AutismKB 2.0

Annotation Detail for HBA1


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Basic Information Top
Gene Symbol:HBA1 ( CD31,MGC126895,MGC126897 )
Gene Full Name: hemoglobin, alpha 1
Band: 16p13.3
Quick LinksEntrez ID:3039; OMIM: 141800; Uniprot ID:HBA_HUMAN; ENSEMBL ID: ENSG00000206172; HGNC ID: 4823
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Desease IDDesease Name
Circulatory system diseases
Hematologic diseases
H00228Thalassemia
No data
Desease Name
HEMATOLOGICAL
haptoglobin
No data
Desease Name
Heinz body anemias, alpha
Methemoglobinemias, alpha
Thalassemias, alpha
Erythremias, alpha
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene results in increased expression of HBA1 mRNAincreases expression 16917068
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of HBA1 mRNAincreases expression 19417177
C520092 cetilistat cetilistat results in decreased expression of HBA1 protein modified formdecreases expression 19461584
C030123 coumarin coumarin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased glycosylation of HBA1 protein]affects cotreatment|decreases reaction|increases glycosylation 19647726
D004958 Estradiol [Progesterone co-treated with Estradiol] results in increased expression of HBA1 mRNAaffects cotreatment|increases expression 17404688
D005472 Fluorouracil TP53 protein affects the reaction [Fluorouracil results in decreased expression of HBA1 mRNA]affects reaction|decreases expression 15016801
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in decreased expression of HBA1 mRNAaffects cotreatment|decreases expression 17183730
D007501 Iron ERAF protein binds to and affects the folding of and affects the stability of [HBA1 protein binds to Iron]affects binding|affects folding|affects stability 16901899
D008741 Methyl Methanesulfonate Methyl Methanesulfonate results in increased methylation of HBA1 proteinincreases methylation 15655799
D008769 Methylnitronitrosoguanidine Methylnitronitrosoguanidine results in increased expression of HBA1 mRNAincreases expression 15120970
D008770 Methylnitrosourea Methylnitrosourea results in increased carbamoylation of HBA1 proteinincreases carbamoylation 15655799
D009151 Mustard Gas Mustard Gas affects the expression of HBA1 mRNAaffects expression 15651846
C055122 orlistat orlistat results in decreased expression of HBA1 protein modified formdecreases expression 19207292
19461584
D011374 Progesterone [Progesterone co-treated with Estradiol] results in increased expression of HBA1 mRNAaffects cotreatment|increases expression 17404688
D011374 Progesterone Progesterone results in increased expression of HBA1 mRNAincreases expression 17404688
C059514 resveratrol resveratrol binds to and affects the folding of HBA1 proteinaffects binding|affects folding 17597382
D013311 Streptozocin coumarin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased glycosylation of HBA1 protein]affects cotreatment|decreases reaction|increases glycosylation 19647726
D013311 Streptozocin [Streptozocin co-treated with Niacinamide] results in increased glycosylation of HBA1 proteinaffects cotreatment|increases glycosylation 19647726
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of HBA1 mRNAdecreases expression 16054898
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in decreased expression of HBA1 mRNAaffects cotreatment|decreases expression 17183730
D009536 Niacinamide coumarin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased glycosylation of HBA1 protein]affects cotreatment|decreases reaction|increases glycosylation 19647726
D009536 Niacinamide [Streptozocin co-treated with Niacinamide] results in increased glycosylation of HBA1 proteinaffects cotreatment|increases glycosylation 19647726
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.1111752688 15322242 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 8.118875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.8619490988
MESH:D058186 Acute Kidney Injury resveratrol 3.7916538975
