AutismKB 2.0

Annotation Detail for HBG1


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Basic Information Top
Gene Symbol:HBG1 ( HBGA,HBGR,HSGGL1 )
Gene Full Name: hemoglobin, gamma A
Band: 11p15.4
Quick LinksEntrez ID:3047; OMIM: 142200; Uniprot ID:HBG1_HUMAN; ENSEMBL ID: ENSG00000213934; HGNC ID: 4831
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
HEMATOLOGICAL
Beta thalassemia/hemoglobin E disease
No data
Desease Name
Fetal hemoglobin quantitative trait locus 1
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of HBG1 mRNAincreases expression 16239168
C014347 decitabine decitabine affects the acetylation of HBG1 geneaffects acetylation 19576949
C014347 decitabine decitabine affects the expression of HBG1 proteinaffects expression 19576949
C014347 decitabine decitabine affects the methylation of HBG1 promoteraffects methylation 19576949
C014347 decitabine decitabine promotes the reaction [HIST3H3 protein modified form binds to HBG1 promoter]affects binding|increases reaction 17696208
C014347 decitabine decitabine promotes the reaction [HIST4H4 protein modified form binds to HBG1 promoter]affects binding|increases reaction 17696208
C014347 decitabine decitabine results in decreased methylation of HBG1 promoterdecreases methylation 17696208
D003633 Dichlorodiphenyl Dichloroethylene Dichlorodiphenyl Dichloroethylene results in decreased expression of HBG1 mRNAdecreases expression 16498641
D004958 Estradiol [Progesterone co-treated with Estradiol] results in increased expression of HBG1 mRNAaffects cotreatment|increases expression 17404688
D005485 Flutamide Flutamide results in decreased expression of HBG1 mRNAdecreases expression 16498641
D019833 Genistein Genistein results in decreased expression of HBG1 mRNAdecreases expression 12075121
C051890 irinotecan irinotecan analog results in decreased expression of HBG1 mRNAdecreases expression 18927307
D008044 Linuron Linuron results in decreased expression of HBG1 mRNAdecreases expression 16498641
D011374 Progesterone [Progesterone co-treated with Estradiol] results in increased expression of HBG1 mRNAaffects cotreatment|increases expression 17404688
D020849 Raloxifene Raloxifene affects the expression of HBG1 mRNAaffects expression 16079270
D018038 Sodium Selenite Sodium Selenite results in decreased expression of HBG1 mRNAdecreases expression 18175754
D014284 Triiodothyronine Triiodothyronine results in increased expression of HBG1 mRNAincreases expression 15953391
C004648 testosterone enanthate testosterone enanthate affects the expression of HBG1 mRNAaffects expression 17440010
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Estradiol 4.5311473722
MESH:D000230 Adenocarcinoma Genistein 4.5311473722
MESH:D000382 Agricultural Workers' Diseases Dichlorodiphenyl Dichloroethylene 4.9116487989
MESH:D000419 Albuminuria Raloxifene 4.6917451421 17308373
MESH:D000544 Alzheimer Disease Raloxifene 2.5515800139
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.4717868700
MESH:D001930 Brain Injuries Progesterone 11.3215665606 15845082 15380490
MESH:D001930 Brain Injuries Raloxifene 11.3216580743
MESH:D001943 Breast Neoplasms decitabine 3.0119208741 18320071
MESH:D001943 Breast Neoplasms Dichlorodiphenyl Dichloroethylene 3.0115061365
MESH:D001943 Breast Neoplasms Estradiol 3.0119861407 17289903 18497071 12948864 14630087 16675129 17018787 17261762
MESH:D001943 Breast Neoplasms Genistein 3.0116873071 17200150 16541309
MESH:D001943 Breast Neoplasms Progesterone 3.0115562024 16175315 17614352
MESH:D001943 Breast Neoplasms Raloxifene 3.0117595753 15572757 17242785 16912660 17952589 17893378 15775269 15758505 17261762 17440819 17049068 16837676
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5816111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.8815700767 16227642 15721981 15673190 10355542 16050911 3786805 16097048 18705752 16192424 16011737 16124888
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.6918788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.6916924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 4.6916924424
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.6119215824
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 4.1517572228
MESH:D002318 Cardiovascular Diseases Genistein 7.6916332659
MESH:D002318 Cardiovascular Diseases Raloxifene 7.6915775269
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.8218566989
