AutismKB 2.0

Annotation Detail for CFH


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Basic Information Top
Gene Symbol:CFH ( AHUS1,AMBP1,ARMD4,ARMS1,CFHL3,FH,FHL1,HF,HF1,HF2,HUS,MGC88246 )
Gene Full Name: complement factor H
Band: 1q31.3
Quick LinksEntrez ID:3075; OMIM: 134370; Uniprot ID:CFAH_HUMAN; ENSEMBL ID: ENSG00000000971; HGNC ID: 4883
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05150Staphylococcus aureus infection
hsa04610Complement and coagulation cascades
No data
No data
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
H00104Alternative complement pathway component defects
Immune system diseases
Primary immunodeficiency
No data
Desease Name
Macular Degeneration
CARDIOVASCULAR
myocardial infarct
macular degeneration, age-related
blood pressure, arterial hypertension
choroidal neovascularization geographic atrophy macular degeneration
heart disease, ischemic
glomerulonephritis
RENAL
atypical hemolytic uremic syndrome
age-related macular degeneration
METABOLIC
VISION
hemolytic uremic syndrome
Desease Name
Meningococcal disease
Age-related macular degeneration
Desease Name
Complement factor H deficiency
Macular degeneration, age-related, 4
Membranoproliferative glomerulonephritis with CFH deficiency
Hemolytic uremic syndrome, atypical, susceptibility to, 1
Basal laminar drusen
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene 1,4-bis(2-(3,5-dichloropyridyloxy))benzene affects the expression of CFH mRNAaffects expression 18281256
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of CFH mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of CFH mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of CFH mRNAincreases expression 18648102
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CFH mRNAaffects expression 16483693
D016589 Astemizole Astemizole results in decreased expression of CFH mRNAdecreases expression 20221588
D003010 Clorgyline Clorgyline results in increased expression of CFH mRNAincreases expression 19691856
D016572 Cyclosporine Cyclosporine results in decreased expression of CFH mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of CFH mRNAdecreases expression 18042831
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of CFH mRNAdecreases expression 19638242
D004958 Estradiol Estradiol affects the expression of CFH mRNAaffects expression 15598610
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of CFH mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of CFH mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of CFH mRNAaffects cotreatment|decreases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of CFH mRNAaffects expression 17351261
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of CFH mRNAincreases expression 15834898
17557909
C056933 fumonisin B1 fumonisin B1 results in decreased expression of CFH mRNAdecreases expression 16221962
C042763 olive oil olive oil analog affects the expression of CFH mRNAaffects expression 17349074
C041786 palm oil palm oil results in decreased expression of CFH mRNAdecreases expression 18042831
C023036 perfluorooctanoic acid perfluorooctanoic acid results in decreased expression of CFH mRNAdecreases expression 18467677
C023036 perfluorooctanoic acid PPARA protein promotes the reaction [perfluorooctanoic acid results in decreased expression of CFH mRNA]decreases expression|increases reaction 18467677
C006253 pirinixic acid pirinixic acid results in decreased expression of CFH mRNAdecreases expression 18467677
16221962
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in decreased expression of CFH mRNA]decreases expression|increases reaction 18467677
D012643 Selenium Selenium results in decreased expression of CFH mRNAdecreases expression 19244175
D013629 Tamoxifen Tamoxifen affects the expression of CFH mRNAaffects expression 17555576
C004648 testosterone enanthate testosterone enanthate affects the expression of CFH mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of CFH mRNAaffects cotreatment|decreases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CFH mRNAincreases expression 16267337
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CFH mRNAdecreases expression 18465118
D014302 Trinitrobenzenesulfonic Acid Trinitrobenzenesulfonic Acid results in increased expression of CFH mRNAincreases expression 17982090
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.4214745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7215322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.4318287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.8117505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.9918653653
MESH:D000230 Adenocarcinoma Estradiol 4.1111473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.1114692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.423712494
MESH:D000236 Adenoma Diethylnitrosamine 6.4210737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 16.5217162532 19061943 19052882 16434500 18056438 17620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 16.5216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 16.5216835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8311748828
MESH:D000799 Angioedema Astemizole 5.532883202
MESH:D001161 Arteriosclerosis Dietary Fats 9.4715238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.4711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5815885639
MESH:D050197 Atherosclerosis olive oil 4.2616216721
OMIM:126700 BASAL LAMINAR DRUSEN marker/mechanism
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.891440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.3719483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.3712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6815746008
MESH:D001943 Breast Neoplasms Dietary Fats 2.2820435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2817474063
MESH:D001943 Breast Neoplasms Estradiol 2.2817261762 12948864 14630087 18497071 19861407 17018787 16675129 17289903
