Annotation Detail for HIF1A
Basic Information Top
| Gene Symbol: | HIF1A ( HIF-1alpha,HIF1,HIF1-ALPHA,MOP1,PASD8,bHLHe78 ) |
|---|---|
| Gene Full Name: | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) |
| Band: | 14q23.2 |
| Quick Links | Entrez ID:3091; OMIM: 603348; Uniprot ID:HIF1A_HUMAN; ENSEMBL ID: ENSG00000100644; HGNC ID: 4910 |
| Relate to Another Database: | SFARIGene; denovo-db |
| No data |
| Pathway ID | Pathway Name |
|---|---|
| hsa04150 | mTOR signaling pathway |
| hsa05211 | Renal cell carcinoma |
| hsa05200 | Pathways in cancer |
| No data |
| Pathway ID | Pathway Name |
|---|---|
| 200122 | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 200151 | VEGFR1 specific signals |
| 200127 | PDGFR-beta signaling pathway |
| 200172 | HIF-1-alpha transcription factor network |
| 200161 | Signaling events mediated by VEGFR1 and VEGFR2 |
| 200118 | AP-1 transcription factor network |
| 200196 | Notch-mediated HES/HEY network |
| Pathway ID | Pathway Name |
|---|---|
| P00056 | VEGF signaling pathway |
| P00005 | Angiogenesis |
| P00030 | Hypoxia response via HIF activation |
| No data |
| No data |
| Desease ID | Desease Name |
|---|---|
| 1742 | Moyamoya disease |
| 1744 | Vasculitis |
| 1746 | Hypertension, Pulmonary |
| 1832 | Congenital abnormality |
| 1856 | Obesity |
| 1870 | Drug abuse |
| 1878 | Ischemia |
| 1904 | Diabetes mellitus |
| 1918 | Atherosclerosis |
| 1934 | Cancer |
| 1954 | Stroke |
| 2025 | Polyarthritis |
| 2040 | Hyperglycemia |
| 2044 | Pre-Eclampsia |
| 2052 | Infection |
| 2164 | Barrett's esophagus |
| 2178 | Retinal disease |
| 2197 | Metabolism disease |
| 2220 | Dermatitis |
| 2222 | Polycythemia |
| 2232 | Aseptic necrosis of bone |
| Desease Name |
|---|
| colorectal cancer |
| CARDIOVASCULAR |
| CANCER |
| stroke, ischemic |
| cervical cancer endometrial cancer ovarian cancer |
| esophageal cancer |
| hypoxia |
| kidney cancer |
| METABOLIC |
| oxygen consumption |
| VISION |
| HIF-1alpha protein expression |
| retinopathy, diabetic |
| diabetes, type 2 |
| osteonecrosis |
| No data |
| No data |
| Chemical ID | Chemical Name | Interaction | Interaction Action | Publication |
|---|---|---|---|---|
| C496879 | 103D5R | 103D5R inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein] | decreases reaction|increases expression | 15695405 |
| C496879 | 103D5R | 103D5R results in decreased expression of and results in decreased activity of HIF1A protein | decreases activity|decreases expression | 15695405 |
| C496879 | 103D5R | 103D5R results in decreased expression of HIF1A mRNA | decreases expression | 15695405 |
| C025205 | 1,10-phenanthroline | 4'-O-methylalpinumisoflavone inhibits the reaction [1,10-phenanthroline deficiency results in increased activity of HIF1A protein] | decreases reaction|increases activity | 19091749 |
| C025205 | 1,10-phenanthroline | alpinumisoflavone inhibits the reaction [1,10-phenanthroline deficiency results in increased activity of HIF1A protein] | decreases reaction|increases activity | 19091749 |
| C097240 | 15-deoxy-delta(12,14)-prostaglandin J2 | 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HIF1A protein | increases expression | 17658243 |
| C097240 | 15-deoxy-delta(12,14)-prostaglandin J2 | 15-deoxy-delta(12,14)-prostaglandin J2 affects the stability of HIF1A protein | affects stability | 17658243 |
| C097240 | 15-deoxy-delta(12,14)-prostaglandin J2 | 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HIF1A protein | increases expression | 17658243 |
| C097240 | 15-deoxy-delta(12,14)-prostaglandin J2 | Acetylcysteine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HIF1A protein] | decreases reaction|increases expression | 17658243 |
| C097240 | 15-deoxy-delta(12,14)-prostaglandin J2 | Buthionine Sulfoximine promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HIF1A protein] | increases expression|increases reaction | 17658243 |
| C097240 | 15-deoxy-delta(12,14)-prostaglandin J2 | Dithiothreitol inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HIF1A protein] | decreases reaction|increases expression | 17658243 |
| C097240 | 15-deoxy-delta(12,14)-prostaglandin J2 | Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HIF1A protein] | decreases reaction|increases expression | 17658243 |
| C029790 | 2,2',3',4,4',5-hexachlorobiphenyl | [2,4,4'-trichlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,3',4,4',5-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of HIF1A mRNA | affects cotreatment|increases expression | 15808785 |
| C070055 | 2,3',4,4',5-pentachlorobiphenyl | [2,4,4'-trichlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,3',4,4',5-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of HIF1A mRNA | affects cotreatment|increases expression | 15808785 |
| C014211 | 2,3,7,8-tetrachlorodibenzofuran | 2,3,7,8-tetrachlorodibenzofuran affects the expression of HIF1A mRNA | affects expression | 18343893 |
| C063002 | 2,3-dimethoxy-1,4-naphthoquinone | 2,3-dimethoxy-1,4-naphthoquinone inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein] | decreases reaction|increases expression | 11514583 |
| C063002 | 2,3-dimethoxy-1,4-naphthoquinone | 2,3-dimethoxy-1,4-naphthoquinone inhibits the reaction [TNF protein results in increased expression of HIF1A protein] | decreases reaction|increases expression | 11514583 |
| C081766 | 2,4,4'-trichlorobiphenyl | [2,4,4'-trichlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,3',4,4',5-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of HIF1A mRNA | affects cotreatment|increases expression | 15808785 |
| C014024 | 2,4,5,2',4',5'-hexachlorobiphenyl | [2,4,4'-trichlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,3',4,4',5-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of HIF1A mRNA | affects cotreatment|increases expression | 15808785 |
| C009828 | 2,4,5,2',5'-pentachlorobiphenyl | [2,4,4'-trichlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,3',4,4',5-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of HIF1A mRNA | affects cotreatment|increases expression | 15808785 |
| C085911 | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-hydroxyestradiol-17 beta results in increased expression of HIF1A protein] | decreases reaction|increases expression | 15050414 |
| C085911 | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased activity of HIF1A protein] | decreases reaction|increases activity | 17082639 |
| C085911 | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein] | decreases reaction|increases expression | 17082639 |
| C085911 | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [FGF2 protein results in increased expression of and results in increased activity of HIF1A protein] | decreases reaction|increases activity|increases expression | 15631803 |
| C085911 | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased expression of HIF1A protein] | decreases reaction|increases expression | 16682453 |
| C085911 | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA] | decreases reaction|increases expression | 18924134 11424089 |
| C085911 | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of HIF1A protein | decreases activity | 15631803 |
| C085911 | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of HIF1A protein | decreases expression | 14726529 15213310 16227395 |
| C028451 | 3,4,3',4'-tetrachlorobiphenyl | [3,4,3',4'-tetrachlorobiphenyl co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl] results in decreased expression of HIF1A mRNA | affects cotreatment|decreases expression | 15808785 |
| C027309 | 3,4,5,3',4',5'-hexachlorobiphenyl | [3,4,3',4'-tetrachlorobiphenyl co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl] results in decreased expression of HIF1A mRNA | affects cotreatment|decreases expression | 15808785 |
| C023035 | 3,4,5,3',4'-pentachlorobiphenyl | [3,4,3',4'-tetrachlorobiphenyl co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl] results in decreased expression of HIF1A mRNA | affects cotreatment|decreases expression | 15808785 |
| C524042 | 3,5-bis(2-fluorobenzylidene)piperidin-4-one | 3,5-bis(2-fluorobenzylidene)piperidin-4-one results in decreased expression of and results in decreased activity of HIF1A protein | decreases activity|decreases expression | 18682687 |
| C524042 | 3,5-bis(2-fluorobenzylidene)piperidin-4-one | VHL protein promotes the reaction [3,5-bis(2-fluorobenzylidene)piperidin-4-one results in decreased expression of HIF1A protein] | decreases expression|increases reaction | 18682687 |
| C025946 | 3-methyladenine | 3-methyladenine inhibits the reaction [CR 3294 results in decreased expression of HIF1A protein] | decreases expression|decreases reaction | 18927491 |
| C090942 | 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole | 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [sodium arsenite results in increased expression of HIF1A protein] | decreases reaction|increases expression | 12482858 |
| C108123 | 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine | 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein] | decreases reaction|increases expression | 15913578 |
| C014036 | 4-hydroxyestradiol-17 beta | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-hydroxyestradiol-17 beta results in increased expression of HIF1A protein] | decreases reaction|increases expression | 15050414 |
| C014036 | 4-hydroxyestradiol-17 beta | 4-hydroxyestradiol-17 beta results in increased expression of HIF1A protein | increases expression | 15050414 |
| C014036 | 4-hydroxyestradiol-17 beta | Sirolimus inhibits the reaction [4-hydroxyestradiol-17 beta results in increased expression of HIF1A protein] | decreases reaction|increases expression | 15050414 |
| C014036 | 4-hydroxyestradiol-17 beta | wortmannin inhibits the reaction [4-hydroxyestradiol-17 beta results in increased expression of HIF1A protein] | decreases reaction|increases expression | 15050414 |
| C507553 | 4'-O-methylalpinumisoflavone | 4'-O-methylalpinumisoflavone inhibits the reaction [1,10-phenanthroline deficiency results in increased activity of HIF1A protein] | decreases reaction|increases activity | 19091749 |
| C507553 | 4'-O-methylalpinumisoflavone | 4'-O-methylalpinumisoflavone inhibits the reaction [Oxygen deficiency results in increased activity of HIF1A protein] | decreases reaction|increases activity | 19091749 |
| C507553 | 4'-O-methylalpinumisoflavone | 4'-O-methylalpinumisoflavone inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein] | decreases reaction|increases expression | 19091749 |
| C029728 | 4-phenylenediamine | 4-phenylenediamine results in increased expression of HIF1A mRNA | increases expression | 16314067 |
| D000082 | Acetaminophen | Acetaminophen affects the expression of HIF1A mRNA | affects expression | 17562736 |
| D000082 | Acetaminophen | Acetaminophen results in increased expression of HIF1A protein | increases expression | 16530163 |
| D000082 | Acetaminophen | Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of HIF1A protein] | decreases reaction|increases expression | 16530163 |
| D000082 | Acetaminophen | Cyclosporine inhibits the reaction [Acetaminophen results in increased expression of HIF1A protein] | decreases reaction|increases expression | 16530163 |
| D000111 | Acetylcysteine | Acetylcysteine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HIF1A protein] | decreases reaction|increases expression | 17658243 |
| D000111 | Acetylcysteine | Acetylcysteine inhibits the reaction [Cisplatin affects the localization of HIF1A protein] | affects localization|decreases reaction | 17066447 |
| D000111 | Acetylcysteine | Acetylcysteine inhibits the reaction [Fluorouracil affects the localization of HIF1A protein] | affects localization|decreases reaction | 17066447 |
| D000111 | Acetylcysteine | Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of HIF1A protein] | decreases reaction|increases expression | 16530163 |
| D016604 | Aflatoxin B1 | Aflatoxin B1 affects the expression of HIF1A protein | affects expression | 20106945 |
| C412373 | AG 1879 | AG 1879 inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein] | decreases reaction|increases expression | 15913578 |
| C000154 | alpinumisoflavone | alpinumisoflavone inhibits the reaction [1,10-phenanthroline deficiency results in increased activity of HIF1A protein] | decreases reaction|increases activity | 19091749 |
| C000154 | alpinumisoflavone | alpinumisoflavone inhibits the reaction [Oxygen deficiency results in increased activity of HIF1A protein] | decreases reaction|increases activity | 19091749 |
| D000535 | Aluminum | Aluminum results in increased localization of HIF1A protein | increases localization | 16979867 |
| D000643 | Ammonium Chloride | Ammonium Chloride affects the expression of HIF1A mRNA | affects expression | 16483693 |
| D000968 | Antimycin A | Antimycin A affects the expression of HIF1A protein | affects expression | 16034640 |
| D047310 | Apigenin | Apigenin results in decreased expression of HIF1A protein | decreases expression | 15947208 |
| D001151 | Arsenic | [Nickel co-treated with Arsenic] results in increased expression of HIF1A protein | affects cotreatment|increases expression | 16386771 |
| C006632 | arsenic trioxide | arsenic trioxide affects the expression of HIF1A mRNA | affects expression | 20458559 |
| C006632 | arsenic trioxide | arsenic trioxide promotes the reaction [cobaltous chloride results in increased expression of HIF1A protein] | increases expression|increases reaction | 16330433 |
| C006632 | arsenic trioxide | arsenic trioxide promotes the reaction [Deferoxamine results in increased expression of HIF1A protein] | increases expression|increases reaction | 16330433 |
| C006632 | arsenic trioxide | arsenic trioxide results in decreased expression of HIF1A mRNA | decreases expression | 19769630 |
| C006632 | arsenic trioxide | arsenic trioxide results in increased expression of HIF1A protein | increases expression | 12482858 |
| C006632 | arsenic trioxide | [Oxygen deficiency co-treated with arsenic trioxide] results in increased expression of HIF1A protein | affects cotreatment|increases expression | 19825857 |
| C015001 | arsenite | arsenite results in increased expression of HIF1A protein | increases expression | 14971644 |
| C015001 | arsenite | arsenite results in increased expression of HIF1A mRNA | increases expression | 15868481 |
| D017638 | Asbestos, Crocidolite | Asbestos, Crocidolite results in increased activity of HIF1A protein | increases activity | 18385176 |
| D017638 | Asbestos, Crocidolite | ferric nitrilotriacetate inhibits the reaction [Asbestos, Crocidolite results in increased activity of HIF1A protein] | decreases reaction|increases activity | 18385176 |
| D001205 | Ascorbic Acid | Ascorbic Acid inhibits the reaction [Quercetin results in increased expression of HIF1A protein] | decreases reaction|increases expression | 17364964 |
| D001564 | Benzo(a)pyrene | Benzo(a)pyrene affects the activity of HIF1A protein | affects activity | 20624995 |
| D001564 | Benzo(a)pyrene | Benzo(a)pyrene inhibits the reaction [cobaltous chloride promotes the reaction [HIF1A protein binds to ARNT protein]] | affects binding|decreases reaction|increases reaction | 20228066 |
| C072553 | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of and results in increased expression of HIF1A protein | decreases degradation|increases expression | 15878343 |
| C072553 | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [deguelin results in increased degradation of HIF1A protein] | decreases reaction|increases degradation | 17764071 |
| C072553 | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [geldanamycin results in increased degradation of HIF1A protein] | decreases reaction|increases degradation | 11980636 |
| C072553 | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [HIF1A protein binds to VHL protein] | affects binding|increases reaction | 17973296 |
