AutismKB 2.0

Annotation Detail for NRG1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:NRG1 ( ARIA,GGF,GGF2,HGL,HRG,HRG1,HRGA,MST131,NDF,SMDF )
Gene Full Name: neuregulin 1
Band: 8p12
Quick LinksEntrez ID:3084; OMIM: 142445; Uniprot ID:NRG1_HUMAN; ENSEMBL ID: ENSG00000157168; HGNC ID: 7997
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04012ErbB signaling pathway
No data
Pathway IDPathway Name
200009ErbB4 signaling events
200136ErbB receptor signaling network
200119ErbB2/ErbB3 signaling events
200021Glypican 1 network
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
Atherosclerosis
CARDIOVASCULAR
PSYCH
psychoses schizophrenia
schizophrenia
METABOLIC
hip geometry
Hirschsprung's disease
Desease Name
Hip geometry
Hirschsprung's disease
Desease Name
Schizophrenia, susceptibility to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of NRG1 mRNAincreases expression 19933214
C488185 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide NRG1 protein alternative form inhibits the reaction [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide results in decreased phosphorylation of and results in decreased activity of MAPK1 protein]decreases activity|decreases phosphorylation|decreases reaction 15231676
C488185 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide NRG1 protein alternative form inhibits the reaction [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide results in decreased phosphorylation of and results in decreased activity of MAPK3 protein]decreases activity|decreases phosphorylation|decreases reaction 15231676
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of NRG1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of NRG1 mRNAaffects expression 21346803
C019499 2-nitrofluorene 2-nitrofluorene results in increased expression of NRG1 mRNAincreases expression 14600272
15890375
C016583 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of NRG1 mRNAincreases expression 15890375
14600272
D000082 Acetaminophen Acetaminophen affects the expression of NRG1 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 results in increased expression of NRG1 mRNAincreases expression 14600272
15890375
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NRG1 mRNAaffects expression 16483693
C081565 arachidonyltrifluoromethane arachidonyltrifluoromethane inhibits the reaction [NRG1 protein alternative form results in increased phosphorylation of and results in increased activity of MAPK1 protein]decreases reaction|increases activity|increases phosphorylation 15231676
C081565 arachidonyltrifluoromethane arachidonyltrifluoromethane inhibits the reaction [NRG1 protein alternative form results in increased phosphorylation of and results in increased activity of MAPK3 protein]decreases reaction|increases activity|increases phosphorylation 15231676
D001151 Arsenic Arsenic results in increased expression of NRG1 mRNAincreases expression 19945496
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of NRG1 mRNAaffects cotreatment|increases expression 18164116
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of NRG1 mRNAdecreases expression 19150397
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of NRG1 mRNAincreases expression 20382639
C070515 bisindolylmaleimide I bisindolylmaleimide I inhibits the reaction [NRG1 protein alternative form results in increased phosphorylation of and results in increased activity of MAPK1 protein]decreases reaction|increases activity|increases phosphorylation 15231676
C070515 bisindolylmaleimide I bisindolylmaleimide I inhibits the reaction [NRG1 protein alternative form results in increased phosphorylation of and results in increased activity of MAPK3 protein]decreases reaction|increases activity|increases phosphorylation 15231676
D002101 Cacodylic Acid Cacodylic Acid results in increased expression of NRG1 mRNAincreases expression 17720352
C105934 celecoxib celecoxib inhibits the reaction [IL1B protein results in increased expression of and results in increased secretion of NRG1 protein]decreases reaction|increases expression|increases secretion 16357062
C105934 celecoxib celecoxib inhibits the reaction [IL1B protein results in increased expression of NRG1 mRNA]decreases reaction|increases expression 16357062
C105934 celecoxib Dinoprostone inhibits the reaction [celecoxib inhibits the reaction [IL1B protein results in increased expression of NRG1 mRNA]]decreases reaction|increases expression 16357062
D003024 Clozapine Clozapine results in increased expression of NRG1 mRNAincreases expression 19502011
D003024 Clozapine NRG1 protein affects the susceptibility to Clozapineaffects response to substance 15706234
D003024 Clozapine Clozapine affects the expression of NRG1 proteinaffects expression 18184445
D016572 Cyclosporine Cyclosporine results in increased expression of NRG1 mRNAincreases expression 20106945
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of NRG1 mRNAaffects cotreatment|increases expression 18164116
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of NRG1 mRNAincreases expression 15890375
D004128 Dimethylnitrosamine Dimethylnitrosamine results in increased expression of NRG1 mRNAincreases expression 14600272
15890375
C547156 dimethylthioarsinic acid dimethylthioarsinic acid results in decreased expression of NRG1 mRNAdecreases expression 19945496
D004317 Doxorubicin NRG1 protein affects the reaction [Doxorubicin affects the phosphorylation of AKT1 protein]affects phosphorylation|affects reaction 15833803
D004317 Doxorubicin NRG1 protein affects the reaction [Doxorubicin affects the phosphorylation of ERBB2 protein]affects phosphorylation|affects reaction 15833803
D004317 Doxorubicin NRG1 protein affects the reaction [Doxorubicin affects the phosphorylation of MAPK1 protein]affects phosphorylation|affects reaction 15833803
D004317 Doxorubicin NRG1 protein affects the reaction [Doxorubicin affects the phosphorylation of MAPK3 protein]affects phosphorylation|affects reaction 15833803
D004317 Doxorubicin NRG1 protein affects the reaction [Doxorubicin affects the phosphorylation of RPS6KB1 protein]affects phosphorylation|affects reaction 15833803
