AutismKB 2.0

Annotation Detail for HAS2


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Basic Information Top
Gene Symbol:HAS2 ( MGC126241,MGC126242 )
Gene Full Name: hyaluronan synthase 2
Band: 8q24.13
Quick LinksEntrez ID:3037; OMIM: 601636; Uniprot ID:HAS2_HUMAN; ENSEMBL ID: ENSG00000170961; HGNC ID: 4819
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of HAS2 mRNAaffects expression 16483693
C015001 arsenite [arsenite co-treated with Benzo(a)pyrene] results in decreased expression of HAS2 mRNAaffects cotreatment|decreases expression 15894712
C015001 arsenite arsenite results in decreased expression of HAS2 mRNAdecreases expression 15894712
18929588
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of HAS2 mRNAincreases expression 18687144
D001564 Benzo(a)pyrene [arsenite co-treated with Benzo(a)pyrene] results in decreased expression of HAS2 mRNAaffects cotreatment|decreases expression 15894712
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of HAS2 mRNAdecreases expression 15894712
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of HAS2 mRNAdecreases expression 20382639
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of HAS2 mRNAincreases expression 15336504
C402665 CP 31398 CP 31398 results in increased expression of HAS2 mRNAincreases expression 15155752
C014347 decitabine decitabine affects the expression of HAS2 mRNAaffects expression 17145863
D002117 Calcitriol Calcitriol results in increased expression of HAS2 mRNAincreases expression 16002434
D004958 Estradiol ESR1 protein affects the reaction [Estradiol results in decreased expression of HAS2 mRNA]affects reaction|decreases expression 14699072
D004958 Estradiol Estradiol affects the expression of HAS2 mRNAaffects expression 14699072
D006820 Hyaluronic Acid HAS2 protein results in increased chemical synthesis of Hyaluronic Acidincreases chemical synthesis 11318944
D006820 Hyaluronic Acid [IL1B protein results in increased expression of HAS2 protein] which results in increased chemical synthesis of Hyaluronic Acidincreases chemical synthesis|increases expression 11318944
C025299 polyphenols polyphenols results in decreased expression of HAS2 mRNAdecreases expression 16293270
D020849 Raloxifene [Raloxifene co-treated with ESR1 protein] results in decreased expression of HAS2 mRNAaffects cotreatment|decreases expression 19059307
C009277 sodium arsenate sodium arsenate results in increased expression of HAS2 mRNAincreases expression 16882884
C017947 sodium arsenite sodium arsenite results in decreased expression of HAS2 mRNAdecreases expression 18812580
D013605 T-2 Toxin T-2 Toxin results in decreased expression of HAS2 mRNAdecreases expression 18196609
D013629 Tamoxifen [Tamoxifen co-treated with ESR1 protein] results in decreased expression of HAS2 mRNAaffects cotreatment|decreases expression 19059307
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of HAS2 mRNAdecreases expression 16443690
D014212 Tretinoin Tretinoin promotes the reaction [CREBBP protein binds to HAS2 promoter]affects binding|increases reaction 17307735
D014212 Tretinoin Tretinoin promotes the reaction [MED1 protein binds to HAS2 promoter]affects binding|increases reaction 17307735
D014212 Tretinoin Tretinoin promotes the reaction [NCOA3 protein binds to HAS2 promoter]affects binding|increases reaction 17307735
D014212 Tretinoin Tretinoin promotes the reaction [SP1 protein binds to HAS2 promoter]affects binding|increases reaction 17307735
D014212 Tretinoin Tretinoin results in increased expression of HAS2 mRNAincreases expression 17307735
D014212 Tretinoin Tretinoin results in increased expression of HAS2 mRNAincreases expression 16604517
C101044 tyrphostin AG 1478 tyrphostin AG 1478 inhibits the reaction [LHB protein results in increased expression of HAS2 mRNA]decreases reaction|increases expression 15459120
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.4714745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7615322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.4718287403
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.2120127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 4.2111473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.606695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.2916835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.6215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.8216712894 17306315
MESH:D000419 Albuminuria Raloxifene 4.5117451421 17308373
MESH:D000505 Alopecia Tretinoin 3.5415955085
MESH:D000544 Alzheimer Disease Raloxifene 2.5215800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8711748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9919183758
MESH:D001169 Arthritis, Experimental Tretinoin 3.0216412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2416292516
MESH:D001249 Asthma Tretinoin 2.3216456186
MESH:D001471 Barrett Esophagus Tretinoin 4.3216935849
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.6612125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.6616206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7115746008
MESH:D001930 Brain Injuries Raloxifene 4.3916580743
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 4.6717474063 20146248
MESH:D001943 Breast Neoplasms Calcitriol 4.6711237771
MESH:D001943 Breast Neoplasms decitabine 4.6719208741 18320071
MESH:D001943 Breast Neoplasms Estradiol 4.6712948864 19861407 17289903 17018787 14630087 17261762 18497071 16675129