| C072553 | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of and results in increased expression of HIF1A protein | decreases degradation|increases expression | 18682687 |
| C072553 | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of HIF1A protein | decreases degradation | 17764071 |
| C072553 | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HIF1A protein modified form | increases expression | 17973296 |
| C072553 | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | Quercetin inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [HIF1A protein binds to VHL protein]] | affects binding|decreases reaction|increases reaction | 17973296 |
| C006780 | bisphenol A | bisphenol A inhibits the reaction [Cobalt results in decreased ubiquitination of and results in decreased degradation of HIF1A protein] | decreases degradation|decreases reaction|decreases ubiquitination | 15147973 |
| C006780 | bisphenol A | bisphenol A inhibits the reaction [HIF1A protein results in increased expression of EPO mRNA] | decreases reaction|increases expression | 15147973 |
| C006780 | bisphenol A | bisphenol A results in increased degradation of HIF1A protein | increases degradation | 15147973 |
| C006780 | bisphenol A | bisphenol A analog results in decreased activity of HIF1A protein | decreases activity | 20432243 |
| C400082 | bortezomib | bortezomib results in increased expression of HIF1A protein | increases expression | 16061869 |
| D019328 | Buthionine Sulfoximine | Buthionine Sulfoximine promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HIF1A protein] | increases expression|increases reaction | 17658243 |
| D019328 | Buthionine Sulfoximine | Buthionine Sulfoximine results in increased activity of HIF1A protein | increases activity | 11841787 |
| D020122 | tert-Butylhydroperoxide | [HIF1A protein results in increased expression of MCL1 protein] which results in decreased susceptibility to tert-Butylhydroperoxide | decreases response to substance|increases expression | 15611089 |
| C110904 | capecitabine | HIF1A protein results in decreased susceptibility to capecitabine | decreases response to substance | 16734730 |
| D002251 | Carbon Tetrachloride | Carbon Tetrachloride results in increased expression of HIF1A mRNA | increases expression | 16713642 |
| D002614 | Chelating Agents | Chelating Agents results in increased expression of HIF1A | increases expression | 16046841 |
| D002857 | Chromium | Chromium results in increased expression of HIF1A protein | increases expression | 16386771 |
| D002857 | Chromium | ferrous sulfate inhibits the reaction [Chromium results in increased expression of HIF1A protein] | decreases reaction|increases expression | 16386771 |
| D002857 | Chromium | [Nickel co-treated with Chromium] results in increased expression of HIF1A protein | affects cotreatment|increases expression | 16386771 |
| C074702 | chromium hexavalent ion | chromium hexavalent ion inhibits the reaction [Nickel results in increased stability of and results in increased expression of HIF1A protein] | decreases reaction|increases expression|increases stability | 19403854 |
| C074702 | chromium hexavalent ion | STAT1 protein affects the reaction [chromium hexavalent ion inhibits the reaction [Nickel results in increased stability of and results in increased expression of HIF1A protein]] | affects reaction|decreases reaction|increases expression|increases stability | 19403854 |
| C011585 | ciclopirox | ciclopirox results in increased expression of and results in increased localization of HIF1A protein | increases expression|increases localization | 14600837 |
| D007464 | Clioquinol | Clioquinol results in decreased hydroxylation of HIF1A protein | decreases hydroxylation | 16973622 |
| D007464 | Clioquinol | Clioquinol results in decreased ubiquitination of HIF1A protein | decreases ubiquitination | 16973622 |
| D007464 | Clioquinol | Clioquinol results in increased expression of HIF1A protein | increases expression | 16973622 |
| D007464 | Clioquinol | [Zinc co-treated with Copper] inhibits the reaction [Clioquinol results in increased expression of HIF1A protein] | affects cotreatment|decreases reaction|increases expression | 16973622 |
| D003035 | Cobalt | bisphenol A inhibits the reaction [Cobalt results in decreased ubiquitination of and results in decreased degradation of HIF1A protein] | decreases degradation|decreases reaction|decreases ubiquitination | 15147973 |
| D003035 | Cobalt | Cobalt results in decreased ubiquitination of and results in decreased degradation of HIF1A protein | decreases degradation|decreases ubiquitination | 15147973 |
| D003035 | Cobalt | Cobalt results in increased stability of and results in increased expression of and results in increased activity of HIF1A protein | increases activity|increases expression|increases stability | 16386771 |
| D003035 | Cobalt | Cobalt results in increased stability of HIF1A protein | increases stability | 16877034 |
| D003035 | Cobalt | ferrous sulfate inhibits the reaction [Cobalt results in increased expression of HIF1A protein] | decreases reaction|increases expression | 16386771 |
| C018021 | cobaltous chloride | 103D5R inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein] | decreases reaction|increases expression | 15695405 |
| C018021 | cobaltous chloride | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased activity of HIF1A protein] | decreases reaction|increases activity | 17082639 |
| C018021 | cobaltous chloride | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein] | decreases reaction|increases expression | 17082639 |
| C018021 | cobaltous chloride | arsenic trioxide promotes the reaction [cobaltous chloride results in increased expression of HIF1A protein] | increases expression|increases reaction | 16330433 |
| C018021 | cobaltous chloride | Benzo(a)pyrene inhibits the reaction [cobaltous chloride promotes the reaction [HIF1A protein binds to ARNT protein]] | affects binding|decreases reaction|increases reaction | 20228066 |
| C018021 | cobaltous chloride | cobaltous chloride affects the localization of HIF1A protein | affects localization | 19196431 |
| C018021 | cobaltous chloride | cobaltous chloride promotes the reaction [HIF1A protein binds to ARNT protein] | affects binding|increases reaction | 20228066 |
| C018021 | cobaltous chloride | cobaltous chloride promotes the reaction [HIF1A protein binds to IL8 promoter] | affects binding|increases reaction | 17082639 |
| C018021 | cobaltous chloride | cobaltous chloride promotes the reaction [HIF1A protein results in increased expression of CTGF mRNA] | increases expression|increases reaction | 17034590 |
| C018021 | cobaltous chloride | cobaltous chloride promotes the reaction [HIF1A protein results in increased expression of CTGF protein] | increases expression|increases reaction | 17034590 |
| C018021 | cobaltous chloride | cobaltous chloride results in decreased expression of HIF1A protein | decreases expression | 16775626 |
| C018021 | cobaltous chloride | cobaltous chloride results in increased activity of HIF1A protein | increases activity | 16682453 17082639 |
| C018021 | cobaltous chloride | cobaltous chloride results in increased expression of HIF1A mRNA | increases expression | 16504308 16859120 |
| C018021 | cobaltous chloride | cobaltous chloride results in increased expression of HIF1A protein | increases expression | 16504308 16798617 17034590 16682453 16026872 16678800 16827160 16775626 17082639 15695405 16932349 |
| C018021 | cobaltous chloride | Cyclosporine inhibits the reaction [cobaltous chloride results in increased activity of HIF1A protein] | decreases reaction|increases activity | 16682453 |
| C018021 | cobaltous chloride | R 59949 inhibits the reaction [cobaltous chloride results in increased activity of HIF1A protein] | decreases reaction|increases activity | 17082639 |
| C018021 | cobaltous chloride | R 59949 inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein] | decreases reaction|increases expression | 17082639 |
| C018021 | cobaltous chloride | SB 203580 inhibits the reaction [cobaltous chloride results in increased activity of HIF1A protein] | decreases reaction|increases activity | 17082639 |
| C018021 | cobaltous chloride | SB 203580 inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein] | decreases reaction|increases expression | 17082639 |
| C018021 | cobaltous chloride | cobaltous chloride results in increased expression of HIF1A | increases expression | 16046841 |
| C018021 | cobaltous chloride | cobaltous chloride affects the localization of HIF1A protein | affects localization | 16772336 |
| C018021 | cobaltous chloride | cobaltous chloride promotes the reaction [[HIF1A protein binds to IL1B promoter] which results in increased expression of IL1B mRNA] | affects binding|increases expression|increases reaction | 16504308 |
| C018021 | cobaltous chloride | cobaltous chloride results in increased activity of HIF1A protein | increases activity | 16772336 |
| C018021 | cobaltous chloride | cobaltous chloride results in increased expression of HIF1A mRNA | increases expression | 16504308 |
| C018021 | cobaltous chloride | cobaltous chloride results in increased expression of HIF1A protein | increases expression | 16504308 16772336 16990490 |
| C018021 | cobaltous chloride | cobaltous chloride results in increased stability of HIF1A protein | increases stability | 17169330 |
| C018021 | cobaltous chloride | Echinomycin inhibits the reaction [cobaltous chloride results in increased activity of HIF1A protein] | decreases reaction|increases activity | 16772336 |
| C018021 | cobaltous chloride | HIF1A gene mutant form inhibits the reaction [cobaltous chloride affects the secretion of APLN protein] | affects secretion|decreases reaction | 17878221 |
| C018021 | cobaltous chloride | HIF1A protein results in increased susceptibility to cobaltous chloride | increases response to substance | 15375294 |
| C018021 | cobaltous chloride | Y 27632 promotes the reaction [cobaltous chloride affects the localization of HIF1A protein] | affects localization|increases reaction | 16772336 |
| C018021 | cobaltous chloride | cobaltous chloride results in increased expression of HIF1A protein | increases expression | 14729976 |
| D003300 | Copper | [Zinc co-treated with Copper] inhibits the reaction [Clioquinol results in increased expression of HIF1A protein] | affects cotreatment|decreases reaction|increases expression | 16973622 |
| C534043 | CR 3294 | 3-methyladenine inhibits the reaction [CR 3294 results in decreased expression of HIF1A protein] | decreases expression|decreases reaction | 18927491 |
| C534043 | CR 3294 | CR 3294 affects the localization of HIF1A protein | affects localization | 18927491 |
| C534043 | CR 3294 | CR 3294 results in decreased expression of HIF1A protein | decreases expression | 18927491 |
| C534043 | CR 3294 | wortmannin inhibits the reaction [CR 3294 results in decreased expression of HIF1A protein] | decreases expression|decreases reaction | 18927491 |
| D003474 | Curcumin | Curcumin results in decreased activity of HIF1A protein | decreases activity | 16880289 |
| D003474 | Curcumin | Curcumin results in decreased expression of and results in decreased activity of HIF1A protein | decreases activity|decreases expression | 18682687 |
| D003474 | Curcumin | Curcumin results in decreased expression of HIF1A mRNA | decreases expression | 18682687 |
| D003474 | Curcumin | VHL protein promotes the reaction [Curcumin results in decreased expression of HIF1A protein] | decreases expression|increases reaction | 18682687 |
| D003520 | Cyclophosphamide | Cyclophosphamide results in increased expression of HIF1A mRNA | increases expression | 15331540 |
| D016572 | Cyclosporine | Cyclosporine inhibits the reaction [cobaltous chloride results in increased activity of HIF1A protein] | decreases reaction|increases activity | 16682453 |
| D016572 | Cyclosporine | Cyclosporine inhibits the reaction [HIF1A protein results in decreased uptake of Cisplatin] | decreases reaction|decreases uptake | 17066447 |
| D016572 | Cyclosporine | Cyclosporine inhibits the reaction [HIF1A protein results in decreased uptake of Fluorouracil] | decreases reaction|decreases uptake | 17066447 |
| D016572 | Cyclosporine | Cyclosporine inhibits the reaction [IGF1 protein results in increased activity of HIF1A protein] | decreases reaction|increases activity | 16682453 |
| D016572 | Cyclosporine | Cyclosporine inhibits the reaction [IGF1 protein results in increased expression of HIF1A protein] | decreases reaction|increases expression | 16682453 |
| D016572 | Cyclosporine | Cyclosporine inhibits the reaction [Acetaminophen results in increased expression of HIF1A protein] | decreases reaction|increases expression | 16530163 |
| C014347 | decitabine | decitabine promotes the reaction [HIF1A protein binds to STC2 promoter] | affects binding|increases reaction | 18394600 |
| D003676 | Deferoxamine | arsenic trioxide promotes the reaction [Deferoxamine results in increased expression of HIF1A protein] | increases expression|increases reaction | 16330433 |
| D003676 | Deferoxamine | Deferoxamine results in increased expression of HIF1A protein | increases expression | 16775626 15840558 |
| D003676 | Deferoxamine | Deferoxamine results in increased stability of and results in increased expression of HIF1A protein | increases expression|increases stability | 17364964 |
| D003676 | Deferoxamine | Deferoxamine results in increased expression of HIF1A | increases expression | 16046841 |
| D003676 | Deferoxamine | Deferoxamine affects the localization of HIF1A protein | affects localization | 16772336 |
| D003676 | Deferoxamine | Deferoxamine results in increased expression of HIF1A protein | increases expression | 11514583 |
| C107676 | deguelin | benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [deguelin results in increased degradation of HIF1A protein] | decreases reaction|increases degradation | 17764071 |
| C107676 | deguelin | deguelin inhibits the reaction [IGF1 protein results in increased expression of HIF1A protein] | decreases reaction|increases expression | 17764071 |
| C107676 | deguelin | deguelin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein] | decreases reaction|increases expression | 17764071 19139008 18575727 |
| C107676 | deguelin | deguelin metabolite inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein] | decreases reaction|increases expression | 19139008 |
| C107676 | deguelin | deguelin results in increased degradation of HIF1A protein | increases degradation | 17764071 |
| C017185 | delphinidin | delphinidin inhibits the reaction [Hydrogen Peroxide results in increased expression of HIF1A protein] | decreases reaction|increases expression | 18603805 |
| D002945 | Cisplatin | Acetylcysteine inhibits the reaction [Cisplatin affects the localization of HIF1A protein] | affects localization|decreases reaction | 17066447 |
| D002945 | Cisplatin | Cisplatin affects the localization of HIF1A protein | affects localization | 17066447 |
| D002945 | Cisplatin | Cisplatin results in decreased activity of HIF1A protein | decreases activity | 17498666 |
| D002945 | Cisplatin | Cisplatin results in decreased expression of HIF1A protein | decreases expression | 17498666 |
| D002945 | Cisplatin | Cisplatin results in decreased susceptibility to HIF1A protein | decreases response to substance | 17066447 |
| D002945 | Cisplatin | Cisplatin results in increased degradation of HIF1A protein | increases degradation | 17498666 |
| D002945 | Cisplatin | Cyclosporine inhibits the reaction [HIF1A protein results in decreased uptake of Cisplatin] | decreases reaction|decreases uptake | 17066447 |
| D002945 | Cisplatin | HIF1A protein affects the susceptibility to Cisplatin | affects response to substance | 16532342 |
| D002945 | Cisplatin | HIF1A protein results in decreased uptake of Cisplatin | decreases uptake | 17066447 |
