AutismKB 2.0

Annotation Detail for HDAC1


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Basic Information Top
Gene Symbol:HDAC1 ( DKFZp686H12203,GON-10,HD1,RPD3,RPD3L1 )
Gene Full Name: histone deacetylase 1
Band: 1p35.2-p35.1
Quick LinksEntrez ID:3065; OMIM: 601241; Uniprot ID:HDAC1_HUMAN; ENSEMBL ID: ENSG00000116478; HGNC ID: 4852
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05016Huntington's disease
hsa04330Notch signaling pathway
hsa04110Cell cycle
hsa05220Chronic myeloid leukemia
hsa05200Pathways in cancer
Pathway IDPathway Name
Signalling by NGF
Pathway IDPathway Name
200171Validated targets of C-MYC transcriptional repression
200070Signaling events mediated by HDAC Class I
200002Regulation of nuclear SMAD2/3 signaling
200027E2F transcription factor network
200013Notch signaling pathway
200142Retinoic acid receptors-mediated signaling
200106Regulation of Wnt-mediated beta catenin signaling and target gene transcription
200097Sumoylation by RanBP2 regulates transcriptional repression
200072Regulation of Telomerase
200077Glucocorticoid receptor regulatory network
200147Hedgehog signaling events mediated by Gli proteins
200102Regulation of Androgen receptor activity
200191Regulation of retinoblastoma protein
200196Notch-mediated HES/HEY network
200052Presenilin action in Notch and Wnt signaling
Pathway IDPathway Name
P00059p53 pathway
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C453963 3-(4-benzoyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide 3-(4-benzoyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide analog results in decreased activity of HDAC1 proteindecreases activity 11960489
C075773 4-phenylbutyric acid [4-phenylbutyric acid affects the acetylation of HDAC1 protein] which affects the expression of TUBB3 proteinaffects acetylation|affects expression 18497984
D006710 Homocysteine decitabine inhibits the reaction [Homocysteine results in decreased expression of HDAC1 protein]decreases expression|decreases reaction 18310117
D006710 Homocysteine Folic Acid inhibits the reaction [Homocysteine results in decreased expression of HDAC1 protein]decreases expression|decreases reaction 18310117
D006710 Homocysteine trichostatin A inhibits the reaction [Homocysteine results in decreased expression of HDAC1 protein]decreases expression|decreases reaction 18310117
D000643 Ammonium Chloride Ammonium Chloride affects the expression of HDAC1 mRNAaffects expression 16483693
D000643 Ammonium Chloride Ammonium Chloride results in increased expression of HDAC1 proteinincreases expression 16483693
C006632 arsenic trioxide arsenic trioxide promotes the reaction [[TGIF1 protein co-treated with HDAC1 protein] binds to CDKN1A promoter]affects binding|affects cotreatment|increases reaction 18210215
C006632 arsenic trioxide arsenic trioxide promotes the reaction [[TGIF1 protein co-treated with HDAC1 protein] results in decreased expression of CDKN1A mRNA]affects cotreatment|decreases expression|increases reaction 18210215
D019324 beta-Naphthoflavone beta-Naphthoflavone results in increased expression of HDAC1 proteinincreases expression 19389873
D001564 Benzo(a)pyrene Benzo(a)pyrene inhibits the reaction [[DNMT1 protein binds to HDAC1 protein] which binds to CYP1A1 promoter]affects binding|decreases reaction 17682057
D001564 Benzo(a)pyrene Chromium inhibits the reaction [Benzo(a)pyrene inhibits the reaction [HDAC1 protein binds to CYP1A1 promoter]]affects binding|decreases reaction 17682057
C072553 benzyloxycarbonylleucyl-leucyl-leucine aldehyde benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin affects the localization of HDAC1 protein]affects localization|decreases reaction 17927689
C072553 benzyloxycarbonylleucyl-leucyl-leucine aldehyde benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of HDAC1 mRNA]decreases expression|decreases reaction 17927689
C072553 benzyloxycarbonylleucyl-leucyl-leucine aldehyde benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of HDAC1 protein]decreases expression|decreases reaction 17927689
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of HDAC1 mRNAdecreases expression 12419474
D002087 Butyrates Butyrates results in decreased activity of HDAC1 proteindecreases activity 15930892
C006963 chlamydocin chlamydocin analog results in decreased activity of HDAC1 proteindecreases activity 16439135
D002857 Chromium Chromium inhibits the reaction [Benzo(a)pyrene inhibits the reaction [HDAC1 protein binds to CYP1A1 promoter]]affects binding|decreases reaction 17682057
D002857 Chromium Chromium promotes the reaction [[DNMT1 protein binds to HDAC1 protein] which binds to CYP1A1 promoter]affects binding|increases reaction 17682057
D002857 Chromium Chromium promotes the reaction [HDAC1 protein binds to CYP1A1 promoter]affects binding|increases reaction 17682057
D002857 Chromium HDAC1 protein affects the reaction [Chromium results in decreased expression of CYP1A1 mRNA]affects reaction|decreases expression 17682057
C019304 ciprofibrate ciprofibrate results in increased expression of HDAC1 mRNAincreases expression 12771043
D003474 Curcumin benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin affects the localization of HDAC1 protein]affects localization|decreases reaction 17927689
D003474 Curcumin benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of HDAC1 mRNA]decreases expression|decreases reaction 17927689
D003474 Curcumin benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of HDAC1 protein]decreases expression|decreases reaction 17927689
D003474 Curcumin Curcumin affects the localization of HDAC1 proteinaffects localization 17927689
D003474 Curcumin Curcumin results in decreased expression of HDAC1 mRNAdecreases expression 17927689
D003474 Curcumin Curcumin results in decreased expression of HDAC1 proteindecreases expression 18161303
17927689
D016572 Cyclosporine Cyclosporine results in decreased expression of HDAC1 mRNAdecreases expression 20106945
C014347 decitabine decitabine inhibits the reaction [HDAC1 protein binds to ABCG2 promoter]affects binding|decreases reaction 16954373
C014347 decitabine decitabine inhibits the reaction [HDAC1 protein binds to BUB1B promoter]affects binding|decreases reaction 17464181
C014347 decitabine decitabine inhibits the reaction [HDAC1 protein binds to CDKN1A promoter]affects binding|decreases reaction 16043219
C014347 decitabine decitabine inhibits the reaction [Homocysteine results in decreased expression of HDAC1 protein]decreases expression|decreases reaction 18310117
D003907 Dexamethasone HDAC1 protein inhibits the reaction [Dexamethasone results in increased expression of UCP3 mRNA]decreases reaction|increases expression 17884810
D004052 Diethylnitrosamine AHR protein inhibits the reaction [Diethylnitrosamine results in decreased expression of HDAC1 mRNA]decreases expression|decreases reaction 19996281
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of HDAC1 mRNAdecreases expression 19996281
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of HDAC1 mRNAincreases expression 12771043