MESH:D001943 Breast Neoplasms Tamoxifen 2.2811161223 17261762 18815881 21152245 17893378 19084267 20135344 19288272 19115204 15668708 19189210 20390343 15565566 19200415 18629630 20859285 19155303 19011961 19189212 19244106 19221464 17049068 20544844 17242785 19410462 20065188 18351453 16273361 20005174 19066611 16873071 18997820 17440819 16818667 19059307 19487384 21138602 16202921 18425577 19142967 18855134 18984771 18821012 19289846 19103187
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.2820435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3316111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6916835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.3819066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 11.1116705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 11.1116705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 11.113581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 11.1119919837 18494052 19394651 11831363 18788625 16779866 16288022 20432363 18506893 18056438 20935162 18978308 16878318 18691550 19701751 16681979 20514400 17162532 18785209 16830150 17428255 20007298 19335982 20524982 19519916 20101231 16807293 19383236 3581430 19107877 19052882 20512989 18210153 16540662 19171122 19822196 3084413 21159647 10672840 16698587 17978847 16328049 20084675 19208518 17055752 16935385 17173139 16569478 19539802 10737359 17138121 18665156 18393292 18971187 17761372 20727157 19418558 20214788 16502159
MESH:D006528 Carcinoma, Hepatocellular Estradiol 11.1116924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 11.1116924424
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.617296757
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.5017572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3018850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases olive oil 4.4516216721
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 20.136135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 20.137505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 20.1312371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 20.1317174075 2727394 7505956 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 20.1318566989
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.9519052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.9516835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 18.4119486331 9022650
MESH:D002779 Cholestasis Cyclosporine 18.4119486331
MESH:D002779 Cholestasis Ethinyl Estradiol 18.4116919318 11677210 17110522 16105132 15861022 17681005 17333356
MESH:D002779 Cholestasis pirinixic acid 18.4119176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0512621046 8697196 16354765 15668235 15340226
MESH:D003092 Colitis Selenium 9.3717936198
MESH:D003092 Colitis Trinitrobenzenesulfonic Acid 9.3718023891 17991707 17936198 16867261 16782535 16804969 18200517 11698051 16474422
MESH:D003093 Colitis, Ulcerative Trinitrobenzenesulfonic Acid 3.4017276891
OMIM:609814 COMPLEMENT FACTOR H DEFICIENCY marker/mechanism
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9514669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2515322242 20055451 10048152
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.4618551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.4618551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.2319031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.6818759878 11298694 8156756 11906362 14531868 8970840 2524372 12868966
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3718249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.373621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.1120387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.1117107852
MESH:D003928 Diabetic Nephropathies Estradiol 8.4719279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.4719279558
MESH:D004244 Dizziness Astemizole 6.343105558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 18.0918551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 18.0918551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 18.096679447 8291058 7440962 1440618 18692083 9653073 18648102 16192314 18289764 9328219 11289319 9022650 6482804
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 18.0919107877
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 18.0916221962
MESH:D056486 Drug-Induced Liver Injury Selenium 18.0915131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 18.0920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6611462148
MESH:D050171 Dyslipidemias Dietary Fats 3.3618367378
MESH:D004487 Edema perfluorooctanoic acid 10.7712083418 17259670
MESH:D004487 Edema pirinixic acid 10.7712083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.7712711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7715322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.5212538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.5219031437
MESH:D016889 Endometrial Neoplasms Estradiol 7.1111473722 19148513 18566989
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.1116202921 20544844 17893378 19155303
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9110568697 9294722
MESH:D004802 Eosinophilia Astemizole 4.671355641
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9916302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.083581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9111564622
MESH:D005234 Fatty Liver Cyclosporine 29.1519224547
MESH:D005234 Fatty Liver Dietary Fats 29.1518296743 17967931 19551842 19004024
MESH:D005234 Fatty Liver Diethylnitrosamine 29.1520387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 29.1515345470
MESH:D005234 Fatty Liver pirinixic acid 29.1520131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 29.1519224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1616709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3311858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.896705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.4014745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.0519069698
