AutismKB 2.0

Annotation Detail for HCK


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Basic Information Top
Gene Symbol:HCK ( JTK9 )
Gene Full Name: hemopoietic cell kinase
Band: 20q11.21
Quick LinksEntrez ID:3055; OMIM: 142370; Uniprot ID:HCK_HUMAN; ENSEMBL ID: ENSG00000101336; HGNC ID: 4840
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04062Chemokine signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
Pathway IDPathway Name
Signaling in Immune system
HIV Infection
Pathway IDPathway Name
200033Signaling events mediated by PTP1B
200187Alpha-synuclein signaling
200121EPHA forward signaling
200127PDGFR-beta signaling pathway
200124IL6-mediated signaling events
200069Thromboxane A2 receptor signaling
200173Ephrin B reverse signaling
200108amb2 Integrin signaling
200021Glypican 1 network
Pathway IDPathway Name
P00049Parkinson disease
Pathway IDPathway Name
500755Nef and signal transduction
Related Diseases/Disorders Top
No data
No data
Desease Name
IMMUNE
chronic obstructive pulmonary disease/COPD
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of HCK mRNAaffects expression 21346803
C108123 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [deoxynivalenol results in increased phosphorylation of and results in increased activity of HCK protein]decreases reaction|increases activity|increases phosphorylation 15772366
D000082 Acetaminophen Acetaminophen affects the expression of HCK mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of HCK mRNAaffects expression 16483693
D002084 Butylated Hydroxytoluene Butylated Hydroxytoluene affects the expression of HCK mRNAaffects expression 18539377
D019256 Cadmium Chloride [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of HCK mRNAaffects cotreatment|decreases expression 12634122
C023600 chromium oxide [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of HCK mRNAaffects cotreatment|decreases expression 12634122
C017133 chromous chloride [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of HCK mRNAaffects cotreatment|decreases expression 12634122
C014347 decitabine decitabine affects the methylation of HCK promoteraffects methylation 17344919
C014347 decitabine [decitabine affects the methylation of HCK promoter] which affects the expression of HCK mRNAaffects expression|affects methylation 17344919
C014347 decitabine decitabine results in increased expression of HCK proteinincreases expression 17344919
C007262 deoxynivalenol deoxynivalenol results in increased phosphorylation of HCK proteinincreases phosphorylation 20181660
C007262 deoxynivalenol 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [deoxynivalenol results in increased phosphorylation of and results in increased activity of HCK protein]decreases reaction|increases activity|increases phosphorylation 15772366
C007262 deoxynivalenol deoxynivalenol results in increased phosphorylation of and results in increased activity of HCK proteinincreases activity|increases phosphorylation 15772366
C007262 deoxynivalenol HCK protein affects the reaction [deoxynivalenol results in increased activity of CASP3 protein]affects reaction|increases activity 15772366
C007262 deoxynivalenol HCK protein affects the reaction [deoxynivalenol results in increased expression of TNF protein]affects reaction|increases expression 15772366
D004041 Dietary Fats Dietary Fats results in decreased expression of HCK mRNAdecreases expression 18042831
C008261 lead acetate [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of HCK mRNAaffects cotreatment|decreases expression 12634122
D026423 S-Nitroso-N-Acetylpenicillamine S-Nitroso-N-Acetylpenicillamine results in decreased expression of HCK mRNAdecreases expression 12102619
D010126 Ozone Ozone results in decreased expression of HCK mRNAdecreases expression 16330353
C041786 palm oil palm oil results in decreased expression of HCK mRNAdecreases expression 18042831
C006253 pirinixic acid pirinixic acid results in decreased expression of HCK mRNAdecreases expression 17426115
C017947 sodium arsenite [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of HCK mRNAaffects cotreatment|decreases expression 12634122
C004648 testosterone enanthate testosterone enanthate affects the expression of HCK mRNAaffects expression 17440010