MESH:D000230 Adenocarcinoma Estradiol 7.1411473722
MESH:D000230 Adenocarcinoma Fluorouracil 7.1417638652
MESH:D000230 Adenocarcinoma Methylnitrosourea 7.1415688392 15113128
MESH:D000236 Adenoma resveratrol 3.2815688382
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.3216835633
MESH:D019896 alpha 1-Antitrypsin Deficiency Iron 5.5916640825
MESH:D017085 alpha-Thalassemia marker/mechanism
MESH:D000544 Alzheimer Disease Iron 4.5416563566 16640825
MESH:D000544 Alzheimer Disease resveratrol 4.5416162502 16183991
MESH:D000550 Amblyopia Valproic Acid 5.1817688650
MESH:D000740 Anemia Fluorouracil 14.5515504547 17963324 16511603
MESH:D000740 Anemia Iron 14.5516434484 16566752
MESH:D000740 Anemia Tetrachlorodibenzodioxin 14.5511748828
MESH:D018798 Anemia, Iron-Deficiency Iron 4.5916569441 17147795 17375513 17163184 17162259
MESH:D000756 Anemia, Sideroblastic Iron 4.7516910769
MESH:D001008 Anxiety Disorders Valproic Acid 3.5217497229
MESH:D001145 Arrhythmias, Cardiac Iron 4.3116604332
MESH:D001169 Arthritis, Experimental resveratrol 3.4617115116
MESH:D001249 Asthma Mustard Gas 2.6910378619
MESH:D001260 Ataxia Telangiectasia Iron 5.3915336622
MESH:D050197 Atherosclerosis Iron 6.9316640825 16632123
MESH:D050197 Atherosclerosis resveratrol 6.9317967414 16873680
MESH:D001321 Autistic Disorder Iron 2.3617352947
MESH:D001321 Autistic Disorder Valproic Acid 2.3620603192 18177632 17507914 16609825 18558336 18775368 18316065 17688650 18985861 19460635 15238991 18940202 19232924 18396377 17157402
MESH:D001424 Bacterial Infections Iron 5.1316640825
MESH:D001714 Bipolar Disorder Valproic Acid 3.0420046352 17594078
MESH:D001768 Blister Mustard Gas 5.1019167455
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.9812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.8815746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.888888407
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.2817868700
MESH:D001930 Brain Injuries Progesterone 4.1915845082 15665606 15380490
MESH:D002545 Brain Ischemia resveratrol 4.2217600658
MESH:D001943 Breast Neoplasms Estradiol 2.9412948864 17018787 17289903 17261762 19861407 14630087 16675129 18497071
MESH:D001943 Breast Neoplasms Fluorouracil 2.9415136595 16557594 19217205 16110121 16595493 18608205 18357371
MESH:D001943 Breast Neoplasms Methylnitrosourea 2.9416253758 11306469 14633655
MESH:D001943 Breast Neoplasms Progesterone 2.9415562024 16175315 17614352
MESH:D001943 Breast Neoplasms resveratrol 2.9417534123 17651959 16393696
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.9420435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.1015286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.9217687719 10378619
MESH:D019121 Burkholderia Infections orlistat 6.5817874328
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4016111702
MESH:D002276 Carcinoid Tumor Fluorouracil 12.4616051944
MESH:D002276 Carcinoid Tumor Streptozocin 12.4616051944
MESH:D002277 Carcinoma Fluorouracil 8.0017121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.0016835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 8.7716705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 8.7716705839
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.7716924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 8.7718930000 16332177 17971768 17045692 16799960 17088986
MESH:D006528 Carcinoma, Hepatocellular resveratrol 8.7716227395 19321006
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.5316675471
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.9918695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.8216757204 17066447 16280240 18986760
MESH:D002294 Carcinoma, Squamous Cell resveratrol 4.8216227395
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3316120746 18670907 18850075
MESH:D009202 Cardiomyopathies Iron 4.0016640825
MESH:D002311 Cardiomyopathy, Dilated Iron 3.4416604332
MESH:D002318 Cardiovascular Diseases resveratrol 3.4315458977
MESH:D002386 Cataract Methylnitrosourea 3.9512484553
