AutismKB 2.0

Annotation Detail for CFHR1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:CFHR1 ( CFHL,CFHL1,CFHL1P,CFHR1P,FHR1,H36-1,H36-2,HFL1,HFL2,MGC104329 )
Gene Full Name: complement factor H-related 1
Band: 1q31.3
Quick LinksEntrez ID:3078; OMIM: 134371; Uniprot ID:FHR1_HUMAN; ENSEMBL ID: ENSG00000080910,ENSG00000244414; HGNC ID: 4888
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
Macular Degeneration
VISION
No data
Desease Name
Macular degeneration, age-related, reduced risk of
Hemolytic uremic syndrome, atypical, susceptibility to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of CFHR1 mRNAaffects expression 17562736
D002945 Cisplatin Cisplatin results in increased expression of CFHR1 proteinincreases expression 16803524
D004958 Estradiol Estradiol affects the expression of CFHR1 mRNAaffects expression 15598610
C017947 sodium arsenite sodium arsenite affects the expression of CFHR1 mRNAaffects expression 19590694
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D058186 Acute Kidney Injury Cisplatin 4.3817670903 12690470 15814532
MESH:D000230 Adenocarcinoma Cisplatin 4.8317638652 11798837
MESH:D000230 Adenocarcinoma Estradiol 4.8311473722
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.4215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.6316712894 17306315
MESH:D000799 Angioedema Acetaminophen 4.5710982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D019046 Bone Marrow Neoplasms Cisplatin 5.6114601052
MESH:D001943 Breast Neoplasms Cisplatin 2.3019526202 18382427
MESH:D001943 Breast Neoplasms Estradiol 2.3012948864 18497071 17261762 16675129 17289903 17018787 14630087 19861407
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 5.0916111702
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.993084413
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 6.9917982673
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.9916924424
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 6.9916507464 17306315 15276417
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.1412023789 16685392
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 5.1917066447 18337622 6189445
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 5.1918572023
MESH:D002386 Cataract Acetaminophen 2.7910977129
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.6318566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 7.6320056578 19524636
MESH:D015179 Colorectal Neoplasms Cisplatin 2.3315273666
MESH:D003928 Diabetic Nephropathies Estradiol 3.7819279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.672444490 16227642 19370779 11834606 17562736 14986274 19420014 19739265 16109766 12958197 12392966 16781746 10774834 14725611 16485898 11421492 19923254 19416960 19085960 17522070 19164858 11461765 16081117 18071297 11743745 14550746 11739529 10915739 12594235 12705907 18713872 12153990 15968718 17906064 16393943 11287661 16177239 11529661 15619225 12540782 10663392
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.8219426721
MESH:D004362 Drug Toxicity Cisplatin 4.1512649298 12231392 19839026 15033597
MESH:D016889 Endometrial Neoplasms Estradiol 3.2211473722 19148513 18566989
MESH:D004938 Esophageal Neoplasms Cisplatin 2.8517638652 15464296 16481741 15173087 16785472
MESH:D005756 Gastritis Acetaminophen 4.4016983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.3116452187
MESH:D005922 Glomerulonephritis, IGA marker/mechanism 21399633
MESH:D006258 Head and Neck Neoplasms Cisplatin 3.9715102660 15464296
MESH:D034381 Hearing Loss Cisplatin 4.6719898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.7715464296
MESH:D006463 Hemolytic-Uremic Syndrome marker/mechanism
MESH:D006558 Herpes Genitalis Estradiol 5.7615709030
MESH:D006689 Hodgkin Disease Cisplatin 8.7916200630 16170182
MESH:D006689 Hodgkin Disease sodium arsenite 8.7912676792
MESH:D019584 Hot Flashes Estradiol 4.4717088409
MESH:D006930 Hyperalgesia Acetaminophen 3.0216870215
MESH:D007248 Infertility, Male sodium arsenite 3.2412646999 15346721