D004317 Doxorubicin Doxorubicin promotes the reaction [HDAC1 protein binds to BIRC5 promoter]affects binding|increases reaction 17124180
D004958 Estradiol Estradiol results in decreased expression of HDAC1 mRNAdecreases expression 16029874
D004958 Estradiol [Tetrachlorodibenzodioxin co-treated with Estradiol] promotes the reaction [HDAC1 protein binds to BRCA1 promoter]affects binding|affects cotreatment|increases reaction 16489025
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of HDAC1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HDAC1 mRNAaffects cotreatment|increases expression 17942748
D005492 Folic Acid Folic Acid inhibits the reaction [Homocysteine results in decreased expression of HDAC1 protein]decreases expression|decreases reaction 18310117
D005839 Gentamicins Gentamicins results in increased expression of HDAC1 proteinincreases expression 19141081
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased expression of HDAC1 mRNAdecreases expression 12419474
C027185 indirubin indirubin promotes the reaction [[tetraarsenic tetrasulfide co-treated with tanshinone] inhibits the reaction [RARB protein binds to HDAC1 protein]]affects binding|affects cotreatment|decreases reaction|increases reaction 18344322
C027185 indirubin [tanshinone co-treated with indirubin] inhibits the reaction [RARB protein binds to HDAC1 protein]affects binding|affects cotreatment|decreases reaction 18344322
C027185 indirubin tetraarsenic tetrasulfide promotes the reaction [[tanshinone co-treated with indirubin] inhibits the reaction [RARB protein binds to HDAC1 protein]]affects binding|affects cotreatment|decreases reaction|increases reaction 18344322
D018021 Lithium Chloride Lithium Chloride inhibits the reaction [HDAC1 protein binds to GCG promoter]affects binding|decreases reaction 19582394
D018021 Lithium Chloride Lithium Chloride inhibits the reaction [HDAC1 protein binds to GIP promoter]affects binding|decreases reaction 19582394
C013598 methoxyacetic acid methoxyacetic acid results in decreased activity of HDAC1 proteindecreases activity 15103026
D011374 Progesterone Progesterone results in decreased expression of HDAC1 mRNAdecreases expression 18037150
C025462 sulindac sulfide sulindac sulfide results in decreased expression of HDAC1 mRNAdecreases expression 16184548
D013629 Tamoxifen Tamoxifen promotes the reaction [HDAC1 protein binds to FOXM1 promoter]affects binding|increases reaction 20208560
C021751 tanshinone indirubin promotes the reaction [[tetraarsenic tetrasulfide co-treated with tanshinone] inhibits the reaction [RARB protein binds to HDAC1 protein]]affects binding|affects cotreatment|decreases reaction|increases reaction 18344322
C021751 tanshinone [tanshinone co-treated with indirubin] inhibits the reaction [RARB protein binds to HDAC1 protein]affects binding|affects cotreatment|decreases reaction 18344322
C021751 tanshinone [tetraarsenic tetrasulfide co-treated with tanshinone] inhibits the reaction [RARB protein binds to HDAC1 protein]affects binding|affects cotreatment|decreases reaction 18344322
C021751 tanshinone tetraarsenic tetrasulfide promotes the reaction [[tanshinone co-treated with indirubin] inhibits the reaction [RARB protein binds to HDAC1 protein]]affects binding|affects cotreatment|decreases reaction|increases reaction 18344322
C534735 tetraarsenic tetrasulfide indirubin promotes the reaction [[tetraarsenic tetrasulfide co-treated with tanshinone] inhibits the reaction [RARB protein binds to HDAC1 protein]]affects binding|affects cotreatment|decreases reaction|increases reaction 18344322
C534735 tetraarsenic tetrasulfide [tetraarsenic tetrasulfide co-treated with tanshinone] inhibits the reaction [RARB protein binds to HDAC1 protein]affects binding|affects cotreatment|decreases reaction 18344322
C534735 tetraarsenic tetrasulfide tetraarsenic tetrasulfide promotes the reaction [[tanshinone co-treated with indirubin] inhibits the reaction [RARB protein binds to HDAC1 protein]]affects binding|affects cotreatment|decreases reaction|increases reaction 18344322
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Estradiol] promotes the reaction [HDAC1 protein binds to BRCA1 promoter]affects binding|affects cotreatment|increases reaction 16489025
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin promotes the reaction [HDAC1 protein binds to BRCA1 promoter]affects binding|increases reaction 16489025
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the reaction [HDAC1 protein binds to CYP1A1 promoter]affects binding|affects reaction 17652329
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HDAC1 mRNAaffects cotreatment|increases expression 17942748
D013876 Thiophenes Thiophenes analog promotes the reaction [Tretinoin results in increased expression of HDAC1 mRNA]increases expression|increases reaction 16140955
C067071 trapoxin B trapoxin B results in decreased activity of HDAC1 proteindecreases activity 15930892
D014212 Tretinoin Thiophenes analog promotes the reaction [Tretinoin results in increased expression of HDAC1 mRNA]increases expression|increases reaction 16140955
D014212 Tretinoin Tretinoin results in increased expression of HDAC1 mRNAincreases expression 16140955
C012589 trichostatin A trichostatin A inhibits the reaction [Homocysteine results in decreased expression of HDAC1 protein]decreases expression|decreases reaction 18310117
C012589 trichostatin A trichostatin A results in decreased activity of HDAC1 proteindecreases activity 15927959
15103026
15930892
D014635 Valproic Acid Valproic Acid results in decreased activity of HDAC1 proteindecreases activity 15103026
C025643 vinclozolin vinclozolin results in decreased expression of HDAC1 mRNAdecreases expression 18042343
D014810 Vitamin E Vitamin E results in increased expression of HDAC1 mRNAincreases expression 19244175
C111237 vorinostat vorinostat results in decreased activity of HDAC1 proteindecreases activity 15930892
C111237 vorinostat vorinostat inhibits the reaction [HDAC1 protein binds to CDKN1A promoter]affects binding|decreases reaction 16043219
C063449 zileuton zileuton results in decreased expression of HDAC1 mRNAdecreases expression 12883083
D015032 Zinc Zinc binds to and results in increased activity of HDAC1 proteinaffects binding|increases activity 16439135
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.0814745880
MESH:D000014 Abnormalities, Drug-Induced methoxyacetic acid 11.771761404 3652986 15959878 12805644 1761407
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 11.7714514962 15322242 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 11.778875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.5219490988
MESH:D000138 Acidosis Ammonium Chloride 3.1118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 10.5617505938
MESH:D000152 Acne Vulgaris zileuton 10.5620436887
MESH:D000169 Acrodermatitis Zinc 4.9516889938 17202136 17190629
MESH:D058186 Acute Kidney Injury Folic Acid 7.9317003819 16316344 16595132
MESH:D058186 Acute Kidney Injury Gentamicins 7.9311274264
MESH:D055371 Acute Lung Injury zileuton 4.5817118201