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 15.756135515
MESH:D002471 Cell Transformation, Neoplastic Estradiol 15.7518566989
MESH:D002471 Cell Transformation, Neoplastic Methylnitronitrosoguanidine 15.752727394
MESH:D002471 Cell Transformation, Neoplastic Methylnitrosourea 15.752727394 7505956
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6820734317
MESH:D054506 Chloracne marker/mechanism 17101203
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1016835633
MESH:D002916 Chylothorax orlistat 6.5817003701
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0815668235 15340226 8697196 12621046 16354765
MESH:D003092 Colitis resveratrol 4.0616474422
MESH:D003110 Colonic Neoplasms Fluorouracil 5.9115001691 16340194 16510598 17169374 17725105 17016597 17018589 17287894 18772588 17172411
MESH:D003110 Colonic Neoplasms Iron 5.9116640825
MESH:D003110 Colonic Neoplasms resveratrol 5.9116338953
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.6615289873 15148649 18383874 16391804 14970324 16303861 18949393 16524972 18288408 20501625 17016601 18448328 17255274 18509181 17094418 16282729 17594712 16331619 17454858 17401013 18802399 17695437
MESH:D015179 Colorectal Neoplasms resveratrol 2.6616550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0014669216 17141729
MESH:D003327 Coronary Disease resveratrol 3.7116507316
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4510048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.4516575769 17688650 8888407
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.6818551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.6818551238
MESH:D007644 Darier Disease Fluorouracil 4.7316733453
MESH:D048909 Diabetes Complications orlistat 5.7819207292
MESH:D003920 Diabetes Mellitus Iron 9.6416640825 16604332
MESH:D003920 Diabetes Mellitus Streptozocin 9.6416285004
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 8.6416873680
MESH:D003921 Diabetes Mellitus, Experimental Streptozocin 8.6419960420 6379147 7637645 12644472 19496084 11055810 15862027 11260395 18603373 18715473 16684804 15298345 16286809 12093613 2177838 19586609 12446591 12083368 8740154 17442507 15831366 17874149 19298542 1374869
MESH:D003922 Diabetes Mellitus, Type 1 Iron 6.0616506275
MESH:D003922 Diabetes Mellitus, Type 1 Streptozocin 6.0618603373
MESH:D003924 Diabetes Mellitus, Type 2 coumarin 13.5419647726
MESH:D003924 Diabetes Mellitus, Type 2 Iron 13.5416506275
MESH:D003924 Diabetes Mellitus, Type 2 Niacinamide 13.5419647726
MESH:D003924 Diabetes Mellitus, Type 2 Streptozocin 13.5419647726 19586609
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 13.5417107852
MESH:D058065 Diabetic Cardiomyopathies Streptozocin 5.6616025228
MESH:D003928 Diabetic Nephropathies Estradiol 14.8519279558
MESH:D003928 Diabetic Nephropathies resveratrol 14.8516286809
MESH:D003928 Diabetic Nephropathies Streptozocin 14.8519682444 19960420
MESH:D003929 Diabetic Neuropathies Progesterone 4.4317187935
MESH:D003930 Diabetic Retinopathy Streptozocin 5.3617662242
MESH:D003967 Diarrhea orlistat 4.6520002075
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 8.8118551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 8.8118551238 21346803
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.8120420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 8.811733752 19641884
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7111462148
MESH:D004421 Dystonia Valproic Acid 3.991851702
MESH:D004487 Edema Mustard Gas 11.199260866 11402378 11428631 11428647
MESH:D004487 Edema resveratrol 11.198985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 11.1912711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8515322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 9.1317692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 9.1317872969
MESH:D016889 Endometrial Neoplasms Estradiol 2.9411473722 19148513 18566989
MESH:D004715 Endometriosis Progesterone 8.7316134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.739294722 10568697