| D002945 | Cisplatin | TP53 protein affects the reaction [Cisplatin results in increased degradation of HIF1A protein] | affects reaction|increases degradation | 17498666 |
| D002945 | Cisplatin | Cisplatin results in increased expression of HIF1A mRNA | increases expression | 18656965 |
| D004008 | Diclofenac | Diclofenac results in decreased expression of HIF1A protein | decreases expression | 12912967 |
| D004052 | Diethylnitrosamine | [Diethylnitrosamine co-treated with N-nitrosomorpholine] results in increased expression of HIF1A mRNA | affects cotreatment|increases expression | 19383236 |
| D004052 | Diethylnitrosamine | [Diethylnitrosamine co-treated with N-nitrosomorpholine] results in increased expression of HIF1A protein | affects cotreatment|increases expression | 19383236 |
| C472511 | dimethylarsinous acid | dimethylarsinous acid results in decreased expression of HIF1A mRNA | decreases expression | 16507463 |
| D004229 | Dithiothreitol | Dithiothreitol inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HIF1A protein] | decreases reaction|increases expression | 17658243 |
| D004229 | Dithiothreitol | Dithiothreitol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of HIF1A protein alternative form] | decreases reaction|increases expression | 14695184 |
| D019297 | 2,4-Dinitrophenol | 2,4-Dinitrophenol results in increased expression of HIF1A mRNA | increases expression | 15740689 |
| C025034 | doxifluridine | HIF1A protein results in decreased susceptibility to doxifluridine | decreases response to substance | 16734730 |
| D004317 | Doxorubicin | Doxorubicin results in decreased activity of HIF1A protein | decreases activity | 17498666 |
| D004317 | Doxorubicin | Doxorubicin results in increased expression of HIF1A protein | increases expression | 17912235 |
| D004317 | Doxorubicin | HIF1A protein affects the susceptibility to Doxorubicin | affects response to substance | 16628086 16532342 |
| D004317 | Doxorubicin | NFKB1 protein affects the reaction [Doxorubicin results in increased expression of HIF1A protein] | affects reaction|increases expression | 17912235 |
| D004317 | Doxorubicin | Doxorubicin results in increased expression of HIF1A protein | increases expression | 17531194 |
| D004448 | Echinomycin | Echinomycin inhibits the reaction [cobaltous chloride results in increased activity of HIF1A protein] | decreases reaction|increases activity | 16772336 |
| D004610 | Ellagic Acid | Ellagic Acid results in decreased expression of HIF1A mRNA | decreases expression | 12002526 |
| C045651 | epigallocatechin gallate | epigallocatechin gallate results in decreased hydroxylation of and results in decreased degradation of HIF1A protein | decreases degradation|decreases hydroxylation | 16005427 |
| C045651 | epigallocatechin gallate | epigallocatechin gallate results in increased expression of and results in increased activity of HIF1A protein | increases activity|increases expression | 16005427 |
| D004958 | Estradiol | Estradiol inhibits the reaction [Progesterone results in increased expression of HIF1A mRNA] | decreases reaction|increases expression | 17275223 |
| D004958 | Estradiol | Estradiol promotes the reaction [[HIF1A protein binds to VEGFA promoter] which results in increased expression of VEGFA mRNA] | affects binding|increases expression|increases reaction | 15774498 |
| D004958 | Estradiol | Estradiol results in increased expression of HIF1A mRNA | increases expression | 15774498 |
| D004958 | Estradiol | Estradiol results in increased expression of HIF1A protein | increases expression | 15774498 |
| D005031 | Ethylenethiourea | Ethylenethiourea results in increased expression of HIF1A mRNA | increases expression | 18801409 |
| C010953 | exochelins | exochelins results in increased stability of and results in increased expression of HIF1A protein | increases expression|increases stability | 12460908 |
| D011345 | Fenofibrate | Fenofibrate results in increased expression of HIF1A mRNA | increases expression | 17118139 |
| C025314 | ferric citrate | ferric citrate inhibits the reaction [Quercetin results in increased expression of HIF1A mRNA] | decreases reaction|increases expression | 17364964 |
| C025314 | ferric citrate | ferric citrate inhibits the reaction [Quercetin results in increased expression of HIF1A protein] | decreases reaction|increases expression | 17364964 |
| C020326 | ferric nitrilotriacetate | ferric nitrilotriacetate inhibits the reaction [Asbestos, Crocidolite results in increased activity of HIF1A protein] | decreases reaction|increases activity | 18385176 |
| C020326 | ferric nitrilotriacetate | ferric nitrilotriacetate inhibits the reaction [Razoxane results in increased activity of HIF1A protein] | decreases reaction|increases activity | 18385176 |
| C024823 | ferric sulfate | ferric sulfate inhibits the reaction [Nickel results in increased stability of HIF1A protein] | decreases reaction|increases stability | 16877034 |
| C020748 | ferrous sulfate | ferrous sulfate inhibits the reaction [Chromium results in increased expression of HIF1A protein] | decreases reaction|increases expression | 16386771 |
| C020748 | ferrous sulfate | ferrous sulfate inhibits the reaction [Cobalt results in increased expression of HIF1A protein] | decreases reaction|increases expression | 16386771 |
| C020748 | ferrous sulfate | ferrous sulfate inhibits the reaction [galangin results in increased expression of HIF1A protein] | decreases reaction|increases expression | 17973296 |
| C020748 | ferrous sulfate | ferrous sulfate inhibits the reaction [Nickel results in increased expression of HIF1A protein] | decreases reaction|increases expression | 16386771 |
| C020748 | ferrous sulfate | ferrous sulfate inhibits the reaction [Quercetin results in increased expression of HIF1A protein] | decreases reaction|increases expression | 17973296 |
| C024352 | fludarabine | fludarabine results in decreased expression of HIF1A mRNA | decreases expression | 15213310 |
| C024352 | fludarabine | fludarabine results in decreased expression of HIF1A protein | decreases expression | 15213310 |
| D005472 | Fluorouracil | Acetylcysteine inhibits the reaction [Fluorouracil affects the localization of HIF1A protein] | affects localization|decreases reaction | 17066447 |
| D005472 | Fluorouracil | Cyclosporine inhibits the reaction [HIF1A protein results in decreased uptake of Fluorouracil] | decreases reaction|decreases uptake | 17066447 |
| D005472 | Fluorouracil | Fluorouracil affects the localization of HIF1A protein | affects localization | 17066447 |
| D005472 | Fluorouracil | Fluorouracil results in decreased susceptibility to HIF1A protein | decreases response to substance | 17066447 |
| D005472 | Fluorouracil | HIF1A protein affects the susceptibility to Fluorouracil | affects response to substance | 16628086 |
| D005472 | Fluorouracil | HIF1A protein results in decreased uptake of Fluorouracil | decreases uptake | 17066447 |
| C037032 | galangin | ferrous sulfate inhibits the reaction [galangin results in increased expression of HIF1A protein] | decreases reaction|increases expression | 17973296 |
| C037032 | galangin | galangin results in increased expression of HIF1A protein | increases expression | 17973296 |
| C037032 | galangin | Iron inhibits the reaction [galangin results in increased expression of HIF1A protein] | decreases reaction|increases expression | 17973296 |
| C001277 | geldanamycin | benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [geldanamycin results in increased degradation of HIF1A protein] | decreases reaction|increases degradation | 11980636 |
| C001277 | geldanamycin | geldanamycin results in decreased expression of HIF1A protein | decreases expression | 14726529 16432534 15319539 |
| C001277 | geldanamycin | geldanamycin results in increased degradation of HIF1A protein | increases degradation | 11980636 |
| C001277 | geldanamycin | lactacystin inhibits the reaction [geldanamycin results in increased degradation of HIF1A protein] | decreases reaction|increases degradation | 11980636 |
| C056507 | gemcitabine | HIF1A protein affects the susceptibility to gemcitabine | affects response to substance | 16628086 |
| D019833 | Genistein | Genistein inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein] | decreases reaction|increases expression | 11514583 |
| D019833 | Genistein | Genistein inhibits the reaction [TNF protein results in increased expression of HIF1A protein] | decreases reaction|increases expression | 11514583 |
| D005839 | Gentamicins | Gentamicins results in increased expression of HIF1A mRNA | increases expression | 18656965 |
| D005912 | Gliotoxin | Gliotoxin results in decreased expression of HIF1A mRNA | decreases expression | 20432243 |
| D005978 | Glutathione | Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HIF1A protein] | decreases reaction|increases expression | 17658243 |
| D005978 | Glutathione | Glutathione inhibits the reaction [Vanadates results in increased expression of HIF1A protein] | decreases reaction|increases expression | 16678800 |
| D006861 | Hydrogen Peroxide | delphinidin inhibits the reaction [Hydrogen Peroxide results in increased expression of HIF1A protein] | decreases reaction|increases expression | 18603805 |
| D006861 | Hydrogen Peroxide | Hydrogen Peroxide results in increased expression of HIF1A protein | increases expression | 15297373 18603805 |
| D006861 | Hydrogen Peroxide | Hydrogen Peroxide results in increased expression of HIF1A protein alternative form | increases expression | 14695184 |
| D007052 | Ibuprofen | Ibuprofen results in decreased expression of HIF1A protein | decreases expression | 12912967 |
| D007501 | Iron | Iron inhibits the reaction [galangin results in increased expression of HIF1A protein] | decreases reaction|increases expression | 17973296 |
| D007501 | Iron | Iron inhibits the reaction [Nickel results in increased stability of HIF1A protein] | decreases reaction|increases stability | 16877034 |
| D007501 | Iron | Iron inhibits the reaction [Quercetin results in increased expression of and affects the localization of HIF1A protein] | affects localization|decreases reaction|increases expression | 19729006 |
| D007501 | Iron | Iron inhibits the reaction [Quercetin results in increased expression of HIF1A protein] | decreases reaction|increases expression | 17973296 |
| D007501 | Iron | [Quercetin results in decreased abundance of Iron] which results in increased expression of HIF1A protein | decreases abundance|increases expression | 17364964 |
| D007501 | Iron | HIF1A gene mutant form results in decreased metabolism of Iron | decreases metabolic processing | 16787915 |
| D007501 | Iron | HIF1A protein results in increased susceptibility to Iron | increases response to substance | 16787915 |
| D007501 | Iron | Iron affects the reaction [HIF1A protein affects the susceptibility to Oxygen] | affects reaction|affects response to substance | 16899821 |
| D020910 | Ketorolac | Ketorolac results in decreased expression of HIF1A protein | decreases expression | 12912967 |
| C067713 | lactacystin | lactacystin inhibits the reaction [geldanamycin results in increased degradation of HIF1A protein] | decreases reaction|increases degradation | 11980636 |
| D008070 | Lipopolysaccharides | Lipopolysaccharides results in increased expression of HIF1A mRNA | increases expression | 19339665 |
| D008070 | Lipopolysaccharides | methyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of HIF1A mRNA] | decreases reaction|increases expression | 19339665 |
| C032881 | lysophosphatidic acid | lysophosphatidic acid results in increased expression of HIF1A protein | increases expression | 17919812 |
| C032881 | lysophosphatidic acid | [lysophosphatidic acid results in increased expression of HIF1A protein] which results in increased expression of VEGFA mRNA | increases expression | 17919812 |
| C032881 | lysophosphatidic acid | [lysophosphatidic acid results in increased expression of HIF1A protein] which results in increased expression of VEGFA protein | increases expression | 17919812 |
| C032881 | lysophosphatidic acid | resveratrol inhibits the reaction [lysophosphatidic acid results in increased expression of HIF1A protein] | decreases reaction|increases expression | 17919812 |
| C030290 | malonic acid | malonic acid affects the expression of HIF1A protein | affects expression | 16034640 |
| D008345 | Manganese | Manganese results in increased expression of and results in increased activity of HIF1A protein | increases activity|increases expression | 16386771 |
| D008345 | Manganese | Manganese results in increased expression of HIF1A mRNA | increases expression | 17175027 |
| C025340 | manganese chloride | manganese chloride results in increased expression of HIF1A mRNA | increases expression | 17175027 |
| C008435 | methyldithiocarbamate | methyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of HIF1A mRNA] | decreases reaction|increases expression | 19339665 |
| D015655 | 1-Methyl-4-phenylpyridinium | 1-Methyl-4-phenylpyridinium inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein] | decreases reaction|increases expression | 12062197 |
| D009151 | Mustard Gas | Mustard Gas results in increased expression of HIF1A mRNA | increases expression | 15674843 |
| D019810 | Sodium Azide | Sodium Azide affects the expression of HIF1A protein | affects expression | 16034640 |
| D009532 | Nickel | chromium hexavalent ion inhibits the reaction [Nickel results in increased stability of and results in increased expression of HIF1A protein] | decreases reaction|increases expression|increases stability | 19403854 |
| D009532 | Nickel | ferric sulfate inhibits the reaction [Nickel results in increased stability of HIF1A protein] | decreases reaction|increases stability | 16877034 |
| D009532 | Nickel | ferrous sulfate inhibits the reaction [Nickel results in increased expression of HIF1A protein] | decreases reaction|increases expression | 16386771 |
| D009532 | Nickel | HIF1A protein promotes the reaction [Nickel results in increased expression of SERPINE1 mRNA] | increases expression|increases reaction | 11504687 |
| D009532 | Nickel | Iron inhibits the reaction [Nickel results in increased stability of HIF1A protein] | decreases reaction|increases stability | 16877034 |
| D009532 | Nickel | [Nickel co-treated with Arsenic] results in increased expression of HIF1A protein | affects cotreatment|increases expression | 16386771 |
| D009532 | Nickel | [Nickel co-treated with Chromium] results in increased expression of HIF1A protein | affects cotreatment|increases expression | 16386771 |
| D009532 | Nickel | Nickel results in decreased expression of HIF1A mRNA | decreases expression | 11504687 |
| D009532 | Nickel | Nickel results in increased expression of and results in decreased degradation of HIF1A protein | decreases degradation|increases expression | 11504687 |
| D009532 | Nickel | Nickel results in increased stability of and results in increased expression of and results in increased activity of HIF1A protein | increases activity|increases expression|increases stability | 16386771 |
| D009532 | Nickel | Nickel results in increased stability of and results in increased expression of HIF1A protein | increases expression|increases stability | 19403854 |
| D009532 | Nickel | Nickel results in increased stability of HIF1A protein | increases stability | 16877034 |
| D009532 | Nickel | STAT1 protein affects the reaction [chromium hexavalent ion inhibits the reaction [Nickel results in increased stability of and results in increased expression of HIF1A protein]] | affects reaction|decreases reaction|increases expression|increases stability | 19403854 |
| D009532 | Nickel | U 0126 inhibits the reaction [Nickel results in increased expression of HIF1A protein] | decreases reaction|increases expression | 11504687 |
| C022838 | nickel chloride | nickel chloride inhibits the reaction [VHL protein binds to HIF1A protein] | affects binding|decreases reaction | 16649251 |