MESH:D005355 Fibrosis Cyclosporine 20.1112639820 12168785
MESH:D005355 Fibrosis Dietary Fats 20.1118296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 20.1120067830
MESH:D005355 Fibrosis Trinitrobenzenesulfonic Acid 20.1117994277
MESH:D005499 Folliculitis Astemizole 5.791671328
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.098708960
MESH:D015432 Glomerulonephritis, Membranoproliferative marker/mechanism
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.917505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2611294989 10048152
MESH:D006333 Heart Failure pirinixic acid 6.6820558911
MESH:D006333 Heart Failure Selenium 6.6817162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2915720958
MESH:D006463 Hemolytic-Uremic Syndrome marker/mechanism
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2111000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.396705139
MESH:D006529 Hepatomegaly 1,4-bis(2-(3,5-dichloropyridyloxy))benzene 25.7916109766
MESH:D006529 Hepatomegaly fumonisin B1 25.7916221962
MESH:D006529 Hepatomegaly perfluorooctanoic acid 25.793609246
MESH:D006529 Hepatomegaly pirinixic acid 25.7916221962 18467677 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 25.7915340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.9015709030
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.6217440010
MESH:D019584 Hot Flashes Estradiol 3.6217088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9216959395 18606429 16354765 8697196 15340226
MESH:D006930 Hyperalgesia perfluorooctanoic acid 3.7512083418
MESH:D006937 Hypercholesterolemia Dietary Fats 3.4721332399
MESH:D006943 Hyperglycemia pirinixic acid 3.0720558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.4921332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.8115034207
MESH:D006973 Hypertension Cyclosporine 4.7810903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.7818670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6816945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3412013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4017937319
MESH:D007249 Inflammation Dietary Fats 15.1520412841
MESH:D007249 Inflammation Diethylnitrosamine 15.1518785209
MESH:D007249 Inflammation perfluorooctanoic acid 15.1512083418
MESH:D007249 Inflammation Tamoxifen 15.1519457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 15.1512200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Trinitrobenzenesulfonic Acid 3.5318200517
MESH:D007251 Influenza, Human Selenium 4.0716624496
MESH:D007333 Insulin Resistance Dietary Fats 11.8011836018 18457598
MESH:D007333 Insulin Resistance Estradiol 11.8016627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 11.8016306350
MESH:D007410 Intestinal Diseases Trinitrobenzenesulfonic Acid 4.4817994277
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.899022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2116580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3115604871
MESH:D007674 Kidney Diseases Cyclosporine 5.698314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 5.6915618244
MESH:D007676 Kidney Failure, Chronic Selenium 3.7616518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 27.7016705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 27.7016705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 27.706582329
MESH:D007680 Kidney Neoplasms Cyclosporine 27.7012371664
MESH:D007680 Kidney Neoplasms Estradiol 27.7015610895
MESH:D007680 Kidney Neoplasms Tamoxifen 27.7018625569
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 5.108812269
MESH:D017513 Lichen Nitidus Astemizole 6.342563723
MESH:D008064 Lipidoses Tamoxifen 3.0615342952 17567588
MESH:D008103 Liver Cirrhosis Dietary Fats 6.4018296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.4020032147 18407596 18665156 18522880 19638242
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.1115034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.7814716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.7815474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 4.7818564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.7812878042
MESH:D008107 Liver Diseases Diethylnitrosamine 2.0717034775
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 17.347678174
MESH:D008113 Liver Neoplasms Diethylnitrosamine 17.3419073162 20137499 19255062 18644402 15885732 21278145 19427195 12112319 20501860 12771043 16942905 19499222 19996281 19812893 20434301 19833225 20583210 18754104 19850985 10737359 20118626 19426721 21167192 20452335 18978307 19638242 19551842 20492335 19294768 20405173 19090486 19690152 15175105 9163691 19254457 21047994 2862719 19256749 18977376 21071580 20101389 2422723 18648771 19642983
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 17.3414757943 18709148
MESH:D008113 Liver Neoplasms pirinixic acid 17.3416377806 15890375 20007298
MESH:D008113 Liver Neoplasms Tamoxifen 17.3416684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 17.3416984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 13.436135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 13.43598648 3712494 1399818 6587162
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 13.439362446 18544905 2563599 18079962 19519916 16267830 18164116 18093689 18282651 18775883 18253720 19539802 19004024 17942915 16842330 3124819 17854601 19009564 19126423 17174075 21159647 18308698
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 13.4312151625
MESH:D008133 Long QT Syndrome Astemizole 4.4918472280 11989578
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.2820512841 21163286 20970405 6695378
MESH:D008175 Lung Neoplasms Tamoxifen 3.2818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.2811884234 19555203
MESH:D008268 Macular Degeneration marker/mechanism 16518403 17554167
MESH:D008288 Malaria Astemizole 4.6516816845
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.6319428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.4711408345 11807958 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental Selenium 9.4715318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 9.4711731420 19196722 14580682 16827153 19196723