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.7817923197
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.0917275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 3.863922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.9020417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.536426943 6254150 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.237750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.003659116
MESH:D004890 Erythema Mustard Gas 5.109357497
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.4316481741 15173087 17638652 16337965 16785472
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9611564622
MESH:D005234 Fatty Liver Iron 8.0016640825
MESH:D005234 Fatty Liver Valproic Acid 8.0014986274 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3911858732
MESH:D005315 Fetal Diseases Valproic Acid 4.8316575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.078888407 18558336
MESH:D005354 Fibrosarcoma Methylnitrosourea 5.1711555667
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.8920067830
MESH:D005414 Flatulence orlistat 6.5820002075
MESH:D005621 Friedreich Ataxia Iron 5.3616604332 16640825
MESH:D005910 Glioma Fluorouracil 6.2916145905
MESH:D005910 Glioma Methylnitrosourea 6.299825942
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5410696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.3415102660 15162350 18337622
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3011294989 10048152
MESH:D006331 Heart Diseases Streptozocin 4.2312093613
OMIM:140700 HEINZ BODY ANEMIAS marker/mechanism
MESH:D006432 Hemochromatosis Iron 4.4416574947 17255318 16640825 16604332 17053826 17236123
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2711000095
MESH:D006486 Hemosiderosis Iron 5.1616604332
MESH:D006525 Hepatitis, Viral, Human Iron 5.4116640825
MESH:D006527 Hepatolenticular Degeneration Iron 4.8717182432
MESH:D006529 Hepatomegaly Iron 8.5416890145
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.5412621046 15340226 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.9815709030
MESH:D006561 Herpes Simplex resveratrol 4.1216876885
MESH:D015658 HIV Infections Iron 3.6416597321
MESH:D019584 Hot Flashes Estradiol 3.7017088409
MESH:D006849 Hydrocephalus Valproic Acid 4.8117688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9915340226 16959395 8697196 16354765 18606429
MESH:D006937 Hypercholesterolemia resveratrol 3.9417188708
MESH:D006949 Hyperlipidemias orlistat 9.6221332399
MESH:D006949 Hyperlipidemias resveratrol 9.6216873680
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8818670907 18850075
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.5616612254
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.2417488730
MESH:D007006 Hypogonadism Iron 4.3516640825
MESH:D007037 Hypothyroidism Iron 5.0216640825
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 11.2715869954
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 11.2717600658
MESH:D007248 Infertility, Male Methylnitrosourea 3.757193160
MESH:D007249 Inflammation Mustard Gas 11.718975870 11402378 9260866 11428631 17524151 9357497 11428620 11428647 16001271
MESH:D007249 Inflammation Progesterone 11.7115869954
MESH:D007249 Inflammation resveratrol 11.7116366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.7112878042 12200463
MESH:D007251 Influenza, Human resveratrol 4.4916624496
MESH:D007333 Insulin Resistance Estradiol 7.7716627594 16393666
MESH:D007333 Insulin Resistance orlistat 7.7717201808
MESH:D019189 Iron Metabolism Disorders Iron 4.9717163184
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2716580747
MESH:D007674 Kidney Diseases Estradiol 6.3615618244
MESH:D007674 Kidney Diseases Streptozocin 6.3612093613
MESH:C531755 Kidney disorder involving deposition of calcium and oxalate or phosphate in the renal tubules orlistat 6.5817185156
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 17.3116705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 17.3116705839
MESH:D007680 Kidney Neoplasms Estradiol 17.3115610895