MESH:D000230 Adenocarcinoma arsenic trioxide 12.0811798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 12.0820127859 20464547
MESH:D000230 Adenocarcinoma Doxorubicin 12.0817418594
MESH:D000230 Adenocarcinoma Estradiol 12.0811473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 12.0814692618
MESH:D000236 Adenoma Benzo(a)pyrene 13.776695378
MESH:D000236 Adenoma beta-Naphthoflavone 13.7719389873
MESH:D000236 Adenoma Diethylnitrosamine 13.776695378 10737359
MESH:D000236 Adenoma Folic Acid 13.7716963246
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 8.5517620307 16434500 19061943 17162532 19052882 18056438
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.5516835633
MESH:D000419 Albuminuria Doxorubicin 4.1121441931
MESH:D019973 Alcohol-Related Disorders Curcumin 4.6217887948
MESH:D000505 Alopecia Tretinoin 3.2615955085
MESH:D000544 Alzheimer Disease Curcumin 8.5215590663
MESH:D000544 Alzheimer Disease Folic Acid 8.5217116317
MESH:D000544 Alzheimer Disease sulindac sulfide 8.5218759972
MESH:D000544 Alzheimer Disease Zinc 8.5217119284 16410023 16325427 16580781
MESH:D000550 Amblyopia Valproic Acid 4.7717688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.5611748828
MESH:D000755 Anemia, Sickle Cell Zinc 4.4716916123
MESH:D001008 Anxiety Disorders Valproic Acid 7.6617497229
MESH:D001008 Anxiety Disorders vinclozolin 7.6619015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.6319183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.0211256880
MESH:D001169 Arthritis, Experimental Dexamethasone 10.6017659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 10.6015885639
MESH:D001169 Arthritis, Experimental Tretinoin 10.6016412693
MESH:D001172 Arthritis, Rheumatoid Curcumin 4.3116807698
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.3116292516
MESH:D001249 Asthma Tretinoin 7.2016456186
MESH:D001249 Asthma zileuton 7.2017944539 8598621 19214143 20332717 9620945 10181070 10764316
MESH:D001249 Asthma Zinc 7.2017085522
MESH:D001250 Asthma, Exercise-Induced zileuton 5.1410984370
MESH:D050197 Atherosclerosis Curcumin 3.0518704882
MESH:D001321 Autistic Disorder Folic Acid 2.3421388746
MESH:D001321 Autistic Disorder Homocysteine 2.3420468076 16297937
MESH:D001321 Autistic Disorder Valproic Acid 2.3418775368 18558336 18940202 18985861 18177632 17507914 17157402 18316065 19460635 15238991 18396377 20603192 17688650 16609825 19232924
MESH:D001327 Autoimmune Diseases Curcumin 4.0519761891
MESH:D001471 Barrett Esophagus Tretinoin 3.9716935849
MESH:D001714 Bipolar Disorder Valproic Acid 2.8317594078 20046352
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 12.9916206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 12.9912125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 12.9916206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.3315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.0315746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.038888407
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.2414601052
MESH:D001929 Brain Edema zileuton 5.4219309543
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.8717868700
MESH:D001930 Brain Injuries Progesterone 9.5715665606 15380490 15845082
MESH:D001930 Brain Injuries Zinc 9.5717109824
MESH:D002545 Brain Ischemia Curcumin 3.8816770732
MESH:D001932 Brain Neoplasms Curcumin 7.6617596214
MESH:D001932 Brain Neoplasms Doxorubicin 7.6617150277
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 11.7820146248 17474063
MESH:D001943 Breast Neoplasms Chromium 11.7815986119
MESH:D001943 Breast Neoplasms Curcumin 11.7818593918 16243823 19250217 18462866
MESH:D001943 Breast Neoplasms decitabine 11.7818320071 19208741
MESH:D001943 Breast Neoplasms Diethylnitrosamine 11.7817474063
MESH:D001943 Breast Neoplasms Doxorubicin 11.7818628466 17983394 15939500 15567936 18695136 15634643 16096432 16935488 16264153 17369602 15136595 15993339 15994142 18382427 19526202 16595493 18234424 15692762 15668708 16115903 17426702 16826403 16322301 11325840
MESH:D001943 Breast Neoplasms Estradiol 11.7814630087 19861407 17261762 17018787 17289903 18497071 12948864 16675129
MESH:D001943 Breast Neoplasms Folic Acid 11.7816777985
MESH:D001943 Breast Neoplasms Progesterone 11.7817614352 15562024 16175315
MESH:D001943 Breast Neoplasms Tamoxifen 11.7811161223 20005174 19189212 20065188 19142967 19103187 19084267 16873071 19011961 18984771 16202921 21138602 15668708 19410462 20135344 19289846 18629630 18997820 19155303 18425577 18855134 16273361 18351453 20859285 15565566 17049068 20544844 19066611 19115204 19059307 19221464 18821012 18815881 19288272 17440819 19487384 19189210 21152245 17893378 19200415 17261762 16818667 17242785 19244106 20390343
MESH:D001943 Breast Neoplasms tanshinone 11.7815849732 19885617
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 11.7820435547
MESH:D001943 Breast Neoplasms Tretinoin 11.7816166294 16443354 16873071
MESH:D001943 Breast Neoplasms vorinostat 11.7816144943
MESH:D016535 Bronchial Hyperreactivity zileuton 4.4412794006 12654629 12388339
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.1416813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 3.9111589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.0116111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.4916050911
MESH:D002276 Carcinoid Tumor Doxorubicin 4.3516051944
MESH:D002277 Carcinoma Curcumin 7.0918593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.0916835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.0619066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.6916168501
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 10.2111135700 16217749 15073043 14691202 15553829
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 10.2118506893 18665156 18393292 20935162 20214788 18785209 17055752 18971187 18210153 16807293 16878318 20007298 3084413 19519916 19052882 19394651 16569478 11831363 10672840 3581430 19701751 20084675 20727157 19822196 17761372 18978308 16328049 16779866 18788625 20432363 19919837 19335982 17978847 10737359 16935385 18056438 19208518 18691550 17138121 16681979 19539802 19418558 17173139 17428255 19171122 21159647 16502159 19107877 16288022 16698587 20524982 16540662 17162532 19383236 18494052 20101231 20512989 16830150 20514400
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 10.2118059187 16023760 16234567 17876044
MESH:D006528 Carcinoma, Hepatocellular Estradiol 10.2116924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 10.2116924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 10.211917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 5.3418414057
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 5.3412391285
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.4119014326
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 2.9416201981 1485588
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.7212490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 16.0920419170
MESH:D002294 Carcinoma, Squamous Cell Curcumin 16.0918462866
MESH:D002294 Carcinoma, Squamous Cell decitabine 16.0919215824
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 16.096189445