D004317 Doxorubicin Doxorubicin results in increased expression of NRG1 protein alternative formincreases expression 17308081
D004317 Doxorubicin NRG1 protein alternative form inhibits the reaction [Doxorubicin results in decreased expression of ATP2A2 protein]decreases expression|decreases reaction 17005195
D004317 Doxorubicin NRG1 protein alternative form inhibits the reaction [Doxorubicin results in decreased expression of GSR mRNA]decreases expression|decreases reaction 17005195
D004958 Estradiol Estradiol results in decreased expression of NRG1 mRNAdecreases expression 20068009
D005472 Fluorouracil NRG1 protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
C056507 gemcitabine gemcitabine results in increased expression of NRG1 mRNAincreases expression 17039268
D005947 Glucose MAPK1 protein promotes the reaction [NRG1 protein results in increased transport of Glucose]increases reaction|increases transport 14711829
D005947 Glucose MAPK3 protein promotes the reaction [NRG1 protein results in increased transport of Glucose]increases reaction|increases transport 14711829
D005947 Glucose [NRG1 protein binds to ERBB3 protein] which results in increased transport of Glucoseaffects binding|increases transport 14711829
D005947 Glucose NRG1 protein results in increased transport of Glucoseincreases transport 14711829
D005947 Glucose PDK1 protein promotes the reaction [NRG1 protein results in increased transport of Glucose]increases reaction|increases transport 14711829
D005947 Glucose PRKCZ protein promotes the reaction [NRG1 protein results in increased transport of Glucose]increases reaction|increases transport 14711829
D005947 Glucose Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [NRG1 protein results in increased transport of Glucose]decreases reaction|increases transport 14711829
D006220 Haloperidol Haloperidol results in increased expression of NRG1 proteinincreases expression 18184445
D006861 Hydrogen Peroxide NRG1 protein alternative form inhibits the reaction [Hydrogen Peroxide results in decreased expression of ATP2A2 protein]decreases expression|decreases reaction 17005195
D007649 Ketamine Ketamine results in decreased expression of NRG1 mRNAdecreases expression 20000043
D008701 Methapyrilene Methapyrilene results in increased expression of NRG1 mRNAincreases expression 15890375
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of NRG1 mRNAincreases expression 17616710
D010126 Ozone Ozone results in increased expression of NRG1 mRNAincreases expression 16716893
C093973 PD 98059 NRG1 protein alternative form inhibits the reaction [PD 98059 results in decreased phosphorylation of and results in decreased activity of MAPK1 protein]decreases activity|decreases phosphorylation|decreases reaction 15231676
C093973 PD 98059 NRG1 protein alternative form inhibits the reaction [PD 98059 results in decreased phosphorylation of and results in decreased activity of MAPK3 protein]decreases activity|decreases phosphorylation|decreases reaction 15231676
D010656 Phenylephrine Phenylephrine results in decreased expression of NRG1 mRNAdecreases expression 16698793
D010656 Phenylephrine Phenylephrine results in decreased expression of NRG1 proteindecreases expression 16698793
D010882 Piperonyl Butoxide Piperonyl Butoxide results in increased expression of NRG1 mRNAincreases expression 15890375
C006253 pirinixic acid pirinixic acid results in decreased expression of NRG1 mRNAdecreases expression 17950772
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in decreased expression of NRG1 mRNA]decreases expression|increases reaction 17950772
C006253 pirinixic acid pirinixic acid results in increased expression of NRG1 mRNAincreases expression 15890375
D015232 Dinoprostone Dinoprostone inhibits the reaction [celecoxib inhibits the reaction [IL1B protein results in increased expression of NRG1 mRNA]]decreases reaction|increases expression 16357062
D015232 Dinoprostone Dinoprostone results in increased expression of NRG1 mRNAincreases expression 16357062
C059514 resveratrol resveratrol inhibits the reaction [NRG1 protein alternative form results in increased expression of MMP9 protein]decreases reaction|increases expression 17651959
C059514 resveratrol resveratrol inhibits the reaction [NRG1 protein alternative form results in increased phosphorylation of MAPK1 protein]decreases reaction|increases phosphorylation 17651959
C059514 resveratrol resveratrol inhibits the reaction [NRG1 protein alternative form results in increased phosphorylation of MAPK3 protein]decreases reaction|increases phosphorylation 17651959
C059514 resveratrol resveratrol results in decreased expression of NRG1 mRNAdecreases expression 12002526
C115461 SC 560 SC 560 results in decreased expression of NRG1 mRNAdecreases expression 14633654
C410733 scriptaid scriptaid affects the expression of NRG1 mRNAaffects expression 18813790
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of NRG1 mRNAincreases expression 19933214
D014108 Tosylphenylalanyl Chloromethyl Ketone Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [NRG1 protein results in increased transport of Glucose]decreases reaction|increases transport 14711829
D014303 Trinitrotoluene Trinitrotoluene affects the expression of NRG1 mRNAaffects expression 21346803
C113580 U 0126 NRG1 protein alternative form inhibits the reaction [U 0126 results in decreased phosphorylation of and results in decreased activity of MAPK1 protein]decreases activity|decreases phosphorylation|decreases reaction 15231676
C113580 U 0126 NRG1 protein alternative form inhibits the reaction [U 0126 results in decreased phosphorylation of and results in decreased activity of MAPK3 protein]decreases activity|decreases phosphorylation|decreases reaction 15231676
D014635 Valproic Acid Valproic Acid results in increased expression of NRG1 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 11.4915322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 11.497525203
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 11.498875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.4919490988
MESH:D000138 Acidosis Ammonium Chloride 3.0718287403
MESH:D000168 Acrocephalosyndactylia U 0126 5.0017694057