D014212 Tretinoin Tretinoin results in increased expression of HCK mRNAincreases expression 16054129
D014212 Tretinoin Tretinoin results in decreased expression of HCK mRNAdecreases expression 16604517
C030665 triphenyltin triphenyltin results in increased expression of HCK proteinincreases expression 12788061
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 3.867525203
MESH:D000138 Acidosis Ammonium Chloride 3.4718287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.0318653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.4016434500
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.6215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.8217306315 16712894
MESH:D000505 Alopecia Tretinoin 3.5415955085
MESH:D000544 Alzheimer Disease Ozone 2.4215513908
MESH:D000799 Angioedema Acetaminophen 3.7610982225
MESH:D001161 Arteriosclerosis Dietary Fats 3.8015238619
MESH:D001169 Arthritis, Experimental Tretinoin 3.0216412693
MESH:D001172 Arthritis, Rheumatoid Ozone 4.6015570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.6016292516
MESH:D001249 Asthma Ozone 4.8617854713 16373670
MESH:D001249 Asthma Tretinoin 4.8616456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4318445737
MESH:D001471 Barrett Esophagus Tretinoin 4.3216935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.7019483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.7016197459 16206674
MESH:D001943 Breast Neoplasms decitabine 1.9619208741 18320071
MESH:D001943 Breast Neoplasms Dietary Fats 1.9620435547
MESH:D001943 Breast Neoplasms Tretinoin 1.9616443354 16873071 16166294
MESH:D016535 Bronchial Hyperreactivity Ozone 3.6014754758 15516495 17626835 18417511 19059883 18315731 16777450
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.5016813970
MESH:D002100 Cachexia Ozone 4.6516183385
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.0816168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.473084413
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 4.4717306315 16507464 15276417
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.471917145
MESH:D002294 Carcinoma, Squamous Cell decitabine 7.4319215824
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 7.4318572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.4316051514 16096774
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 12.0814694615
MESH:D002386 Cataract Acetaminophen 12.0810977129
MESH:D002386 Cataract Tretinoin 12.0817460283
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 2.9320056578 19524636
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.5016129372
MESH:D002779 Cholestasis pirinixic acid 2.7619176532
MESH:D002822 Choriocarcinoma Tretinoin 5.0816461808
MESH:D002972 Cleft Palate Tretinoin 2.639407595
MESH:D003092 Colitis Tretinoin 3.6217035595
MESH:D003110 Colonic Neoplasms decitabine 2.3217616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 4.0815095906
MESH:D019465 Craniofacial Abnormalities lead acetate 3.1219769572
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.129211117 16925845 9224671 17551590 9142499 10589399 8800419 14991402 9125849 9664655
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3818249437
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 3.8821346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.8818071297 17522070 12705907 16177239 10915739 19085960 11287661 15968718 11743745 11834606 12392966 11421492 16485898 17906064 14550746 16109766 12540782 19739265 14986274 11461765 10774834 16781746 19420014 19416960 12153990 12958197 16393943 16227642 2444490 14725611 15619225 16081117 19164858 11529661 10663392 18713872 19923254 17562736 12594235 11739529 19370779
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0219426721
MESH:D050171 Dyslipidemias Dietary Fats 3.3918367378
MESH:D004487 Edema pirinixic acid 2.4012083418
MESH:D004489 Edema, Cardiac Tretinoin 4.3918230668
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.0319294695
MESH:D016889 Endometrial Neoplasms Tretinoin 3.0516569247
MESH:D005124 Eye Abnormalities Tretinoin 3.519664655 16938888
MESH:D005234 Fatty Liver Dietary Fats 7.4317967931 19004024 19551842 18296743
MESH:D005234 Fatty Liver pirinixic acid 7.4319236843 20131406
MESH:D005317 Fetal Growth Retardation lead acetate 5.3019769572
