AutismKB 2.0

Annotation Detail for HCRTR1


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Basic Information Top
Gene Symbol:HCRTR1 ( OX1R )
Gene Full Name: hypocretin (orexin) receptor 1
Band: 1p35.2
Quick LinksEntrez ID:3061; OMIM: 602392; Uniprot ID:OX1R_HUMAN; ENSEMBL ID: ENSG00000121764; HGNC ID: 4848
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
Pathway IDPathway Name
Signaling by GPCR
No data
No data
Pathway IDPathway Name
500409Orexin and neuropeptides FF and QRFP bind to their respective receptors
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C420062 1-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea 1-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea binds to and results in decreased activity of HCRTR1 proteinaffects binding|decreases activity 11459658
C420062 1-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea 1-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea binds to and results in decreased activity of HCRTR1 proteinaffects binding|decreases activity 17638707
D000643 Ammonium Chloride Ammonium Chloride affects the expression of HCRTR1 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in decreased expression of HCRTR1 mRNAdecreases expression 15761015
C062876 cetrorelix cetrorelix results in decreased expression of HCRTR1 mRNAdecreases expression 17638707
D004317 Doxorubicin Doxorubicin results in decreased expression of HCRTR1 mRNAdecreases expression 16404146
D010424 Pentobarbital Pentobarbital results in decreased expression of HCRTR1 mRNAdecreases expression 17638707
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of HCRTR1 mRNAaffects binding|decreases expression|increases activity 19710929
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.9518287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.4218653653
MESH:D000230 Adenocarcinoma arsenic trioxide 4.7619825857 11798837
MESH:D000230 Adenocarcinoma Doxorubicin 4.7617418594
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8816434500
MESH:D000419 Albuminuria Doxorubicin 4.8721441931
MESH:D001008 Anxiety Disorders Pentobarbital 4.9518313124 11141031
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.9616206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.9619483382
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 5.1414601052
MESH:D001932 Brain Neoplasms Doxorubicin 4.0717150277
MESH:D001943 Breast Neoplasms Doxorubicin 2.5915939500 15692762 18628466 16595493 16096432 16322301 15136595 15994142 19526202 16115903 18695136 15668708 17426702 15993339 16264153 16935488 15567936 15634643 18234424 18382427 17369602 11325840 17983394 16826403
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.6311589617
MESH:D002276 Carcinoid Tumor Doxorubicin 5.2516051944
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 3.3115073043 16217749 11135700 14691202 15553829
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 3.3118059187 16023760 16234567 17876044
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.3219014326
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.271485588 16201981
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3812490120
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 2.706189445
MESH:D009202 Cardiomyopathies Doxorubicin 3.7016269455 16612575 17351982 17974986 15476868 16952015 17131338 16242529 16109756 16278810 17308081 15811867 17329180 17382496 16364871 16455267 18627295 17924179 16731534 15792986 15505089 17928571 17519947 17007740 16651473
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 3.0216243910 17334414
MESH:D002779 Cholestasis pirinixic acid 3.0319176532
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.6520501625
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.6518802399 18259882
MESH:D023903 Coronary Restenosis arsenic trioxide 4.5112609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.4015213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5318249437
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 2.5017416283
MESH:D004362 Drug Toxicity Doxorubicin 3.8718602426
MESH:D004487 Edema pirinixic acid 2.7612083418
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.6217359293
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.6018037988
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3612903497
MESH:D005234 Fatty Liver arsenic trioxide 8.6715073043
MESH:D005234 Fatty Liver pirinixic acid 8.6720131406 19236843
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.9819069698
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5916904648
MESH:D005909 Glioblastoma Doxorubicin 3.5217150277
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.7015692506
MESH:D006331 Heart Diseases Doxorubicin 3.6714766674 16244371 16244372 16144979 16879835 18674790 17875725 16707910 16495754 12587719 18006777 17888722 16330681
MESH:D006333 Heart Failure Doxorubicin 7.5817481944
MESH:D006333 Heart Failure pirinixic acid 7.5820558911
MESH:D006394 Hemangiosarcoma Doxorubicin 4.1815692506