MESH:D058186 Acute Kidney Injury resveratrol 3.4216538975
MESH:D055371 Acute Lung Injury pirinixic acid 2.6718653653
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 9.0016033868
MESH:D000230 Adenocarcinoma Doxorubicin 9.0017418594
MESH:D000230 Adenocarcinoma Estradiol 9.0011473722
MESH:D000230 Adenocarcinoma Fluorouracil 9.0017638652
MESH:D000236 Adenoma 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 17.9116176798
MESH:D000236 Adenoma beta-Naphthoflavone 17.9119389873
MESH:D000236 Adenoma Diethylnitrosamine 17.916695378 10737359
MESH:D000236 Adenoma Dimethylnitrosamine 17.9119555203
MESH:D000236 Adenoma resveratrol 17.9115688382
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 14.4619061943 18056438 17620307 17162532 19052882 16434500
MESH:D018248 Adenoma, Liver Cell pirinixic acid 14.4616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 14.4616835633
MESH:D011125 Adenomatous Polyposis Coli celecoxib 9.0816215675 19003578
MESH:D011125 Adenomatous Polyposis Coli Dinoprostone 9.0817942926
MESH:D018246 Adrenocortical Adenoma Arsenic 4.7217306315
MESH:D000380 Agranulocytosis Clozapine 4.5814617031 12649775 16160616
MESH:D000419 Albuminuria Doxorubicin 4.0821441931
MESH:D000544 Alzheimer Disease Ozone 3.9415513908
MESH:D000544 Alzheimer Disease resveratrol 3.9416162502 16183991
MESH:D000550 Amblyopia Valproic Acid 4.7417688650
MESH:D000686 Amyloidosis Diethylstilbestrol 4.0215469931
MESH:D000740 Anemia Fluorouracil 7.2816511603 15504547 17963324
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.2811748828
MESH:D000799 Angioedema Acetaminophen 3.3510982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.1917497229
MESH:D001014 Aortic Aneurysm Dinoprostone 5.1410231640
MESH:D017544 Aortic Aneurysm, Abdominal Dinoprostone 5.1510388637
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.6917460149
MESH:D020261 Arsenic Poisoning Arsenic 2.7118414634 16251483 16835338 12569548
MESH:D001169 Arthritis, Experimental resveratrol 7.1017115116
MESH:D001169 Arthritis, Experimental Tosylphenylalanyl Chloromethyl Ketone 7.1018706406
MESH:D001172 Arthritis, Rheumatoid Ozone 2.4315570426
MESH:D001249 Asthma Ozone 2.4817854713 16373670
MESH:D050197 Atherosclerosis Arsenic 5.8919371607 12928151
MESH:D050197 Atherosclerosis resveratrol 5.8916873680 17967414
MESH:D001321 Autistic Disorder Acetaminophen 2.1018445737
MESH:D001321 Autistic Disorder Haloperidol 2.1018080171 19368416
MESH:D001321 Autistic Disorder Valproic Acid 2.1015238991 16609825 20603192 18775368 18316065 18940202 17688650 17157402 17507914 19232924 18558336 18396377 18177632 19460635 18985861
MESH:D001477 Bartter Syndrome Dinoprostone 5.2615976003
MESH:D001714 Bipolar Disorder Valproic Acid 2.8117594078 20046352
MESH:D001778 Blood Coagulation Disorders pirinixic acid 7.3219483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.3212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.2915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 6.9515746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 6.958888407
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.2014601052
MESH:D001919 Bradycardia Phenylephrine 4.0615306635
MESH:D002545 Brain Ischemia resveratrol 3.8017600658
MESH:D001932 Brain Neoplasms Doxorubicin 3.3917150277
MESH:D001943 Breast Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 6.3220146248
MESH:D001943 Breast Neoplasms Cacodylic Acid 6.3217474063
MESH:D001943 Breast Neoplasms Diethylnitrosamine 6.3217474063
MESH:D001943 Breast Neoplasms Diethylstilbestrol 6.3217129689 15324884
MESH:D001943 Breast Neoplasms Doxorubicin 6.3218234424 15692762 16264153 16322301 16096432 16935488 18628466 17983394 18695136 16595493 19526202 11325840 16826403 15136595 16115903 15634643 15993339 18382427 17369602 17426702 15567936 15994142 15668708 15939500
MESH:D001943 Breast Neoplasms Estradiol 6.3219861407 17261762 12948864 16675129 17289903 17018787 18497071 14630087
MESH:D001943 Breast Neoplasms Fluorouracil 6.3218357371 16595493 19217205 16557594 18608205 15136595 16110121
MESH:D001943 Breast Neoplasms gemcitabine 6.3218382427 17039268
MESH:D001943 Breast Neoplasms resveratrol 6.3216393696 17534123 17651959
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 6.3220435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.2916777450 14754758 17626835 18417511 15516495 18315731 19059883
MESH:D002100 Cachexia Ozone 4.2516183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.9816111702
MESH:D002276 Carcinoid Tumor Doxorubicin 10.7016051944
MESH:D002276 Carcinoid Tumor Fluorouracil 10.7016051944
MESH:D002277 Carcinoma Dimethylnitrosamine 11.7619555203
MESH:D002277 Carcinoma Fluorouracil 11.7617121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 11.7616835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.3015504454 17687452
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 26.8216705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 26.8216705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 26.823084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 26.8221507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Arsenic 26.8216507464 17306315
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 26.8220727157 19519916 18788625 16807293 16569478 11831363 19418558 20432363 18210153 19822196 19701751 18056438 18971187 17138121 19919837 20935162 10737359 18494052 20214788 20084675 19383236 20101231 10672840 18506893 19107877 17428255 3084413 20524982 18665156 19335982 16935385 21159647 19208518 19394651 18393292 16681979 16502159 17162532 16328049 17978847 16878318 17173139 17055752 17761372 20512989 16779866 20514400 16540662 19052882 18691550 19539802 20007298 18978308 19171122 16698587 16288022 16830150 18785209 3581430
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 26.8215948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 26.8216234567 18059187 17876044 16023760
MESH:D006528 Carcinoma, Hepatocellular Estradiol 26.8216924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 26.8218930000 17971768 16799960 16332177 17045692 17088986
MESH:D006528 Carcinoma, Hepatocellular resveratrol 26.8219321006 16227395