MESH:D007680 Kidney Neoplasms Fluorouracil 17.3116985049
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1416294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.5316087638
MESH:D020961 Lewy Body Disease Iron 5.3616563566
MESH:D017880 Limb Deformities, Congenital Methylnitrosourea 4.1515526292
MESH:D008103 Liver Cirrhosis Iron 7.3916640825
MESH:D008103 Liver Cirrhosis orlistat 7.3917404856
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.2414659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.2412878042
MESH:D008108 Liver Diseases, Alcoholic Iron 4.9416737972 17207112
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 14.007678174
MESH:D008113 Liver Neoplasms Fluorouracil 14.0018383874 17045692 16603448 15113037
MESH:D008113 Liver Neoplasms Iron 14.0016640825 20302851
MESH:D008113 Liver Neoplasms resveratrol 14.0019812893 19073162 19321006 20405173
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.0016984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 5.592876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.5912151625
MESH:D038061 Lower Extremity Deformities, Congenital Methylnitrosourea 5.4016080182
MESH:D008171 Lung Diseases Mustard Gas 3.4018702808 18161513
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.2117228818
MESH:D008175 Lung Neoplasms Fluorouracil 6.5415246190
MESH:D008175 Lung Neoplasms Iron 6.5416640825
MESH:D008175 Lung Neoplasms Methylnitrosourea 6.5418062963
MESH:D008175 Lung Neoplasms Mustard Gas 6.543148597 8781369
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.5419555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.7315086387
MESH:D008207 Lymphatic Metastasis orlistat 5.8218770866 20805790
MESH:D008223 Lymphoma Methylnitrosourea 3.9611418001 16257854
MESH:D016393 Lymphoma, B-Cell Methylnitrosourea 10.3314633661
MESH:D016393 Lymphoma, B-Cell resveratrol 10.3317088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.8114749477
MESH:D008268 Macular Degeneration Iron 3.9416640825
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.1915688416
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 13.9811408345 11807958 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental Methylnitrosourea 13.9815313902 10838139 11807958 16944150 10767621 17131329 16619500 17020996 15113128 15688392 11751437 19196723 16051031 14633655 16827153 12931682 14999141
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 13.9817203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 13.9811606380 8985016
MESH:D020149 Manganese Poisoning Estradiol 4.4319453300
MESH:D008545 Melanoma orlistat 3.9718770866 20805790
MESH:D008545 Melanoma resveratrol 3.9717992120
MESH:D008659 Metabolic Diseases resveratrol 4.3117112576
MESH:D008708 Methemoglobinemia marker/mechanism
MESH:D053842 Microsatellite Instability Methylnitronitrosoguanidine 5.8317671175
MESH:D008881 Migraine Disorders Valproic Acid 3.1418803445 18765137
MESH:D009062 Mouth Neoplasms Fluorouracil 3.5818986760 16757204
MESH:D009101 Multiple Myeloma resveratrol 3.4217164350 17049120 17935668 16490592 14749477 16267019
MESH:D020528 Multiple Sclerosis, Chronic Progressive Iron 5.6217086897
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.8117962980
MESH:D009135 Muscular Diseases orlistat 5.3918430571
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.968888407
MESH:D009164 Mycobacterium Infections orlistat 5.4421442799
MESH:D009181 Mycoses Iron 5.4116640825
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.1217596541
MESH:D009203 Myocardial Infarction resveratrol 3.0016525036 17125593 17188708 17015251 16317513 16456233
MESH:D017202 Myocardial Ischemia Iron 15.0516604332
MESH:D017202 Myocardial Ischemia resveratrol 15.0517015251 17125593
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 15.0512213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.5616810080
MESH:D015428 Myocardial Reperfusion Injury Iron 8.5616604332
MESH:D009205 Myocarditis resveratrol 4.7017322642