MESH:D054506 Chloracne marker/mechanism 17101203
MESH:D019457 Chromosome Breakage Sodium Selenite 4.8615894690
MESH:D003072 Cognition Disorders Raloxifene 4.7215800139
MESH:D003110 Colonic Neoplasms decitabine 6.0217616700
MESH:D003110 Colonic Neoplasms Genistein 6.0217182828
MESH:D003110 Colonic Neoplasms irinotecan 6.0217287894 17725105
MESH:D015179 Colorectal Neoplasms decitabine 2.7818981723
MESH:D015179 Colorectal Neoplasms irinotecan 2.7818509181 18259882 17454858 16391804 16303861 17159606 15273666
MESH:D003865 Depressive Disorder, Major Raloxifene 4.2317474826
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.8516285004
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.5016647724
MESH:D003928 Diabetic Nephropathies Estradiol 9.2519279558
MESH:D003928 Diabetic Nephropathies Raloxifene 9.2515920148 17451421 17308373
MESH:D003929 Diabetic Neuropathies Progesterone 4.6017187935
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 4.077179309 15968718 7120509 9327722 11566570 2869522 10915739 16177239 3786805 4309450 3732212 21278145 15027814 16227642 6884620 17522070 19336974 19085960 10092053 7440962 15998439 6623471
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 4.0715131321
MESH:D004417 Dyspnea Dichlorodiphenyl Dichloroethylene 5.4016487989
MESH:D004487 Edema Raloxifene 3.4215860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 9.6517692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 9.6515845917
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.2519294695
MESH:D004714 Endometrial Hyperplasia Genistein 4.7116402032
MESH:D016889 Endometrial Neoplasms Estradiol 7.6811473722 19148513 18566989
MESH:D016889 Endometrial Neoplasms Genistein 7.6811473722
MESH:D004715 Endometriosis Progesterone 3.8416134523
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.2617595544 12631006 19224547 15959796 12795759 16239168 16045604 61145
MESH:D005234 Fatty Liver Raloxifene 8.2617473493
MESH:D005355 Fibrosis Carbon Tetrachloride 3.5618705752
MESH:D005909 Glioblastoma Genistein 3.3116598420
MESH:D006258 Head and Neck Neoplasms decitabine 3.5419215824
MESH:D006331 Heart Diseases Raloxifene 3.5911110106
MESH:D006505 Hepatitis Carbon Tetrachloride 10.1019900420 19110552
MESH:D006505 Hepatitis Dichlorodiphenyl Dichloroethylene 10.1016487989
MESH:D006558 Herpes Genitalis Estradiol 5.1715709030
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.8817440010
MESH:D019584 Hot Flashes Estradiol 3.8917088409
MESH:D017588 Hyperandrogenism Flutamide 5.5915356085
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6516899240
MESH:D006973 Hypertension Raloxifene 2.8915787275 17577099
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1915338365
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.5115869954
MESH:D007248 Infertility, Male decitabine 7.5617581917
MESH:D007248 Infertility, Male Dichlorodiphenyl Dichloroethylene 7.5612948891 17192596
MESH:D007249 Inflammation Progesterone 2.6415869954
MESH:D007333 Insulin Resistance Estradiol 7.6116393666 16627594
MESH:D007333 Insulin Resistance Sodium Selenite 7.6114714311
MESH:D007674 Kidney Diseases Estradiol 2.6315618244
MESH:D007680 Kidney Neoplasms Estradiol 3.0515610895
MESH:D007889 Leiomyoma Raloxifene 4.5816973256
MESH:D007938 Leukemia decitabine 6.6519235587 18980019
MESH:D007938 Leukemia Genistein 6.6517468513 18980019
MESH:D007951 Leukemia, Myeloid decitabine 4.0818454857 17236224 19117987
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.3918460780 18206229 17679729 18704418 19010910 19387464
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.6018055864
MESH:D017880 Limb Deformities, Congenital Dichlorodiphenyl Dichloroethylene 4.7512745335
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8517174718 16943688 17334410 11408273 17157831 11903743 16239168 16221502 21278145
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5918481824 15338365 18166357 18251166 12609069 17708605 18429990 17698563 20821823 18420326 11481614 18472332 12586293 18472094 15052691 14512876 14724832 17557913 16097048 15370692 16033810 18006644 15650968 12666154 14716833 16136751 15893842 12898905 18263696 12546737 10355542 18395914 12958196 15673190 15996030 17976157 17565644 14620537 15362042 15931870 18339082 16638106 17721639 17922224 18205269 12445418 16027843 17481882 15057751 16015684 18705752 17805973 16116963 12389079 17944888 17714472 18395095 17761835 18317297 18054572 18279442 12649538 15123356 17823541 15959796 18277467 12741479 17869086 17900296 14748882 12667390 15818738 17640975 18412020 18210741 15925388 18187930 15730626 18418968 18376398 15876570 12632514 17766677 14716496 16248980 16011737 17631135 18156304 17525996 12445421 12632512 13678700 16192424