MESH:D006528 Carcinoma, Hepatocellular SC 560 26.8216391822
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.1116675471
MESH:D002292 Carcinoma, Renal Cell celecoxib 9.5416369983
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 9.5416201981 1485588
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 9.5418695887
MESH:D002294 Carcinoma, Squamous Cell Arsenic 12.5715504454 18922899 17687452
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 12.5716033868
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 12.576189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 12.5717066447 16757204 18986760 16280240
MESH:D002294 Carcinoma, Squamous Cell resveratrol 12.5716227395
MESH:D002295 Carcinoma, Transitional Cell Arsenic 3.6618640142
MESH:D006332 Cardiomegaly Phenylephrine 5.9311179087 17124262 16170337 15728586 17287366 11754973
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 5.9316120746 18670907 18850075
MESH:D009202 Cardiomyopathies Doxorubicin 3.2015505089 18627295 16612575 16242529 16278810 16731534 17924179 16269455 16952015 16364871 15811867 15476868 16109756 17351982 17974986 16651473 17382496 17519947 15792986 17131338 17007740 17308081 17928571 17329180 16455267
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.7616243910 17334414
MESH:D002318 Cardiovascular Diseases Arsenic 10.2915738583 19152805 17938729
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 10.2916936243
MESH:D002318 Cardiovascular Diseases resveratrol 10.2915458977
MESH:D002340 Carotid Artery Diseases Arsenic 3.9016973168 18022660
MESH:D002375 Catalepsy Haloperidol 4.421977408 15215559
MESH:D002386 Cataract Acetaminophen 6.5110977129
MESH:D002386 Cataract Trinitrotoluene 6.5114694615 15817613
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 21.926135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 21.9220889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 21.9212371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 21.9217174075 21159647 2727394 7505956
MESH:D002471 Cell Transformation, Neoplastic Dinoprostone 21.9216192471
MESH:D002471 Cell Transformation, Neoplastic Estradiol 21.9218566989
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.5220734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 7.9619052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 7.9616835633
MESH:D002779 Cholestasis Cyclosporine 6.5419486331
MESH:D002779 Cholestasis pirinixic acid 6.5419176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.8912621046 8697196 16354765 15668235 15340226
MESH:D003072 Cognition Disorders Clozapine 4.4917123785
MESH:D003092 Colitis resveratrol 3.6616474422
MESH:D003110 Colonic Neoplasms celecoxib 5.3816004971
MESH:D003110 Colonic Neoplasms Fluorouracil 5.3817287894 17725105 17169374 16510598 17018589 15001691 17172411 18772588 16340194 17016597
MESH:D003110 Colonic Neoplasms resveratrol 5.3816338953
MESH:D015179 Colorectal Neoplasms celecoxib 4.4011197048 18349538
MESH:D015179 Colorectal Neoplasms Doxorubicin 4.4018259882 18802399
MESH:D015179 Colorectal Neoplasms Fluorouracil 4.4017094418 18383874 17454858 16331619 17401013 18802399 17016601 16282729 17594712 20501625 14970324 16524972 17255274 17695437 15148649 15289873 18448328 16303861 16391804 18288408 18509181 18949393
MESH:D015179 Colorectal Neoplasms resveratrol 4.4016550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 7.9117141729 14669216
MESH:D000013 Congenital Abnormalities Trinitrotoluene 7.9115095906
MESH:D003327 Coronary Disease resveratrol 3.4316507316
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.3015322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.3016575769 8888407 17688650
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.0916002989 12952375
MESH:D003490 Cyanosis 2,4-dinitrotoluene 16.0518551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 16.0518551238
MESH:D003490 Cyanosis Trinitrotoluene 16.0518551238
MESH:D007644 Darier Disease Fluorouracil 4.3016733453
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.3920210726
MESH:D003704 Dementia Haloperidol 4.1411575062
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.1818249437
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.3716873680
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 6.3216402076
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.3220387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.3217107852
MESH:D003928 Diabetic Nephropathies Estradiol 7.6619279558
MESH:D003928 Diabetic Nephropathies resveratrol 7.6616286809
MESH:D003967 Diarrhea Dinoprostone 4.1010446763 7237001 11488427
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.0615331141
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 22.5221346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 22.5218551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 22.5218071297 15619225 11739529 16109766 19923254 16781746 14550746 12392966 12594235 15968718 2444490 11287661 10774834 19085960 11461765 11421492 12540782 12705907 19416960 14725611 16393943 19739265 18713872 17906064 11529661 16081117 19370779 17522070 12153990 19420014 17562736 14986274 11743745 10915739 16485898 16227642 10663392 16177239 19164858 11834606 12958197
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 22.5219107877
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 22.528172417
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 22.5217416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 22.5220420201
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 22.5221346803 18551238
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 22.521733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.6019426721
MESH:D004362 Drug Toxicity Doxorubicin 6.9018602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 6.9011462148
MESH:D050171 Dyslipidemias Clozapine 3.8316402076
MESH:D004421 Dystonia Valproic Acid 3.601851702
MESH:D004487 Edema bisindolylmaleimide I 12.968273558
MESH:D004487 Edema pirinixic acid 12.9612083418
MESH:D004487 Edema resveratrol 12.968985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 12.9611000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.4116714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 3.5717872969
