AutismKB 2.0

Annotation Detail for KCNIP3


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Basic Information Top
Gene Symbol:KCNIP3 ( CSEN,DREAM,KCHIP3,MGC18289 )
Gene Full Name: Kv channel interacting protein 3, calsenilin
Band: 2q11.1
Quick LinksEntrez ID:30818; OMIM: 604662; Uniprot ID:CSEN_HUMAN; ENSEMBL ID: ENSG00000115041; HGNC ID: 15523
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of KCNIP3 mRNAaffects expression 16483693
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of KCNIP3 mRNAaffects expression 12734012
D003024 Clozapine Clozapine results in decreased expression of KCNIP3 mRNAdecreases expression 18797397
D003024 Clozapine Clozapine results in increased expression of KCNIP3 mRNAincreases expression 17266109
D006220 Haloperidol Haloperidol results in decreased expression of KCNIP3 mRNAdecreases expression 18797397
D006220 Haloperidol Haloperidol results in decreased expression of KCNIP3 proteindecreases expression 18797397
C076029 olanzapine olanzapine results in decreased expression of KCNIP3 mRNAdecreases expression 18797397
C076029 olanzapine olanzapine results in decreased expression of KCNIP3 proteindecreases expression 18797397
D010622 Phencyclidine Phencyclidine results in increased expression of KCNIP3 mRNAincreases expression 17266109
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of KCNIP3 mRNAdecreases expression 19465110
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.2415322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.9518287403
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7716835633
MESH:D000380 Agranulocytosis Clozapine 5.4112649775 16160616 14617031
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D001321 Autistic Disorder Haloperidol 2.8418080171 19368416
MESH:D001321 Autistic Disorder olanzapine 2.8418685284 17069543
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6820435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.1410355542 15721981 16050911 16227642 16011737 15700767 16097048 15673190 16192424 16124888 18705752 3786805
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 1.8518788625
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5018850075 18670907 16120746
MESH:D002375 Catalepsy Haloperidol 5.3115215559 1977408
MESH:D002389 Catatonia olanzapine 6.6918071103 16772815
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2012621046 15340226 16354765 8697196 15668235
MESH:D003072 Cognition Disorders Clozapine 5.3217123785
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 10048152 20055451
MESH:D016757 Death, Sudden, Cardiac Haloperidol 5.1520210726
MESH:D003704 Dementia Haloperidol 4.8611575062
MESH:D002658 Developmental Disabilities olanzapine 4.8717069543
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 4.6916402076
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.6917107852
MESH:D006970 Disorders of Excessive Somnolence Clozapine 6.0015331141
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.954309450 6623471 19085960 7120509 9327722 19336974 16177239 11566570 10915739 15998439 21278145 7179309 17522070 6884620 15968718 3786805 2869522 3732212 7440962 10092053 16227642 15027814
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.9520420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9611462148
MESH:D050171 Dyslipidemias Clozapine 4.3816402076
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.3516714409 18230668 15322242
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.299294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2111564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 3.4519224547 17595544 12795759 16045604 12631006 16239168 61145 15959796
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D005355 Fibrosis Carbon Tetrachloride 9.8218705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.8220067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4610048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.9219110552 19900420
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2516120746 15340226 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.498697196 16354765 15340226 18606429 16959395
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.9316899240
MESH:D006948 Hyperkinesis Clozapine 5.3016046005
MESH:D006963 Hyperphagia olanzapine 6.6317933447
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9918850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.4515338365
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9812200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6216580747
MESH:D008064 Lipidoses Clozapine 4.1517567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9416943688 17174718 11408273 11903743 21278145 16221502 17334410 16239168 17157831
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.3516192424 17557913 17976157 15338365 15057751 16027843 12741479 18054572 18279442 14748882 18263696 12898905 12609069 18251166 15996030 18376398 12445421 18277467 14716833 12632514 16116963 16015684 15876570 17714472 15959796 12666154 17631135 17823541 18166357 12546737 18317297 17805973 16011737 15730626 15123356 18210741 20821823 16248980 17922224 18412020 18418968 18395914 10355542 17708605 17525996 14716496 12667390 15818738 17944888 17761835 16638106 15673190 18187930 18472332 18395095 12445418 16097048 18006644 17766677 15925388 17640975 17869086 15650968 12649538 17565644 17481882 15362042 17698563 18156304 16136751 12586293 14512876 12632512 15931870 16033810 15370692 18705752 14620537 18420326 18472094 13678700 12389079 17721639 18205269 15052691 11481614 15893842 18429990 17900296 18481824 12958196 18339082 14724832
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3512878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1316964402 17285989 15720792 15830285 16246199
MESH:D017093 Liver Failure Carbon Tetrachloride 4.5215123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.9514706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.6919294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.6916984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.3012014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.3012151625
MESH:D008133 Long QT Syndrome olanzapine 4.9420210726
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D001523 Mental Disorders Clozapine 15.8916856516
MESH:D001523 Mental Disorders Haloperidol 15.8916856516
MESH:D001523 Mental Disorders olanzapine 15.8916856516
MESH:D008659 Metabolic Diseases olanzapine 5.6719142110
MESH:D024821 Metabolic Syndrome X Clozapine 4.6519142101
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5414600291
MESH:D009765 Obesity Clozapine 5.5918515891 19142110
MESH:D009765 Obesity olanzapine 5.5918515891
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5911399792 11118676 11222880 11896295
MESH:D011595 Psychomotor Agitation Haloperidol 13.0411575062
MESH:D011595 Psychomotor Agitation olanzapine 13.0418685284
MESH:D011618 Psychotic Disorders Clozapine 9.8115331141
MESH:D011618 Psychotic Disorders Haloperidol 9.8111575062
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012559 Schizophrenia Clozapine 6.1120107430 16141801 20521326 20168265 11763009 17123785 17726453 19369910 20580759 11151749 18855531 20521320 20452607 17667964 18806925
MESH:D012559 Schizophrenia Haloperidol 6.1119369910 18513383 1830565 20107430
MESH:D012559 Schizophrenia olanzapine 6.1120107430 17726453 20521326
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1516192470
MESH:D017180 Tachycardia, Ventricular Haloperidol 12.0720210726
MESH:D017180 Tachycardia, Ventricular olanzapine 12.0720210726
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
MESH:D015430 Weight Gain Clozapine 11.1917502770 20521320 16402076 20107430 20564506 16141801
MESH:D015430 Weight Gain olanzapine 11.1917933447 19434072 20107430
MESH:D015431 Weight Loss Clozapine 5.4717933447
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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