pirinixic acid 12.9212083418
MESH:D004487 Edema Raloxifene 12.9215860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 12.9212711302 11000095
MESH:D004489 Edema, Cardiac 3,4,5,3',4'-pentachlorobiphenyl 18.2217686920
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 18.2215322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 18.2218230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 12.7415138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 12.7412538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 12.7415845917
MESH:D016889 Endometrial Neoplasms Estradiol 6.3211473722 19148513 18566989
MESH:D016889 Endometrial Neoplasms Tretinoin 6.3216569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.6010568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.633659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.383922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.6320417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.136401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.787750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.533659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.6216302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 6.503581430
MESH:D004938 Esophageal Neoplasms Ethanol 6.5016704527
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 6.5015264214 15547721 15547733 15150132 16510608 15623463 16805852 16704527 15878914
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.6111564622
MESH:D005124 Eye Abnormalities Tretinoin 7.6116938888 9664655
MESH:D005218 Fat Necrosis Thioacetamide 5.2216456712
MESH:D005234 Fatty Liver Amiodarone 46.9914986274
MESH:D005234 Fatty Liver Carbon Tetrachloride 46.9917595544 15959796 16239168 16045604 61145 12795759 19224547 12631006
MESH:D005234 Fatty Liver Clofibrate 46.9919224547
MESH:D005234 Fatty Liver Cyclosporine 46.9919224547
MESH:D005234 Fatty Liver Diethylnitrosamine 46.9921071580 20387270
MESH:D005234 Fatty Liver Ethanol 46.9918620774 19236843 16409862
MESH:D005234 Fatty Liver Ethinyl Estradiol 46.9915345470
MESH:D005234 Fatty Liver Fish Oils 46.9918620774
MESH:D005234 Fatty Liver pirinixic acid 46.9919236843 20131406
MESH:D005234 Fatty Liver Raloxifene 46.9917473493
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.1717920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.8116946407 15513904 10194807 15451040
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.9811858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.526705139
MESH:D005355 Fibrosis Carbon Tetrachloride 17.2418705752
MESH:D005355 Fibrosis Cyclosporine 17.2412168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 17.2420067830
MESH:D005355 Fibrosis Tretinoin 17.2417994277
MESH:D005756 Gastritis Acetaminophen 9.4816983495
MESH:D005756 Gastritis Ethanol 9.4815046732
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.738708960
MESH:D005909 Glioblastoma Tretinoin 2.6817312396
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.597505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1010696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 2.8516096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.6616084493
MESH:D006330 Heart Defects, Congenital 2,3,7,8-tetrachlorodibenzofuran 13.8411294989
MESH:D006330 Heart Defects, Congenital 3,4,5,3',4'-pentachlorobiphenyl 13.8417686920 20471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 13.8410048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 13.8414991402 9664655
MESH:D006331 Heart Diseases Raloxifene 3.1911110106
MESH:D006333 Heart Failure pirinixic acid 2.2320558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.9315720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9011000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.1417276928 15929193 18665440
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 13.056705139
MESH:D006505 Hepatitis Carbon Tetrachloride 13.0519900420 19110552
MESH:D006505 Hepatitis Thioacetamide 13.0516456712
MESH:D006529 Hepatomegaly Amiodarone 27.6115265979
MESH:D006529 Hepatomegaly fumonisin B1 27.6116221962
MESH:D006529 Hepatomegaly perfluorooctanoic acid 27.613609246
MESH:D006529 Hepatomegaly Phenobarbital 27.6116109766
MESH:D006529 Hepatomegaly pirinixic acid 27.6119772884 16221962 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 27.6116120746 12621046 15340226
MESH:D006558 Herpes Genitalis Estradiol 4.5315709030
MESH:C538320 Histidinemia marker/mechanism
MESH:D019584 Hot Flashes Estradiol 3.2617088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.5516354765 15340226 18606429 8697196 16959395
MESH:D006930 Hyperalgesia Acetaminophen 20.4216870215
MESH:D006930 Hyperalgesia Alendronate 20.4216769263
MESH:D006930 Hyperalgesia Ethanol 20.4218783367
MESH:D006930 Hyperalgesia perfluorooctanoic acid 20.4212083418
MESH:D006930 Hyperalgesia Tretinoin 20.4216870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.0416899240
MESH:D006937 Hypercholesterolemia Amiodarone 3.448137927 9751232
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.0916778211
MESH:D006943 Hyperglycemia pirinixic acid 2.7620558911
MESH:D006949 Hyperlipidemias Fish Oils 4.3115752949
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.4615034207
MESH:D006968 Hypersensitivity, Delayed Corn Oil 11.0411484837
MESH:D006968 Hypersensitivity, Delayed Fish Oils 11.0411484837
MESH:D006973 Hypertension Cyclosporine 7.3710903974
MESH:D006973 Hypertension Raloxifene 7.3717577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 7.3718670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.6115338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.3316569931 16945680