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.2116402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 10.6216804899 15700306
MESH:D016889 Endometrial Neoplasms Doxorubicin 10.6217359293
MESH:D016889 Endometrial Neoplasms Estradiol 10.6219148513 11473722 18566989
MESH:D004715 Endometriosis celecoxib 7.9615652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.969294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.6618037988
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.3717923197
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.6817275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 3.423922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.6720417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.186254150 7562514 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 3.827750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.583659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.6216302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 9.2120426865
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 9.2117016578
MESH:D004938 Esophageal Neoplasms Fluorouracil 9.2116481741 17638652 16785472 16337965 15173087
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 9.2115547733 15547721 15264214 15150132 16510608 15623463 16704527 16805852 15878914
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.6511564622
MESH:D005234 Fatty Liver Cyclosporine 15.2019224547
MESH:D005234 Fatty Liver Diethylnitrosamine 15.2020387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 15.2019236843 20131406
MESH:D005234 Fatty Liver Valproic Acid 15.2019224547 14986274
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.3516534752 16513791 15751030 16611131 16002989
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.9811858732
MESH:D005315 Fetal Diseases Valproic Acid 4.3916575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.678888407 18558336
MESH:D005334 Fever Dinoprostone 4.4616997862 11852909
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.1019069698
MESH:D005355 Fibrosis Cyclosporine 6.9112168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 6.9120067830
MESH:D005534 Foot Diseases Arsenic 5.066392382
MESH:D005756 Gastritis Acetaminophen 3.1816983495
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.4616452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.738708960
MESH:D005909 Glioblastoma Doxorubicin 3.0317150277
MESH:D005910 Glioma Fluorouracil 2.6616145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1010696789
MESH:D006261 Headache Ketamine 5.5211554966
MESH:D006258 Head and Neck Neoplasms Doxorubicin 6.8015692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 6.8015162350 18337622 15102660
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.0610048152 11294989
MESH:D006331 Heart Diseases Doxorubicin 3.1416244371 16495754 16244372 16144979 18006777 16707910 16879835 12587719 14766674 16330681 17875725 17888722 18674790
MESH:D006333 Heart Failure Doxorubicin 6.0117481944
MESH:D006333 Heart Failure pirinixic acid 6.0120558911
MESH:D006394 Hemangiosarcoma Doxorubicin 3.4715692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.9315720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9011000095
MESH:D006529 Hepatomegaly pirinixic acid 11.7419176532 16221962 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 11.7416120746 15340226 12621046
MESH:D006529 Hepatomegaly Trinitrotoluene 11.7415817613
MESH:D006558 Herpes Genitalis Estradiol 4.5315709030
MESH:D006561 Herpes Simplex resveratrol 3.7016876885
MESH:D006689 Hodgkin Disease Doxorubicin 3.0118501091 17606976 15147373
MESH:D019584 Hot Flashes Estradiol 3.2617088409
MESH:D006849 Hydrocephalus Valproic Acid 4.3817688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.558697196 16959395 15340226 16354765 18606429
MESH:D006930 Hyperalgesia Acetaminophen 6.8316870215
MESH:D006930 Hyperalgesia Dinoprostone 6.8316793879
MESH:D006937 Hypercholesterolemia resveratrol 3.5717188708
MESH:D006943 Hyperglycemia pirinixic acid 2.7620558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.0317050553
MESH:D006948 Hyperkinesis Clozapine 4.4216046005
MESH:D006949 Hyperlipidemias resveratrol 3.5816873680
MESH:D006965 Hyperplasia Diethylstilbestrol 3.9614722030 12960047
MESH:D006973 Hypertension Arsenic 10.679931084 11953799 16076760
MESH:D006973 Hypertension Cyclosporine 10.6710903974
MESH:D006973 Hypertension Phenylephrine 10.6712717712 8949925
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 10.6718850075 18670907
MESH:D006984 Hypertrophy Phenylephrine 4.1212791704 18502941
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 3.8817488730
MESH:D006987 Hypesthesia Arsenic 5.0616093927
MESH:D007021 Hypospadias Diethylstilbestrol 4.1016002989
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.1717600658
MESH:D007246 Infertility Diethylstilbestrol 3.8915036965
MESH:D007248 Infertility, Male Trinitrotoluene 3.3512150543
MESH:D007249 Inflammation bisindolylmaleimide I 9.818273558
MESH:D007249 Inflammation Diethylnitrosamine 9.8118785209
MESH:D007249 Inflammation resveratrol 9.8116366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 9.8112878042 12200463
MESH:D007251 Influenza, Human resveratrol 4.0516624496
MESH:D007333 Insulin Resistance Estradiol 6.1016627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 6.1016306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 2.9016580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.9415604871
MESH:D007642 Keratosis Arsenic 4.5012749816 16930632
MESH:D007674 Kidney Diseases Acetaminophen 12.0015629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 12.0010903974 8314463 18776723
MESH:D007674 Kidney Diseases Doxorubicin 12.0015369732 16775033 15699352
MESH:D007674 Kidney Diseases Estradiol 12.0015618244
MESH:D007676 Kidney Failure, Chronic Doxorubicin 8.6816707910
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 8.6816518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 23.9616705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 23.9616705839
MESH:D007680 Kidney Neoplasms Cyclosporine 23.9612371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 23.9616762066 14681315 15003126