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.1418551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.147678174 18551238
MESH:D009369 Neoplasms Fluorouracil 8.4416928823 18600527 18239605
MESH:D009369 Neoplasms Methylnitrosourea 8.4415533788
MESH:D009369 Neoplasms orlistat 8.4418710210
MESH:D009374 Neoplasms, Experimental Methylnitrosourea 15.2312696579
MESH:D009374 Neoplasms, Experimental orlistat 15.2319381703
MESH:D009374 Neoplasms, Experimental resveratrol 15.238985016
MESH:D009389 Neovascularization, Pathologic Estradiol 10.2917289903
MESH:D009389 Neovascularization, Pathologic orlistat 10.2917012255
MESH:D009404 Nephrotic Syndrome Iron 4.4617178036
MESH:D009421 Nervous System Malformations Estradiol 9.2516427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.2514600291
MESH:D009436 Neural Tube Defects Valproic Acid 3.0816359493 8888407
MESH:D009442 Neurilemmoma Methylnitrosourea 5.4211555667
MESH:D019636 Neurodegenerative Diseases Iron 8.6717296847 16604332
MESH:D019636 Neurodegenerative Diseases resveratrol 8.6717652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.3417929310
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.3916436463
MESH:D009503 Neutropenia Mustard Gas 3.917688884 16761898
MESH:C541083 Non-alcoholic Fatty Liver Disease orlistat 5.5017404856
MESH:D009765 Obesity cetilistat 6.2419461584
MESH:D009765 Obesity orlistat 6.2416938137 19461584 20002075 21442799 19046740 20540997 19207292 20599501 20065556 21438711 18773755 20518802
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.6916049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.6916049721
MESH:D010003 Osteoarthritis Iron 3.9316640825
MESH:D010024 Osteoporosis Iron 3.8216640825 16648989
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.1917513867
MESH:D010051 Ovarian Neoplasms Estradiol 4.8019401270
MESH:D010051 Ovarian Neoplasms Progesterone 4.8016525653 17393432
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.5916929163 15113037 16500647 19003803
MESH:D010190 Pancreatic Neoplasms Methylnitrosourea 5.5916965848
MESH:D010195 Pancreatitis orlistat 4.7816938137 20065556
MESH:D010212 Papilloma Iron 4.4212065085
MESH:D020447 Parasomnias Iron 5.9617352947
MESH:D010300 Parkinson Disease Iron 3.3016563566 16640825
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1912520081
MESH:D010391 Pemphigoid, Bullous Niacinamide 6.3911026799
MESH:D010900 Pituitary Diseases Iron 5.6216604332
MESH:D011041 Poisoning Iron 8.7916604332
MESH:D011041 Poisoning Mustard Gas 8.7915727166
MESH:D011085 Polycystic Ovary Syndrome orlistat 5.2317201808
MESH:D011087 Polycythemia Vera marker/mechanism
MESH:D017119 Porphyria Cutanea Tarda Iron 10.8116640825
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 10.8118163543
MESH:D011225 Pre-Eclampsia Iron 4.3716640825
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 15.9316679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 15.9311118676 11222880 11399792 11896295
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 15.9320603192
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8220887781
MESH:D011471 Prostatic Neoplasms Estradiol 2.1516740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.1519082440 18626508
MESH:D011471 Prostatic Neoplasms Methylnitrosourea 2.1512376480 15682402
MESH:D011471 Prostatic Neoplasms resveratrol 2.1517718901 17636462 15767336 17675339 16731767 17804756
MESH:D011528 Protozoan Infections Iron 5.9616640825
MESH:D011537 Pruritus Mustard Gas 4.0318058305
MESH:D019310 Pseudolymphoma Valproic Acid 4.4912752131 11422049
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9017720292 17266442 10334151 17894541 17620002
MESH:D012004 Rectal Neoplasms Fluorouracil 3.9518722050 15538739 16160472 18286688
MESH:D012035 Refsum Disease orlistat 6.0120871815
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.5316325855
MESH:D015427 Reperfusion Injury resveratrol 3.2416314181 17520802 16317513 17058453 15827377
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7718990726
MESH:D012148 Restless Legs Syndrome Iron 4.5016930377