MESH:D001943 Breast Neoplasms Raloxifene 4.6717261762 17595753 17952589 17440819 17049068 15775269 15572757 17242785 15758505 16837676 16912660 17893378
MESH:D001943 Breast Neoplasms Tamoxifen 4.6720135344 19487384 18351453 21138602 18855134 18821012 19115204 20390343 11161223 18984771 19084267 19244106 15668708 19142967 19011961 17440819 19155303 20065188 18629630 18997820 16202921 21152245 19189210 19289846 19221464 19200415 17893378 19410462 20544844 16818667 19189212 16873071 18815881 19066611 15565566 17261762 20859285 20005174 19059307 16273361 17049068 19103187 17242785 19288272 18425577
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.6720435547
MESH:D001943 Breast Neoplasms Tretinoin 4.6716166294 16443354 16873071
MESH:D016535 Bronchial Hyperreactivity tyrphostin AG 1478 4.8112794006
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.5016813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3816111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7316835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.4219066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.0816168501
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.4716924424
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 6.4716507464 17306315 15276417
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.4716924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.471917145
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 14.0720419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 14.0711237771
MESH:D002294 Carcinoma, Squamous Cell decitabine 14.0719215824
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 14.0718572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 14.0716096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 9.2317572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 9.2317572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3218850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Raloxifene 3.3815775269
MESH:D002386 Cataract Tretinoin 3.0417460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.8420889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 10.8418566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 10.8420056578 19524636
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.5016129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0816835633
MESH:D002822 Choriocarcinoma Tretinoin 5.0816461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.6415340226 12621046 8697196 15668235 16354765
MESH:D002972 Cleft Palate Tretinoin 5.649407595
MESH:D003072 Cognition Disorders Raloxifene 4.5315800139
MESH:D003092 Colitis Tretinoin 3.6217035595
MESH:D003110 Colonic Neoplasms arsenite 5.8915037631
MESH:D003110 Colonic Neoplasms decitabine 5.8917616700
MESH:D003110 Colonic Neoplasms polyphenols 5.8916293270
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9817141729 14669216
MESH:D019465 Craniofacial Abnormalities sodium arsenate 3.8210525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8210048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.8210589399 9664655 17551590 14991402 16925845 9142499 9224671 9211117 8800419 9125849
MESH:D003711 Demyelinating Diseases Tamoxifen 4.2819031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.0817474826
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6517107852
MESH:D003928 Diabetic Nephropathies Estradiol 14.5819279558
MESH:D003928 Diabetic Nephropathies Raloxifene 14.5815920148 17451421 17308373
MESH:D003928 Diabetic Nephropathies Tamoxifen 14.5819279558
MESH:D056486 Drug-Induced Liver Injury polyphenols 6.2619370779
MESH:D056486 Drug-Induced Liver Injury sodium arsenate 6.2618186108
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.2620420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6911462148
MESH:D004487 Edema Raloxifene 6.5815860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.5812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.6715322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 11.6718230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 14.9615138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 14.9615845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 14.9619031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.0319294695
MESH:D016889 Endometrial Neoplasms Estradiol 12.0919148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 12.0916202921 17893378 20544844 19155303
MESH:D016889 Endometrial Neoplasms Tretinoin 12.0916569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9410568697 9294722
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.2720426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.2716530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.6111564622
MESH:D005124 Eye Abnormalities Tretinoin 8.619664655 16938888
MESH:D005234 Fatty Liver arsenite 12.8118296743
MESH:D005234 Fatty Liver Raloxifene 12.8117473493
MESH:D005234 Fatty Liver Tamoxifen 12.8114986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1816709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3711858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.4414745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.1019069698
MESH:D005355 Fibrosis arsenite 14.3418296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.3420067830
MESH:D005355 Fibrosis Tretinoin 14.3417994277
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.5916452187