MESH:D007680 Kidney Neoplasms Estradiol 23.9615610895
MESH:D007680 Kidney Neoplasms Fluorouracil 23.9616985049
MESH:D007859 Learning Disorders Diethylstilbestrol 3.5917184923
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.6616085563
MESH:D007948 Leukemia, Monocytic, Acute PD 98059 10.4716972261
MESH:D007948 Leukemia, Monocytic, Acute U 0126 10.4716972261
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.0617596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 6.8217339181
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 6.8216087638
MESH:D008064 Lipidoses Clozapine 3.6117567588
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.5518522880 20032147 18665156 18407596 19638242
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 7.7418095165 12918455 15864749 15591649 15086199 14568256 15067225 15383259 17036385 18371158 15492853 17203207 16042886 16009107 18364076 18637143 15942678 15366600 17465448 15842777 17196135 17201889 15763062 15577212 17432682 15571005 16169303 15369754 16544323 18239293 14659978 18629640 17719030 14726149 15479170 17724770 15298665 15744066 18210741 17534399 14709902 15733078 17198567 16570917 17881167 18567088 15099470 15793283 17348192 15161499 15081153 15798949 18672772 15723089 18237412 14643895 15138612 15504291 17666798 12925901 15339415 16603200 16270385 17640959 16627068
MESH:D008106 Liver Cirrhosis, Experimental Dinoprostone 7.7415816358
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 7.7416595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 7.7414659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 7.7415474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 7.7412878042
MESH:D008107 Liver Diseases Acetaminophen 8.1916611625 19784758 19014921 19460945 11587558 12969438 16610002 12587719
MESH:D008107 Liver Diseases Arsenic 8.1911134558
MESH:D008107 Liver Diseases Diethylnitrosamine 8.1917034775
MESH:D008107 Liver Diseases Dinoprostone 8.1915816358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.2716871587 17185352
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 8.2717457977
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 50.727678174
MESH:D008113 Liver Neoplasms 2-nitrofluorene 50.7215890375
MESH:D008113 Liver Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 50.7215890375
MESH:D008113 Liver Neoplasms Aflatoxin B1 50.729163691 2125692 15890375 18177683
MESH:D008113 Liver Neoplasms Arsenic 50.7216368122
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 50.7219389873 21295105
MESH:D008113 Liver Neoplasms Diethylnitrosamine 50.7219551842 9163691 19690152 19996281 20434301 20405173 18977376 20583210 19294768 19073162 20118626 19833225 18644402 21047994 19850985 20492335 15175105 18978307 2422723 19812893 19090486 15885732 19254457 16942905 19426721 12771043 20101389 10737359 18754104 20137499 18648771 19427195 19499222 19638242 19256749 20501860 2862719 20452335 12112319 19255062 21167192 19642983 21071580 21278145
MESH:D008113 Liver Neoplasms Diethylstilbestrol 50.7215890375 16712894
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 50.7215890375 3113478
MESH:D008113 Liver Neoplasms Fluorouracil 50.7215113037 16603448 18383874 17045692
MESH:D008113 Liver Neoplasms Methapyrilene 50.7215890375
MESH:D008113 Liver Neoplasms Piperonyl Butoxide 50.7219690152 20101389 18648771 15890375
MESH:D008113 Liver Neoplasms pirinixic acid 50.7220007298 16377806 15890375
MESH:D008113 Liver Neoplasms resveratrol 50.7219321006 19073162 20405173 19812893
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 50.7216984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 23.436135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 23.438603461
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 23.4318164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 23.439362446 2563599 19519916 18775883 18253720 17854601 16842330 21159647 18282651 16267830 17942915 19539802 18544905 17174075 18164116 19009564 18079962 18093689 18308698 3124819 19126423 19004024
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 23.436150874 1848544 15603536
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 23.4316842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 23.4312151625
MESH:D008171 Lung Diseases Ozone 3.0419066396 8266340
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 3.7717228818
MESH:D055370 Lung Injury Ozone 3.3820417186
MESH:D008175 Lung Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 13.8618508827 16061637 15893417 17139156 18813816 12438228 19931552 9255578 14755239 16401635 15172992
MESH:D008175 Lung Neoplasms Aflatoxin B1 13.8614755239
MESH:D008175 Lung Neoplasms Arsenic 13.8617306315 17976673 19168569
MESH:D008175 Lung Neoplasms Diethylnitrosamine 13.8620970405 21163286 20512841 6695378
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 13.8616061637 19555203 11884234
MESH:D008175 Lung Neoplasms Doxorubicin 13.866189445 17418594
MESH:D008175 Lung Neoplasms Fluorouracil 13.8615246190
MESH:D008175 Lung Neoplasms Ozone 13.867614698 8597069
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 13.8611884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.3015086387
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.6615166399
MESH:D008223 Lymphoma Diethylstilbestrol 6.5715700306
MESH:D008223 Lymphoma Doxorubicin 6.5716098063
MESH:D016393 Lymphoma, B-Cell resveratrol 3.8517088997
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 7.5617654614
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 7.5614749477
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.0915621674
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.0216002989
MESH:D015674 Mammary Neoplasms, Animal resveratrol 3.7615688416
MESH:D008325 Mammary Neoplasms, Experimental celecoxib 11.7119196722 12104042
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 11.7115458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 11.7111807958 16891317 11408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 11.7111606380 8985016
MESH:D020149 Manganese Poisoning Estradiol 3.9919453300
MESH:D008545 Melanoma Doxorubicin 4.7316827129
