AutismKB 2.0

Annotation Detail for EHD2


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Basic Information Top
Gene Symbol:EHD2 ( FLJ96617,PAST2 )
Gene Full Name: EH-domain containing 2
Band: 19q13.33
Quick LinksEntrez ID:30846; OMIM: 605890; Uniprot ID:EHD2_HUMAN; ENSEMBL ID: ENSG00000024422; HGNC ID: 3243
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of EHD2 mRNA]affects expression|affects reaction 19414516
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of EHD2 mRNA]affects expression|affects reaction 19414516
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of EHD2 mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of EHD2 mRNAaffects expression 17562736
D000242 Cyclic AMP 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of EHD2 mRNA]affects expression|affects reaction 19414516
D000643 Ammonium Chloride Ammonium Chloride affects the expression of EHD2 mRNAaffects expression 16483693
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of EHD2 mRNAaffects cotreatment|increases expression 18164116
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of EHD2 mRNAaffects cotreatment|increases expression 18164116
D005472 Fluorouracil EHD2 protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
D012643 Selenium Selenium results in increased expression of EHD2 mRNAincreases expression 19244175
D014212 Tretinoin Tretinoin results in increased expression of EHD2 mRNAincreases expression 16788091
C025643 vinclozolin vinclozolin affects the expression of EHD2 mRNAaffects expression 19015723
D014810 Vitamin E Vitamin E results in increased expression of EHD2 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.7118287403
MESH:D000230 Adenocarcinoma Fluorouracil 2.4517638652
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 11.583712494
MESH:D000236 Adenoma beta-Naphthoflavone 11.5819389873
MESH:D000236 Adenoma Diethylnitrosamine 11.586695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.0516434500 17620307 19061943 19052882 17162532 18056438
MESH:D000505 Alopecia Tretinoin 3.7015955085
MESH:D000740 Anemia Fluorouracil 3.8115504547 17963324 16511603
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D001008 Anxiety Disorders vinclozolin 3.7319015723
MESH:D001169 Arthritis, Experimental Tretinoin 3.1416412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2916292516
MESH:D001249 Asthma Tretinoin 2.3716456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001471 Barrett Esophagus Tretinoin 4.5316935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.1911289319 1440618
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.7216206674 16197459
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9317474063
MESH:D001943 Breast Neoplasms Fluorouracil 1.9315136595 18357371 16557594 19217205 18608205 16595493 16110121
MESH:D001943 Breast Neoplasms Tretinoin 1.9316873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.7416813970
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.0716050911
MESH:D002276 Carcinoid Tumor Fluorouracil 4.8416051944
MESH:D002277 Carcinoma Fluorouracil 3.6517121937
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.3316168501
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 9.043581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.043084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 9.0417761372 18788625 19335982 19701751 17162532 20727157 18691550 16878318 19418558 18506893 18494052 18210153 16807293 3084413 20524982 19052882 20084675 17138121 20432363 19171122 20101231 17978847 18971187 16502159 18785209 19539802 20935162 20514400 18665156 17173139 17428255 16328049 18056438 16288022 19383236 19919837 20512989 18978308 16681979 16935385 3581430 17055752 10737359 16569478 19394651 16830150 19519916 16698587 20007298 20214788 19822196 19208518 18393292 16540662 19107877 10672840 16779866 21159647 11831363
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 9.0418930000 16332177 17088986 17045692 16799960 17971768
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 9.041917145
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.657296757
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.6518695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.8217066447 16280240 18986760 16757204
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.8216096774 16051514
MESH:D002386 Cataract Acetaminophen 7.4310977129
MESH:D002386 Cataract Tretinoin 7.4317460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.947505956
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.942727394 17174075 21159647 7505956
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.7416129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.7819052882
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.2319486331 9022650
MESH:D002822 Choriocarcinoma Tretinoin 5.3316461808
MESH:D002972 Cleft Palate Tretinoin 2.719407595
MESH:D003092 Colitis Selenium 9.9717936198
MESH:D003092 Colitis Tretinoin 9.9717035595
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2517287894 15001691 16340194 16510598 17172411 18772588 17016597 17725105 17018589 17169374