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 16.0916096774 16051514
MESH:D002294 Carcinoma, Squamous Cell Zinc 16.0916543248
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.2217572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1118850075 18670907 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.2316455267 15505089 15792986 17329180 16242529 16109756 17382496 17308081 17928571 16651473 17974986 16269455 17007740 15476868 15811867 17519947 16952015 16364871 16278810 17131338 16612575 16731534 17924179 18627295 17351982
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.7817334414 16243910
MESH:D002318 Cardiovascular Diseases Folic Acid 10.5216755160
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 10.5216936243
MESH:D002318 Cardiovascular Diseases Zinc 10.5216936243
MESH:D002386 Cataract Tretinoin 2.8217460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 9.3112371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 9.3117174075 7505956 2727394 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 9.3118566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.1416129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.5320734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.0519052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.0516835633
MESH:D002779 Cholestasis Cyclosporine 6.6519486331
MESH:D002779 Cholestasis Ethinyl Estradiol 6.6516919318 15861022 17681005 11677210 16105132 17110522 17333356
MESH:D002822 Choriocarcinoma Tretinoin 4.6916461808
MESH:D002971 Cleft Lip Folic Acid 3.7321254359
MESH:D002972 Cleft Palate Folic Acid 8.6921254359 8946559
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 8.6915340226 15668235 8697196 12621046 16354765
MESH:D002972 Cleft Palate Tretinoin 8.699407595
MESH:D003092 Colitis Curcumin 8.1716782535 18200517 16804969
MESH:D003092 Colitis Tretinoin 8.1717035595
MESH:D003103 Coloboma Curcumin 4.1418809619
MESH:D003110 Colonic Neoplasms Butyrates 10.0115936596
MESH:D003110 Colonic Neoplasms Curcumin 10.0119359593 16340194
MESH:D003110 Colonic Neoplasms decitabine 10.0117616700
MESH:D003110 Colonic Neoplasms Dexamethasone 10.0115824018
MESH:D003110 Colonic Neoplasms zileuton 10.0118927292
MESH:D015179 Colorectal Neoplasms arsenic trioxide 4.4120501625
MESH:D015179 Colorectal Neoplasms decitabine 4.4118981723
MESH:D015179 Colorectal Neoplasms Doxorubicin 4.4118259882 18802399
MESH:D015179 Colorectal Neoplasms Folic Acid 4.4117116713 17245555 16963246 17087956 16985020
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.6817141729 14669216
MESH:D016510 Corneal Neovascularization Curcumin 4.4518497527
MESH:D003324 Coronary Artery Disease Homocysteine 3.5816379339
MESH:D023903 Coronary Restenosis arsenic trioxide 3.7512609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 10.8110525206
MESH:D019465 Craniofacial Abnormalities Dexamethasone 10.8117728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 10.8110048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 10.819664655 10589399 14991402 17551590 8800419 16925845 9224671 9125849 9211117 9142499
MESH:D019465 Craniofacial Abnormalities Valproic Acid 10.8116575769 17688650 8888407
MESH:D019465 Craniofacial Abnormalities Vitamin E 10.8119769572
MESH:D019465 Craniofacial Abnormalities Zinc 10.8119302082
MESH:D003456 Cryptorchidism vinclozolin 3.9114966744
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.6815213294
MESH:D003665 Decompression Sickness zileuton 5.7618309904
MESH:D003711 Demyelinating Diseases Tamoxifen 3.9219031437
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 2.9912438553
MESH:D003920 Diabetes Mellitus Zinc 3.8216479319
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 9.1818403477
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 9.1820387270
MESH:D003924 Diabetes Mellitus, Type 2 Folic Acid 9.1816886840
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 9.1817107852
MESH:D003928 Diabetic Nephropathies Curcumin 12.8218204486
MESH:D003928 Diabetic Nephropathies Estradiol 12.8219279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 12.8219279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.0517187935
MESH:D003967 Diarrhea Dexamethasone 7.117237001
MESH:D003967 Diarrhea vorinostat 7.1120479100
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 10.3819107877
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 10.3817416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 10.3820420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 10.381733752 19641884
MESH:D056486 Drug-Induced Liver Injury zileuton 10.3817944539
MESH:D004362 Drug Toxicity Doxorubicin 11.8918602426
MESH:D004362 Drug Toxicity Gentamicins 11.8911033412 15033597
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 11.8911462148
MESH:D004381 Duodenal Ulcer Curcumin 3.6217351913
MESH:D004421 Dystonia Valproic Acid 3.631851702
MESH:C538011 Eales disease Vitamin E 4.249068938
MESH:D004485 Eczema Dexamethasone 4.0312438553
MESH:D004487 Edema Dexamethasone 9.3719703484
MESH:D004487 Edema Tetrachlorodibenzodioxin 9.3712711302 11000095
MESH:D004487 Edema zileuton 9.379831321 17118201 11698051 7990266 8273558 7812673 19703484
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.4015322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 10.4018230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 12.8312538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 12.8317692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 12.8319031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 12.4919294695
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 12.4919294695
MESH:D016889 Endometrial Neoplasms Doxorubicin 20.1317359293
MESH:D016889 Endometrial Neoplasms Estradiol 20.1319148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Folic Acid 20.1317301261
MESH:D016889 Endometrial Neoplasms Tamoxifen 20.1317893378 16202921 20544844 19155303
MESH:D016889 Endometrial Neoplasms Tretinoin 20.1316569247
MESH:D004715 Endometriosis Progesterone 7.6216134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.629294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.6918037988
MESH:D019446 Endotoxemia zileuton 4.9015328337
MESH:D004802 Eosinophilia zileuton 4.478621850 10764316
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.713659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.4616628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.6920417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.216254150 7562514 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 3.857750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.613659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.6516302075
MESH:D004938 Esophageal Neoplasms arsenic trioxide 6.5112903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 6.5116530937
MESH:D004938 Esophageal Neoplasms Zinc 6.5116543248
MESH:D017889 Exfoliation Syndrome Folic Acid 11.8816504073
MESH:D017889 Exfoliation Syndrome Homocysteine 11.8816504073
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.7011564622
MESH:D005124 Eye Abnormalities Tretinoin 7.709664655 16938888
