AutismKB 2.0

Annotation Detail for HBD


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Basic Information Top
Gene Symbol:HBD ( - )
Gene Full Name: hemoglobin, delta
Band: 11p15.4
Quick LinksEntrez ID:3045; OMIM: 142000; Uniprot ID:HBD_HUMAN; ENSEMBL ID: ENSG00000223609; HGNC ID: 4829
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
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Desease Name
HEMATOLOGICAL
Beta thalassemia/hemoglobin E disease
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D003010 Clorgyline Clorgyline results in increased expression of HBD mRNAincreases expression 19691856
D004958 Estradiol [Progesterone co-treated with Estradiol] results in increased expression of HBD mRNAaffects cotreatment|increases expression 17404688
C076994 perfluorooctane sulfonic acid perfluorooctane sulfonic acid results in decreased expression of HBD mRNAdecreases expression 17560707
D011374 Progesterone [Progesterone co-treated with Estradiol] results in increased expression of HBD mRNAaffects cotreatment|increases expression 17404688
D011374 Progesterone Progesterone results in increased expression of HBD mRNAincreases expression 18070364
D014212 Tretinoin Tretinoin results in increased expression of HBD mRNAincreases expression 16249480
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Estradiol 2.1611473722
MESH:D000505 Alopecia Tretinoin 3.9015955085
MESH:D001169 Arthritis, Experimental Tretinoin 3.2816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3316292516
MESH:D001249 Asthma Tretinoin 2.4316456186
MESH:D001471 Barrett Esophagus Tretinoin 4.8416935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.9816206674 16197459
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.9517868700
MESH:D001930 Brain Injuries Progesterone 4.7415665606 15380490 15845082
MESH:D001943 Breast Neoplasms Estradiol 1.9212948864 14630087 17289903 18497071 19861407 17018787 16675129 17261762
MESH:D001943 Breast Neoplasms Progesterone 1.9216175315 15562024 17614352
MESH:D001943 Breast Neoplasms Tretinoin 1.9216443354 16873071 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.1316813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 5.0016111702
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.7716168501
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.1416924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.141917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3716096774 16051514
MESH:D002386 Cataract Tretinoin 3.2817460283
MESH:D002471 Cell Transformation, Neoplastic Estradiol 3.0018566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.1316129372
MESH:D054506 Chloracne marker/mechanism 17101203
MESH:D002822 Choriocarcinoma Tretinoin 5.7716461808
MESH:D002972 Cleft Palate Tretinoin 2.799407595
MESH:D003092 Colitis Tretinoin 4.1917035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.8310589399 9211117 17551590 9142499 16925845 9224671 9125849 14991402 8800419 9664655
MESH:D003928 Diabetic Nephropathies Estradiol 3.7419279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.9817187935
MESH:D004489 Edema, Cardiac Tretinoin 5.0818230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 4.2217692515
MESH:D016889 Endometrial Neoplasms Estradiol 8.1411473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Tretinoin 8.1416569247
MESH:D004715 Endometriosis Progesterone 4.1116134523
MESH:D005124 Eye Abnormalities Tretinoin 3.8416938888 9664655
MESH:D005355 Fibrosis Tretinoin 3.9917994277
MESH:D005909 Glioblastoma perfluorooctane sulfonic acid 8.3017162496
MESH:D005909 Glioblastoma Tretinoin 8.3017312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.4116096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.7716084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.059664655 14991402
MESH:D006558 Herpes Genitalis Estradiol 5.6415709030
MESH:D019584 Hot Flashes Estradiol 4.3617088409
MESH:D006930 Hyperalgesia Tretinoin 3.5016870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 5.0516778211
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.8915869954
MESH:D007249 Inflammation Progesterone 2.7515869954
MESH:D007333 Insulin Resistance Estradiol 3.1816393666 16627594
MESH:D007410 Intestinal Diseases Tretinoin 4.2517994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.2717551590 15992940
MESH:D007674 Kidney Diseases Estradiol 2.7615618244
MESH:D007680 Kidney Neoplasms Estradiol 3.2815610895
MESH:D007938 Leukemia Tretinoin 2.9217143497
MESH:D007951 Leukemia, Myeloid Tretinoin 4.0716482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1217596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3717217047 17649720 16935935 19642359 12679006 19035177 16331271 17294898 17506722 16823087 17368321 17712046 19029980 17339181 15748426 16788101 19225113 17107899 16140955 9834237 17301526 19075265 16766008 16891316 17361223
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.559224671
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.5514659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.5518397230 16248980
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.7716891317 11807958 11408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.7717203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 5.0919453300
MESH:D008527 Medulloblastoma Tretinoin 2.9017453147
MESH:D008545 Melanoma Tretinoin 1.9816752155
MESH:D008591 Meningomyelocele Tretinoin 4.9116940565
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2617596541
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.5516810080
MESH:D009369 Neoplasms Tretinoin 2.5516946489 16594593
MESH:D009389 Neovascularization, Pathologic Estradiol 4.2717289903
MESH:D009421 Nervous System Malformations Estradiol 11.1816427766 11399458
MESH:D009421 Nervous System Malformations Tretinoin 11.189125849
MESH:D009436 Neural Tube Defects Tretinoin 3.279142499
MESH:D010051 Ovarian Neoplasms Estradiol 8.4219401270
MESH:D010051 Ovarian Neoplasms Progesterone 8.4217393432 16525653
MESH:D010051 Ovarian Neoplasms Tretinoin 8.4216936753
MESH:D010146 Pain Tretinoin 3.2016870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5615976015
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.2620887781
MESH:D011471 Prostatic Neoplasms Clorgyline 3.5219691856
MESH:D011471 Prostatic Neoplasms Estradiol 3.5216740699
MESH:D011507 Proteinuria Tretinoin 4.0116636307
MESH:D011625 Pterygium Tretinoin 5.3316723453
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.5016283617 16116481
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9518045962
MESH:D012878 Skin Neoplasms Tretinoin 2.7516467112
MESH:D013119 Spinal Cord Injuries Progesterone 4.8216503802 15862959
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013964 Thyroid Neoplasms Tretinoin 3.2916026305 17045167
MESH:D013978 Tibial Fractures Estradiol 5.3019048282
MESH:D014062 Tongue Neoplasms Tretinoin 4.1416051514
MESH:D014376 Tuberculosis Tretinoin 3.4316040207
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 4.0216129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.2216752155
MESH:D014820 Vitiligo Tretinoin 4.5016761959
MESH:D009396 Wilms Tumor Tretinoin 4.2916287080
Pathway ID Pathway Name
KEGG:05143 African trypanosomiasis
REACT:604 Hemostasis
KEGG:05144 Malaria
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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