| C022838 | nickel chloride | nickel chloride results in increased stability of and results in increased expression of HIF1A protein | increases expression|increases stability | 16649251 |
| C022838 | nickel chloride | HIF1A protein affects the susceptibility to nickel chloride | affects response to substance | 12839937 |
| C029938 | nickel sulfate | nickel sulfate results in increased expression of HIF1A mRNA | increases expression | 16314067 |
| D009569 | Nitric Oxide | Nitric Oxide results in decreased stability of and results in decreased expression of HIF1A protein | decreases expression|decreases stability | 16310922 |
| D009582 | Nitrofurantoin | Nitrofurantoin results in increased activity of HIF1A protein | increases activity | 11841787 |
| D009599 | Nitroprusside | Nitroprusside results in decreased activity of HIF1A protein | decreases activity | 15465035 |
| D009599 | Nitroprusside | Nitroprusside results in decreased expression of HIF1A mRNA | decreases expression | 15465035 |
| D009599 | Nitroprusside | Nitroprusside results in decreased expression of HIF1A protein | decreases expression | 15465035 |
| C014707 | nitrosobenzylmethylamine | nitrosobenzylmethylamine results in increased expression of HIF1A mRNA | increases expression | 17616710 |
| D026422 | S-Nitrosoglutathione | S-Nitrosoglutathione results in increased expression of HIF1A mRNA | increases expression | 11514583 |
| D026422 | S-Nitrosoglutathione | 2,3-dimethoxy-1,4-naphthoquinone inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein] | decreases reaction|increases expression | 11514583 |
| D026422 | S-Nitrosoglutathione | AKT1 protein mutant form inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein] | decreases reaction|increases expression | 11514583 |
| D026422 | S-Nitrosoglutathione | Genistein inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein] | decreases reaction|increases expression | 11514583 |
| D026422 | S-Nitrosoglutathione | PIK3R1 protein mutant form inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein] | decreases reaction|increases expression | 11514583 |
| D026422 | S-Nitrosoglutathione | S-Nitrosoglutathione results in increased expression of HIF1A protein | increases expression | 11514583 |
| D026422 | S-Nitrosoglutathione | wortmannin inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein] | decreases reaction|increases expression | 11514583 |
| C002741 | N-nitrosomorpholine | [Diethylnitrosamine co-treated with N-nitrosomorpholine] results in increased expression of HIF1A mRNA | affects cotreatment|increases expression | 19383236 |
| C002741 | N-nitrosomorpholine | [Diethylnitrosamine co-treated with N-nitrosomorpholine] results in increased expression of HIF1A protein | affects cotreatment|increases expression | 19383236 |
| C044387 | N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine | N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [HIF1A protein binds to CREBBP protein] | affects binding|decreases reaction | 16579968 |
| C044387 | N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine | N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased ubiquitination of and results in increased expression of HIF1A protein | decreases ubiquitination|increases expression | 16579968 |
| C044387 | N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine | N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of HIF1A protein | increases expression | 16973622 |
| C044387 | N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine | N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased stability of and results in increased expression of HIF1A protein | increases expression|increases stability | 16579968 |
| C044387 | N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine | zinc chloride inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased stability of and results in increased expression of HIF1A protein] | decreases reaction|increases expression|increases stability | 16579968 |
| C044387 | N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine | Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased stability of and results in increased expression of HIF1A protein] | decreases reaction|increases expression|increases stability | 16579968 |
| D009665 | Noscapine | Noscapine results in increased degradation of and results in decreased expression of and results in decreased activity of HIF1A protein | decreases activity|decreases expression|increases degradation | 16596621 |
| D009840 | Oligomycins | Oligomycins results in decreased expression of HIF1A protein | decreases expression | 15840558 |
| C029341 | oxophenylarsine | oxophenylarsine results in increased expression of HIF1A protein | increases expression | 11514583 |
| D010100 | Oxygen | Oxygen deficiency results in increased expression of HIF1A mRNA | increases expression | 14991911 |
| D010100 | Oxygen | Tetrachlorodibenzodioxin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA] | decreases reaction|increases expression | 14991911 |
| D010100 | Oxygen | 1-Methyl-4-phenylpyridinium inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein] | decreases reaction|increases expression | 12062197 |
| D010100 | Oxygen | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA] | decreases reaction|increases expression | 11424089 18924134 |
| D010100 | Oxygen | 4'-O-methylalpinumisoflavone inhibits the reaction [Oxygen deficiency results in increased activity of HIF1A protein] | decreases reaction|increases activity | 19091749 |
| D010100 | Oxygen | 4'-O-methylalpinumisoflavone inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein] | decreases reaction|increases expression | 19091749 |
| D010100 | Oxygen | [AKT1 protein affects the reaction [Sulindac analog results in decreased expression of HIF1A protein]] which affects the susceptibility to Oxygen | affects reaction|affects response to substance|decreases expression | 18924134 |
| D010100 | Oxygen | alpinumisoflavone inhibits the reaction [Oxygen deficiency results in increased activity of HIF1A protein] | decreases reaction|increases activity | 19091749 |
| D010100 | Oxygen | deguelin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein] | decreases reaction|increases expression | 19139008 17764071 18575727 |
| D010100 | Oxygen | deguelin metabolite inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein] | decreases reaction|increases expression | 19139008 |
| D010100 | Oxygen | HIF1A affects the reaction [Oxygen deficiency affects the expression of BIRC5 mRNA] | affects expression|affects reaction | 16628086 |
| D010100 | Oxygen | HIF1A affects the reaction [Oxygen deficiency affects the expression of BIRC5 protein] | affects expression|affects reaction | 16628086 |
| D010100 | Oxygen | HIF1A protein affects the reaction [Oxygen deficiency results in increased expression of BACE1 mRNA] | affects reaction|increases expression | 19196431 |
| D010100 | Oxygen | HIF1A protein affects the reaction [Oxygen deficiency results in increased expression of BACE1 protein] | affects reaction|increases expression | 19196431 |
| D010100 | Oxygen | HIF1A protein promotes the reaction [Oxygen deficiency results in increased expression of STC2 mRNA] | increases expression|increases reaction | 18394600 |
| D010100 | Oxygen | Oxygen deficiency affects the localization of HIF1A protein | affects localization | 18924134 19196431 |
| D010100 | Oxygen | [Oxygen deficiency co-treated with arsenic trioxide] results in increased expression of HIF1A protein | affects cotreatment|increases expression | 19825857 |
| D010100 | Oxygen | [Oxygen deficiency co-treated with Tetrachlorodibenzodioxin] results in decreased stability of HIF1A protein | affects cotreatment|decreases stability | 18072750 |
| D010100 | Oxygen | Oxygen deficiency results in decreased degradation of HIF1A protein | decreases degradation | 12376345 |
| D010100 | Oxygen | Oxygen deficiency results in increased activity of HIF1A protein | increases activity | 19542490 |
| D010100 | Oxygen | Oxygen deficiency results in increased expression of and results in increased activity of HIF1A protein | increases activity|increases expression | 12054621 |
| D010100 | Oxygen | Oxygen deficiency results in increased expression of HIF1A mRNA | increases expression | 18924134 17889387 17671207 11424089 |
| D010100 | Oxygen | Oxygen deficiency results in increased expression of HIF1A protein | increases expression | 17599377 17671207 19825857 12062197 17889387 |
| D010100 | Oxygen | Oxygen deficiency results in increased stability of HIF1A protein | increases stability | 18072750 |
| D010100 | Oxygen | phenylmethylpyrazolone inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA] | decreases reaction|increases expression | 17889387 |
| D010100 | Oxygen | phenylmethylpyrazolone inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein] | decreases reaction|increases expression | 17889387 |
| D010100 | Oxygen | PRKCD protein promotes the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA] | increases expression|increases reaction | 11424089 |
| D010100 | Oxygen | Quercetin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA] | decreases reaction|increases expression | 11424089 |
| D010100 | Oxygen | Rotenone inhibits the reaction [Oxygen deficiency results in decreased degradation of HIF1A protein] | decreases degradation|decreases reaction | 12376345 |
| D010100 | Oxygen | Rotenone inhibits the reaction [Oxygen deficiency results in increased activity of HIF1A protein] | decreases reaction|increases activity | 19542490 19091749 |
| D010100 | Oxygen | Rotenone inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein] | decreases reaction|increases expression | 12062197 19091749 |
| D010100 | Oxygen | Tetradecanoylphorbol Acetate inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA] | decreases reaction|increases expression | 11424089 |
| D010100 | Oxygen | wortmannin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA] | decreases reaction|increases expression | 11424089 |
| D010100 | Oxygen | HIF1A gene mutant form inhibits the reaction [Oxygen deficiency results in increased secretion of APLN protein] | decreases reaction|increases secretion | 17878221 |
| D010100 | Oxygen | Oxygen deficiency affects the localization of HIF1A protein | affects localization | 17878221 |
| D010100 | Oxygen | 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein] | decreases reaction|increases expression | 15913578 |
| D010100 | Oxygen | AG 1879 inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein] | decreases reaction|increases expression | 15913578 |
| D010100 | Oxygen | Oxygen deficiency results in increased expression of HIF1A protein | increases expression | 15913578 |
| D010100 | Oxygen | Rotenone inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein] | decreases reaction|increases expression | 15913578 |
| D010100 | Oxygen | EGLN1 protein affects the reaction [HIF1A protein affects the susceptibility to Oxygen] | affects reaction|affects response to substance | 16899821 |
| D010100 | Oxygen | HIF1A protein affects the susceptibility to Oxygen | affects response to substance | 16899821 |
| D010100 | Oxygen | Iron affects the reaction [HIF1A protein affects the susceptibility to Oxygen] | affects reaction|affects response to substance | 16899821 |
| D010100 | Oxygen | Oxygen deficiency results in decreased ubiquitination of and results in decreased degradation of HIF1A protein | decreases degradation|decreases ubiquitination | 12054621 |
| C410127 | PCB 180 | [2,4,4'-trichlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,3',4,4',5-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of HIF1A mRNA | affects cotreatment|increases expression | 15808785 |
| C093973 | PD 98059 | PD 98059 inhibits the reaction [FGF2 protein results in increased activity of HIF1A protein] | decreases reaction|increases activity | 15631803 |
| C093973 | PD 98059 | PD 98059 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of HIF1A protein alternative form] | decreases reaction|increases expression | 14695184 |
| C093973 | PD 98059 | PD 98059 results in decreased expression of HIF1A mRNA | decreases expression | 15169887 |
| C093973 | PD 98059 | PD 98059 results in decreased expression of HIF1A protein | decreases expression | 16227395 |
| C494474 | perchlorate | perchlorate results in increased expression of HIF1A mRNA | increases expression | 18801409 |
| C005435 | phenylmethylpyrazolone | phenylmethylpyrazolone inhibits the reaction [HIF1A protein binds to VEGFA promoter] | affects binding|decreases reaction | 17889387 |
| C005435 | phenylmethylpyrazolone | [phenylmethylpyrazolone inhibits the reaction [HIF1A protein binds to VEGFA promoter]] which affects the expression of VEGFA mRNA | affects binding|affects expression|decreases reaction | 17889387 |
| C005435 | phenylmethylpyrazolone | phenylmethylpyrazolone inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA] | decreases reaction|increases expression | 17889387 |
| C005435 | phenylmethylpyrazolone | phenylmethylpyrazolone inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein] | decreases reaction|increases expression | 17889387 |
| C018637 | phorone | phorone results in increased activity of HIF1A protein | increases activity | 11841787 |
| C006253 | pirinixic acid | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of HIF1A mRNA | affects binding|increases activity|increases expression | 19710929 |
| C006253 | pirinixic acid | pirinixic acid results in increased expression of HIF1A mRNA | increases expression | 17426115 17118139 18445702 |
| D011374 | Progesterone | Estradiol inhibits the reaction [Progesterone results in increased expression of HIF1A mRNA] | decreases reaction|increases expression | 17275223 |
| D011374 | Progesterone | Progesterone results in increased expression of HIF1A mRNA | increases expression | 17275223 |
| D011374 | Progesterone | Progesterone results in increased expression of HIF1A | increases expression | 15845616 |
| D011435 | Propyl Gallate | Propyl Gallate results in decreased degradation of HIF1A protein | decreases degradation | 17056012 |
| D011435 | Propyl Gallate | Propyl Gallate results in increased expression of HIF1A protein | increases expression | 17056012 |
| D011794 | Quercetin | Ascorbic Acid inhibits the reaction [Quercetin results in increased expression of HIF1A protein] | decreases reaction|increases expression | 17364964 |
| D011794 | Quercetin | ferric citrate inhibits the reaction [Quercetin results in increased expression of HIF1A mRNA] | decreases reaction|increases expression | 17364964 |
| D011794 | Quercetin | ferric citrate inhibits the reaction [Quercetin results in increased expression of HIF1A protein] | decreases reaction|increases expression | 17364964 |
| D011794 | Quercetin | ferrous sulfate inhibits the reaction [Quercetin results in increased expression of HIF1A protein] | decreases reaction|increases expression | 17973296 |
| D011794 | Quercetin | Iron inhibits the reaction [Quercetin results in increased expression of and affects the localization of HIF1A protein] | affects localization|decreases reaction|increases expression | 19729006 |
| D011794 | Quercetin | Iron inhibits the reaction [Quercetin results in increased expression of HIF1A protein] | decreases reaction|increases expression | 17973296 |
| D011794 | Quercetin | Quercetin affects the localization of HIF1A protein | affects localization | 20804812 |
| D011794 | Quercetin | Quercetin inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [HIF1A protein binds to VHL protein]] | affects binding|decreases reaction|increases reaction | 17973296 |
| D011794 | Quercetin | Quercetin inhibits the reaction [HIF1A protein binds to VHL protein] | affects binding|decreases reaction | 17973296 |
| D011794 | Quercetin | Quercetin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA] | decreases reaction|increases expression | 11424089 |