MESH:D005221 Fatigue vorinostat 5.1420479100
MESH:D005234 Fatty Liver arsenic trioxide 30.7515073043
MESH:D005234 Fatty Liver Curcumin 30.7519297423
MESH:D005234 Fatty Liver Cyclosporine 30.7519224547
MESH:D005234 Fatty Liver Diethylnitrosamine 30.7521071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 30.7515345470
MESH:D005234 Fatty Liver Tamoxifen 30.7519224547 14986274
MESH:D005234 Fatty Liver Valproic Acid 30.7519224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 2.9516709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0111858732
MESH:D005315 Fetal Diseases Valproic Acid 4.4216575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.708888407 18558336
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.0714745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 9.9319069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 9.9319069698
MESH:D005355 Fibrosis Curcumin 17.5218705752
MESH:D005355 Fibrosis Cyclosporine 17.5212168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 17.5220067830
MESH:D005355 Fibrosis Tretinoin 17.5217994277
MESH:D005532 Foot Deformities, Congenital methoxyacetic acid 5.293652986
MESH:D005596 Fractures, Closed zileuton 5.3919544365
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.8316904648
MESH:D005756 Gastritis Folic Acid 10.1517171786
MESH:D005756 Gastritis Zinc 10.1517241300
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.2518462866
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.4816973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.8416417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.768708960
MESH:D005901 Glaucoma Folic Acid 10.4616504073
MESH:D005901 Glaucoma Homocysteine 10.4616504073
MESH:D005909 Glioblastoma Curcumin 14.5117596214
MESH:D005909 Glioblastoma Doxorubicin 14.5117150277
MESH:D005909 Glioblastoma Tretinoin 14.5117312396
MESH:D005909 Glioblastoma trichostatin A 14.5118801729
MESH:D005910 Glioma tanshinone 3.8316955220
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1310696789
MESH:D006130 Growth Disorders Zinc 3.6617217573
MESH:D006258 Head and Neck Neoplasms Curcumin 15.9118462866 18829502
MESH:D006258 Head and Neck Neoplasms decitabine 15.9119215824
MESH:D006258 Head and Neck Neoplasms Doxorubicin 15.9115692506
MESH:D006258 Head and Neck Neoplasms Tretinoin 15.9116096774
MESH:D034381 Hearing Loss Gentamicins 4.5017868369 18024279 15968427 19130971
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.6916084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 23.0320471113
MESH:D006330 Heart Defects, Congenital Folic Acid 23.0317286298 16524890
MESH:D006330 Heart Defects, Congenital Homocysteine 23.0319638421
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 23.0310048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 23.039664655 14991402
MESH:D006330 Heart Defects, Congenital Vitamin E 23.0316080930
MESH:D006331 Heart Diseases Doxorubicin 3.1716495754 18674790 16244372 16144979 18006777 16707910 14766674 12587719 16879835 17888722 17875725 16244371 16330681
MESH:D006333 Heart Failure Doxorubicin 6.4817481944
MESH:D006333 Heart Failure Zinc 6.4817162251
MESH:D006335 Heart Injuries Zinc 5.3117074742
MESH:D016481 Helicobacter Infections Zinc 4.1117241300
MESH:D006394 Hemangiosarcoma Doxorubicin 3.5015692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.9715720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9311000095
MESH:D006527 Hepatolenticular Degeneration Zinc 4.2517276780
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.4912621046 15340226 16120746
MESH:D006529 Hepatomegaly zileuton 7.498661344
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.6017701891
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 5.387520565
MESH:D006548 Hernia, Diaphragmatic Vitamin E 5.3816863852 16490937
MESH:D006558 Herpes Genitalis Estradiol 4.5715709030
MESH:D006679 HIV Seropositivity Folic Acid 5.0417209195
MESH:D006689 Hodgkin Disease Doxorubicin 3.0415147373 17606976 18501091
MESH:D019584 Hot Flashes Estradiol 8.5117088409
MESH:D019584 Hot Flashes Vitamin E 8.5114716179
MESH:D006849 Hydrocephalus Valproic Acid 4.4117688650
MESH:D006869 Hydronephrosis Lithium Chloride 11.4819797860
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 11.4818606429 8697196 16959395 15340226 16354765
MESH:D006930 Hyperalgesia Tretinoin 2.8616870215
MESH:D053565 Hypercalciuria Gentamicins 5.2517652376
MESH:D006937 Hypercholesterolemia Curcumin 3.6518704882
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.1216778211
MESH:D020138 Hyperhomocysteinemia Folic Acid 8.5716397167 16395265 16755160 16865747 16433478
MESH:D020138 Hyperhomocysteinemia Homocysteine 8.5718234410 17369066 17292331
MESH:D006968 Hypersensitivity, Delayed indirubin 5.4711275354
MESH:D006973 Hypertension Cyclosporine 7.4710903974
MESH:D006973 Hypertension Dexamethasone 7.4717042910
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 7.4718850075 18670907
MESH:D006976 Hypertension, Pulmonary zileuton 4.3414726295
MESH:D017379 Hypertrophy, Left Ventricular tanshinone 4.8419662366
MESH:D007021 Hypospadias Ethinyl Estradiol 3.3716569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 10.3715869954
MESH:D020244 Infarction, Middle Cerebral Artery zileuton 10.3719309543
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.0412013081
MESH:D007248 Infertility, Male decitabine 9.4417581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 9.4417937319
MESH:D007248 Infertility, Male vinclozolin 9.4416467254
MESH:D007249 Inflammation Curcumin 20.4018403477 16956363 17151092
MESH:D007249 Inflammation Dexamethasone 20.408960868 11099482
MESH:D007249 Inflammation Diethylnitrosamine 20.4018785209
MESH:D007249 Inflammation Progesterone 20.4015869954
MESH:D007249 Inflammation Tamoxifen 20.4019457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 20.4012200463 12878042
MESH:D007249 Inflammation zileuton 20.4018059327 8621850 8960868 18295198 9831321 17118201 18309904 7812673
MESH:D015212 Inflammatory Bowel Diseases Curcumin 6.2418200517 18596194
MESH:D015212 Inflammatory Bowel Diseases zileuton 6.2415339030
MESH:D007251 Influenza, Human Vitamin E 3.7516624496
MESH:D007333 Insulin Resistance Estradiol 2.6716627594 16393666
MESH:D007410 Intestinal Diseases Tretinoin 3.3317994277
MESH:D007414 Intestinal Neoplasms Curcumin 3.8310783313
MESH:D007511 Ischemia Zinc 4.1916584753
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.5816580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.5815992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.9815604871
MESH:D007673 Kidney Cortex Necrosis Gentamicins 5.2618842672
MESH:D007674 Kidney Diseases Chromium 24.6717934191
MESH:D007674 Kidney Diseases Cyclosporine 24.6718776723 10903974 8314463
MESH:D007674 Kidney Diseases Doxorubicin 24.6715699352 16775033 15369732
MESH:D007674 Kidney Diseases Estradiol 24.6715618244
MESH:D007674 Kidney Diseases Gentamicins 24.6717934191 18289764 19349640
MESH:D007674 Kidney Diseases Vitamin E 24.6712488133
MESH:D007674 Kidney Diseases Zinc 24.6716960431
MESH:D007676 Kidney Failure, Chronic Doxorubicin 14.4716707910