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0017255274 16391804 17594712 16524972 18949393 18448328 18288408 17695437 17016601 17401013 17454858 20501625 17094418 15148649 16303861 18802399 15289873 18383874 14970324 16331619 18509181 16282729
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.729142499 16925845 14991402 10589399 9664655 17551590 9125849 8800419 9224671 9211117
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.7219769572
MESH:D003456 Cryptorchidism vinclozolin 4.4714966744
MESH:D007644 Darier Disease Fluorouracil 4.9516733453
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.9418759878 12868966 8970840 11906362 11298694 8156756 14531868 2524372
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.612952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2120387270
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 9.2316192314 18289764 18648102 18692083 1440618 6679447 8291058 11289319 9022650 9328219 7440962 9653073 6482804
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.2312153990 12392966 17906064 16393943 10915739 19370779 18713872 19416960 10663392 19739265 14550746 16781746 2444490 16109766 19923254 11287661 11529661 11834606 15619225 11461765 12594235 16227642 11743745 15968718 19164858 12705907 11739529 16081117 10774834 16485898 19420014 19085960 12540782 14725611 14986274 11421492 17562736 18071297 17522070 12958197 16177239
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 9.2319107877
MESH:D056486 Drug-Induced Liver Injury Selenium 9.2315131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:C538011 Eales disease Vitamin E 4.889068938
MESH:D004489 Edema, Cardiac Tretinoin 4.6418230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.1816569247
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2916302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.613581430
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.6117638652 16337965 16785472 15173087 16481741
MESH:D005124 Eye Abnormalities Tretinoin 3.669664655 16938888
MESH:D005234 Fatty Liver Diethylnitrosamine 3.2921071580 20387270
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.196705139
MESH:D005355 Fibrosis Tretinoin 3.6517994277
MESH:D005756 Gastritis Acetaminophen 3.8516983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.0916973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.4716417039
MESH:D005909 Glioblastoma Tretinoin 3.0717312396
MESH:D005910 Glioma Fluorouracil 2.9116145905
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.157505956
MESH:D006258 Head and Neck Neoplasms Fluorouracil 8.0318337622 15162350 15102660
MESH:D006258 Head and Neck Neoplasms Tretinoin 8.0316096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.3316084493
MESH:D006330 Heart Defects, Congenital Tretinoin 6.969664655 14991402
MESH:D006330 Heart Defects, Congenital Vitamin E 6.9616080930
MESH:D006333 Heart Failure Selenium 3.1417162251
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.646705139
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7316863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.1514716179
MESH:D006930 Hyperalgesia Acetaminophen 7.9216870215
MESH:D006930 Hyperalgesia Tretinoin 7.9216870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7116778211
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0815034207
MESH:D007248 Infertility, Male vinclozolin 3.1116467254
MESH:D007249 Inflammation Diethylnitrosamine 2.4318785209
MESH:D007251 Influenza, Human Selenium 11.5516624496
MESH:D007251 Influenza, Human Vitamin E 11.5516624496
MESH:D007410 Intestinal Diseases Tretinoin 3.9017994277
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.199022650 8074119
MESH:D007569 Jaw Abnormalities Tretinoin 4.0115992940 17551590
MESH:D007674 Kidney Diseases Acetaminophen 6.1715629191 12587719
MESH:D007674 Kidney Diseases Vitamin E 6.1712488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.9916518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.796582329
MESH:D007680 Kidney Neoplasms Fluorouracil 7.7916985049
MESH:D007938 Leukemia Tretinoin 2.8217143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.8119285840 16932348 16482212
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0916294345 19850784 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2216788101 17301526 17339181 16935935 17712046 19075265 19642359 16140955 16891316 17368321 17294898 17217047 19035177 19225113 17107899 12679006 9834237 17506722 17649720 19029980 17361223 16331271 16823087 15748426 16766008
MESH:D007984 Leydig Cell Tumor vinclozolin 4.8916417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.389224671
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8818407596 18522880 19638242 20032147 18665156
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.269327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.5816248980 18397230
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.5816169303
MESH:D008107 Liver Diseases Acetaminophen 3.9919014921 12587719 12969438 16611625 19460945 11587558 16610002 19784758
MESH:D008107 Liver Diseases Diethylnitrosamine 3.9917034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3416871587 17185352