MESH:D006529 Hepatomegaly pirinixic acid 3.3516221962 19772884 19176532 18467677
MESH:D006689 Hodgkin Disease Doxorubicin 3.6518501091 17606976 15147373
MESH:D006943 Hyperglycemia pirinixic acid 3.4520558911
MESH:D007333 Insulin Resistance pirinixic acid 2.8016306350
MESH:D007674 Kidney Diseases Doxorubicin 3.2015369732 15699352 16775033
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.4416707910
MESH:D007938 Leukemia arsenic trioxide 2.9515070760
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.6016085563
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0817077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.7016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.0419077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1716467208 16968895 20471514 19850784 17050201
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3816891316 16966277 15213294 15622746 11468182 17869043 17649720 19225113 17107899 16330433 12712474 11161223 17712046 12018890 19035177 12679006 19642359 17217047 16823087 15748426 9834237 15336539 19075265 16331271 16112521
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.6816882451
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 2.5416439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.5415474484
MESH:D008113 Liver Neoplasms arsenic trioxide 4.7714682389
MESH:D008113 Liver Neoplasms pirinixic acid 4.7720007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.6820377131
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 6.6816842330 17085340
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5615213294
MESH:D008175 Lung Neoplasms arsenic trioxide 2.6911798837 19825857
MESH:D008175 Lung Neoplasms Doxorubicin 2.696189445 17418594
MESH:D008223 Lymphoma Doxorubicin 3.6516098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 4.0217654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.9315621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 3.1915458769
MESH:D008545 Melanoma Doxorubicin 2.3216827129
MESH:D008654 Mesothelioma Doxorubicin 3.1517638057
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.7815792986
MESH:D052016 Mucositis Doxorubicin 5.1917415656
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2914977855 19417148 19549372 11468182 15949261
MESH:D009135 Muscular Diseases pirinixic acid 3.8616239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.1218349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2816882451 16105982
MESH:D009203 Myocardial Infarction Doxorubicin 6.0419429709 15857846
MESH:D009203 Myocardial Infarction pirinixic acid 6.0419151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1616411023
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2916624393
MESH:D009362 Neoplasm Metastasis Doxorubicin 3.0418259882
MESH:D009369 Neoplasms pirinixic acid 2.0617405874
MESH:D009401 Nephrosis Doxorubicin 5.1316899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.2516889571 15640375
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2810525206
MESH:D009447 Neuroblastoma Doxorubicin 3.3915555623
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D012516 Osteosarcoma Doxorubicin 4.3415930896
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4719769630 12452020 16624393
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.6015580305
MESH:D010235 Paraganglioma arsenic trioxide 4.4719927285
MESH:D003557 Phyllodes Tumor Doxorubicin 5.6017983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.6017638057
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.3319131511
MESH:D011471 Prostatic Neoplasms Doxorubicin 3.3316729912 16888761 15897917 15749863 18437689 16868541
MESH:D012021 Reflex, Abnormal Pentobarbital 6.4210930210
MESH:D051437 Renal Insufficiency Doxorubicin 4.5817922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.5019058328
MESH:D012509 Sarcoma Doxorubicin 4.2517203757 16767912 17710206 15625365 18313854 15675481
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 11.4016646077
MESH:D012512 Sarcoma, Ewing's Doxorubicin 11.4016326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 5.1917846226
MESH:D012640 Seizures Pentobarbital 4.079754883 10087439
MESH:D012878 Skin Neoplasms Doxorubicin 3.0615692506
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.9317203757 15625365 16767912
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D013375 Substance Withdrawal Syndrome Pentobarbital 5.249754883 11529278
MESH:D013964 Thyroid Neoplasms arsenic trioxide 8.0419014326
MESH:D013964 Thyroid Neoplasms Doxorubicin 8.0416010429 17909728
MESH:D016171 Torsades de Pointes arsenic trioxide 4.3615213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.5612845720 20435036 12973940 11780464
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 5.5617653716
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.5817678736 16364871 17334414 17638931
Pathway ID Pathway Name
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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