MESH:D012162 Retinal Degeneration Methylnitrosourea 4.3618155124 18172121
MESH:D012175 Retinoblastoma Methylnitrosourea 5.4211555667
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.1119155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8318045962
MESH:D012559 Schizophrenia Valproic Acid 2.0619110320 15737665
MESH:D012640 Seizures 2,4-dinitrotoluene 9.5518551238
MESH:D012640 Seizures 2,6-dinitrotoluene 9.5518551238
MESH:D012640 Seizures Valproic Acid 9.551511512 15475178 11044598 17978042 11738929 16876388 3137016 14763951
MESH:D012871 Skin Diseases Mustard Gas 2.7012880345 15451306 16961503
MESH:D012878 Skin Neoplasms Iron 9.4112065085
MESH:D012878 Skin Neoplasms resveratrol 9.4115837718 8985016
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.4116192470
MESH:D013119 Spinal Cord Injuries Progesterone 4.2216503802 15862959
MESH:D016135 Spinal Dysraphism Valproic Acid 3.7319490988
MESH:D013226 Status Epilepticus Valproic Acid 4.4912833885
MESH:D013274 Stomach Neoplasms Fluorouracil 3.6819015929 16951190 17522103 18567086 18396642 17498489 16424979 19084572 15786421 17172411
MESH:D013274 Stomach Neoplasms Methylnitrosourea 3.6816257854 15930296 18593901
MESH:D013274 Stomach Neoplasms orlistat 3.6819381703
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.4216321402
MESH:D013398 Sudden Infant Death Iron 5.3916640825
MESH:D013789 Thalassemia marker/mechanism
MESH:D013953 Thymus Neoplasms Methylnitrosourea 5.1711418001
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8512697716
MESH:D013964 Thyroid Neoplasms Methylnitrosourea 3.877505956 3078959
MESH:D013978 Tibial Fractures Estradiol 4.6319048282
MESH:D014062 Tongue Neoplasms Fluorouracil 9.7816280240
MESH:D014062 Tongue Neoplasms resveratrol 9.7816227395
MESH:D014178 Translocation, Genetic Valproic Acid 5.1817262798
MESH:D014376 Tuberculosis Iron 4.0416597321
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.463119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 4.9316049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 4.9316049721
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.588888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 11.7810091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 11.7810091137
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 9.4116803524
MESH:D002583 Uterine Cervical Neoplasms resveratrol 9.4117473185
MESH:D014594 Uterine Neoplasms resveratrol 4.0717044934
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5412125929
MESH:D014689 Venous Insufficiency coumarin 5.7212708602
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.2417488730
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1915886252
Pathway ID Pathway Name
KEGG:05143 African trypanosomiasis
KEGG:05144 Malaria
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29198
    • No data
    Releated disease ID Related disease Name
    PA443886Diabetes Mellitus
    PA447306diabetes mellitus type 2 and obesity
    PA443890Diabetes Mellitus, Type 2
    PA446431alpha-Thalassemia
    PA152209815HbH Disease
    Releated drug ID Related drug Name
    PA450970pioglitazone
    PA451283rosiglitazone
    PA452631thiazolidinediones
    PA449789glycine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00358 antagonist Mefloquine Antimalarials
    DB00893 activator Omni 2000tab Anti-anemic Agents;Iron Supplement
    DB02126 - 4-Carboxycinnamic Acid
    DB07427 - 2-[(2-methoxy-5-methylphenoxy)methyl]pyridine
    DB07428 - 4-[(5-methoxy-2-methylphenoxy)methyl]pyridine
    DB07645 - SEBACIC ACID
    DB08077 - 2-[4-({[(3,5-DICHLOROPHENYL)AMINO]CARBONYL}AMINO)PHENOXY]-2-METHYLPROPANOIC ACID
    DB08262 - 2,6-DICARBOXYNAPHTHALENE
    DB08380 - 2-[P-[2-P-CHLOROBENZAMIDO)ETHYL]PHENOXY]-2-METHYLPROPIONIC ACID
    DB08486 - 2-{4-[(3,5-DIMETHYLANILINO)-CARBONYL-METHYL]-PHENOXY}-2-METHYLPROPIONIC ACID
    DB08632 - 1,3,5-BENZENETRICARBOXYLIC ACID
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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