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 14.4716518626
MESH:D007676 Kidney Failure, Chronic Zinc 14.4716518626
MESH:D007680 Kidney Neoplasms Cyclosporine 10.2412371664
MESH:D007680 Kidney Neoplasms Estradiol 10.2415610895
MESH:D007680 Kidney Neoplasms Tamoxifen 10.2418625569
MESH:D007683 Kidney Tubular Necrosis, Acute Gentamicins 4.9211231351
MESH:D007889 Leiomyoma Curcumin 4.1518555241
MESH:D016773 Leishmaniasis, Cutaneous Gentamicins 4.1010219319
MESH:D007938 Leukemia arsenic trioxide 13.0015070760
MESH:D007938 Leukemia Curcumin 13.0018462866
MESH:D007938 Leukemia decitabine 13.0018980019 19235587
MESH:D007938 Leukemia Tretinoin 13.0017143497
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.6916085563
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 8.4117077332 12560223
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 8.4116106398
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 3.8516972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 12.4414633726
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive tetraarsenic tetrasulfide 12.4419208803
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive zileuton 12.4419823023 19503090
MESH:D007951 Leukemia, Myeloid arsenic trioxide 13.6519077051
MESH:D007951 Leukemia, Myeloid decitabine 13.6517236224 19117987 18454857
MESH:D007951 Leukemia, Myeloid Tretinoin 13.6519285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 10.5916467208 17050201 16968895 19850784 20471514
MESH:D015470 Leukemia, Myeloid, Acute decitabine 10.5918460780 18206229 17679729 18704418 19010910 19387464
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 10.5919850784 16294345 17596541
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 10.5918206229
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 10.5916294345 17596541
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.0018055864
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 11.1919075265 16330433 17649720 16331271 12712474 15622746 17107899 12679006 19035177 12018890 17712046 19225113 9834237 15336539 15213294 16966277 16891316 15748426 16112521 17869043 19642359 11161223 16823087 17217047 11468182
MESH:D015473 Leukemia, Promyelocytic, Acute Thiophenes 11.1916140955 16140954
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 11.1916891316 16140955 9834237 17506722 17107899 17368321 17339181 19225113 17361223 15748426 19075265 17712046 19642359 12679006 19035177 16331271 17294898 16766008 17301526 16935935 19029980 17217047 16823087 17649720 16788101
MESH:D015458 Leukemia, T-Cell arsenic trioxide 10.2816882451
MESH:D015458 Leukemia, T-Cell Curcumin 10.2816106398
MESH:D007984 Leydig Cell Tumor vinclozolin 4.2816417039
MESH:D017880 Limb Deformities, Congenital methoxyacetic acid 7.5612805644 15959878
MESH:D017880 Limb Deformities, Congenital Tretinoin 7.569224671
MESH:D008064 Lipidoses Tamoxifen 2.8317567588 15342952
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.5718665156 18407596 20032147 19638242 18522880
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 11.9918006644 18705752 17355460
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 11.9916718785
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 11.9916439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 11.9914716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 11.9918564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 11.9912878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 11.9918397230 16248980
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 11.9916169303
MESH:D008107 Liver Diseases Curcumin 5.9316956363
MESH:D008107 Liver Diseases Diethylnitrosamine 5.9317034775
MESH:D008107 Liver Diseases Folic Acid 5.9316877991
MESH:D008113 Liver Neoplasms arsenic trioxide 18.9614682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 18.9621137059 20195826
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 18.9621295105 19389873
MESH:D008113 Liver Neoplasms ciprofibrate 18.9612771043
MESH:D008113 Liver Neoplasms Diethylnitrosamine 18.9619638242 19642983 18644402 20501860 19426721 18978307 19294768 21047994 20101389 20118626 12112319 19073162 21278145 19427195 20137499 19551842 19812893 16942905 18977376 20492335 12771043 20405173 18648771 10737359 19690152 2862719 20452335 19833225 18754104 9163691 19499222 21071580 19254457 2422723 15175105 19256749 19996281 19090486 15885732 20583210 19850985 21167192 19255062 20434301
MESH:D008113 Liver Neoplasms Tamoxifen 18.9616684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 18.9616984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 15.5620377131
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 15.5618164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 15.5618308698 19539802 3124819 18079962 17174075 19126423 17942915 19009564 2563599 16267830 9362446 18544905 18253720 18775883 16842330 17854601 19519916 18282651 19004024 21159647 18093689 18164116
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 15.5616842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 15.5612151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.0015213294
MESH:D008171 Lung Diseases Vitamin E 2.8716863852
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 3.8017228818
MESH:D008175 Lung Neoplasms arsenic trioxide 14.0019825857 11798837
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 14.0018569708 18816296 20135361 20464547 20064080 18520028 6695378 17053015 20869020
MESH:D008175 Lung Neoplasms Curcumin 14.0018462866 19359593 16243823
MESH:D008175 Lung Neoplasms Dexamethasone 14.0015824018 11195469
MESH:D008175 Lung Neoplasms Diethylnitrosamine 14.0021163286 20970405 20512841 6695378
MESH:D008175 Lung Neoplasms Doxorubicin 14.0017418594 6189445
MESH:D008175 Lung Neoplasms Tamoxifen 14.0018625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 14.0019555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 14.0011062179
MESH:D008180 Lupus Erythematosus, Systemic Folic Acid 3.2017718048
MESH:D008223 Lymphoma Curcumin 10.7518462866
MESH:D008223 Lymphoma decitabine 10.7519470736
MESH:D008223 Lymphoma Doxorubicin 10.7516098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.4217654614
MESH:D016399 Lymphoma, T-Cell Curcumin 10.0916173963
MESH:D016399 Lymphoma, T-Cell Doxorubicin 10.0915621674
MESH:D016410 Lymphoma, T-Cell, Cutaneous vorinostat 5.2420479100
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.3119428831
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 15.6515458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 15.6511807958 11408345 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 15.6517203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 15.6519196722 14580682 16827153 11731420 19196723
MESH:D008325 Mammary Neoplasms, Experimental Zinc 15.6512773700
MESH:D020149 Manganese Poisoning Estradiol 11.1019453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.1019453300
MESH:D019767 Maxillofacial Abnormalities Folic Acid 5.2416832597
MESH:D008527 Medulloblastoma Tretinoin 2.5917453147
MESH:D008545 Melanoma Curcumin 11.2117885582 18462866