MESH:D007333 Insulin Resistance Estradiol 3.2116627594 16393666
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.8615464296
MESH:D007674 Kidney Diseases Acetaminophen 16.1915629191 12587719
MESH:D007674 Kidney Diseases Cisplatin 16.1915190930 18289764 12649298 19839026 12231392
MESH:D007674 Kidney Diseases Estradiol 16.1915618244
MESH:D007674 Kidney Diseases sodium arsenite 16.1920008137
MESH:D007680 Kidney Neoplasms Estradiol 3.3215610895
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 5.5211231351
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 1.6814716833 14659978
MESH:D008107 Liver Diseases Acetaminophen 1.7019784758 12587719 19014921 11587558 12969438 16611625 19460945 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6316871587 17185352
MESH:D008113 Liver Neoplasms sodium arsenite 2.4815276417 16712894
MESH:D008171 Lung Diseases sodium arsenite 3.4219095001
MESH:D008175 Lung Neoplasms Cisplatin 2.796189445 17225452 11798837
MESH:D008175 Lung Neoplasms sodium arsenite 2.7916712894 17077188 17306315 19931552 15276417
MESH:D008268 Macular Degeneration marker/mechanism
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.7911807958 17203775 16891317 11408345
MESH:D020149 Manganese Poisoning Estradiol 5.2119453300
MESH:D008545 Melanoma Cisplatin 3.7017023156 16432458 12374674 16248763 17761969 18505091 12883367 16809738 18332650 18176117 12393984 15577323 11135225
MESH:D008545 Melanoma sodium arsenite 3.7019082730 16487513
MESH:D018328 Melanoma, Amelanotic Cisplatin 5.4115990972
MESH:D008546 Melanoma, Experimental Acetaminophen 4.1319513568
MESH:D008654 Mesothelioma Cisplatin 3.3717638057
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.5916810080
MESH:D009369 Neoplasms Cisplatin 5.8716773208
MESH:D009369 Neoplasms sodium arsenite 5.8711559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 4.2220056578
MESH:D009389 Neovascularization, Pathologic Estradiol 4.3617289903
MESH:D009395 Nephritis, Interstitial Cisplatin 5.2115464296
MESH:D009421 Nervous System Malformations Estradiol 4.1616427766 11399458
MESH:D009436 Neural Tube Defects sodium arsenite 3.3812854658
MESH:D009447 Neuroblastoma Cisplatin 3.628761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2118514411
MESH:D017599 Neuroectodermal Tumors Cisplatin 5.338761367
MESH:D010051 Ovarian Neoplasms Cisplatin 8.5319769630 17225452 6897625 15464296
MESH:D010051 Ovarian Neoplasms Estradiol 8.5319401270
MESH:D010051 Ovarian Neoplasms sodium arsenite 8.5317306315 15276417
MESH:D010146 Pain Acetaminophen 2.7316870215
MESH:D010190 Pancreatic Neoplasms Cisplatin 3.1019003803
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.8115464296
MESH:D010997 Pleural Neoplasms Cisplatin 6.0717638057
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.3120887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.1516740699
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.1516039940
MESH:D051437 Renal Insufficiency Cisplatin 4.9715464296
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.9314601052
MESH:D012878 Skin Neoplasms sodium arsenite 2.8519524636 18572023
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 6.0715464296
MESH:D016135 Spinal Dysraphism sodium arsenite 4.1012854658
MESH:D013274 Stomach Neoplasms Cisplatin 2.3315958060 17522103 18396642
MESH:D013736 Testicular Neoplasms Cisplatin 5.0917225452 15464296
MESH:D013978 Tibial Fractures Estradiol 5.4119048282
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 5.7617225452 12973940 15464296
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 5.7617306315 16712894 16452187 11723127
MESH:D014581 Urticaria Acetaminophen 3.4410982225
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 10.9516803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 10.9511813266
MESH:D014625 Vaginal Neoplasms Cisplatin 5.1715577323
MESH:D014652 Vascular Diseases sodium arsenite 5.0617056641
MESH:D014839 Vomiting Cisplatin 5.4411897121
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved