AutismKB 2.0

Annotation Detail for HDLBP


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Basic Information Top
Gene Symbol:HDLBP ( FLJ16432,HBP,PRO2900,VGL )
Gene Full Name: high density lipoprotein binding protein
Band: 2q37.3
Quick LinksEntrez ID:3069; OMIM: 142695; Uniprot ID:VIGLN_HUMAN; ENSEMBL ID: ENSG00000115677; HGNC ID: 4857
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of HDLBP mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of HDLBP mRNAaffects expression 21346803
C024709 2,6-di-tert-butyl-4-methylene-2,5-cyclohexadienone 2,6-di-tert-butyl-4-methylene-2,5-cyclohexadienone binds to HDLBP proteinaffects binding 16533022
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of HDLBP mRNAincreases expression 18648102
D000643 Ammonium Chloride Ammonium Chloride affects the expression of HDLBP mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of HDLBP mRNAincreases expression 20127859
C110172 BHTOH-QM BHTOH-QM binds to HDLBP proteinaffects binding 16533022
D016572 Cyclosporine Cyclosporine results in increased expression of HDLBP mRNAincreases expression 20106945
D004958 Estradiol Estradiol results in decreased expression of HDLBP mRNAdecreases expression 20068009
D012643 Selenium Selenium results in increased expression of HDLBP mRNAincreases expression 19244175
D015215 Zidovudine Zidovudine results in decreased expression of HDLBP mRNAdecreases expression 16894629
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.7518287403
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 5.009612607
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.3920127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 4.3911473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.853712494
MESH:D000236 Adenoma Benzo(a)pyrene 6.856695378
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2519183758
MESH:D001321 Autistic Disorder marker/mechanism 19365831
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.2411289319 1440618
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0420146248 17474063
MESH:D001943 Breast Neoplasms Estradiol 2.0412948864 19861407 17289903 18497071 14630087 17018787 17261762 16675129
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.6616111702
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.7316705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.7316705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.733581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.7316924424
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.737296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0820419170
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 16.806135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 16.807505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 16.8012371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 16.8018566989
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.229022650 19486331
MESH:D002779 Cholestasis Cyclosporine 8.2219486331
MESH:D003092 Colitis Selenium 3.9517936198
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.4918551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.4918551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.978970840 18759878 14531868 8156756 11906362 12868966 2524372 11298694
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.642952479 3621924
MESH:D003928 Diabetic Nephropathies Estradiol 3.5419279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.3118551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.3121346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 9.3118692083 9328219 18289764 1440618 7440962 16192314 6482804 6679447 9022650 9653073 11289319 18648102 8291058
MESH:D056486 Drug-Induced Liver Injury Selenium 9.3115131321
MESH:D004362 Drug Toxicity Zidovudine 4.1115040536
MESH:D016889 Endometrial Neoplasms Estradiol 3.0711473722 18566989 19148513
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.473581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4716530937
MESH:D005234 Fatty Liver Cyclosporine 8.4519224547
MESH:D005234 Fatty Liver Zidovudine 8.4518299183
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.246705139
MESH:D005355 Fibrosis Cyclosporine 3.3212639820 12168785
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.418708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.197505956
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7220471113
MESH:D006333 Heart Failure Selenium 3.1517162251
MESH:D006402 Hematologic Diseases Zidovudine 4.8612579204
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6215720958
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.676705139
MESH:D006558 Herpes Genitalis Estradiol 5.2515709030
MESH:D015658 HIV Infections Zidovudine 3.5620032539 11141242 11698656 17358032 11363243
MESH:D019584 Hot Flashes Estradiol 3.9717088409
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.1115034207
MESH:D006973 Hypertension Cyclosporine 2.1410903974
MESH:D007251 Influenza, Human Selenium 4.4116624496
MESH:D007333 Insulin Resistance Estradiol 3.0516393666 16627594
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.249022650 8074119
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6615604871
MESH:D007674 Kidney Diseases Cyclosporine 6.198314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 6.1915618244
MESH:D007676 Kidney Failure, Chronic Selenium 4.0216518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 30.7716705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 30.7716705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 30.776582329
MESH:D007680 Kidney Neoplasms Cyclosporine 30.7712371664
MESH:D007680 Kidney Neoplasms Estradiol 30.7715610895
MESH:D007680 Kidney Neoplasms Zidovudine 30.7712579204
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.5520370541
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.289327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 1.6814716833 14659978
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.657678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.6521137059 20195826
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.176135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.17598648 1399818 3712494 6587162
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.6717053015 20135361 20464547 6695378 18569708 18520028 18816296 20064080 20869020
MESH:D008175 Lung Neoplasms Zidovudine 2.6718800350
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.3111408345 11807958 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.3115318939
MESH:D020149 Manganese Poisoning Estradiol 4.7019453300
MESH:D008654 Mesothelioma Selenium 2.8415107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0116801185
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 6.0617358032
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3016381670
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3916810080
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.0018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.007678174 18551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.523581430
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2311141357
MESH:D009389 Neovascularization, Pathologic Estradiol 3.9317289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4119348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 3.8116427766 11399458
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.006679447
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 15.8512819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 15.8516049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 15.854026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.243988306
MESH:D010051 Ovarian Neoplasms Estradiol 2.2519401270
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.667296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.696228378
MESH:D010954 Plasmacytoma Selenium 5.1115087411
MESH:D011230 Precancerous Conditions Cyclosporine 3.3512371664
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0220887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.0717292933
MESH:D011471 Prostatic Neoplasms Estradiol 3.0716740699
MESH:D011565 Psoriasis Cyclosporine 2.2716882103
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.483692021
MESH:D012640 Seizures 2,4-dinitrotoluene 6.1818551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.1818551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4310029692 19755658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.632093021 20155912
MESH:D013274 Stomach Neoplasms Zidovudine 2.6317696246
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.997505956 6582329 3712494 6587162 1399818
MESH:D013978 Tibial Fractures Estradiol 4.9019048282
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 12.3216049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 12.3216049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 12.328074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 12.3217053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.6510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.6510091137
MESH:D014605 Uveitis Cyclosporine 4.201336536
MESH:D014625 Vaginal Neoplasms Zidovudine 4.9312579204
MESH:D014985 Xerophthalmia Cyclosporine 4.6617120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29235
    • No data
    Releated disease ID Related disease Name
    PA443560Breast Neoplasms
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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