MESH:D008545 Melanoma decitabine 11.2117785578 16505122
MESH:D008545 Melanoma Doxorubicin 11.2116827129
MESH:D008545 Melanoma Tamoxifen 11.2112393984 19393235
MESH:D008545 Melanoma Tretinoin 11.2116752155
MESH:D008545 Melanoma trichostatin A 11.2116505122
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.7315990972
MESH:D008569 Memory Disorders Curcumin 3.7317263510
MESH:D008591 Meningomyelocele Homocysteine 10.9416602021
MESH:D008591 Meningomyelocele Tretinoin 10.9416940565
MESH:D008654 Mesothelioma Doxorubicin 2.8717638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.3216801185
MESH:D008881 Migraine Disorders Valproic Acid 2.8718765137 18803445
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.0915792986
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.8416381670
MESH:D052016 Mucositis Doxorubicin 4.3417415656
MESH:D009101 Multiple Myeloma arsenic trioxide 19.2119549372 19417148 11468182 15949261 14977855
MESH:D009101 Multiple Myeloma Curcumin 19.2119372569
MESH:D009101 Multiple Myeloma decitabine 19.2118172295
MESH:D009101 Multiple Myeloma Dexamethasone 19.2115867202 15744524 16118317
MESH:D009101 Multiple Myeloma trichostatin A 19.2118172295
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.4617962980
MESH:D009137 Muscular Dystrophy, Animal Gentamicins 5.8118694830
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.628888407
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.2118349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 20.2016105982 16882451
MESH:D009190 Myelodysplastic Syndromes decitabine 20.2019010910 16882708 19157545 18608210
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 20.209809623
MESH:D009190 Myelodysplastic Syndromes Tretinoin 20.2017596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 20.2017596541
MESH:D009203 Myocardial Infarction Doxorubicin 5.6015857846 19429709
MESH:D009203 Myocardial Infarction Homocysteine 5.6017412321
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.6612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 2.9316810080
MESH:D009298 Nasal Polyps zileuton 5.7610665187
MESH:D009325 Nausea vorinostat 5.0620479100
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 8.8916624393
MESH:D009361 Neoplasm Invasiveness Curcumin 8.8918495463
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 8.369029167 3581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 8.3618259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 8.3619393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.3519410462
MESH:D009369 Neoplasms 4-phenylbutyric acid 9.9619116145
MESH:D009369 Neoplasms Benzo(a)pyrene 9.9611141357
MESH:D009369 Neoplasms decitabine 9.9617925555 19116145 19470736
MESH:D009369 Neoplasms Tretinoin 9.9616946489 16594593
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 9.3012497104
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 9.3019189210 19200415 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.2817289903
MESH:D009401 Nephrosis Doxorubicin 4.3216899518 16636307
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.9817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 8.0319348381 18481113
MESH:D009404 Nephrotic Syndrome Doxorubicin 8.0316889571 15640375
MESH:D009421 Nervous System Malformations Estradiol 13.8411399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 13.8414600291
MESH:D009421 Nervous System Malformations Tretinoin 13.849125849
MESH:D009423 Nervous System Neoplasms Curcumin 5.1718462866
MESH:D009436 Neural Tube Defects arsenic trioxide 14.8810525206
MESH:D009436 Neural Tube Defects Folic Acid 14.8817438019
MESH:D009436 Neural Tube Defects Tretinoin 14.889142499
MESH:D009436 Neural Tube Defects Valproic Acid 14.8816359493 8888407
MESH:D009447 Neuroblastoma Doxorubicin 3.0215555623
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 2.9720387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.6520387270
MESH:D009503 Neutropenia Folic Acid 4.0916322990
MESH:D009765 Obesity Curcumin 2.6319297423
MESH:D010024 Osteoporosis Curcumin 3.1918719352
MESH:D012516 Osteosarcoma Doxorubicin 3.7515930896
MESH:D010051 Ovarian Neoplasms arsenic trioxide 20.4312452020 16624393 19769630
MESH:D010051 Ovarian Neoplasms Curcumin 20.4318462866 19020741
MESH:D010051 Ovarian Neoplasms decitabine 20.4319259094 19331143
MESH:D010051 Ovarian Neoplasms Estradiol 20.4319401270
MESH:D010051 Ovarian Neoplasms Progesterone 20.4316525653 17393432
MESH:D010051 Ovarian Neoplasms Tretinoin 20.4316936753
MESH:D010051 Ovarian Neoplasms trichostatin A 20.4319331143
MESH:D010146 Pain Tretinoin 6.0916870215
MESH:D010146 Pain zileuton 6.0915935457
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 18.1415580305
MESH:D010190 Pancreatic Neoplasms Curcumin 18.1417440100 19401701 19196508
MESH:D010190 Pancreatic Neoplasms decitabine 18.1419294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 18.1416540662
MESH:D010190 Pancreatic Neoplasms Tretinoin 18.1415976015
MESH:D010190 Pancreatic Neoplasms trichostatin A 18.1419294695
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.2711578682
MESH:D010212 Papilloma Hydrogen Peroxide 3.6512065085
MESH:D010235 Paraganglioma arsenic trioxide 3.7419927285
MESH:D010300 Parkinson Disease Homocysteine 3.4016275827
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.7812520081
MESH:D010538 Peritonitis zileuton 4.8117371808
MESH:D003557 Phyllodes Tumor Doxorubicin 4.6917983394
MESH:D010997 Pleural Neoplasms Doxorubicin 4.6917638057
MESH:D011141 Polyuria Lithium Chloride 5.5419692487
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.1318163543
MESH:D011230 Precancerous Conditions Cyclosporine 7.6712371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 7.672563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.2821297632
MESH:D011225 Pre-Eclampsia Zinc 3.8217114810
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 13.6111896295 11118676 11222880 11399792
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 13.6120603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 13.6118220299 18042343 19015723
MESH:D055728 Primary Myelofibrosis decitabine 10.9517616702
MESH:D055728 Primary Myelofibrosis trichostatin A 10.9517616702
MESH:D011469 Prostatic Diseases vinclozolin 4.4818220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.4820887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.3019131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.3017292933
MESH:D011471 Prostatic Neoplasms Curcumin 3.3018156803 18769126 12497104 11398177 15129424 18226269 10851300
MESH:D011471 Prostatic Neoplasms Doxorubicin 3.3018437689 16729912 16868541 15897917 15749863 16888761
MESH:D011471 Prostatic Neoplasms Estradiol 3.3016740699
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.3015067354
MESH:D011471 Prostatic Neoplasms trichostatin A 3.3019789329 18798265
MESH:D011471 Prostatic Neoplasms Vitamin E 3.3015084515
MESH:D011471 Prostatic Neoplasms vorinostat 3.3017218635
MESH:D011471 Prostatic Neoplasms Zinc 3.3016606632 16517595 16700911 12429649
MESH:D011472 Prostatitis vinclozolin 4.4818629315
MESH:D011507 Proteinuria Gentamicins 8.1515033597