| D011794 | Quercetin | [Quercetin results in decreased abundance of Iron] which results in increased expression of HIF1A protein | decreases abundance|increases expression | 17364964 |
| D011794 | Quercetin | Quercetin results in decreased activity of HIF1A protein | decreases activity | 20804812 |
| D011794 | Quercetin | Quercetin results in decreased ubiquitination of and results in increased expression of HIF1A protein | decreases ubiquitination|increases expression | 17973296 |
| D011794 | Quercetin | Quercetin results in increased expression of and affects the localization of HIF1A protein | affects localization|increases expression | 19729006 |
| D011794 | Quercetin | Quercetin results in increased expression of and results in decreased degradation of and results in increased activity of and results in increased localization of HIF1A protein | decreases degradation|increases activity|increases expression|increases localization | 12054621 |
| D011794 | Quercetin | Quercetin results in increased expression of HIF1A mRNA | increases expression | 17364964 |
| D011794 | Quercetin | Quercetin results in increased stability of and results in increased expression of HIF1A protein | increases expression|increases stability | 17364964 |
| C058544 | R 59949 | R 59949 inhibits the reaction [cobaltous chloride results in increased activity of HIF1A protein] | decreases reaction|increases activity | 17082639 |
| C058544 | R 59949 | R 59949 inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein] | decreases reaction|increases expression | 17082639 |
| D011929 | Razoxane | ferric nitrilotriacetate inhibits the reaction [Razoxane results in increased activity of HIF1A protein] | decreases reaction|increases activity | 18385176 |
| D011929 | Razoxane | Razoxane results in increased activity of HIF1A protein | increases activity | 18385176 |
| D017382 | Reactive Oxygen Species | Reactive Oxygen Species results in increased expression of HIF1A mRNA | increases expression | 16524376 |
| C059514 | resveratrol | resveratrol affects the expression of HIF1A protein | affects expression | 17473185 |
| C059514 | resveratrol | resveratrol inhibits the reaction [lysophosphatidic acid results in increased expression of HIF1A protein] | decreases reaction|increases expression | 17919812 |
| C059514 | resveratrol | resveratrol results in decreased expression of HIF1A mRNA | decreases expression | 12002526 |
| C059514 | resveratrol | resveratrol results in increased degradation of HIF1A protein | increases degradation | 17919812 |
| C059514 | resveratrol | resveratrol results in increased ubiquitination of and results in increased degradation of HIF1A protein | increases degradation|increases ubiquitination | 16227395 |
| D012402 | Rotenone | Rotenone inhibits the reaction [Oxygen deficiency results in decreased degradation of HIF1A protein] | decreases degradation|decreases reaction | 12376345 |
| D012402 | Rotenone | Rotenone inhibits the reaction [Oxygen deficiency results in increased activity of HIF1A protein] | decreases reaction|increases activity | 19091749 19542490 |
| D012402 | Rotenone | Rotenone inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein] | decreases reaction|increases expression | 12062197 19091749 |
| D012402 | Rotenone | Rotenone inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein] | decreases reaction|increases expression | 15913578 |
| D012402 | Rotenone | Rotenone affects the expression of HIF1A protein | affects expression | 16034640 |
| D012402 | Rotenone | Succinic Acid inhibits the reaction [Rotenone affects the expression of HIF1A protein] | affects expression|decreases reaction | 16034640 |
| C010327 | salinomycin | salinomycin results in decreased expression of HIF1A mRNA | decreases expression | 19682730 |
| C093642 | SB 203580 | SB 203580 inhibits the reaction [cobaltous chloride results in increased activity of HIF1A protein] | decreases reaction|increases activity | 17082639 |
| C093642 | SB 203580 | SB 203580 inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein] | decreases reaction|increases expression | 17082639 |
| C093642 | SB 203580 | SB 203580 inhibits the reaction [sodium arsenite results in increased expression of HIF1A protein] | decreases reaction|increases expression | 12482858 |
| C093642 | SB 203580 | SB 203580 results in decreased expression of HIF1A protein | decreases expression | 14695184 |
| D020123 | Sirolimus | Sirolimus inhibits the reaction [4-hydroxyestradiol-17 beta results in increased expression of HIF1A protein] | decreases reaction|increases expression | 15050414 |
| D020123 | Sirolimus | Sirolimus inhibits the reaction [IGF1 protein results in increased expression of HIF1A protein] | decreases reaction|increases expression | 16682453 |
| D020123 | Sirolimus | Sirolimus results in decreased expression of HIF1A protein | decreases expression | 15634505 |
| D020123 | Sirolimus | Sirolimus results in decreased expression of HIF1A mRNA | decreases expression | 19335982 |
| C009277 | sodium arsenate | sodium arsenate results in increased expression of HIF1A mRNA | increases expression | 16882884 |
| C017947 | sodium arsenite | 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [sodium arsenite results in increased expression of HIF1A protein] | decreases reaction|increases expression | 12482858 |
| C017947 | sodium arsenite | PRKAA1 protein affects the reaction [sodium arsenite results in increased expression of HIF1A protein] | affects reaction|increases expression | 16678800 |
| C017947 | sodium arsenite | SB 203580 inhibits the reaction [sodium arsenite results in increased expression of HIF1A protein] | decreases reaction|increases expression | 12482858 |
| C017947 | sodium arsenite | sodium arsenite results in increased expression of and affects the localization of HIF1A protein | affects localization|increases expression | 12482858 |
| C017947 | sodium arsenite | sodium arsenite results in increased expression of HIF1A mRNA | increases expression | 20339138 12760830 |
| C017947 | sodium arsenite | sodium arsenite results in increased expression of HIF1A protein | increases expression | 16678800 |
| C017947 | sodium arsenite | sodium arsenite results in increased expression of HIF1A protein | increases expression | 12482858 |
| C105686 | SU 5402 | SU 5402 inhibits the reaction [FGF2 protein results in increased expression of and results in increased activity of HIF1A protein] | decreases reaction|increases activity|increases expression | 15631803 |
| C116890 | SU 5416 | SU 5416 results in decreased expression of HIF1A protein | decreases expression | 15474452 |
| D019802 | Succinic Acid | Succinic Acid inhibits the reaction [Rotenone affects the expression of HIF1A protein] | affects expression|decreases reaction | 16034640 |
| D013467 | Sulindac | AKT1 protein affects the reaction [Sulindac analog results in decreased expression of HIF1A protein] | affects reaction|decreases expression | 18924134 |
| D013467 | Sulindac | [AKT1 protein affects the reaction [Sulindac analog results in decreased expression of HIF1A protein]] which affects the susceptibility to Oxygen | affects reaction|affects response to substance|decreases expression | 18924134 |
| D013467 | Sulindac | Sulindac analog results in decreased expression of HIF1A mRNA | decreases expression | 18924134 |
| D013467 | Sulindac | Sulindac analog results in decreased expression of HIF1A protein | decreases expression | 18924134 |
| D014284 | Triiodothyronine | Triiodothyronine results in increased expression of HIF1A mRNA | increases expression | 15507505 |
| D013629 | Tamoxifen | HIF1A protein results in decreased susceptibility to Tamoxifen | decreases response to substance | 19671742 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA] | decreases reaction|increases expression | 14991911 |
| D013749 | Tetrachlorodibenzodioxin | [Oxygen deficiency co-treated with Tetrachlorodibenzodioxin] results in decreased stability of HIF1A protein | affects cotreatment|decreases stability | 18072750 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin affects the expression of HIF1A mRNA | affects expression | 18343893 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin results in increased expression of HIF1A mRNA | increases expression | 15328365 19465110 |
| D013755 | Tetradecanoylphorbol Acetate | Dithiothreitol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of HIF1A protein alternative form] | decreases reaction|increases expression | 14695184 |
| D013755 | Tetradecanoylphorbol Acetate | PD 98059 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of HIF1A protein alternative form] | decreases reaction|increases expression | 14695184 |
| D013755 | Tetradecanoylphorbol Acetate | Tetradecanoylphorbol Acetate inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA] | decreases reaction|increases expression | 11424089 |
| D013755 | Tetradecanoylphorbol Acetate | Tetradecanoylphorbol Acetate results in increased expression of HIF1A mRNA alternative form | increases expression | 14695184 |
| D013755 | Tetradecanoylphorbol Acetate | Tetradecanoylphorbol Acetate results in increased expression of HIF1A protein alternative form | increases expression | 14695184 |
| D019772 | Topotecan | Topotecan results in decreased expression of HIF1A protein | decreases expression | 15930297 |
| D014212 | Tretinoin | HIF1A protein affects the susceptibility to Tretinoin | affects response to substance | 19285840 |
| D014212 | Tretinoin | Tretinoin results in increased expression of HIF1A protein | increases expression | 19285840 |
| D014268 | Trifluoperazine | Trifluoperazine results in decreased expression of HIF1A protein | decreases expression | 18822394 |
| C113580 | U 0126 | U 0126 inhibits the reaction [Nickel results in increased expression of HIF1A protein] | decreases reaction|increases expression | 11504687 |
| D014638 | Vanadates | CAT protein inhibits the reaction [Vanadates results in increased expression of HIF1A protein] | decreases reaction|increases expression | 16678800 |
| D014638 | Vanadates | Glutathione inhibits the reaction [Vanadates results in increased expression of HIF1A protein] | decreases reaction|increases expression | 16678800 |
| D014638 | Vanadates | PRKAA1 protein affects the reaction [Vanadates results in increased expression of HIF1A protein] | affects reaction|increases expression | 16678800 |
| D014638 | Vanadates | Vanadates results in increased expression of and results in increased activity of HIF1A protein | increases activity|increases expression | 15297373 |
| D014638 | Vanadates | Vanadates results in increased expression of HIF1A protein | increases expression | 16678800 |
| D014639 | Vanadium | Vanadium results in increased expression of and results in increased activity of HIF1A protein | increases activity|increases expression | 16386771 |
| D002762 | Cholecalciferol | Cholecalciferol results in increased expression of HIF1A mRNA | increases expression | 17170073 16508948 |
| C009687 | wortmannin | wortmannin inhibits the reaction [4-hydroxyestradiol-17 beta results in increased expression of HIF1A protein] | decreases reaction|increases expression | 15050414 |
| C009687 | wortmannin | wortmannin inhibits the reaction [CR 3294 results in decreased expression of HIF1A protein] | decreases expression|decreases reaction | 18927491 |
| C009687 | wortmannin | wortmannin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA] | decreases reaction|increases expression | 11424089 |
| C009687 | wortmannin | wortmannin results in decreased expression of HIF1A protein | decreases expression | 14726529 |
| C009687 | wortmannin | wortmannin inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein] | decreases reaction|increases expression | 11514583 |
| C009687 | wortmannin | wortmannin inhibits the reaction [TNF protein results in increased expression of HIF1A protein] | decreases reaction|increases expression | 11514583 |
| C108830 | Y 27632 | Y 27632 promotes the reaction [cobaltous chloride affects the localization of HIF1A protein] | affects localization|increases reaction | 16772336 |
| D015032 | Zinc | [Zinc co-treated with Copper] inhibits the reaction [Clioquinol results in increased expression of HIF1A protein] | affects cotreatment|decreases reaction|increases expression | 16973622 |
| D015032 | Zinc | Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased stability of and results in increased expression of HIF1A protein] | decreases reaction|increases expression|increases stability | 16579968 |
| D015032 | Zinc | Zinc results in increased expression of HIF1A protein | increases expression | 16330433 |
| C016837 | zinc chloride | zinc chloride inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased stability of and results in increased expression of HIF1A protein] | decreases reaction|increases expression|increases stability | 16579968 |
| C017803 | zinc protoporphyrin | zinc protoporphyrin inhibits the reaction [HIF1A protein results in increased activity of SOD2 protein] | decreases reaction|increases activity | 17066447 |
| Disease ID | Disease Name | Direct Evidence | Inference Chemical Name | Inference Score | Publication |
|---|---|---|---|---|---|
| MESH:D000008 | Abdominal Neoplasms | Sulindac | 9.38 | 14745880 | |
| MESH:D000008 | Abdominal Neoplasms | Tamoxifen | 9.38 | 14745880 | |
| MESH:D015746 | Abdominal Pain | SU 5416 | 6.11 | 12673719 | |
| MESH:D000014 | Abnormalities, Drug-Induced | Tetrachlorodibenzodioxin | 1.82 | 15322242 14514962 11752688 | |
| MESH:D000138 | Acidosis | Ammonium Chloride | 2.49 | 18287403 | |
| MESH:D000168 | Acrocephalosyndactylia | U 0126 | 4.42 | 17694057 | |
| MESH:D000169 | Acrodermatitis | Zinc | 4.32 | 16889938 17190629 17202136 | |
| MESH:D058186 | Acute Kidney Injury | Cisplatin | 20.80 | 12690470 17670903 15814532 | |
| MESH:D058186 | Acute Kidney Injury | Diclofenac | 20.80 | 7897758 | |
| MESH:D058186 | Acute Kidney Injury | Gentamicins | 20.80 | 11274264 | |
| MESH:D058186 | Acute Kidney Injury | Ibuprofen | 20.80 | 6375363 | |
| MESH:D058186 | Acute Kidney Injury | resveratrol | 20.80 | 16538975 | |
| MESH:D058186 | Acute Kidney Injury | Sulindac | 20.80 | 7897758 | |
| MESH:D055371 | Acute Lung Injury | Lipopolysaccharides | 17.97 | 18653653 11850527 | |
| MESH:D055371 | Acute Lung Injury | Nickel | 17.97 | 16166738 | |
| MESH:D055371 | Acute Lung Injury | nickel sulfate | 17.97 | 19131640 16100012 11954676 12718980 | |
| MESH:D055371 | Acute Lung Injury | Oxygen | 17.97 | 16759491 | |
| MESH:D055371 | Acute Lung Injury | pirinixic acid | 17.97 | 18653653 | |
| MESH:D000230 | Adenocarcinoma | arsenic trioxide | 22.67 | 19825857 11798837 | |
| MESH:D000230 | Adenocarcinoma | Benzo(a)pyrene | 22.67 | 20127859 20464547 | |
| MESH:D000230 | Adenocarcinoma | Cisplatin | 22.67 | 17638652 11798837 | |
| MESH:D000230 | Adenocarcinoma | Doxorubicin | 22.67 | 17418594 | |
| MESH:D000230 | Adenocarcinoma | Estradiol | 22.67 | 11473722 | |
| MESH:D000230 | Adenocarcinoma | Ethylenethiourea | 22.67 | 7955072 | |
| MESH:D000230 | Adenocarcinoma | Fluorouracil | 22.67 | 17638652 | |
| MESH:D000230 | Adenocarcinoma | Genistein | 22.67 | 11473722 | |
| MESH:D000230 | Adenocarcinoma | Ibuprofen | 22.67 | 10697514 | |
| MESH:D000230 | Adenocarcinoma | Sulindac | 22.67 | 11910360 | |
| MESH:D000236 | Adenoma | Benzo(a)pyrene | 9.83 | 6695378 | |
| MESH:D000236 | Adenoma | Diethylnitrosamine | 9.83 | 6695378 10737359 | |
| MESH:D000236 | Adenoma | resveratrol | 9.83 | 15688382 | |
| MESH:D000236 | Adenoma | Sulindac | 9.83 | 10223192 | |
| MESH:D018248 | Adenoma, Liver Cell | 3,4,5,3',4'-pentachlorobiphenyl | 16.20 | 16628245 | |
| MESH:D018248 | Adenoma, Liver Cell | Diethylnitrosamine | 16.20 | 16434500 19052882 18056438 17620307 17162532 19061943 | |
| MESH:D018248 | Adenoma, Liver Cell | pirinixic acid | 16.20 | 16434500 | |
