AutismKB 2.0

Annotation Detail for SOX8


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Basic Information Top
Gene Symbol:SOX8 ( MGC24837 )
Gene Full Name: SRY (sex determining region Y)-box 8
Band: 16p13.3
Quick LinksEntrez ID:30812; OMIM: 605923; Uniprot ID:SOX8_HUMAN; ENSEMBL ID: ENSG00000005513; HGNC ID: 11203
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of SOX8 mRNAdecreases expression 18648102
D001374 Azacitidine Azacitidine results in decreased expression of SOX8 mRNAdecreases expression 18033690
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 3.003712494
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 6.091440618 11289319
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 1.783581430 7296757
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.867296757
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 3.087505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.519022650 19486331
MESH:D015179 Colorectal Neoplasms Azacitidine 2.7319934284
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.5518759878 8156756 2524372 12868966 11906362 11298694 8970840 14531868
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 4.102952479 3621924
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 2.0618648102 6679447 11289319 7440962 9653073 9328219 6482804 18692083 9022650 18289764 8291058 1440618 16192314
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.193581430
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 6.096705139
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.647505956
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 4.196705139
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.7015034207
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 6.098074119 9022650
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.406582329
MESH:D007938 Leukemia Azacitidine 3.8919148494
MESH:D007951 Leukemia, Myeloid Azacitidine 5.1719077051
MESH:D015470 Leukemia, Myeloid, Acute Azacitidine 3.0618720364 17596541
MESH:D054429 Leukemia, Myelomonocytic, Juvenile Azacitidine 5.8019299654
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.4715034207 9327722
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.80598648 3712494 6587162 1399818
MESH:D008175 Lung Neoplasms Azacitidine 2.7321224363
MESH:D009006 Monosomy Azacitidine 7.1519299654
MESH:D009101 Multiple Myeloma Azacitidine 4.3118443271 19549372
MESH:D009190 Myelodysplastic Syndromes Azacitidine 4.2417611569 18720364 17596541 19805378
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.623581430
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.216679447
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.924026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 6.093988306
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 4.247296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.546228378
MESH:D011471 Prostatic Neoplasms Azacitidine 4.0618324645
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.743692021
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.266587162 6582329 3712494 1399818 7505956
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.428074119
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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