MESH:D005909 Glioblastoma Tretinoin 2.9517312396
MESH:D018149 Glucose Intolerance sodium arsenate 5.0019446573
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5110696789
MESH:D006258 Head and Neck Neoplasms decitabine 7.6319215824
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.6316096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.0816084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.8220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.8210048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 10.829664655 14991402
MESH:D006331 Heart Diseases Raloxifene 3.4711110106
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2511000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.8116120746 15340226 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.9515709030
MESH:D006689 Hodgkin Disease sodium arsenite 3.0812676792
MESH:D019584 Hot Flashes Estradiol 3.6717088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.968697196 16354765 15340226 16959395 18606429
MESH:D006930 Hyperalgesia Tretinoin 3.1416870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.4816778211
MESH:D006973 Hypertension Raloxifene 5.1217577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1218850075 18670907
MESH:D007248 Infertility, Male decitabine 6.7117581917
MESH:D007248 Infertility, Male sodium arsenite 6.7115346721 12646999
MESH:D007249 Inflammation polyphenols 8.0916366677
MESH:D007249 Inflammation Tamoxifen 8.0919457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.0912878042 12200463
MESH:D007333 Insulin Resistance Estradiol 2.9116627594 16393666
MESH:D007410 Intestinal Diseases Tretinoin 3.6817994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.6616580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.6615992940 17551590
MESH:D007674 Kidney Diseases Estradiol 5.9415618244
MESH:D007674 Kidney Diseases sodium arsenite 5.9420008137
MESH:D007680 Kidney Neoplasms Estradiol 7.1415610895
MESH:D007680 Kidney Neoplasms Tamoxifen 7.1418625569
MESH:D007889 Leiomyoma Raloxifene 4.4116973256
MESH:D007938 Leukemia decitabine 6.2818980019 19235587
MESH:D007938 Leukemia Tretinoin 6.2817143497
MESH:D007951 Leukemia, Myeloid decitabine 9.2918454857 19117987 17236224
MESH:D007951 Leukemia, Myeloid Tretinoin 9.2919285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute decitabine 3.9219010910 18704418 18460780 18206229 17679729 19387464
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.9219850784 16294345 17596541
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.3818055864
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.0917294898 17506722 16788101 16935935 16823087 16140955 9834237 16331271 17712046 17368321 19642359 19225113 17649720 15748426 17339181 16766008 17361223 17301526 19035177 19029980 19075265 17107899 16891316 17217047 12679006
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.249224671
MESH:D008064 Lipidoses Tamoxifen 3.0917567588 15342952
MESH:D008103 Liver Cirrhosis arsenite 3.3718296743
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.8514716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 4.8518564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.8512878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 4.8516248980 18397230
MESH:D008107 Liver Diseases polyphenols 2.7616698588
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 10.4121137059 20195826
MESH:D008113 Liver Neoplasms sodium arsenite 10.4115276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 10.4116684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.4116984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.0512151625
MESH:D008171 Lung Diseases sodium arsenite 3.1119095001
MESH:D055370 Lung Injury Asbestos, Crocidolite 3.9417365036
MESH:D008175 Lung Neoplasms arsenite 6.4716809336
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.4718569708 20064080 18816296 17053015 20464547 20869020 18520028 6695378 20135361
MESH:D008175 Lung Neoplasms sodium arsenite 6.4717306315 17077188 16712894 19931552 15276417
MESH:D008175 Lung Neoplasms Tamoxifen 6.4718625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.4711884234 19555203
MESH:D008223 Lymphoma decitabine 3.3519470736
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.6719428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.7811408345 11807958 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 5.7819196723 14580682 16827153 11731420 19196722
MESH:D020149 Manganese Poisoning Estradiol 12.3819453300
MESH:D020149 Manganese Poisoning Tamoxifen 12.3819453300
MESH:D008527 Medulloblastoma Tretinoin 2.7517453147
MESH:D008545 Melanoma decitabine 7.1817785578 16505122
MESH:D008545 Melanoma sodium arsenite 7.1819082730 16487513
MESH:D008545 Melanoma Tamoxifen 7.1812393984 19393235
MESH:D008545 Melanoma Tretinoin 7.1816752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.1015990972
MESH:D008591 Meningomyelocele Tretinoin 4.3416940565
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.1518303189 16966607 16166281
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.4715863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1216381670
MESH:D009101 Multiple Myeloma decitabine 7.2918172295
MESH:D009101 Multiple Myeloma Raloxifene 7.2916497877
MESH:D009139 Musculoskeletal Abnormalities sodium arsenate 4.7718186108
MESH:D009190 Myelodysplastic Syndromes decitabine 7.3119157545 16882708 19010910 18608210