MESH:D007037 Hypothyroidism Amiodarone 10.0317991464 18020914
MESH:D007037 Hypothyroidism Propylthiouracil 10.0318031379 8137927
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.0112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.1617937319
MESH:D007249 Inflammation Diethylnitrosamine 6.8018785209
MESH:D007249 Inflammation perfluorooctanoic acid 6.8012083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 6.8012200463 12878042
MESH:D007333 Insulin Resistance Estradiol 6.1016627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 6.1016306350
MESH:D007410 Intestinal Diseases Tretinoin 3.2917994277
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.529022650 8074119
MESH:D007569 Jaw Abnormalities Ethanol 14.6615513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 14.6616580747
MESH:D007569 Jaw Abnormalities Tretinoin 14.6615992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.9415604871
MESH:D007674 Kidney Diseases Acetaminophen 8.2612587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 8.2618776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 8.2615618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 19.1316705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 19.1316705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 19.136582329
MESH:D007680 Kidney Neoplasms Cyclosporine 19.1312371664
MESH:D007680 Kidney Neoplasms Estradiol 19.1315610895
MESH:D007859 Learning Disorders Ethanol 3.7415451040
MESH:D007889 Leiomyoma Raloxifene 4.0516973256
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 3.7019248655
MESH:D007938 Leukemia Tretinoin 2.5117143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.2616482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 1.9917596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.8316331271 19075265 17368321 17107899 17506722 17294898 17217047 17339181 19225113 16823087 16140955 9834237 19029980 17649720 12679006 16891316 16766008 16788101 15748426 17712046 16935935 17361223 17301526 19035177 19642359
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 4.748812269
MESH:D017880 Limb Deformities, Congenital Ethanol 7.1417676605
MESH:D017880 Limb Deformities, Congenital Tretinoin 7.149224671
MESH:D008064 Lipidoses Amiodarone 3.1615342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 13.4411408273 16221502 16943688 17334410 21278145 17174718 16239168 11903743 17157831
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 13.4418522880 18407596 18665156 19638242 20032147
MESH:D008103 Liver Cirrhosis Ethanol 13.4415289165
MESH:D008103 Liver Cirrhosis Phenobarbital 13.4421047994
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.6118295389
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 2.889327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 9.7214620537 18263696 18472094 13678700 18395914 17721639 16248980 17631135 18054572 16027843 15931870 15893842 14512876 18705752 18210741 16116963 17823541 15052691 12666154 18317297 17922224 18420326 15370692 12667390 16638106 17525996 12898905 17640975 17714472 14716496 15925388 18166357 17805973 18395095 16015684 18429990 17557913 15362042 15338365 12958196 18412020 16097048 14748882 18418968 12445418 16011737 18006644 15650968 16136751 10355542 15818738 17976157 17869086 18156304 18472332 18339082 17481882 17944888 18251166 12609069 12389079 12632512 12546737 14716833 12649538 17766677 17698563 15123356 18376398 18187930 18277467 17900296 15730626 14724832 17708605 12741479 12632514 16033810 17761835 15876570 15673190 18279442 12586293 12445421 17565644 18205269 15996030 20821823 15959796 11481614 15057751 16192424 18481824
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 9.7214716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 9.7218166357
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 9.7215474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 9.7212878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 9.7212557150 18032466 12085344 17629604 18263696 18458672 12679928 15316131 16097051 16126171 15334695 18295389 16098781 11682029 16489207 15288472 18606216 15474484 17127702 16343077 15288473 15158331 12531686 15095483 16511523 17355460 18395095 15716488 17050028 17292413 12891558 18031379 11481614 18380797 11172339 15465738 15075984 16248980 14739098 12175628 15078482 15362042 10677585 18416461 18615449
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 9.7218397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 10.8919014921 11587558 19784758 12587719 12969438 16611625 19460945 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 10.8916964402 17285989 16246199 15830285 15720792
MESH:D008107 Liver Diseases Diethylnitrosamine 10.8917034775
MESH:D008107 Liver Diseases Phenobarbital 10.8919363144
MESH:D008107 Liver Diseases Thioacetamide 10.8915158337 16337175 18374380
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.1817207112 17347304
MESH:D017093 Liver Failure Carbon Tetrachloride 3.6915123358
MESH:D017114 Liver Failure, Acute Acetaminophen 13.8016871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 13.8016899240 14706259
MESH:D017114 Liver Failure, Acute Thioacetamide 13.8015313186 15633222 17276928 12479984
MESH:D008113 Liver Neoplasms 2,4,5,2',4',5'-hexachlorobiphenyl 29.8518644402 16835634
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 29.857678174
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 29.8519389873 21295105
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 29.8519294768