| MESH:D018248 | Adenoma, Liver Cell | Tetrachlorodibenzodioxin | 16.20 | 16835633 | |
| MESH:D011125 | Adenomatous Polyposis Coli | Sulindac | 3.63 | 15623613 11535846 12394442 11874996 16460482 19003578 17611924 | |
| MESH:D000310 | Adrenal Gland Neoplasms | sodium arsenite | 3.60 | 15276417 | |
| MESH:D018246 | Adrenocortical Adenoma | Arsenic | 10.15 | 17306315 | |
| MESH:D018246 | Adrenocortical Adenoma | sodium arsenite | 10.15 | 17306315 16712894 | |
| MESH:D000419 | Albuminuria | Doxorubicin | 3.51 | 21441931 | |
| MESH:D019973 | Alcohol-Related Disorders | Curcumin | 3.98 | 17887948 | |
| MESH:D000505 | Alopecia | Tretinoin | 2.70 | 15955085 | |
| MESH:D019896 | alpha 1-Antitrypsin Deficiency | Iron | 4.57 | 16640825 | |
| MESH:D000544 | Alzheimer Disease | Aluminum | 18.18 | 10721010 17662457 | |
| MESH:D000544 | Alzheimer Disease | Clioquinol | 18.18 | 16648635 17308104 | |
| MESH:D000544 | Alzheimer Disease | Copper | 18.18 | 16962711 17119284 16866297 16325427 16886094 16410023 | |
| MESH:D000544 | Alzheimer Disease | Curcumin | 18.18 | 15590663 | |
| MESH:D000544 | Alzheimer Disease | Ibuprofen | 18.18 | 18351690 | |
| MESH:D000544 | Alzheimer Disease | Iron | 18.18 | 16640825 16563566 | |
| MESH:D000544 | Alzheimer Disease | Nitric Oxide | 18.18 | 17556102 | |
| MESH:D000544 | Alzheimer Disease | resveratrol | 18.18 | 16162502 16183991 | |
| MESH:D000544 | Alzheimer Disease | Zinc | 18.18 | 16410023 16325427 16580781 17119284 | |
| MESH:D000690 | Amyotrophic Lateral Sclerosis | Copper | 3.52 | 10694572 | |
| MESH:D000707 | Anaphylaxis | Ibuprofen | 4.19 | 9532969 | |
| MESH:D000740 | Anemia | Fluorouracil | 9.32 | 16511603 17963324 15504547 | |
| MESH:D000740 | Anemia | Iron | 9.32 | 16566752 16434484 | |
| MESH:D000740 | Anemia | Tetrachlorodibenzodioxin | 9.32 | 11748828 | |
| MESH:D000743 | Anemia, Hemolytic | Quercetin | 3.25 | 17084956 | |
| MESH:D018798 | Anemia, Iron-Deficiency | Copper | 7.24 | 16614410 | |
| MESH:D018798 | Anemia, Iron-Deficiency | Iron | 7.24 | 16569441 17375513 17162259 17147795 17163184 | |
| MESH:D000755 | Anemia, Sickle Cell | Zinc | 3.86 | 16916123 | |
| MESH:D000756 | Anemia, Sideroblastic | Iron | 12.17 | 16910769 | |
| MESH:D000756 | Anemia, Sideroblastic | Manganese | 12.17 | 16910769 | |
| MESH:D000756 | Anemia, Sideroblastic | manganese chloride | 12.17 | 16910769 | |
| MESH:D000799 | Angioedema | Acetaminophen | 2.75 | 10982225 | |
| MESH:D000860 | Anoxia | Oxygen | 3.98 | 20872349 | |
| MESH:D017544 | Aortic Aneurysm, Abdominal | Benzo(a)pyrene | 3.01 | 19183758 | |
| MESH:D001145 | Arrhythmias, Cardiac | Iron | 3.42 | 16604332 | |
| MESH:D020261 | Arsenic Poisoning | Arsenic | 2.43 | 12569548 18414634 16835338 16251483 | |
| MESH:D001161 | Arteriosclerosis | Cyclophosphamide | 3.55 | 15014928 | |
| MESH:D001169 | Arthritis, Experimental | resveratrol | 4.91 | 17115116 | |
| MESH:D001169 | Arthritis, Experimental | Tretinoin | 4.91 | 16412693 | |
| MESH:D001172 | Arthritis, Rheumatoid | Curcumin | 5.10 | 16807698 | |
| MESH:D001172 | Arthritis, Rheumatoid | phenylmethylpyrazolone | 5.10 | 16390820 | |
| MESH:D001172 | Arthritis, Rheumatoid | Tretinoin | 5.10 | 16292516 | |
| MESH:D001249 | Asthma | epigallocatechin gallate | 7.12 | 16516891 | |
| MESH:D001249 | Asthma | Mustard Gas | 7.12 | 10378619 | |
| MESH:D001249 | Asthma | Tretinoin | 7.12 | 16456186 | |
| MESH:D001249 | Asthma | Zinc | 7.12 | 17085522 | |
| MESH:D001260 | Ataxia Telangiectasia | Iron | 9.53 | 15336622 | |
| MESH:D001260 | Ataxia Telangiectasia | Quercetin | 9.53 | 15336622 | |
| MESH:D050197 | Atherosclerosis | Arsenic | 12.52 | 12928151 19371607 | |
| MESH:D050197 | Atherosclerosis | Curcumin | 12.52 | 18704882 | |
| MESH:D050197 | Atherosclerosis | Iron | 12.52 | 16632123 16640825 | |
| MESH:D050197 | Atherosclerosis | Oxygen | 12.52 | 16391483 | |
| MESH:D050197 | Atherosclerosis | resveratrol | 12.52 | 16873680 17967414 | |
| MESH:D001321 | Autistic Disorder | Acetaminophen | 2.12 | 18445737 | |
| MESH:D001321 | Autistic Disorder | Glutathione | 2.12 | 19056591 16917939 18929414 19267885 | |
| MESH:D001321 | Autistic Disorder | Iron | 2.12 | 17352947 | |
| MESH:D001321 | Autistic Disorder | Sirolimus | 2.12 | 21115397 | |
| MESH:D001327 | Autoimmune Diseases | Cholecalciferol | 17.24 | 16142846 | |
| MESH:D001327 | Autoimmune Diseases | Curcumin | 17.24 | 19761891 | |
| MESH:D001327 | Autoimmune Diseases | epigallocatechin gallate | 17.24 | 19761891 | |
| MESH:D001327 | Autoimmune Diseases | Quercetin | 17.24 | 19761891 | |
| MESH:D001424 | Bacterial Infections | Iron | 4.12 | 16640825 | |
| MESH:D001471 | Barrett Esophagus | Tretinoin | 3.36 | 16935849 | |
| MESH:D001768 | Blister | Mustard Gas | 4.08 | 19167455 | |
| MESH:D001778 | Blood Coagulation Disorders | arsenic trioxide | 18.48 | 16206674 | |
| MESH:D001778 | Blood Coagulation Disorders | ferrous sulfate | 18.48 | 6421970 | |
| MESH:D001778 | Blood Coagulation Disorders | pirinixic acid | 18.48 | 19483382 | |
| MESH:D001778 | Blood Coagulation Disorders | Tetrachlorodibenzodioxin | 18.48 | 12125929 | |
| MESH:D001778 | Blood Coagulation Disorders | Tretinoin | 18.48 | 16206674 16197459 | |
| MESH:D001836 | Body Weight Changes | Tetrachlorodibenzodioxin | 2.70 | 15340226 | |
| MESH:D001848 | Bone Diseases, Developmental | Tetrachlorodibenzodioxin | 1.96 | 15746008 | |
| MESH:D019046 | Bone Marrow Neoplasms | Cisplatin | 8.43 | 14601052 | |
| MESH:D019046 | Bone Marrow Neoplasms | Doxorubicin | 8.43 | 14601052 | |
| MESH:D001862 | Bone Resorption | bisphenol A | 2.88 | 11985600 | |
| MESH:D001913 | Bowen's Disease | Sulindac | 4.26 | 11207687 | |
| MESH:D020201 | Brain Hemorrhage, Traumatic | Progesterone | 4.24 | 17868700 | |
| MESH:D001930 | Brain Injuries | Nitroprusside | 12.55 | 14637104 | |
| MESH:D001930 | Brain Injuries | Progesterone | 12.55 | 15665606 15380490 15845082 | |
| MESH:D001930 | Brain Injuries | Zinc | 12.55 | 17109824 | |
| MESH:D002545 | Brain Ischemia | Curcumin | 11.00 | 16770732 | |
| MESH:D002545 | Brain Ischemia | Ibuprofen | 11.00 | 15837124 | |
| MESH:D002545 | Brain Ischemia | resveratrol | 11.00 | 17600658 | |
| MESH:D001932 | Brain Neoplasms | Copper | 9.25 | 17079463 | |
| MESH:D001932 | Brain Neoplasms | Curcumin | 9.25 | 17596214 | |
| MESH:D001932 | Brain Neoplasms | Doxorubicin | 9.25 | 17150277 | |
| MESH:D001943 | Breast Neoplasms | 4-hydroxyestradiol-17 beta | 40.87 | 16675129 | |
| MESH:D001943 | Breast Neoplasms | Apigenin | 40.87 | 17132221 16541309 | |
| MESH:D001943 | Breast Neoplasms | Ascorbic Acid | 40.87 | 16443354 | |
| MESH:D001943 | Breast Neoplasms | Benzo(a)pyrene | 40.87 | 17474063 20146248 | |
| MESH:D001943 | Breast Neoplasms | bisphenol A | 40.87 | 17123778 | |
| MESH:D001943 | Breast Neoplasms | capecitabine | 40.87 | 12972520 18473752 | |
| MESH:D001943 | Breast Neoplasms | Chromium | 40.87 | 15986119 | |
| MESH:D001943 | Breast Neoplasms | Cisplatin | 40.87 | 19526202 18382427 | |
| MESH:D001943 | Breast Neoplasms | Cobalt | 40.87 | 15986119 | |
| MESH:D001943 | Breast Neoplasms | Copper | 40.87 | 17079463 15986119 | |
| MESH:D001943 | Breast Neoplasms | Curcumin | 40.87 | 19250217 16243823 18593918 18462866 | |
| MESH:D001943 | Breast Neoplasms | Cyclophosphamide | 40.87 | 11325840 16978400 18234424 17020986 17388661 15136595 18323546 12006526 15093573 | |
| MESH:D001943 | Breast Neoplasms | decitabine | 40.87 | 18320071 19208741 | |
| MESH:D001943 | Breast Neoplasms | Deferoxamine | 40.87 | 15993339 | |
| MESH:D001943 | Breast Neoplasms | deguelin | 40.87 | 18593368 17035597 | |
| MESH:D001943 | Breast Neoplasms | Diethylnitrosamine | 40.87 | 17474063 | |
| MESH:D001943 | Breast Neoplasms | Doxorubicin | 40.87 | 18628466 16322301 16264153 17426702 16826403 11325840 15939500 15692762 16096432 15567936 18695136 18382427 19526202 15993339 15136595 15668708 17983394 15634643 17369602 16935488 15994142 16595493 16115903 18234424 | |
| MESH:D001943 | Breast Neoplasms | Estradiol | 40.87 | 19861407 16675129 12948864 18497071 17289903 17261762 14630087 17018787 | |
| MESH:D001943 | Breast Neoplasms | Fluorouracil | 40.87 | 15136595 16595493 19217205 16557594 18357371 18608205 16110121 | |
| MESH:D001943 | Breast Neoplasms | gemcitabine | 40.87 | 17039268 18382427 | |
| MESH:D001943 | Breast Neoplasms | Genistein | 40.87 | 16873071 16541309 17200150 | |
| MESH:D001943 | Breast Neoplasms | Nickel | 40.87 | 15986119 | |
| MESH:D001943 | Breast Neoplasms | Nitric Oxide | 40.87 | 15631943 | |
| MESH:D001943 | Breast Neoplasms | Oxygen | 40.87 | 17263869 | |
| MESH:D001943 | Breast Neoplasms | Progesterone | 40.87 | 16175315 15562024 17614352 | |
| MESH:D001943 | Breast Neoplasms | Quercetin | 40.87 | 18628248 | |
| MESH:D001943 | Breast Neoplasms | resveratrol | 40.87 | 17534123 17651959 16393696 | |
| MESH:D001943 | Breast Neoplasms | salinomycin | 40.87 | 19682730 | |
| MESH:D001943 | Breast Neoplasms | Sulindac | 40.87 | 16642371 | |
| MESH:D001943 | Breast Neoplasms | Tamoxifen | 40.87 | 20005174 19011961 19066611 19155303 21152245 18351453 16873071 18815881 18997820 17893378 20065188 18855134 17440819 19189212 18821012 18629630 18984771 19221464 17261762 15565566 21138602 19189210 19244106 19142967 17242785 11161223 19487384 20135344 17049068 16202921 19200415 20544844 19288272 19115204 18425577 19410462 19103187 19084267 16273361 15668708 19059307 20390343 20859285 16818667 19289846 | |
| MESH:D001943 | Breast Neoplasms | Tetrachlorodibenzodioxin | 40.87 | 20435547 | |
| MESH:D001943 | Breast Neoplasms | Tretinoin | 40.87 | 16166294 16443354 16873071 | |
| MESH:D001943 | Breast Neoplasms | Vanadium | 40.87 | 15565634 | |
| MESH:D001989 | Bronchiolitis Obliterans | Mustard Gas | 4.08 | 15286001 | |
| MESH:D029481 | Bronchitis, Chronic | Mustard Gas | 3.88 | 17687719 10378619 | |
| MESH:D001997 | Bronchopulmonary Dysplasia | Tretinoin | 3.51 | 16813970 | |
| MESH:D002051 | Burkitt Lymphoma | arsenic trioxide | 3.31 | 11589617 | |
| MESH:D002100 | Cachexia | Ibuprofen | 4.39 | 15141370 | |
| MESH:D002105 | Cadmium Poisoning | Quercetin | 4.44 | 16962696 | |
| MESH:D002177 | Candidiasis | ciclopirox | 6.01 | 16640825 | |
| MESH:D002181 | Candidiasis, Vulvovaginal | Estradiol | 3.38 | 16111702 | |
| MESH:D002252 | Carbon Tetrachloride Poisoning | Carbon Tetrachloride | 2.73 | 18705752 15673190 16011737 16227642 3786805 15721981 16097048 15700767 10355542 16192424 16124888 16050911 | |
| MESH:D002276 | Carcinoid Tumor | Doxorubicin | 8.72 | 16051944 | |
| MESH:D002276 | Carcinoid Tumor | Fluorouracil | 8.72 | 16051944 | |
| MESH:D002277 | Carcinoma | Curcumin | 8.72 | 18593918 | |
| MESH:D002277 | Carcinoma | Fluorouracil | 8.72 | 17121937 | |
| MESH:D002277 | Carcinoma | Tetrachlorodibenzodioxin | 8.72 | 16835633 | |
| MESH:D002280 | Carcinoma, Basal Cell | Arsenic | 2.86 | 17687452 15504454 | |
| MESH:D018270 | Carcinoma, Ductal, Breast | Tamoxifen | 3.44 | 19066611 | |
| MESH:D018236 | Carcinoma, Embryonal | Tretinoin | 4.06 | 16168501 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Acetaminophen | 46.01 | 3084413 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Aflatoxin B1 | 46.01 | 21507988 12907637 12619106 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Arsenic | 46.01 | 17306315 16507464 | |
| MESH:D006528 | Carcinoma, Hepatocellular | arsenic trioxide | 46.01 | 15073043 16217749 11135700 15553829 14691202 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Carbon Tetrachloride | 46.01 | 18788625 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Cisplatin | 46.01 | 17982673 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Cyclophosphamide | 46.01 | 19701751 | |
| MESH:D006528 | Carcinoma, Hepatocellular | deguelin | 46.01 | 18575727 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Diethylnitrosamine | 46.01 | 18393292 20101231 3084413 20524982 16935385 16779866 17055752 20935162 17173139 16830150 17761372 17162532 18506893 20007298 18210153 17428255 19208518 20512989 17138121 16540662 16569478 16807293 19539802 19107877 16288022 18978308 19052882 18494052 21159647 19383236 18788625 11831363 16502159 18785209 19701751 20084675 16328049 19335982 19171122 19394651 10672840 3581430 19919837 16698587 16878318 19822196 20214788 19519916 20514400 18691550 20727157 20432363 17978847 18971187 10737359 19418558 18056438 16681979 18665156 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Doxorubicin | 46.01 | 18059187 17876044 16234567 16023760 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Estradiol | 46.01 | 16924424 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Fluorouracil | 46.01 | 17088986 17045692 16799960 16332177 17971768 18930000 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Genistein | 46.01 | 16924424 | |
| MESH:D006528 | Carcinoma, Hepatocellular | N-nitrosomorpholine | 46.01 | 10629087 15010824 9466558 16935385 1917145 15543204 8364915 9029167 19335982 1701930 19383236 1967229 2885971 11509945 9311599 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Quercetin | 46.01 | 12508355 19519916 | |
| MESH:D006528 | Carcinoma, Hepatocellular | resveratrol | 46.01 | 16227395 19321006 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Sirolimus | 46.01 | 19335982 | |
| MESH:D006528 | Carcinoma, Hepatocellular | sodium arsenite | 46.01 | 17306315 16507464 15276417 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Tamoxifen | 46.01 | 16924424 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Tretinoin | 46.01 | 1917145 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Vanadium | 46.01 | 16830150 16878318 | |
| MESH:D002278 | Carcinoma in Situ | bisphenol A | 3.90 | 17123778 | |
| MESH:D018827 | Carcinoma, Lewis Lung | Cyclophosphamide | 7.92 | 16152834 | |
| MESH:D018827 | Carcinoma, Lewis Lung | resveratrol | 7.92 | 16675471 | |
| MESH:D002289 | Carcinoma, Non-Small-Cell Lung | bortezomib | 5.97 | 16052434 | |
| MESH:D002289 | Carcinoma, Non-Small-Cell Lung | Cisplatin | 5.97 | 12023789 16685392 | |
| MESH:D002289 | Carcinoma, Non-Small-Cell Lung | Curcumin | 5.97 | 18414057 | |
| MESH:D021441 | Carcinoma, Pancreatic Ductal | Quercetin | 3.89 | 17234771 | |
| MESH:D002291 | Carcinoma, Papillary | arsenic trioxide | 3.77 | 19014326 | |
| MESH:D002292 | Carcinoma, Renal Cell | Cyclophosphamide | 13.20 | 16201981 | |
| MESH:D002292 | Carcinoma, Renal Cell | Doxorubicin | 13.20 | 16201981 1485588 | |
| MESH:D002292 | Carcinoma, Renal Cell | ferric nitrilotriacetate | 13.20 | 8340253 | |
| MESH:D002292 | Carcinoma, Renal Cell | Fluorouracil | 13.20 | 18695887 | |
| MESH:D002292 | Carcinoma, Renal Cell | N-nitrosomorpholine | 13.20 | 7921415 1429202 | |
| MESH:D018288 | Carcinoma, Small Cell | arsenic trioxide | 3.14 | 12490120 | |
| MESH:D002294 | Carcinoma, Squamous Cell | marker/mechanism | 17201171 | ||
| MESH:D002294 | Carcinoma, Squamous Cell | Acetylcysteine | 40.75 | 17015178 | |
| MESH:D002294 | Carcinoma, Squamous Cell | Arsenic | 40.75 | 17687452 15504454 18922899 | |
| MESH:D002294 | Carcinoma, Squamous Cell | Benzo(a)pyrene | 40.75 | 20419170 | |
| MESH:D002294 | Carcinoma, Squamous Cell | Cisplatin | 40.75 | 17066447 18337622 6189445 | |
| MESH:D002294 | Carcinoma, Squamous Cell | Curcumin | 40.75 | 18462866 | |
| MESH:D002294 | Carcinoma, Squamous Cell | decitabine | 40.75 | 19215824 | |
| MESH:D002294 | Carcinoma, Squamous Cell | Doxorubicin | 40.75 | 6189445 | |
| MESH:D002294 | Carcinoma, Squamous Cell | Fluorouracil | 40.75 | 16757204 17066447 18986760 16280240 | |
| MESH:D002294 | Carcinoma, Squamous Cell | Glutathione | 40.75 | 17015178 | |
| MESH:D002294 | Carcinoma, Squamous Cell | resveratrol | 40.75 | 16227395 | |
| MESH:D002294 | Carcinoma, Squamous Cell | Sirolimus | 40.75 | 19435901 | |
| MESH:D002294 | Carcinoma, Squamous Cell | sodium arsenite | 40.75 | 18572023 | |
| MESH:D002294 | Carcinoma, Squamous Cell | Tetradecanoylphorbol Acetate | 40.75 | 18922899 | |
| MESH:D002294 | Carcinoma, Squamous Cell | Tretinoin | 40.75 | 16096774 16051514 | |