MESH:D008545 Melanoma Glucose 4.7314993021
MESH:D008545 Melanoma resveratrol 4.7317992120
MESH:D008546 Melanoma, Experimental Acetaminophen 3.0919513568
MESH:D001523 Mental Disorders Clozapine 6.7716856516
MESH:D001523 Mental Disorders Haloperidol 6.7716856516
MESH:D008654 Mesothelioma Doxorubicin 2.8517638057
MESH:D008659 Metabolic Diseases resveratrol 3.9417112576
MESH:D024821 Metabolic Syndrome X Clozapine 4.0119142101
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.2916801185
MESH:D008679 Metaplasia Ozone 4.6110496685
MESH:D008881 Migraine Disorders Valproic Acid 2.8418765137 18803445
MESH:D020326 Migraine without Aura Dinoprostone 4.8011304026
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.0615792986
MESH:D009062 Mouth Neoplasms Fluorouracil 3.2618986760 16757204
MESH:D052016 Mucositis Doxorubicin 4.3017415656
MESH:D009101 Multiple Myeloma celecoxib 6.7316123214
MESH:D009101 Multiple Myeloma resveratrol 6.7317049120 14749477 17935668 16490592 16267019 17164350
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.3817962980
MESH:D009135 Muscular Diseases pirinixic acid 3.0316239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.598888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 2.8617596541
MESH:D009203 Myocardial Infarction Doxorubicin 8.2015857846 19429709
MESH:D009203 Myocardial Infarction pirinixic acid 8.2019151258
MESH:D009203 Myocardial Infarction resveratrol 8.2017188708 16317513 16525036 17125593 16456233 17015251
MESH:D017202 Myocardial Ischemia Arsenic 13.0615371236
MESH:D017202 Myocardial Ischemia resveratrol 13.0617125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 13.0612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.0016810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.0016411023
MESH:D009205 Myocarditis resveratrol 4.2717322642
MESH:D009336 Necrosis 2,4-dinitrotoluene 14.9718551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 14.9718551238 7678174
MESH:D009336 Necrosis Trinitrotoluene 14.9718551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.163581430 9029167
MESH:D009362 Neoplasm Metastasis Doxorubicin 5.1618259882
MESH:D009369 Neoplasms Diethylstilbestrol 6.7915313581
MESH:D009369 Neoplasms Fluorouracil 6.7918600527 16928823 18239605
MESH:D009369 Neoplasms pirinixic acid 6.7917405874
MESH:D009374 Neoplasms, Experimental resveratrol 3.538985016
MESH:D009376 Neoplasms, Hormone-Dependent celecoxib 4.9419196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.2517289903
MESH:D009401 Nephrosis Doxorubicin 4.2916636307 16899518
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.9417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 7.9319348381 18481113
MESH:D009404 Nephrotic Syndrome Doxorubicin 7.9316889571 15640375
MESH:D009421 Nervous System Malformations Diethylstilbestrol 13.7111399458
MESH:D009421 Nervous System Malformations Estradiol 13.7111399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 13.7114600291
MESH:D009436 Neural Tube Defects Arsenic 6.3616620997
MESH:D009436 Neural Tube Defects Valproic Acid 6.3616359493 8888407
MESH:D009447 Neuroblastoma Doxorubicin 3.0015555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 11.7518514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 11.7520387270
MESH:D019636 Neurodegenerative Diseases resveratrol 11.7517652729
MESH:D020078 Neurogenic Inflammation Arsenic 9.2117056641
MESH:D020078 Neurogenic Inflammation resveratrol 9.2117929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.6220387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.1016436463
MESH:D009765 Obesity Clozapine 4.2218515891 19142110
MESH:D009765 Obesity pirinixic acid 4.2220558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 12.7416049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 12.7416049721
MESH:D009784 Occupational Diseases Trinitrotoluene 12.7417852074 12819281 14694615
MESH:D010005 Osteoarthropathy, Secondary Hypertrophic Dinoprostone 5.9818500342
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 3.8117513867
MESH:D012516 Osteosarcoma Doxorubicin 3.7215930896
MESH:D010051 Ovarian Neoplasms Arsenic 7.0217306315
MESH:D010051 Ovarian Neoplasms Estradiol 7.0219401270
MESH:D010051 Ovarian Neoplasms U 0126 7.0216211241
MESH:D010146 Pain Acetaminophen 2.0116870215
MESH:D010149 Pain, Postoperative Ketamine 5.6311554966
MESH:D010190 Pancreatic Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 10.7912384795
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 10.7916540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 10.7919003803 16929163 15113037 16500647
MESH:D010190 Pancreatic Neoplasms gemcitabine 10.7911504793 18992248 18383843 16929163 17440100
MESH:D010212 Papilloma Hydrogen Peroxide 3.6212065085
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.7512520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 3.7216093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.506392382 15371236 16905509
MESH:D010538 Peritonitis Ozone 3.6616369182
MESH:D003557 Phyllodes Tumor Doxorubicin 4.6617983394
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.6714722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.1915687265 16977796
MESH:D010997 Pleural Neoplasms Doxorubicin 4.6617638057
MESH:D011014 Pneumonia Ozone 3.9118381685 18929643 18007984
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.1018163543
MESH:D011230 Precancerous Conditions Cyclosporine 7.5812371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 7.582563599
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 19.2717184923
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 19.2716679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 19.2711896295 11118676 11399792 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 19.2720603192
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.4520887781
MESH:D011471 Prostatic Neoplasms Arsenic 2.0216140617
MESH:D011471 Prostatic Neoplasms celecoxib 2.0215570007 17908994
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.0215846301 15046698 17136230
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.0218437689 15897917 15749863 16729912 16868541 16888761