MESH:D008113 Liver Neoplasms Clofibric Acid 29.8517602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 29.8519638242 16942905 19499222 19090486 21278145 19073162 19426721 19850985 20452335 20583210 19294768 20434301 12112319 19812893 18754104 19256749 19690152 2862719 18644402 15885732 12771043 10737359 20137499 19551842 18648771 9163691 19996281 21047994 15175105 2422723 18977376 19833225 19254457 21071580 20101389 20118626 19642983 19427195 21167192 19255062 20405173 20501860 20492335 18978307
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 29.8518709148 14757943
MESH:D008113 Liver Neoplasms Phenobarbital 29.8519073162 19812893 19482888 8742319 21047994 15975961
MESH:D008113 Liver Neoplasms pirinixic acid 29.8520007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 29.8516984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 23.432876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 23.431399818 3712494 598648 6587162
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 23.4318164116
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 23.4312014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 23.4318282651 19539802 17942915 16267830 19004024 18079962 18164116 19009564 18544905 18775883 3124819 19519916 18308698 9362446 16842330 17174075 2563599 18253720 21159647 17854601 18093689 19126423
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 23.436150874 1399818 2563599 17172636 18308698
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 23.4312151625
MESH:D008133 Long QT Syndrome Amiodarone 3.2117391786 15350150 11989578
MESH:D008171 Lung Diseases Amiodarone 3.0412587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 3.9818516814
MESH:D008175 Lung Neoplasms alpha-Tocopherol 4.4216401635
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.4221163286 20512841 20970405 6695378
MESH:D008175 Lung Neoplasms Methoxsalen 4.4215893417
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.4219555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.2511408345 11807958 16891317 17203775
MESH:D020149 Manganese Poisoning Estradiol 3.9919453300
MESH:D008527 Medulloblastoma Tretinoin 2.5717453147
MESH:D008545 Melanoma Tretinoin 1.8716752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.0919513568
MESH:D008569 Memory Disorders Ethanol 3.7318411066 15451040
MESH:D008591 Meningomyelocele Tretinoin 3.9516940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.2916801185
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.0615863610
MESH:D009101 Multiple Myeloma Raloxifene 3.0916497877
MESH:D009135 Muscular Diseases pirinixic acid 3.0316239165
MESH:D009181 Mycoses Amiodarone 4.4017974566 12754197
MESH:D009182 Mycosis Fungoides Methoxsalen 6.1416259964
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.7917596541
MESH:D009203 Myocardial Infarction alpha-Tocopherol 5.4019595682
MESH:D009203 Myocardial Infarction pirinixic acid 5.4019151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.6312213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.0016810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.0016411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 3.9917484760
MESH:D009232 Myxoma Raloxifene 5.0616343187
MESH:D009336 Necrosis 2,4-dinitrotoluene 8.7318551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 8.737678174 18551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 4.983581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 4.983581430 9029167
MESH:D009369 Neoplasms 2,4,5,2',4',5'-hexachlorobiphenyl 6.898820588
MESH:D009369 Neoplasms pirinixic acid 6.8917405874
MESH:D009369 Neoplasms Tretinoin 6.8916946489 16594593
MESH:D009389 Neovascularization, Pathologic Estradiol 3.2517289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.9417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.8718481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 13.6616427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 13.6614600291
MESH:D009421 Nervous System Malformations Tretinoin 13.669125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 6.146679447
MESH:D009436 Neural Tube Defects Tretinoin 6.149142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 6.8618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 6.8620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.6220387270
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 10.489802331
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 10.489802331
MESH:D009765 Obesity pirinixic acid 1.6820558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 12.6212819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 12.6216049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 12.626482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.523988306
MESH:D010018 Osteomalacia Phenobarbital 3.8817016548
MESH:D010024 Osteoporosis Alendronate 6.7517882678
MESH:D010024 Osteoporosis Raloxifene 6.7517882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 3.7815579764 15758505 17893378 17823083
MESH:D010051 Ovarian Neoplasms Estradiol 4.2219401270
MESH:D010051 Ovarian Neoplasms Tretinoin 4.2216936753
MESH:D010146 Pain Acetaminophen 5.2916870215
MESH:D010146 Pain Tretinoin 5.2916870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 10.7116540662
MESH:D010190 Pancreatic Neoplasms Ethanol 10.7112384795
MESH:D010190 Pancreatic Neoplasms Phenobarbital 10.7116965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 10.7115976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.2411578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.017296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.7512520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 3.976228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.1018163543