MESH:D005355 Fibrosis Dietary Fats 8.5418296743
MESH:D005355 Fibrosis Tretinoin 8.5417994277
MESH:D005756 Gastritis Acetaminophen 3.5916983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.5916452187
MESH:D005909 Glioblastoma Tretinoin 2.9517312396
MESH:D005922 Glomerulonephritis, IGA deoxynivalenol 4.9415173396 16524712
MESH:D006258 Head and Neck Neoplasms decitabine 7.6319215824
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.6316096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.0816084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.859664655 14991402
MESH:D006333 Heart Failure pirinixic acid 2.4820558911
MESH:D006529 Hepatomegaly pirinixic acid 2.9119176532 16221962 19772884 18467677
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.6717440010
MESH:D006689 Hodgkin Disease sodium arsenite 3.0812676792
MESH:D006930 Hyperalgesia Acetaminophen 7.3916870215
MESH:D006930 Hyperalgesia Tretinoin 7.3916870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.5121332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.4816778211
MESH:D006943 Hyperglycemia pirinixic acid 9.5820558911
MESH:D006943 Hyperglycemia triphenyltin 9.5810522495
MESH:D006949 Hyperlipidemias Dietary Fats 3.5321332399
MESH:D006967 Hypersensitivity Butylated Hydroxytoluene 4.4317604070
MESH:D015228 Hypertriglyceridemia triphenyltin 5.8710522495
MESH:D007246 Infertility triphenyltin 5.9415205045
MESH:D007248 Infertility, Male decitabine 6.7117581917
MESH:D007248 Infertility, Male sodium arsenite 6.7115346721 12646999
MESH:D007249 Inflammation Dietary Fats 2.3920412841
MESH:D007333 Insulin Resistance Dietary Fats 7.0518457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 7.0516306350
MESH:D007410 Intestinal Diseases Tretinoin 3.6817994277
MESH:D007569 Jaw Abnormalities Tretinoin 3.8217551590 15992940
MESH:D007674 Kidney Diseases Acetaminophen 9.8612587719 15629191
MESH:D007674 Kidney Diseases Cadmium Chloride 9.8616962696
MESH:D007674 Kidney Diseases sodium arsenite 9.8620008137
MESH:D007938 Leukemia decitabine 6.2818980019 19235587
MESH:D007938 Leukemia Tretinoin 6.2817143497
MESH:D007951 Leukemia, Myeloid decitabine 9.2918454857 19117987 17236224
MESH:D007951 Leukemia, Myeloid Tretinoin 9.2919285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute decitabine 3.9217679729 18704418 18460780 19387464 19010910 18206229
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.9217596541 16294345 19850784
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.3818055864
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.0917339181 15748426 19035177 16140955 19642359 17506722 17712046 16935935 16891316 16766008 9834237 17217047 17107899 19029980 17361223 19225113 19075265 17368321 16788101 16331271 17649720 12679006 17294898 17301526 16823087
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.249224671
MESH:D008103 Liver Cirrhosis Dietary Fats 2.8318296743
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3215474484
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.3216248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 1.6119014921 12587719 12969438 16611625 19784758 16610002 19460945 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.1617185352 16871587
MESH:D008113 Liver Neoplasms Butylated Hydroxytoluene 7.3818177683
MESH:D008113 Liver Neoplasms pirinixic acid 7.3815890375 16377806 20007298
MESH:D008113 Liver Neoplasms sodium arsenite 7.3815276417 16712894
MESH:D008171 Lung Diseases Ozone 7.328266340 19066396
MESH:D008171 Lung Diseases sodium arsenite 7.3219095001
MESH:D055370 Lung Injury Ozone 3.7620417186
MESH:D008175 Lung Neoplasms Butylated Hydroxytoluene 3.6019925653 15390079 18597497 11246140 11696405 19359593 16337739
MESH:D008175 Lung Neoplasms Ozone 3.608597069 7614698
MESH:D008175 Lung Neoplasms sodium arsenite 3.6017306315 15276417 16712894 17077188 19931552
MESH:D008223 Lymphoma decitabine 3.3519470736
MESH:D008325 Mammary Neoplasms, Experimental Butylated Hydroxytoluene 3.691500032
MESH:D008527 Medulloblastoma Tretinoin 2.7517453147
MESH:D008545 Melanoma decitabine 5.0516505122 17785578
MESH:D008545 Melanoma sodium arsenite 5.0516487513 19082730
MESH:D008545 Melanoma Tretinoin 5.0516752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4819513568