MESH:D011471 Prostatic Neoplasms Estradiol 2.0216740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.0218626508 19082440
MESH:D011471 Prostatic Neoplasms resveratrol 2.0217718901 15767336 17636462 17675339 17804756 16731767
MESH:D011507 Proteinuria Arsenic 3.5621343184
MESH:D019310 Pseudolymphoma Valproic Acid 4.0411422049 12752131
MESH:D011565 Psoriasis Cyclosporine 2.0416882103
MESH:D011595 Psychomotor Agitation Haloperidol 4.4811575062
MESH:D011618 Psychotic Disorders Clozapine 7.9715331141
MESH:D011618 Psychotic Disorders Haloperidol 7.9711575062
MESH:D012004 Rectal Neoplasms Fluorouracil 3.6018286688 15538739 16160472 18722050
MESH:D051437 Renal Insufficiency Doxorubicin 3.7517922066
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.0916325855
MESH:D015427 Reperfusion Injury pirinixic acid 5.7119058328
MESH:D015427 Reperfusion Injury resveratrol 5.7115827377 16314181 16317513 17058453 17520802
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.3718990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 3.7219155313
MESH:D012509 Sarcoma Doxorubicin 3.5717710206 16767912 18313854 15625365 17203757 15675481
MESH:D012512 Sarcoma, Ewing's Doxorubicin 3.7814601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.3017846226
MESH:D012559 Schizophrenia marker/mechanism 12145742 17460065
MESH:D012559 Schizophrenia Clozapine 7.2520452607 17726453 18806925 16141801 18855531 20168265 11763009 17667964 20521326 19369910 20107430 17123785 20580759 20521320 11151749
MESH:D012559 Schizophrenia Haloperidol 7.2518513383 1830565 20107430 19369910
MESH:D012559 Schizophrenia Ketamine 7.2520000043
MESH:D012559 Schizophrenia Valproic Acid 7.2519110320 15737665
MESH:D012640 Seizures 2,4-dinitrotoluene 11.3218551238
MESH:D012640 Seizures 2,6-dinitrotoluene 11.3218551238
MESH:D012640 Seizures Trinitrotoluene 11.3218551238
MESH:D012640 Seizures Valproic Acid 11.323137016 17978042 1511512 16876388 15475178 11738929 14763951 11044598
MESH:D012852 Sinusitis Phenylephrine 4.227327846
MESH:D012871 Skin Diseases Arsenic 2.6117453740 18709164 16702368 19834688 17548696 17938729 15952646 16759981 16353154 17050553 6392382
MESH:D012878 Skin Neoplasms Arsenic 19.2517050553 15504454 16251483 19538983 17029826 17976673
MESH:D012878 Skin Neoplasms Doxorubicin 19.2515692506
MESH:D012878 Skin Neoplasms Glucose 19.2514993021
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 19.2512065085
MESH:D012878 Skin Neoplasms resveratrol 19.2515837718 8985016
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 19.2516192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.0916767912 17203757 15625365
MESH:D013088 Spermatocele Diethylstilbestrol 4.2216002989 16709447
MESH:D016135 Spinal Dysraphism Valproic Acid 3.4019490988
MESH:D013158 Splenic Diseases Dimethylnitrosamine 4.7712587719
MESH:D013163 Splenomegaly Trinitrotoluene 4.7215817613
MESH:D013226 Status Epilepticus Valproic Acid 4.0412833885
MESH:D013274 Stomach Neoplasms celecoxib 5.7615609394
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 5.7618456281
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 5.7616033868
MESH:D013274 Stomach Neoplasms Fluorouracil 5.7619015929 18396642 16424979 18567086 15786421 19084572 17498489 16951190 17522103 17172411
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 5.7612958204 17575124
MESH:D013276 Stomach Ulcer marker/mechanism 16357062
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.0516321402
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.2520210726
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.4112697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 6.067505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 6.0616010429 17909728
MESH:D013978 Tibial Fractures Estradiol 4.1919048282
MESH:D014062 Tongue Neoplasms Fluorouracil 8.5816280240
MESH:D014062 Tongue Neoplasms resveratrol 8.5816227395
MESH:D014178 Translocation, Genetic Valproic Acid 4.7417262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.033119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 17.1116049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 17.1116049721
MESH:D001749 Urinary Bladder Neoplasms Arsenic 17.1111144890 15987713 19322015 19429237 17976673 18640142 17306315
MESH:D001749 Urinary Bladder Neoplasms Cacodylic Acid 17.1115537745
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 17.1117306315 16452187 16712894
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 17.1117653716
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.178888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 10.3710091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 10.3710091137
MESH:D014581 Urticaria Acetaminophen 2.5310982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 13.5116175088
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 13.5116803524
MESH:D002583 Uterine Cervical Neoplasms resveratrol 13.5117473185
MESH:D014591 Uterine Diseases Diethylstilbestrol 4.6714652134
MESH:D014594 Uterine Neoplasms celecoxib 13.6418645019
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 13.6415809267 16690809
MESH:D014594 Uterine Neoplasms resveratrol 13.6417044934
MESH:D014605 Uveitis Cyclosporine 3.491336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 3.9616002989 16513791
MESH:D014652 Vascular Diseases Arsenic 4.2517056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1012125929
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 8.7617334414 16364871 17678736 17638931
MESH:D018487 Ventricular Dysfunction, Left resveratrol 8.7617488730
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.7515886252
MESH:D015430 Weight Gain Clozapine 4.0616402076 16141801 17502770 20521320 20564506 20107430
MESH:D015431 Weight Loss Clozapine 4.5917933447
MESH:D014985 Xerophthalmia Cyclosporine 3.9417120751
Pathway ID Pathway Name
KEGG:04012 ErbB signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA31776
    • No data
    Releated disease ID Related disease Name
    PA444478Hirschsprung Disease
    PA447216Schizophrenia
    Releated drug ID Related drug Name
    PA452229antidepressants
    PA450635nitric oxide
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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