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 7.7919389873 21295105
MESH:D008113 Liver Neoplasms Diethylnitrosamine 7.7918977376 19256749 20101389 19073162 19254457 20434301 18648771 18978307 20583210 19090486 19996281 20118626 19255062 20492335 15175105 19833225 2862719 20452335 19499222 21167192 19638242 19850985 19294768 21047994 18754104 2422723 18644402 19812893 19426721 10737359 21278145 19427195 19690152 20405173 12112319 15885732 20137499 16942905 12771043 20501860 19642983 21071580 19551842 9163691
MESH:D008113 Liver Neoplasms Fluorouracil 7.7917045692 15113037 16603448 18383874
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.313712494 598648 1399818 6587162
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 10.3118164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.3118164116 18775883 18253720 19539802 2563599 19009564 21159647 16267830 18544905 18282651 18093689 9362446 18079962 16842330 17854601 19519916 19004024 17174075 18308698 17942915 3124819 19126423
MESH:D008171 Lung Diseases Vitamin E 3.2516863852
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.5520512841 20970405 21163286 6695378
MESH:D008175 Lung Neoplasms Fluorouracil 3.5515246190
MESH:D008175 Lung Neoplasms Vitamin E 3.5511062179
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.9515086387
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8315318939
MESH:D008527 Medulloblastoma Tretinoin 2.8217453147
MESH:D008545 Melanoma Tretinoin 1.9516752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D008591 Meningomyelocele Tretinoin 4.5616940565
MESH:D008654 Mesothelioma Selenium 2.8315107826
MESH:D020326 Migraine without Aura Cyclic AMP 5.2811304026
MESH:D009062 Mouth Neoplasms Fluorouracil 3.7116757204 18986760
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1417596541
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.833581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.839029167 3581430
MESH:D009369 Neoplasms Fluorouracil 5.3216928823 18600527 18239605
MESH:D009369 Neoplasms Tretinoin 5.3216946489 16594593
MESH:D009421 Nervous System Malformations Tretinoin 3.909125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.466679447
MESH:D009436 Neural Tube Defects Tretinoin 7.469142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.4918514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.4920387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2920387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5116436463
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.524026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.193988306
MESH:D010051 Ovarian Neoplasms Tretinoin 2.3716936753
MESH:D010146 Pain Acetaminophen 6.8916870215
MESH:D010146 Pain Tretinoin 6.8916870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 8.8416540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 8.8419003803 16929163 16500647 15113037
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.8415976015
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.627296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.646228378
MESH:D010954 Plasmacytoma Selenium 5.0615087411
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.652563599
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.0519015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 5.0918220299
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.3219082440 18626508
MESH:D011471 Prostatic Neoplasms Vitamin E 3.3215084515
MESH:D011472 Prostatitis vinclozolin 5.0918629315
MESH:D011507 Proteinuria Tretinoin 3.7216636307
MESH:D011625 Pterygium Tretinoin 4.9516723453
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1118722050 15538739 18286688 16160472
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.463692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.2216116481 16283617
MESH:D012871 Skin Diseases Vitamin E 2.4618709164
MESH:D012878 Skin Neoplasms Tretinoin 2.6516467112
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.4418456281
MESH:D013274 Stomach Neoplasms Fluorouracil 3.4419015929 18396642 15786421 16424979 17498489 16951190 19084572 17172411 18567086 17522103
MESH:D013274 Stomach Neoplasms Tretinoin 3.4417261132
MESH:D020521 Stroke Vitamin E 3.6116517955
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 12.456582329 7505956 3712494 6587162 1399818
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 12.457505956
MESH:D013964 Thyroid Neoplasms Tretinoin 12.4516026305 17045167
MESH:D014062 Tongue Neoplasms Fluorouracil 10.1816280240
MESH:D014062 Tongue Neoplasms Tretinoin 10.1816051514
MESH:D014376 Tuberculosis Tretinoin 3.2916040207
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.318074119
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 9.8016803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 9.8016129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.7816752155
MESH:D014820 Vitiligo Tretinoin 4.1816761959
MESH:D009396 Wilms Tumor Tretinoin 4.0716287080
Pathway ID Pathway Name
KEGG:04144 Endocytosis
REACT:604 Hemostasis
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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