MESH:D011230 Precancerous Conditions Corn Oil 18.5614668109
MESH:D011230 Precancerous Conditions Cyclosporine 18.5612371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 18.562563599
MESH:D011230 Precancerous Conditions Phenobarbital 18.562563599
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 8.0617132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.0611399792 11896295 11118676 11222880
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.2915572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.4520887781
MESH:D011471 Prostatic Neoplasms Calcitriol 2.8316289102 12479363 18247401 16644109 15754350
MESH:D011471 Prostatic Neoplasms Estradiol 2.8316740699
MESH:D011471 Prostatic Neoplasms Raloxifene 2.8316536755 16220300 15731164
MESH:D011507 Proteinuria Tretinoin 3.1616636307
MESH:D011537 Pruritus Ethinyl Estradiol 2.8315861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 4.0012752131
MESH:D011565 Psoriasis Cyclosporine 5.7116882103
MESH:D011565 Psoriasis Methoxsalen 5.7116259964
MESH:D011625 Pterygium Tretinoin 4.3016723453
MESH:D011657 Pulmonary Eosinophilia alpha-Tocopherol 5.4914606601
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.6512832656 11597910 12490602
MESH:D011693 Purpura Raloxifene 5.0615770314
MESH:D015427 Reperfusion Injury pirinixic acid 2.1319058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.3718990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.013692021
MESH:D012174 Retinitis Pigmentosa alpha-Tocopherol 3.8216849425
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.6516116481 16283617
MESH:D012640 Seizures 2,4-dinitrotoluene 11.3118551238
MESH:D012640 Seizures 2,6-dinitrotoluene 11.3118551238
MESH:D012640 Seizures Ethanol 11.319754883
MESH:D012640 Seizures Phenobarbital 11.313137016 16876388 11442880 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 4.336407741
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.6018724381
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 4.7416192470
MESH:D012878 Skin Neoplasms Tretinoin 4.7416467112
MESH:D013088 Spermatocele Ethinyl Estradiol 3.4516709447
MESH:D013272 Stomach Diseases Omeprazole 4.1318545984
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.2618456281
MESH:D013274 Stomach Neoplasms Ethanol 4.2618456281
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 4.2617575124 12958204
MESH:D013274 Stomach Neoplasms Tretinoin 4.2617261132
MESH:D013276 Stomach Ulcer Amiodarone 9.7118087811
MESH:D013276 Stomach Ulcer Ethanol 9.719562338 11906479 9211565 16755016 17189318 17918041
MESH:D013276 Stomach Ulcer Omeprazole 9.7118237397 16755016 15991576 11906479 10750652 17977527
MESH:D020521 Stroke Raloxifene 3.4416837676
MESH:D013375 Substance Withdrawal Syndrome Ethanol 3.839754883
MESH:D013610 Tachycardia Amiodarone 3.8311238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.7319225199
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.1711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.7415669648
MESH:D013959 Thyroid Diseases Amiodarone 10.4019731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 10.4012697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 18.526587162 6582329 7505956 3712494 1399818
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 18.527505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 18.521399818
MESH:D013964 Thyroid Neoplasms Propylthiouracil 18.5215710170
MESH:D013964 Thyroid Neoplasms Tretinoin 18.5216026305 17045167
MESH:D013971 Thyrotoxicosis Amiodarone 4.3818020914 19584973
MESH:D013978 Tibial Fractures Estradiol 12.0619048282
MESH:D013978 Tibial Fractures Raloxifene 12.0619048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.3616051514
MESH:D016171 Torsades de Pointes Amiodarone 3.7111989578 17467628
MESH:D014376 Tuberculosis Tretinoin 2.9116040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 10.1616049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 10.1616049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 10.168074119
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 10.1617572228
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 10.3710091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 10.3710091137
MESH:D014581 Urticaria Acetaminophen 2.5310982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.2616129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.8414692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.1116752155
MESH:D014605 Uveitis Cyclosporine 3.491336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1012125929
MESH:D014689 Venous Insufficiency coumarin 5.2812708602
MESH:D054556 Venous Thromboembolism Raloxifene 4.7116837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.1014671159 15869587
MESH:D014820 Vitiligo Methoxsalen 9.8916259964
MESH:D014820 Vitiligo Tretinoin 9.8916761959
MESH:D014846 Vulvar Neoplasms Raloxifene 5.0616343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.7515886252
MESH:D009396 Wilms Tumor Tretinoin 3.5616287080
MESH:D014985 Xerophthalmia Cyclosporine 3.9417120751
Pathway ID Pathway Name
KEGG:00340 Histidine metabolism
KEGG:01100 Metabolic pathways
REACT:13 Metabolism of amino acids and derivatives
KEGG:00910 Nitrogen metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29181
    • No data
    No data
    Releated drug ID Related drug Name
    PA449882l-histidine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00117 - L-Histidine Dietary supplement;Micronutrient;Conditionally Essential Amino Acids
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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