| MESH:D002294 | Carcinoma, Squamous Cell | Zinc | 40.75 | 16543248 | |
| MESH:D002295 | Carcinoma, Transitional Cell | Arsenic | 10.51 | 18640142 | |
| MESH:D002295 | Carcinoma, Transitional Cell | Nitrofurantoin | 10.51 | 15028437 | |
| MESH:D002295 | Carcinoma, Transitional Cell | Tamoxifen | 10.51 | 17572228 | |
| MESH:D006332 | Cardiomegaly | Copper | 7.27 | 17327471 | |
| MESH:D006332 | Cardiomegaly | Quercetin | 7.27 | 19794523 | |
| MESH:D006332 | Cardiomegaly | Tetrachlorodibenzodioxin | 7.27 | 18670907 16120746 18850075 | |
| MESH:D009202 | Cardiomyopathies | Doxorubicin | 8.61 | 16455267 16364871 16278810 15476868 17382496 17351982 16242529 18627295 15811867 17131338 15792986 16651473 16952015 16731534 16612575 17308081 17329180 17519947 17924179 16109756 17007740 17974986 17928571 16269455 15505089 | |
| MESH:D009202 | Cardiomyopathies | Iron | 8.61 | 16640825 | |
| MESH:D009202 | Cardiomyopathies | Razoxane | 8.61 | 17519947 | |
| MESH:D002311 | Cardiomyopathy, Dilated | Doxorubicin | 4.37 | 17334414 16243910 | |
| MESH:D002311 | Cardiomyopathy, Dilated | Iron | 4.37 | 16604332 | |
| MESH:D002318 | Cardiovascular Diseases | Arsenic | 13.93 | 15738583 17938729 19152805 | |
| MESH:D002318 | Cardiovascular Diseases | Genistein | 13.93 | 16332659 | |
| MESH:D002318 | Cardiovascular Diseases | Hydrogen Peroxide | 13.93 | 16936243 | |
| MESH:D002318 | Cardiovascular Diseases | resveratrol | 13.93 | 15458977 | |
| MESH:D002318 | Cardiovascular Diseases | Zinc | 13.93 | 16936243 | |
| MESH:D002340 | Carotid Artery Diseases | Arsenic | 3.35 | 18022660 16973168 | |
| MESH:D002386 | Cataract | Acetaminophen | 4.69 | 10977129 | |
| MESH:D002386 | Cataract | Tretinoin | 4.69 | 17460283 | |
| MESH:D002471 | Cell Transformation, Neoplastic | 4-hydroxyestradiol-17 beta | 19.18 | 18566989 18226522 | |
| MESH:D002471 | Cell Transformation, Neoplastic | Acetylcysteine | 19.18 | 18226522 | |
| MESH:D002471 | Cell Transformation, Neoplastic | Cyclosporine | 19.18 | 12371664 | |
| MESH:D002471 | Cell Transformation, Neoplastic | Diethylnitrosamine | 19.18 | 7505956 17174075 2727394 21159647 | |
| MESH:D002471 | Cell Transformation, Neoplastic | Estradiol | 19.18 | 18566989 | |
| MESH:D002471 | Cell Transformation, Neoplastic | sodium arsenite | 19.18 | 19524636 20056578 | |
| MESH:D002471 | Cell Transformation, Neoplastic | Vanadium | 19.18 | 17174075 | |
| MESH:D002543 | Cerebral Hemorrhage | phenylmethylpyrazolone | 4.77 | 19095969 | |
| MESH:D018290 | Cervical Intraepithelial Neoplasia | Tretinoin | 3.51 | 16129372 | |
| MESH:D018281 | Cholangiocarcinoma | 3,4,5,3',4'-pentachlorobiphenyl | 10.73 | 16628245 | |
| MESH:D018281 | Cholangiocarcinoma | Diethylnitrosamine | 10.73 | 19052882 | |
| MESH:D018281 | Cholangiocarcinoma | Tetrachlorodibenzodioxin | 10.73 | 16835633 | |
| MESH:D002779 | Cholestasis | Cyclosporine | 8.50 | 19486331 | |
| MESH:D002779 | Cholestasis | Nitric Oxide | 8.50 | 16919318 | |
| MESH:D002779 | Cholestasis | pirinixic acid | 8.50 | 19176532 | |
| MESH:D002822 | Choriocarcinoma | Tretinoin | 4.06 | 16461808 | |
| MESH:D002972 | Cleft Palate | Tetrachlorodibenzodioxin | 3.72 | 12621046 15340226 16354765 8697196 15668235 | |
| MESH:D002972 | Cleft Palate | Tretinoin | 3.72 | 9407595 | |
| MESH:D003092 | Colitis | Curcumin | 10.05 | 18200517 16804969 16782535 | |
| MESH:D003092 | Colitis | resveratrol | 10.05 | 16474422 | |
| MESH:D003092 | Colitis | Tretinoin | 10.05 | 17035595 | |
| MESH:D003103 | Coloboma | Curcumin | 3.55 | 18809619 | |
| MESH:D003110 | Colonic Neoplasms | arsenite | 19.11 | 15037631 | |
| MESH:D003110 | Colonic Neoplasms | Curcumin | 19.11 | 16340194 19359593 | |
| MESH:D003110 | Colonic Neoplasms | decitabine | 19.11 | 17616700 | |
| MESH:D003110 | Colonic Neoplasms | Fluorouracil | 19.11 | 16340194 17169374 17725105 18772588 15001691 17016597 16510598 17287894 17172411 17018589 | |
| MESH:D003110 | Colonic Neoplasms | Genistein | 19.11 | 17182828 | |
| MESH:D003110 | Colonic Neoplasms | Iron | 19.11 | 16640825 | |
| MESH:D003110 | Colonic Neoplasms | Quercetin | 19.11 | 11134977 19440933 15741050 16640504 17148506 17191121 19056647 | |
| MESH:D003110 | Colonic Neoplasms | resveratrol | 19.11 | 16338953 | |
| MESH:D003110 | Colonic Neoplasms | Sulindac | 19.11 | 12902858 12458338 | |
| MESH:D003110 | Colonic Neoplasms | Vanadium | 19.11 | 18155637 | |
| MESH:D015179 | Colorectal Neoplasms | arsenic trioxide | 10.48 | 20501625 | |
| MESH:D015179 | Colorectal Neoplasms | capecitabine | 10.48 | 18473752 18448328 | |
| MESH:D015179 | Colorectal Neoplasms | Cisplatin | 10.48 | 15273666 | |
| MESH:D015179 | Colorectal Neoplasms | decitabine | 10.48 | 18981723 | |
| MESH:D015179 | Colorectal Neoplasms | Doxorubicin | 10.48 | 18802399 18259882 | |
| MESH:D015179 | Colorectal Neoplasms | Fluorouracil | 10.48 | 16331619 17094418 17454858 15289873 17695437 17016601 16524972 17594712 18802399 18448328 20501625 14970324 18383874 17255274 16303861 18288408 17401013 18949393 16282729 16391804 18509181 15148649 | |
| MESH:D015179 | Colorectal Neoplasms | Quercetin | 10.48 | 18852136 18095365 | |
| MESH:D015179 | Colorectal Neoplasms | resveratrol | 10.48 | 16550006 | |
| MESH:D015179 | Colorectal Neoplasms | Sulindac | 10.48 | 11197048 10666051 18059344 11076880 | |
| MESH:D003139 | Common Cold | Ascorbic Acid | 4.38 | 17323712 | |
| MESH:D000013 | Congenital Abnormalities | Tetrachlorodibenzodioxin | 2.12 | 14669216 17141729 | |
| MESH:D016510 | Corneal Neovascularization | Curcumin | 3.83 | 18497527 | |
| MESH:D003327 | Coronary Disease | resveratrol | 2.95 | 16507316 | |
| MESH:D023903 | Coronary Restenosis | arsenic trioxide | 3.15 | 12609071 | |
| MESH:D003329 | Coronary Vasospasm | capecitabine | 4.77 | 17465463 | |
| MESH:D003371 | Cough | Noscapine | 5.61 | 16596228 | |
| MESH:D019465 | Craniofacial Abnormalities | 3,4,5,3',4'-pentachlorobiphenyl | 7.92 | 17686920 | |
| MESH:D019465 | Craniofacial Abnormalities | arsenic trioxide | 7.92 | 10525206 | |
| MESH:D019465 | Craniofacial Abnormalities | Reactive Oxygen Species | 7.92 | 15736158 | |
| MESH:D019465 | Craniofacial Abnormalities | sodium arsenate | 7.92 | 10525206 | |
| MESH:D019465 | Craniofacial Abnormalities | Tetrachlorodibenzodioxin | 7.92 | 10048152 15322242 20055451 | |
| MESH:D019465 | Craniofacial Abnormalities | Tretinoin | 7.92 | 14991402 16925845 9224671 17551590 9664655 10589399 9142499 8800419 9211117 9125849 | |
| MESH:D019465 | Craniofacial Abnormalities | Zinc | 7.92 | 19302082 | |
| MESH:D003550 | Cystic Fibrosis | Acetylcysteine | 6.03 | 19747007 | |
| MESH:D003550 | Cystic Fibrosis | Glutathione | 6.03 | 19747007 | |
| MESH:D003556 | Cystitis | Cyclophosphamide | 3.89 | 17010015 10498854 17979934 16614059 18710439 15643279 18295254 18433785 11948286 12913760 10700343 18093676 12161096 16413132 16651033 18372110 16989017 12388444 18483878 15276878 | |
| MESH:D007644 | Darier Disease | Fluorouracil | 3.71 | 16733453 | |
| MESH:D016757 | Death, Sudden, Cardiac | arsenic trioxide | 3.08 | 15213294 | |
| MESH:D015140 | Dementia, Vascular | Nitric Oxide | 4.87 | 17556102 | |
| MESH:D003711 | Demyelinating Diseases | Tamoxifen | 3.30 | 19031437 | |
| MESH:D017449 | Dermatitis, Allergic Contact | 4-phenylenediamine | 8.39 | 18759875 16533241 16823706 11298694 11906362 19470301 | |
| MESH:D017449 | Dermatitis, Allergic Contact | cobaltous chloride | 8.39 | 15059100 11298694 16823706 | |
| MESH:D017449 | Dermatitis, Allergic Contact | Nickel | 8.39 | 17244072 19470301 17100760 | |
| MESH:D017449 | Dermatitis, Allergic Contact | nickel sulfate | 8.39 | 11298694 16780908 16823706 | |
| MESH:D003876 | Dermatitis, Atopic | pirinixic acid | 1.79 | 18249437 | |
| MESH:D003877 | Dermatitis, Contact | 4-phenylenediamine | 6.88 | 11531941 | |
| MESH:D003877 | Dermatitis, Contact | Nickel | 6.88 | 2952479 | |
| MESH:D002658 | Developmental Disabilities | 2,3',4,4',5-pentachlorobiphenyl | 4.63 | 19647017 | |
| MESH:D003920 | Diabetes Mellitus | Iron | 6.48 | 16604332 16640825 | |
| MESH:D003920 | Diabetes Mellitus | Zinc | 6.48 | 16479319 | |
| MESH:D003921 | Diabetes Mellitus, Experimental | Cyclophosphamide | 8.71 | 11751995 10990075 15331540 | |
| MESH:D003921 | Diabetes Mellitus, Experimental | Quercetin | 8.71 | 19496084 | |
| MESH:D003921 | Diabetes Mellitus, Experimental | resveratrol | 8.71 | 16873680 | |
| MESH:D003922 | Diabetes Mellitus, Type 1 | Cyclophosphamide | 4.29 | 18772604 | |
| MESH:D003922 | Diabetes Mellitus, Type 1 | Iron | 4.29 | 16506275 | |
| MESH:D003924 | Diabetes Mellitus, Type 2 | Ascorbic Acid | 14.05 | 16506275 | |
| MESH:D003924 | Diabetes Mellitus, Type 2 | Curcumin | 14.05 | 18403477 | |
| MESH:D003924 | Diabetes Mellitus, Type 2 | Diethylnitrosamine | 14.05 | 20387270 | |
| MESH:D003924 | Diabetes Mellitus, Type 2 | epigallocatechin gallate | 14.05 | 16988119 | |
| MESH:D003924 | Diabetes Mellitus, Type 2 | Genistein | 14.05 | 16647724 | |
| MESH:D003924 | Diabetes Mellitus, Type 2 | Iron | 14.05 | 16506275 | |
| MESH:D003924 | Diabetes Mellitus, Type 2 | Tetrachlorodibenzodioxin | 14.05 | 17107852 | |
| MESH:D003928 | Diabetic Nephropathies | Curcumin | 13.70 | 18204486 | |
| MESH:D003928 | Diabetic Nephropathies | Estradiol | 13.70 | 19279558 | |
| MESH:D003928 | Diabetic Nephropathies | resveratrol | 13.70 | 16286809 | |
| MESH:D003928 | Diabetic Nephropathies | Tamoxifen | 13.70 | 19279558 | |
| MESH:D003929 | Diabetic Neuropathies | Progesterone | 3.43 | 17187935 | |
| MESH:D003930 | Diabetic Retinopathy | Sulindac | 4.14 | 12861449 17621415 | |
| MESH:D003967 | Diarrhea | SU 5416 | 4.31 | 12673719 | |
| MESH:D056486 | Drug-Induced Liver Injury | Acetaminophen | 15.83 | 11739529 12958197 15619225 16081117 19420014 11834606 12540782 11421492 12392966 16227642 18713872 19085960 19370779 15968718 12153990 16177239 19164858 17906064 19923254 12705907 17562736 10915739 10774834 18071297 2444490 16109766 11743745 11287661 16393943 17522070 16485898 14986274 14550746 19739265 10663392 14725611 12594235 16781746 11529661 11461765 19416960 | |
| MESH:D056486 | Drug-Induced Liver Injury | Acetylcysteine | 15.83 | 11287661 | |
| MESH:D056486 | Drug-Induced Liver Injury | Carbon Tetrachloride | 15.83 | 17522070 10915739 9327722 16177239 15968718 4309450 6884620 7440962 10092053 16227642 7120509 2869522 19336974 19085960 3732212 15998439 11566570 6623471 21278145 15027814 7179309 3786805 | |
| MESH:D056486 | Drug-Induced Liver Injury | Diethylnitrosamine | 15.83 | 19107877 | |
| MESH:D056486 | Drug-Induced Liver Injury | Doxorubicin | 15.83 | 17416283 | |
| MESH:D056486 | Drug-Induced Liver Injury | Gliotoxin | 15.83 | 19739265 | |
| MESH:D056486 | Drug-Induced Liver Injury | Nitrofurantoin | 15.83 | 19789166 8373174 1551546 19214031 | |
| MESH:D056486 | Drug-Induced Liver Injury | sodium arsenate | 15.83 | 18186108 | |
| MESH:D056486 | Drug-Induced Liver Injury | Tetrachlorodibenzodioxin | 15.83 | 20420201 | |
| MESH:D056487 | Drug-Induced Liver Injury, Chronic | Acetaminophen | 3.00 | 19426721 | |
| MESH:D004362 | Drug Toxicity | Cisplatin | 16.56 | 12231392 12649298 19839026 15033597 | |
| MESH:D004362 | Drug Toxicity | Doxorubicin | 16.56 | 18602426 | |
| MESH:D004362 | Drug Toxicity | Gentamicins | 16.56 | 15033597 11033412 | |
| MESH:D004362 | Drug Toxicity | phenylmethylpyrazolone | 16.56 | 12231392 12649298 | |
| MESH:D004362 | Drug Toxicity | Tetrachlorodibenzodioxin | 16.56 | 11462148 | |
| MESH:D004374 | Ductus Arteriosus, Patent | Ibuprofen | 4.53 | 16133044 18446180 18450898 | |
| MESH:D004381 | Duodenal Ulcer | Curcumin | 3.04 | 17351913 | |
| MESH:D050171 | Dyslipidemias | Fenofibrate | 3.57 | 16707586 | |
| MESH:D004417 | Dyspnea | Oxygen | 7.56 | 20016425 | |
| MESH:D004417 | Dyspnea | SU 5416 | 7.56 | 12649163 12673719 | |
| MESH:C538011 | Eales disease | Ascorbic Acid | 4.38 | 9068938 | |
| MESH:D004487 | Edema | Diclofenac | 14.62 | 16273134 | |
| MESH:D004487 | Edema | Mustard Gas | 14.62 | 9260866 11428647 11402378 11428631 | |
| MESH:D004487 | Edema | pirinixic acid | 14.62 | 12083418 | |
| MESH:D004487 | Edema | resveratrol | 14.62 | 8985016 | |
| MESH:D004487 | Edema | Tetrachlorodibenzodioxin | 14.62 | 12711302 11000095 | |
| MESH:D004487 | Edema | Tetradecanoylphorbol Acetate | 14.62 | 16716910 9599246 15177302 7812673 11698051 8273558 8113982 | |
| MESH:D004489 | Edema, Cardiac | 3,4,5,3',4'-pentachlorobiphenyl | 14.80 | 17686920 | |
| MESH:D004489 | Edema, Cardiac | Tetrachlorodibenzodioxin | 14.80 | 15322242 16714409 18230668 | |
| MESH:D004489 | Edema, Cardiac | Tretinoin | 14.80 | 18230668 | |
| MESH:D004681 | Encephalomyelitis, Autoimmune, Experimental | 15-deoxy-delta(12,14)-prostaglandin J2 | 13.65 | 16844232 | |
| MESH:D004681 | Encephalomyelitis, Autoimmune, Experimental | Progesterone | 13.65 | 17692515 | |
| MESH:D004681 | Encephalomyelitis, Autoimmune, Experimental | resveratrol | 13.65 | 17872969 | |
| MESH:D004681 | Encephalomyelitis, Autoimmune, Experimental | Tamoxifen | 13.65 | 19031437 | |
| MESH:D004701 | Endocrine Gland Neoplasms | decitabine | 4.02 | 19294695 | |
| MESH:D004714 | Endometrial Hyperplasia | Genistein | 3.51 | 16402032 | |
| MESH:D016889 | Endometrial Neoplasms | Doxorubicin | 22.76 | 17359293 | |
| MESH:D016889 | Endometrial Neoplasms | Estradiol | 22.76 | 19148513 11473722 18566989 | |
| MESH:D016889 | Endometrial Neoplasms | Ethylenethiourea | 22.76 | 7955072 | |
| MESH:D016889 | Endometrial Neoplasms | Fenofibrate | 22.76 | 16569247 | |
| MESH:D016889 | Endometrial Neoplasms | Genistein | 22.76 | 11473722 | |
| MESH:D016889 | Endometrial Neoplasms | Tamoxifen | 22.76 | 16202921 17893378 19155303 20544844 | |
| MESH:D016889 | Endometrial Neoplasms | Tretinoin | 22.76 | 16569247 | |
| MESH:D004715 | Endometriosis | Ibuprofen | 13.99 | 15652904 | |
| MESH:D004715 | Endometriosis | Progesterone | 13.99 | 16134523 | |
| MESH:D004715 | Endometriosis | Sulindac | 13.99 | 15652904 | |
| MESH:D004715 | Endometriosis | Tetrachlorodibenzodioxin | 13.99 | 10568697 9294722 | |
| MESH:D004719 | Endomyocardial Fibrosis | Doxorubicin | 4.06 | 18037988 | |
| MESH:D019446 | Endotoxemia | Ibuprofen | 11.65 | 11545620 | |
| MESH:D019446 | Endotoxemia | Lipopolysaccharides | 11.65 | 17637181 15821434 15328337 | |
| MESH:D019446 | Endotoxemia | phenylmethylpyrazolone | 11.65 | 12954792 | |
| MESH:D020345 | Enterocolitis, Necrotizing | resveratrol | 3.79 | 17923197 | |
| MESH:D004802 | Eosinophilia | Cyclophosphamide | 3.19 | 11006010 | |
| MESH:D004890 | Erythema | Mustard Gas | 4.08 | 9357497 | |
| MESH:D004931 | Esophageal Achalasia | Diethylnitrosamine | 4.02 | 16302075 | |
| MESH:D004938 | Esophageal Neoplasms | marker/mechanism | 17201171 | ||
| MESH:D004938 | Esophageal Neoplasms | arsenic trioxide | 14.14 | 12903497 | |
| MESH:D004938 | Esophageal Neoplasms | Benzo(a)pyrene | 14.14 | 16530937 | |
| MESH:D004938 | Esophageal Neoplasms | Cisplatin | 14.14 | 16481741 15173087 17638652 15464296 16785472 | |
| MESH:D004938 | Esophageal Neoplasms | Fluorouracil | 14.14 | 17638652 16337965 16481741 15173087 16785472 | |
| MESH:D004938 | Esophageal Neoplasms | nitrosobenzylmethylamine | 14.14 | 15150132 16510608 16805852 15878914 15547721 15547733 15623463 15264214 16704527 | |
| MESH:D004938 | Esophageal Neoplasms | Sulindac | 14.14 | 12235107 | |
| MESH:D004938 | Esophageal Neoplasms | Zinc | 14.14 | 16543248 | |
| MESH:D005124 | Eye Abnormalities | Tetrachlorodibenzodioxin | 5.90 | 11564622 | |
| MESH:D005124 | Eye Abnormalities | Tretinoin | 5.90 | 9664655 16938888 | |
| MESH:D005128 | Eye Diseases | Ketorolac | 5.99 | 11084241 | |
| MESH:D005221 | Fatigue | SU 5416 | 5.31 | 12673719 12649163 | |
| MESH:D005234 | Fatty Liver | arsenic trioxide | 35.05 | 15073043 | |
| MESH:D005234 | Fatty Liver | arsenite | 35.05 | 18296743 | |
| MESH:D005234 | Fatty Liver | Carbon Tetrachloride | 35.05 | 12631006 16239168 12795759 16045604 15959796 17595544 61145 19224547 | |
| MESH:D005234 | Fatty Liver | Curcumin | 35.05 | 19297423 | |
| MESH:D005234 | Fatty Liver | Cyclosporine | 35.05 | 19224547 | |