MESH:D008591 Meningomyelocele Tretinoin 4.3416940565
MESH:D008679 Metaplasia Ozone 5.0210496685
MESH:D009101 Multiple Myeloma decitabine 3.2818172295
MESH:D009135 Muscular Diseases pirinixic acid 3.4216239165
MESH:D009190 Myelodysplastic Syndromes decitabine 7.3119010910 18608210 19157545 16882708
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.3117596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1119151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8816411023
MESH:D009369 Neoplasms decitabine 11.5119116145 19470736 17925555
MESH:D009369 Neoplasms pirinixic acid 11.5117405874
MESH:D009369 Neoplasms sodium arsenite 11.5111559025
MESH:D009369 Neoplasms Tretinoin 11.5116946489 16594593
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.5820056578
MESH:D009421 Nervous System Malformations Tretinoin 3.699125849
MESH:D009436 Neural Tube Defects sodium arsenite 7.1212854658
MESH:D009436 Neural Tube Defects Tretinoin 7.129142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8018514411
MESH:D009765 Obesity Dietary Fats 4.3620132043 21332399 11836018 17217161 20518802 16723640 18457598 19632207 18674790
MESH:D009765 Obesity pirinixic acid 4.3620558911
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 4.0214694615
MESH:D010051 Ovarian Neoplasms decitabine 7.7719331143 19259094
MESH:D010051 Ovarian Neoplasms sodium arsenite 7.7717306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 7.7716936753
MESH:D010146 Pain Acetaminophen 6.3416870215
MESH:D010146 Pain Tretinoin 6.3416870215
MESH:D010190 Pancreatic Neoplasms decitabine 5.2719294695
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.2715976015
MESH:D010538 Peritonitis Ozone 4.0416369182
MESH:D011014 Pneumonia Butylated Hydroxytoluene 11.0411893704
MESH:D011014 Pneumonia Ozone 11.0418381685 18929643 18007984
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma marker/mechanism 17344919
MESH:D055728 Primary Myelofibrosis decitabine 4.6417616702
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.3316039940
MESH:D011507 Proteinuria Tretinoin 3.5216636307
MESH:D011625 Pterygium Tretinoin 4.7116723453
MESH:D015427 Reperfusion Injury pirinixic acid 2.3419058328
MESH:D012208 Rhabdomyosarcoma decitabine 10.6719155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 10.6716283617 16116481
MESH:D012878 Skin Neoplasms sodium arsenite 5.6619524636 18572023
MESH:D012878 Skin Neoplasms Tretinoin 5.6616467112
MESH:D016135 Spinal Dysraphism sodium arsenite 3.7312854658
MESH:D013274 Stomach Neoplasms decitabine 2.5219037991
MESH:D013274 Stomach Neoplasms Tretinoin 2.5217261132
MESH:D013964 Thyroid Neoplasms 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine 11.8616940797
MESH:D013964 Thyroid Neoplasms decitabine 11.8617967635
MESH:D013964 Thyroid Neoplasms Tretinoin 11.8617045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 3.7116051514
MESH:D014376 Tuberculosis Tretinoin 3.1716040207
MESH:D001749 Urinary Bladder Neoplasms decitabine 5.1419087683 17616700
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 5.1411723127 17306315 16452187 16712894
MESH:D014581 Urticaria Acetaminophen 2.8910982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 9.1511813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 9.1516129372
MESH:D014604 Uveal Neoplasms decitabine 12.5617785578
MESH:D014604 Uveal Neoplasms Tretinoin 12.5616752155
MESH:D014652 Vascular Diseases sodium arsenite 4.3417056641
MESH:D014820 Vitiligo Tretinoin 3.9716761959
MESH:D015430 Weight Gain Dietary Fats 3.6616723640
MESH:D009396 Wilms Tumor Tretinoin 3.8916287080
Pathway ID Pathway Name
KEGG:04062 Chemokine signaling pathway
KEGG:04666 Fc gamma R-mediated phagocytosis
REACT:6185 HIV Infection
REACT:6900 Signaling in Immune system
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29216
    • No data
    No data
    Releated drug ID Related drug Name
    PA449092colchicine
    PA449396dopamine
    PA451578tacrolimus
    PA448478l-arginine
    PA450635nitric oxide
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB01809 - 1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine
    DB01962 - Phosphonotyrosine
    DB04216 - Quercetin Antioxidants
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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