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.3117596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9512213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.2116810080
MESH:D009232 Myxoma Raloxifene 5.4716343187
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5119393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4919410462
MESH:D009369 Neoplasms Benzo(a)pyrene 11.5211141357
MESH:D009369 Neoplasms decitabine 11.5219470736 19116145 17925555
MESH:D009369 Neoplasms sodium arsenite 11.5211559025
MESH:D009369 Neoplasms Tretinoin 11.5216946489 16594593
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.5820056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.9219200415 19189210 19196722
MESH:D009389 Neovascularization, Pathologic arsenite 9.8715738583
MESH:D009389 Neovascularization, Pathologic Estradiol 9.8717289903
MESH:D009421 Nervous System Malformations Estradiol 15.8311399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.8314600291
MESH:D009421 Nervous System Malformations Tretinoin 15.839125849
MESH:D009436 Neural Tube Defects sodium arsenate 11.9319446573 18186108 11749123 10525206
MESH:D009436 Neural Tube Defects sodium arsenite 11.9312854658
MESH:D009436 Neural Tube Defects Tretinoin 11.939142499
MESH:D010024 Osteoporosis Raloxifene 3.3417882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.1417823083 15579764 17893378 15758505
MESH:D010051 Ovarian Neoplasms decitabine 11.0819259094 19331143
MESH:D010051 Ovarian Neoplasms Estradiol 11.0819401270
MESH:D010051 Ovarian Neoplasms sodium arsenite 11.0817306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 11.0816936753
MESH:D010146 Pain Tretinoin 2.8316870215
MESH:D010190 Pancreatic Neoplasms decitabine 5.2719294695
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.2715976015
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1712520081
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.8110923243
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4718163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.1111118676 11222880 11896295 11399792
MESH:D055728 Primary Myelofibrosis decitabine 4.6417616702
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.6915572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8020887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0917292933
MESH:D011471 Prostatic Neoplasms Calcitriol 2.0916289102 18247401 15754350 12479363 16644109
MESH:D011471 Prostatic Neoplasms Estradiol 2.0916740699
MESH:D011471 Prostatic Neoplasms Hyaluronic Acid 2.0916864594
MESH:D011471 Prostatic Neoplasms Raloxifene 2.0916220300 16536755 15731164
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.0916039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0915067354
MESH:D011507 Proteinuria Tretinoin 3.5216636307
MESH:D011625 Pterygium Tretinoin 4.7116723453
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.0017322281 17365031 17975199 15814490
MESH:D011693 Purpura Raloxifene 5.4715770314
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7518990726
MESH:D012208 Rhabdomyosarcoma decitabine 10.6719155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 10.6716283617 16116481
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 17.4810029692 19755658
MESH:D012878 Skin Neoplasms sodium arsenite 17.4818572023 19524636
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 17.488532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 17.4816192470
MESH:D012878 Skin Neoplasms Tretinoin 17.4816467112
MESH:D013088 Spermatocele Tamoxifen 4.2116709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.9519457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.7312854658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.332093021 20155912
MESH:D013274 Stomach Neoplasms decitabine 3.3319037991
MESH:D013274 Stomach Neoplasms Tretinoin 3.3317261132
MESH:D020521 Stroke Raloxifene 3.7516837676
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.1717997062
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8212697716
MESH:D013964 Thyroid Neoplasms decitabine 7.0717967635
MESH:D013964 Thyroid Neoplasms Tretinoin 7.0717045167 16026305
MESH:D013978 Tibial Fractures Estradiol 13.4419048282
MESH:D013978 Tibial Fractures Raloxifene 13.4419048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.7116051514
MESH:D014376 Tuberculosis Tretinoin 3.1716040207
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 15.4517053015
MESH:D001749 Urinary Bladder Neoplasms decitabine 15.4517616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 15.4517572228
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 15.4517306315 16452187 16712894 11723127
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 15.4516712894 17572228 8653321
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 9.1511813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 9.1516129372
MESH:D014604 Uveal Neoplasms decitabine 12.5617785578
MESH:D014604 Uveal Neoplasms Tretinoin 12.5616752155
MESH:D014652 Vascular Diseases sodium arsenite 4.3417056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5112125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.1316837676
MESH:D014820 Vitiligo Tretinoin 3.9716761959
MESH:D014846 Vulvar Neoplasms Raloxifene 5.4716343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1715886252
MESH:D009396 Wilms Tumor Tretinoin 3.8916287080
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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