MESH:D020149 Manganese Poisoning Estradiol 12.2219453300
MESH:D020149 Manganese Poisoning Tamoxifen 12.2219453300
MESH:D008545 Melanoma Tamoxifen 1.8612393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.0515990972
MESH:D008589 Meningococcal Infections marker/mechanism 20694013
MESH:D008654 Mesothelioma Selenium 2.7415107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6616801185
MESH:D009135 Muscular Diseases pirinixic acid 3.3816239165
MESH:D009203 Myocardial Infarction marker/mechanism
MESH:D009203 Myocardial Infarction pirinixic acid 2.0919151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.9116810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.9116411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 9.9118551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 9.917678174 18551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 9.163581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 9.163581430 9029167
MESH:D009362 Neoplasm Metastasis Tamoxifen 9.1619393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4719410462
MESH:D009369 Neoplasms pirinixic acid 1.8917405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.8719200415 19189210 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.6017289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1718481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 9.0416427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.0414600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.836679447
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.2320387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9920387270
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 4.829802331
MESH:D009759 Nystagmus, Pathologic Astemizole 6.346135121
MESH:D009765 Obesity Dietary Fats 4.3221332399 16723640 18674790 18457598 17217161 19632207 20518802 20132043 11836018
MESH:D009765 Obesity pirinixic acid 4.3220558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 14.3912819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 14.3916049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 14.396482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.893988306
MESH:D010051 Ovarian Neoplasms Estradiol 2.1819401270
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.3816540662
MESH:D010195 Pancreatitis Trinitrobenzenesulfonic Acid 4.0817698068
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5611578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.357296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1212520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.346228378
MESH:D010954 Plasmacytoma Selenium 4.7615087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4318163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.5712371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.572563599
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 9.2317132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.2311896295 11399792 11222880 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.7620887781
MESH:D011471 Prostatic Neoplasms Clorgyline 2.7219691856
MESH:D011471 Prostatic Neoplasms Estradiol 2.7216740699
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.7215067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.1816919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.1816882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.3219058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7118990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.283692021
MESH:D012221 Rhinitis, Allergic, Perennial Astemizole 5.3010822083
MESH:D012640 Seizures 2,4-dinitrotoluene 5.5718551238
MESH:D012640 Seizures 2,6-dinitrotoluene 5.5718551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 1.9816192470
MESH:D013088 Spermatocele Ethinyl Estradiol 11.1316709447
MESH:D013088 Spermatocele Tamoxifen 11.1316709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.9119457130
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7518456281
MESH:D013276 Stomach Ulcer olive oil 4.4012498302 16252198
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0415669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7712697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 6.791399818 6582329 6587162 3712494 7505956
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 6.797505956
MESH:D013978 Tibial Fractures Estradiol 4.5619048282
MESH:D016171 Torsades de Pointes Astemizole 5.089583453 8256756
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 11.4916049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 11.4916049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 11.498074119
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 11.4917572228 16712894 8653321
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 11.5510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 11.5510091137
MESH:D014581 Urticaria Astemizole 4.672859714 3080510 1976298 1683191 2565098 2147912 2885854 2568189 2568013 3097109 3134034 2883202
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1714692618
MESH:D014605 Uveitis Cyclosporine 3.851336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4215869587 14671159
MESH:D014717 Vertigo Astemizole 6.343105558
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1215886252
MESH:D015430 Weight Gain Dietary Fats 3.6216723640
MESH:D014985 Xerophthalmia Cyclosporine 4.3117120751
Pathway ID Pathway Name
KEGG:04610 Complement and coagulation cascades
KEGG:05150 Staphylococcus aureus infection
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29261
    • Releated gene ID Related gene Name
    PA29261CFH
    Releated disease ID Related disease Name
    PA134850558Macular Degeneration
    PA446438Kidney Failure
    PA134850558Macular Degeneration
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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