MESH:D011507 Proteinuria Tretinoin 8.1516636307
MESH:D011537 Pruritus Ethinyl Estradiol 8.4015861022 16919318
MESH:D011537 Pruritus zileuton 8.4017827870 19657356
MESH:D019310 Pseudolymphoma Valproic Acid 4.0812752131 11422049
MESH:D011565 Psoriasis Cyclosporine 2.0616882103
MESH:D011625 Pterygium Tretinoin 4.3416723453
MESH:D011654 Pulmonary Edema zileuton 4.9618309904
MESH:D011656 Pulmonary Emphysema Curcumin 4.1319168576
MESH:D051437 Renal Insufficiency Doxorubicin 14.7817922066
MESH:D051437 Renal Insufficiency Folic Acid 14.7815728788
MESH:D051437 Renal Insufficiency Gentamicins 14.7815728788 17132701
MESH:D015427 Reperfusion Injury zileuton 4.039865762 15266012
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 7.9210666014 18379247
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 7.9218379247 11700416
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4118990726
MESH:D012162 Retinal Degeneration Zinc 3.7916584753
MESH:D012173 Retinitis Gentamicins 5.8118644591
MESH:D012208 Rhabdomyosarcoma decitabine 16.1019155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 16.1016283617 16116481
MESH:D012208 Rhabdomyosarcoma Valproic Acid 16.1019155313
MESH:D012220 Rhinitis zileuton 4.4520332717
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.6818045962
MESH:D012509 Sarcoma Curcumin 8.2618462866
MESH:D012509 Sarcoma Doxorubicin 8.2615675481 18313854 16767912 17710206 15625365 17203757
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 8.8516646077
MESH:D012512 Sarcoma, Ewing's Doxorubicin 8.8516326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.3417846226
MESH:D012559 Schizophrenia Folic Acid 5.2716641680
MESH:D012559 Schizophrenia Homocysteine 5.2716641680
MESH:D012559 Schizophrenia Valproic Acid 5.2719110320 15737665
MESH:D012640 Seizures Valproic Acid 2.4411044598 11738929 14763951 15475178 3137016 16876388 1511512 17978042
MESH:D018805 Sepsis Curcumin 3.7018389075
MESH:D012852 Sinusitis zileuton 5.0610665187
MESH:D012871 Skin Diseases Folic Acid 4.7718709164
MESH:D012871 Skin Diseases Vitamin E 4.7718709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 19.4919755658 10029692
MESH:D012878 Skin Neoplasms Doxorubicin 19.4915692506
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 19.4912065085
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 19.498532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 19.4916192470
MESH:D012878 Skin Neoplasms Tretinoin 19.4916467112
MESH:D020181 Sleep Apnea, Obstructive zileuton 5.4119118273
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.1216767912 15625365 17203757
MESH:D013088 Spermatocele Ethinyl Estradiol 10.0216709447
MESH:D013088 Spermatocele Tamoxifen 10.0216709447
MESH:D013118 Spinal Cord Diseases Folic Acid 5.0416361298
MESH:D013119 Spinal Cord Injuries Progesterone 16.0016503802 15862959
MESH:D013119 Spinal Cord Injuries Tamoxifen 16.0019457130
MESH:D013119 Spinal Cord Injuries zileuton 16.0018059327
MESH:D016135 Spinal Dysraphism Valproic Acid 3.4319490988
MESH:D013226 Status Epilepticus Valproic Acid 4.0812833885
MESH:D013272 Stomach Diseases Dexamethasone 3.8715472012
MESH:D013274 Stomach Neoplasms arsenic trioxide 7.5417007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 7.5420155912 2093021
MESH:D013274 Stomach Neoplasms decitabine 7.5419037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 7.5418456281
MESH:D013274 Stomach Neoplasms Folic Acid 7.5417171786
MESH:D013274 Stomach Neoplasms Tretinoin 7.5417261132
MESH:D013276 Stomach Ulcer Curcumin 6.2119188055 16631530
MESH:D013276 Stomach Ulcer Dexamethasone 6.2115138204
MESH:D020521 Stroke Folic Acid 7.7016517955
MESH:D020521 Stroke Vitamin E 7.7016517955
MESH:D013576 Syndactyly methoxyacetic acid 5.201761407 1761404
MESH:D013733 Testicular Diseases methoxyacetic acid 4.8818486176 6499806
MESH:D013921 Thrombocytopenia vorinostat 4.5820479100
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.2011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.7715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.4412697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 23.5519014326
MESH:D013964 Thyroid Neoplasms Butyrates 23.5517967635
MESH:D013964 Thyroid Neoplasms decitabine 23.5517967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 23.557505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 23.5517909728 16010429
MESH:D013964 Thyroid Neoplasms Tretinoin 23.5517045167 16026305
MESH:D013978 Tibial Fractures Estradiol 4.2219048282
MESH:D014062 Tongue Neoplasms Tretinoin 8.6716051514
MESH:D014062 Tongue Neoplasms Zinc 8.6716543248
MESH:D016171 Torsades de Pointes arsenic trioxide 3.5115213294
MESH:D014178 Translocation, Genetic Valproic Acid 4.7717262798
MESH:D014376 Tuberculosis Tretinoin 2.9416040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.073119515
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 17.3312845720 20435036 12973940 11780464
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 17.3317053015
MESH:D001749 Urinary Bladder Neoplasms Curcumin 17.3318593936
MESH:D001749 Urinary Bladder Neoplasms decitabine 17.3319087683 17616700
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 17.3317653716
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 17.3316712894 17572228 8653321
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.208888407
MESH:D014565 Urogenital Neoplasms Curcumin 4.8118462866
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.2816129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.2614692618
MESH:D014594 Uterine Neoplasms sulindac sulfide 8.2618645019
MESH:D014604 Uveal Neoplasms decitabine 11.2917785578
MESH:D014604 Uveal Neoplasms Tretinoin 11.2916752155
MESH:D014605 Uveitis Cyclosporine 10.231336536
MESH:D014605 Uveitis Dexamethasone 10.231336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1312125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.1314671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 3.7817678736 16364871 17334414 17638931
MESH:D015837 Vestibular Diseases Gentamicins 5.0918776599
MESH:D014820 Vitiligo Tretinoin 3.6316761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.7815886252
MESH:D009396 Wilms Tumor Tretinoin 3.5816287080
MESH:D014985 Xerophthalmia Cyclosporine 3.9817120751
Pathway ID Pathway Name
KEGG:04110 Cell cycle
KEGG:05220 Chronic myeloid leukemia
REACT:604 Hemostasis
KEGG:05016 Huntington's disease
KEGG:04330 Notch signaling pathway
KEGG:05200 Pathways in cancer
REACT:11061 Signalling by NGF
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29226
    • No data
    No data
    Releated drug ID Related drug Name
    PA164768822chlorotrianisene
    PA164754789conjugated estrogens
    PA164745534dienestrol
    PA449307diethylstilbestrol
    PA449503estradiol
    PA449509estrogens
    PA449512estrone
    PA449527ethinyl estradiol
    PA451846valproic acid
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB02546 inhibitor Vorinostat Antineoplastic Agents;Enzyme Inhibitors;Anticarcinogenic Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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