AutismKB 2.0

Annotation Detail for HCLS1


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Basic Information Top
Gene Symbol:HCLS1 ( CTTNL,HS1 )
Gene Full Name: hematopoietic cell-specific Lyn substrate 1
Band: 3q13.33
Quick LinksEntrez ID:3059; OMIM: 601306; Uniprot ID:HCLS1_HUMAN; ENSEMBL ID: ENSG00000180353; HGNC ID: 4844
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05131Shigellosis
hsa05130Pathogenic Escherichia coli infection
hsa04530Tight junction
hsa05100Bacterial invasion of epithelial cells
No data
Pathway IDPathway Name
200003Fc-epsilon receptor I signaling in mast cells
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of HCLS1 mRNAaffects expression 17562736
D003913 Dextroamphetamine Dextroamphetamine results in decreased expression of HCLS1 mRNAdecreases expression 12558987
D004317 Doxorubicin HCLS1 protein affects the susceptibility to Doxorubicinaffects response to substance 16217747
D016685 Mitomycin HCLS1 protein affects the susceptibility to Mitomycinaffects response to substance 16217747
C004648 testosterone enanthate testosterone enanthate affects the expression of HCLS1 mRNAaffects expression 17440010
D014747 Vinblastine HCLS1 protein affects the susceptibility to Vinblastineaffects response to substance 16217747
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Doxorubicin 2.6317418594
MESH:D000419 Albuminuria Doxorubicin 4.9321441931
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 5.2214601052
MESH:D001932 Brain Neoplasms Doxorubicin 4.1117150277
MESH:D001943 Breast Neoplasms Doxorubicin 2.5819526202 16595493 15136595 16826403 16096432 17369602 15939500 15634643 18695136 17983394 16264153 15994142 18628466 15692762 17426702 11325840 15567936 15993339 18382427 16322301 15668708 18234424 16115903 16935488
MESH:D002276 Carcinoid Tumor Doxorubicin 5.3316051944
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.113084413
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 3.1117876044 16023760 16234567 18059187
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 7.3816201981 1485588
MESH:D002292 Carcinoma, Renal Cell Vinblastine 7.381485588
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 2.706189445
MESH:D009202 Cardiomyopathies Doxorubicin 3.7215476868 16952015 16109756 17928571 16651473 17974986 17519947 16455267 17351982 16278810 17308081 16242529 16269455 17924179 16731534 18627295 17329180 15792986 15505089 17382496 16364871 15811867 17131338 17007740 16612575
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 3.0317334414 16243910
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.9918259882 18802399
MESH:D015179 Colorectal Neoplasms Vinblastine 2.9918802399
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.1416177239 10774834 12958197 11529661 16227642 17562736 12594235 12392966 19085960 19164858 11834606 11739529 14986274 12540782 18071297 12705907 14725611 2444490 10915739 19923254 16081117 15619225 11287661 16393943 19739265 11743745 19416960 19370779 16109766 12153990 11421492 19420014 17522070 18713872 17906064 16485898 15968718 14550746 11461765 10663392 16781746
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 4.1417416283
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D004362 Drug Toxicity Doxorubicin 3.9018602426
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.6417359293
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.6818037988
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 5.0519069698
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D005909 Glioblastoma Doxorubicin 3.5417150277
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.7315692506
MESH:D006331 Heart Diseases Doxorubicin 3.6916879835 17888722 17875725 16144979 16495754 16707910 16244372 18674790 18006777 12587719 14766674 16244371 16330681
MESH:D006333 Heart Failure Doxorubicin 3.5217481944
MESH:D006394 Hemangiosarcoma Doxorubicin 4.2315692506
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 6.2717440010
MESH:D006689 Hodgkin Disease Doxorubicin 8.7618501091 17606976 15147373
MESH:D006689 Hodgkin Disease Vinblastine 8.7618501091 18180244
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D007674 Kidney Diseases Acetaminophen 6.6115629191 12587719
MESH:D007674 Kidney Diseases Doxorubicin 6.6115699352 15369732 16775033
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.4816707910
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.6816085563
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 2.1516595196 16439617
MESH:D008107 Liver Diseases Acetaminophen 1.6919014921 12587719 19784758 16610002 12969438 19460945 16611625 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5417185352 16871587
MESH:D008113 Liver Neoplasms Mitomycin 3.3615113037
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 3.1917085340 16842330
MESH:D008175 Lung Neoplasms Doxorubicin 2.1517418594 6189445
MESH:D008223 Lymphoma Doxorubicin 3.6816098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 4.0617654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.9815621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 3.2115458769
MESH:D008545 Melanoma Doxorubicin 3.9316827129
MESH:D008545 Melanoma Vinblastine 3.9316248763 12374674 17761969 15577320 15577323 18332650 18505091 18176117 16432458 16809738
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D008654 Mesothelioma Doxorubicin 3.1617638057
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.8315792986
MESH:D009041 Motion Sickness Dextroamphetamine 6.041613127
MESH:D052016 Mucositis Doxorubicin 5.2517415656
MESH:D009203 Myocardial Infarction Doxorubicin 3.0515857846 19429709
MESH:D009362 Neoplasm Metastasis Doxorubicin 3.0518259882
MESH:D009401 Nephrosis Doxorubicin 5.1916636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.2916889571 15640375
MESH:D009447 Neuroblastoma Doxorubicin 3.4015555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D009503 Neutropenia Vinblastine 4.9217378895
MESH:D012516 Osteosarcoma Doxorubicin 4.3715930896
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D010190 Pancreatic Neoplasms Mitomycin 3.5415113037
MESH:D003557 Phyllodes Tumor Doxorubicin 5.6817983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.6817638057
MESH:D011471 Prostatic Neoplasms Doxorubicin 3.5018437689 16888761 16729912 15749863 15897917 16868541
MESH:D051437 Renal Insufficiency Doxorubicin 4.6417922066
MESH:D012509 Sarcoma Doxorubicin 4.2918313854 15625365 17203757 17710206 15675481 16767912
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.6216326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 5.2517846226
MESH:D012878 Skin Neoplasms Doxorubicin 3.0815692506
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.9817203757 16767912 15625365
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.6117909728 16010429
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 2.8617653716
MESH:D014581 Urticaria Acetaminophen 3.3310982225
MESH:D014625 Vaginal Neoplasms Vinblastine 5.4615577323
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.6417638931 17334414 16364871 17678736
Pathway ID Pathway Name
KEGG:05100 Bacterial invasion of epithelial cells
KEGG:05130 Pathogenic Escherichia coli infection
KEGG:05131 Shigellosis
KEGG:04530 Tight junction
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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