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.5914716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 3.5917823541
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1015830285 16246199 16964402 15720792 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 4.2715123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.7714706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 2.2519294768
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.6612014681 15583823
MESH:D008223 Lymphoma decitabine 3.4719470736
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.1514737004
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 10.3216891317 11807958 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Genistein 10.3214578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 10.3217203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.6219453300
MESH:D008545 Melanoma decitabine 2.2516505122 17785578
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.6915863610
MESH:D052016 Mucositis irinotecan 5.1217159606
MESH:D009101 Multiple Myeloma decitabine 7.6918172295
MESH:D009101 Multiple Myeloma Raloxifene 7.6916497877
MESH:D009190 Myelodysplastic Syndromes decitabine 3.4319157545 18608210 19010910 16882708
MESH:D009203 Myocardial Infarction Genistein 2.8917141266
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.7216810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 8.7217141266
MESH:D009232 Myxoma Raloxifene 5.6916343187
MESH:D009362 Neoplasm Metastasis irinotecan 3.2018259882
MESH:D009369 Neoplasms decitabine 2.7517925555 19116145 19470736
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8517289903
MESH:D009421 Nervous System Malformations Estradiol 10.0916427766 11399458
MESH:D009421 Nervous System Malformations Genistein 10.0916427766
MESH:D009447 Neuroblastoma irinotecan 3.528761367
MESH:D017599 Neuroectodermal Tumors irinotecan 4.858761367
MESH:D010024 Osteoporosis Genistein 7.4919401787
MESH:D010024 Osteoporosis Raloxifene 7.4917882678 19059307 15775268
MESH:D015663 Osteoporosis, Postmenopausal Genistein 10.4416169203
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 10.4415758505 17823083 17893378 15579764
MESH:D010051 Ovarian Neoplasms decitabine 11.5219331143 19259094
MESH:D010051 Ovarian Neoplasms Estradiol 11.5219401270
MESH:D010051 Ovarian Neoplasms Genistein 11.5219005980
MESH:D010051 Ovarian Neoplasms Progesterone 11.5216525653 17393432
MESH:D010190 Pancreatic Neoplasms decitabine 2.7919294695
MESH:D011085 Polycystic Ovary Syndrome Flutamide 5.0915356085
MESH:D055728 Primary Myelofibrosis decitabine 4.8317616702
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9720887781
MESH:D011471 Prostatic Neoplasms Estradiol 1.8916740699
MESH:D011471 Prostatic Neoplasms Flutamide 1.893169114
MESH:D011471 Prostatic Neoplasms Genistein 1.8916925846 15256057 15378649
MESH:D011471 Prostatic Neoplasms Raloxifene 1.8916536755 15731164 16220300
MESH:D011471 Prostatic Neoplasms Sodium Selenite 1.8918760546
MESH:D011693 Purpura Raloxifene 5.6915770314
MESH:D012208 Rhabdomyosarcoma decitabine 4.4919155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8818045962
MESH:D013119 Spinal Cord Injuries Progesterone 4.4015862959 16503802
MESH:D013274 Stomach Neoplasms decitabine 2.7719037991
MESH:D013274 Stomach Neoplasms irinotecan 2.7715723263
MESH:D020521 Stroke Raloxifene 3.8916837676
MESH:D013964 Thyroid Neoplasms decitabine 3.3917967635
MESH:D013978 Tibial Fractures Estradiol 14.1719048282
MESH:D013978 Tibial Fractures Raloxifene 14.1719048282
MESH:D001749 Urinary Bladder Neoplasms decitabine 5.4617616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 5.4617572228
MESH:D014570 Urologic Diseases Dichlorodiphenyl Dichloroethylene 5.8716487989
MESH:D014604 Uveal Neoplasms decitabine 5.0517785578
MESH:D054556 Venous Thromboembolism Raloxifene 5.3416837676
MESH:D014846 Vulvar Neoplasms Raloxifene 5.6916343187
Pathway ID Pathway Name
REACT:604 Hemostasis
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB03014 - Heme
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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