| MESH:D005234 | Fatty Liver | Diethylnitrosamine | 35.05 | 20387270 21071580 | |
| MESH:D005234 | Fatty Liver | Iron | 35.05 | 16640825 | |
| MESH:D005234 | Fatty Liver | phenylmethylpyrazolone | 35.05 | 12795759 | |
| MESH:D005234 | Fatty Liver | pirinixic acid | 35.05 | 19236843 20131406 | |
| MESH:D005234 | Fatty Liver | Tamoxifen | 35.05 | 19224547 14986274 | |
| MESH:D052776 | Female Urogenital Diseases | Tamoxifen | 2.46 | 16709447 | |
| MESH:D005313 | Fetal Death | Tetrachlorodibenzodioxin | 2.40 | 11858732 | |
| MESH:D005334 | Fever | Ibuprofen | 6.31 | 16997862 | |
| MESH:D005334 | Fever | Lipopolysaccharides | 6.31 | 11852909 9205823 | |
| MESH:D018221 | Fibromatosis, Abdominal | Sulindac | 9.37 | 14745880 | |
| MESH:D018221 | Fibromatosis, Abdominal | Tamoxifen | 9.37 | 14745880 | |
| MESH:D018222 | Fibromatosis, Aggressive | Doxorubicin | 13.35 | 19069698 | |
| MESH:D018222 | Fibromatosis, Aggressive | Sulindac | 13.35 | 19069698 | |
| MESH:D018222 | Fibromatosis, Aggressive | Tamoxifen | 13.35 | 19069698 | |
| MESH:D005355 | Fibrosis | arsenite | 25.69 | 18296743 | |
| MESH:D005355 | Fibrosis | Carbon Tetrachloride | 25.69 | 18705752 | |
| MESH:D005355 | Fibrosis | Curcumin | 25.69 | 18705752 | |
| MESH:D005355 | Fibrosis | Cyclosporine | 25.69 | 12168785 12639820 | |
| MESH:D005355 | Fibrosis | Quercetin | 25.69 | 19474275 | |
| MESH:D005355 | Fibrosis | Tetrachlorodibenzodioxin | 25.69 | 20067830 | |
| MESH:D005355 | Fibrosis | Tretinoin | 25.69 | 17994277 | |
| MESH:D005534 | Foot Diseases | Arsenic | 4.46 | 6392382 | |
| MESH:D005621 | Friedreich Ataxia | Iron | 4.36 | 16604332 16640825 | |
| MESH:D005706 | Gallbladder Neoplasms | arsenic trioxide | 3.22 | 16904648 | |
| MESH:D005739 | Gas Poisoning | Oxygen | 4.12 | 20016425 | |
| MESH:D005756 | Gastritis | Acetaminophen | 7.54 | 16983495 | |
| MESH:D005756 | Gastritis | Zinc | 7.54 | 17241300 | |
| MESH:D005764 | Gastroesophageal Reflux | Sulindac | 3.97 | 11910360 | |
| MESH:D005770 | Gastrointestinal Neoplasms | Curcumin | 3.64 | 18462866 | |
| MESH:D005833 | Genital Neoplasms, Female | sodium arsenite | 3.60 | 16452187 | |
| MESH:D005885 | Gingival Hyperplasia | Cyclosporine | 3.14 | 8708960 | |
| MESH:D005909 | Glioblastoma | Curcumin | 17.36 | 17596214 | |
| MESH:D005909 | Glioblastoma | Doxorubicin | 17.36 | 17150277 | |
| MESH:D005909 | Glioblastoma | Genistein | 17.36 | 16598420 | |
| MESH:D005909 | Glioblastoma | Manganese | 17.36 | 17043766 | |
| MESH:D005909 | Glioblastoma | Quercetin | 17.36 | 19804834 | |
| MESH:D005909 | Glioblastoma | Tretinoin | 17.36 | 17312396 | |
| MESH:D005910 | Glioma | Fluorouracil | 6.79 | 16145905 | |
| MESH:D005910 | Glioma | Noscapine | 6.79 | 16596228 | |
| MESH:D005910 | Glioma | Quercetin | 6.79 | 17643826 | |
| MESH:D018316 | Gliosarcoma | Cyclophosphamide | 4.43 | 11389073 | |
| MESH:D018149 | Glucose Intolerance | sodium arsenate | 4.06 | 19446573 | |
| MESH:D006042 | Goiter | perchlorate | 4.29 | 18801409 | |
| MESH:D006058 | Gonadal Disorders | Tetrachlorodibenzodioxin | 3.49 | 10696789 | |
| MESH:D006086 | Graft vs Host Disease | Cyclophosphamide | 3.98 | 15172196 16376943 11014644 | |
| MESH:D006130 | Growth Disorders | Zinc | 3.16 | 17217573 | |
| MESH:D006261 | Headache | Nitric Oxide | 8.08 | 11554966 11284996 | |
| MESH:D006261 | Headache | SU 5416 | 8.08 | 12673719 12649163 | |
| MESH:D006258 | Head and Neck Neoplasms | Cisplatin | 23.75 | 15464296 15102660 | |
| MESH:D006258 | Head and Neck Neoplasms | Curcumin | 23.75 | 18829502 18462866 | |
| MESH:D006258 | Head and Neck Neoplasms | decitabine | 23.75 | 19215824 | |
| MESH:D006258 | Head and Neck Neoplasms | Doxorubicin | 23.75 | 15692506 | |
| MESH:D006258 | Head and Neck Neoplasms | Fluorouracil | 23.75 | 15162350 15102660 18337622 | |
| MESH:D006258 | Head and Neck Neoplasms | Sirolimus | 23.75 | 19435901 | |
| MESH:D006258 | Head and Neck Neoplasms | Tretinoin | 23.75 | 16096774 | |
| MESH:D034381 | Hearing Loss | Cisplatin | 7.12 | 19898482 | |
| MESH:D034381 | Hearing Loss | Gentamicins | 7.12 | 17868369 19130971 15968427 18024279 | |
| MESH:D006317 | Hearing Loss, Noise-Induced | Tretinoin | 4.06 | 16084493 | |
| MESH:D006319 | Hearing Loss, Sensorineural | Cisplatin | 3.48 | 15464296 | |
| MESH:D006330 | Heart Defects, Congenital | 2,3,7,8-tetrachlorodibenzofuran | 20.86 | 11294989 | |
| MESH:D006330 | Heart Defects, Congenital | 3,4,3',4'-tetrachlorobiphenyl | 20.86 | 11294989 | |
| MESH:D006330 | Heart Defects, Congenital | 3,4,5,3',4'-pentachlorobiphenyl | 20.86 | 20471113 17686920 | |
| MESH:D006330 | Heart Defects, Congenital | Ascorbic Acid | 20.86 | 16080930 | |
| MESH:D006330 | Heart Defects, Congenital | Benzo(a)pyrene | 20.86 | 20471113 | |
| MESH:D006330 | Heart Defects, Congenital | Tetrachlorodibenzodioxin | 20.86 | 11294989 10048152 | |
| MESH:D006330 | Heart Defects, Congenital | Tretinoin | 20.86 | 14991402 9664655 | |
| MESH:D006331 | Heart Diseases | Doxorubicin | 5.63 | 16495754 16707910 16879835 16144979 16244372 12587719 17875725 14766674 18006777 18674790 16330681 16244371 17888722 | |
| MESH:D006331 | Heart Diseases | Razoxane | 5.63 | 17875725 | |
| MESH:D006333 | Heart Failure | Doxorubicin | 7.34 | 17481944 | |
| MESH:D006333 | Heart Failure | pirinixic acid | 7.34 | 20558911 | |
| MESH:D006333 | Heart Failure | Zinc | 7.34 | 17162251 | |
| MESH:D006335 | Heart Injuries | Zinc | 4.67 | 17074742 | |
| MESH:D016481 | Helicobacter Infections | Zinc | 3.52 | 17241300 | |
| MESH:D006390 | Hemangioendothelioma | Razoxane | 5.31 | 15380572 | |
| MESH:D006394 | Hemangiosarcoma | Doxorubicin | 2.93 | 15692506 | |
| MESH:D006432 | Hemochromatosis | Iron | 3.62 | 16604332 16640825 17236123 16574947 17053826 17255318 | |
| MESH:D006457 | Hemoglobinuria, Paroxysmal | Cyclosporine | 3.34 | 15720958 | |
| MESH:D006463 | Hemolytic-Uremic Syndrome | Lipopolysaccharides | 3.41 | 16366002 | |
| MESH:D006467 | Hemophilia A | Cyclophosphamide | 4.23 | 11918545 | |
| MESH:D006470 | Hemorrhage | Tetrachlorodibenzodioxin | 2.34 | 11000095 | |
| MESH:D006486 | Hemosiderosis | Iron | 4.12 | 16604332 | |
| MESH:D006504 | Hepatic Veno-Occlusive Disease | Cyclophosphamide | 4.43 | 14986274 | |
| MESH:D006505 | Hepatitis | Carbon Tetrachloride | 2.58 | 19900420 19110552 | |
| MESH:D006521 | Hepatitis, Chronic | Copper | 13.28 | 17338147 | |
| MESH:D006521 | Hepatitis, Chronic | Diclofenac | 13.28 | 14986274 | |
| MESH:D006521 | Hepatitis, Chronic | Nitrofurantoin | 13.28 | 14986274 | |
| MESH:D006525 | Hepatitis, Viral, Human | Iron | 4.37 | 16640825 | |
| MESH:D006527 | Hepatolenticular Degeneration | Copper | 12.57 | 17182432 16607473 17276780 17109627 19888908 | |
| MESH:D006527 | Hepatolenticular Degeneration | Iron | 12.57 | 17182432 | |
| MESH:D006527 | Hepatolenticular Degeneration | Zinc | 12.57 | 17276780 | |
| MESH:D006529 | Hepatomegaly | Iron | 8.48 | 16890145 | |
| MESH:D006529 | Hepatomegaly | pirinixic acid | 8.48 | 18467677 16221962 19176532 19772884 | |
| MESH:D006529 | Hepatomegaly | Tetrachlorodibenzodioxin | 8.48 | 15340226 12621046 16120746 | |
| MESH:D015417 | Hereditary Sensory and Motor Neuropathy | Curcumin | 3.98 | 17701891 | |
| MESH:D006548 | Hernia, Diaphragmatic | Ascorbic Acid | 2.96 | 16863852 16490937 | |
| MESH:D006558 | Herpes Genitalis | Estradiol | 3.93 | 15709030 | |
| MESH:D006561 | Herpes Simplex | resveratrol | 3.12 | 16876885 | |
| MESH:D015658 | HIV Infections | Iron | 4.81 | 16597321 | |
| MESH:D015658 | HIV Infections | Nickel | 4.81 | 17263646 | |
| MESH:D006689 | Hodgkin Disease | Cisplatin | 9.89 | 16200630 16170182 | |
| MESH:D006689 | Hodgkin Disease | Cyclophosphamide | 9.89 | 16135485 17606976 | |
| MESH:D006689 | Hodgkin Disease | Doxorubicin | 9.89 | 17606976 15147373 18501091 | |
| MESH:D006689 | Hodgkin Disease | sodium arsenite | 9.89 | 12676792 | |
| MESH:D019584 | Hot Flashes | Estradiol | 2.67 | 17088409 | |
| MESH:D006869 | Hydronephrosis | Tetrachlorodibenzodioxin | 2.95 | 15340226 18606429 8697196 16959395 16354765 | |
| MESH:D006930 | Hyperalgesia | Acetaminophen | 4.64 | 16870215 | |
| MESH:D006930 | Hyperalgesia | Tretinoin | 4.64 | 16870215 | |
| MESH:D006932 | Hyperbilirubinemia | Carbon Tetrachloride | 3.45 | 16899240 | |
| MESH:D006934 | Hypercalcemia | bortezomib | 4.46 | 18089816 | |
| MESH:D053565 | Hypercalciuria | Gentamicins | 4.63 | 17652376 | |
| MESH:D006937 | Hypercholesterolemia | Curcumin | 6.11 | 18704882 | |
| MESH:D006937 | Hypercholesterolemia | resveratrol | 6.11 | 17188708 | |
| MESH:D006940 | Hyperemia | Nitric Oxide | 4.53 | 11156591 | |
| MESH:D017681 | Hypereosinophilic Syndrome | Tretinoin | 3.51 | 16778211 | |
| MESH:D006943 | Hyperglycemia | pirinixic acid | 6.02 | 20558911 | |
| MESH:D006943 | Hyperglycemia | Quercetin | 6.02 | 11834736 18262572 | |
| MESH:D017488 | Hyperkeratosis, Epidermolytic | Arsenic | 3.48 | 17050553 | |
| MESH:D006949 | Hyperlipidemias | resveratrol | 3.03 | 16873680 | |
| MESH:D006973 | Hypertension | Arsenic | 10.19 | 9931084 16076760 11953799 | |
| MESH:D006973 | Hypertension | Cobalt | 10.19 | 17039479 | |
| MESH:D006973 | Hypertension | Cyclosporine | 10.19 | 10903974 | |
| MESH:D006973 | Hypertension | Quercetin | 10.19 | 18356687 | |
| MESH:D006973 | Hypertension | Tetrachlorodibenzodioxin | 10.19 | 18850075 18670907 | |
| MESH:D006975 | Hypertension, Portal | Carbon Tetrachloride | 3.03 | 15338365 | |
| MESH:D006976 | Hypertension, Pulmonary | Nitric Oxide | 3.58 | 15838368 | |
| MESH:D006984 | Hypertrophy | Ibuprofen | 7.87 | 16672835 | |
| MESH:D006984 | Hypertrophy | Sirolimus | 7.87 | 19211884 | |
| MESH:D017379 | Hypertrophy, Left Ventricular | phenylmethylpyrazolone | 7.55 | 15824197 | |
| MESH:D017379 | Hypertrophy, Left Ventricular | resveratrol | 7.55 | 17488730 | |
| MESH:D006987 | Hypesthesia | Arsenic | 4.46 | 16093927 | |
| MESH:D007006 | Hypogonadism | Iron | 3.55 | 16640825 | |
| MESH:D007037 | Hypothyroidism | Iron | 4.02 | 16640825 | |
| MESH:D007154 | Immune System Diseases | Cyclophosphamide | 4.23 | 16076520 | |
| MESH:D007235 | Infant, Premature, Diseases | Ibuprofen | 4.74 | 16133044 | |
| MESH:D020244 | Infarction, Middle Cerebral Artery | Progesterone | 7.98 | 15869954 | |
| MESH:D020244 | Infarction, Middle Cerebral Artery | resveratrol | 7.98 | 17600658 | |
| MESH:D007248 | Infertility, Male | 2,2',3',4,4',5-hexachlorobiphenyl | 9.53 | 12948891 | |
| MESH:D007248 | Infertility, Male | Cyclophosphamide | 9.53 | 16517039 7193160 | |
| MESH:D007248 | Infertility, Male | decitabine | 9.53 | 17581917 | |
| MESH:D007248 | Infertility, Male | sodium arsenite | 9.53 | 15346721 12646999 | |
| MESH:D007249 | Inflammation | Aluminum | 35.39 | 16052892 | |
| MESH:D007249 | Inflammation | Curcumin | 35.39 | 18403477 16956363 17151092 | |
| MESH:D007249 | Inflammation | Diclofenac | 35.39 | 16273134 | |
| MESH:D007249 | Inflammation | Diethylnitrosamine | 35.39 | 18785209 | |
| MESH:D007249 | Inflammation | Ibuprofen | 35.39 | 3291741 | |
| MESH:D007249 | Inflammation | Lipopolysaccharides | 35.39 | 17237260 9205823 12878042 17255318 17963957 | |
| MESH:D007249 | Inflammation | Mustard Gas | 35.39 | 17524151 11428631 16001271 11428647 8975870 11402378 9260866 9357497 11428620 | |
| MESH:D007249 | Inflammation | Nickel | 35.39 | 16166738 | |
| MESH:D007249 | Inflammation | Progesterone | 35.39 | 15869954 | |
| MESH:D007249 | Inflammation | resveratrol | 35.39 | 16366677 | |
| MESH:D007249 | Inflammation | Sulindac | 35.39 | 3291741 | |
| MESH:D007249 | Inflammation | Tamoxifen | 35.39 | 19457130 | |
| MESH:D007249 | Inflammation | Tetrachlorodibenzodioxin | 35.39 | 12878042 12200463 | |
| MESH:D007249 | Inflammation | Tetradecanoylphorbol Acetate | 35.39 | 7562506 7812673 15177302 8273558 11698051 | |
| MESH:D015212 | Inflammatory Bowel Diseases | Curcumin | 2.64 | 18200517 18596194 | |
| MESH:D007251 | Influenza, Human | Quercetin | 7.57 | 16624496 | |
| MESH:D007251 | Influenza, Human | resveratrol | 7.57 | 16624496 | |
| MESH:D007333 | Insulin Resistance | bisphenol A | 7.62 | 16393666 | |
| MESH:D007333 | Insulin Resistance | Estradiol | 7.62 | 16393666 16627594 | |
| MESH:D007333 | Insulin Resistance | pirinixic acid | 7.62 | 16306350 | |
| MESH:D007410 | Intestinal Diseases | Nitric Oxide | 6.63 | 10210152 11713966 11574821 | |
| MESH:D007410 | Intestinal Diseases | Tretinoin | 6.63 | 17994277 | |
| MESH:D007414 | Intestinal Neoplasms | Curcumin | 6.89 | 10783313 | |
| MESH:D007414 | Intestinal Neoplasms | Sulindac | 6.89 | 10213222 12584176 10223192 12628509 12663524 12351151 | |
| MESH:D007417 | Intestinal Polyps | Sulindac | 3.97 | 11245490 12394442 | |
| MESH:D002532 | Intracranial Aneurysm | phenylmethylpyrazolone | 7.50 | 19381132 | |
| MESH:D002532 | Intracranial Aneurysm | Reactive Oxygen Species | 7.50 | 19381132 | |
| MESH:D019189 | Iron Metabolism Disorders | Iron | 8.22 | 17163184 | |
| MESH:D019189 | Iron Metabolism Disorders | Lipopolysaccharides | 8.22 | 17255318 | |
| MESH:D007511 | Ischemia | phenylmethylpyrazolone | 7.84 | 16301206 | |
| MESH:D007511 | Ischemia | Zinc | 7.84 | 16584753 | |
| MESH:D007569 | Jaw Abnormalities | Tetrachlorodibenzodioxin | 6.63 | 16580747 | |
| MESH:D007569 | Jaw Abnormalities | Tretinoin | 6.63 | 15992940 17551590 | |
| MESH:D007627 | Keloid | Quercetin | 3.89 | 17086741 | |
| MESH:D007638 | Keratoconjunctivitis Sicca | Cyclosporine | 3.34 | 15604871 | |
| MESH:D007642 | Keratosis | Arsenic | 3.91 | 12749816 16930632 | |
| MESH:D007673 | Kidney Cortex Necrosis | Cisplatin | 9.69 | 15464296 | |
| MESH:D007673 | Kidney Cortex Necrosis | Gentamicins | 9.69 | 18842672 | |
| MESH:D007674 | Kidney Diseases | Acetaminophen | 35.71 | 15629191 12587719 | |
| MESH:D007674 | Kidney Diseases | Chromium | 35.71 | 17934191 | |
| MESH:D007674 | Kidney Diseases | Cisplatin | 35.71 | 12231392 12649298 15190930 19839026 18289764 | |
| MESH:D007674 | Kidney Diseases | Cyclosporine | 35.71 | 10903974 8314463 18776723 | |
| MESH:D007674 | Kidney Diseases | Doxorubicin | 35.71 | 16775033 15369732 15699352 | |
| MESH:D007674 | Kidney Diseases | Estradiol | 35.71 | 15618244 | |
| MESH:D007674 | Kidney Diseases | ferric nitrilotriacetate | 35.71 | 15834431 18617210 | |
| MESH:D007674 | Kidney Diseases | Gentamicins | 35.71 | 19349640 18289764 17934191 | |
| MESH:D007674 | Kidney Diseases | phenylmethylpyrazolone | 35.71 | 18085390 | |
| MESH:D007674 | Kidney Diseases | Quercetin | 35.71 | 16962696 | |
| MESH:D007674 | Kidney Diseases | sodium arsenite | 35.71 | 20008137 | |
| MESH:D007674 | Kidney Diseases | Zinc | 35.71 | 16960431 | |
| MESH:D007676 | Kidney Failure, Chronic | Copper | 15.82 | 16518626 | |
| MESH:D007676 | Kidney Failure, Chronic | Doxorubicin | 15.82 | 16707910 | |
| MESH:D007676 | Kidney Failure, Chronic | Hydrogen Peroxide | 15.82 | 16518626 | |
| MESH:D007676 | Kidney Failure, Chronic | Zinc | 15.82 | 16518626 | |
| MESH:D007680 | Kidney Neoplasms | Cyclosporine | 13.70 | 12371664 | |
| MESH:D007680 | Kidney Neoplasms | Estradiol | 13.70 | 15610895 | |
| MESH:D007680 | Kidney Neoplasms | ferric nitrilotriacetate | 13.70 | 18055543 9667754 | |
| MESH:D007680 | Kidney Neoplasms | Fluorouracil | 13.70 | 16985049 | |
| MESH:D007680 | Kidney Neoplasms | Tamoxifen | 13.70 | 18625569 | |
| MESH:D007683 | Kidney Tubular Necrosis, Acute | Cisplatin | 8.38 | 11231351 | |
| MESH:D007683 | Kidney Tubular Necrosis, Acute | Gentamicins | 8.38 | 11231351 | |
| MESH:D007859 | Learning Disorders | Copper | 3.75 | 17134702 | |
| MESH:D007889 | Leiomyoma | Curcumin | 3.55 | 18555241 | |
| MESH:D007896 | Leishmaniasis | Nitric Oxide | 3.72 | 17218153 | |
| MESH:D016773 | Leishmaniasis, Cutaneous | Gentamicins | 3.55 | 10219319 | |
| MESH:D007938 | Leukemia | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one | 22.90 | 12970779 | |
| MESH:D007938 | Leukemia | arsenic trioxide | 22.90 | 15070760 | |
| MESH:D007938 | Leukemia | Curcumin | 22.90 | 18462866 | |
| MESH:D007938 | Leukemia | Cyclophosphamide | 22.90 | 10602166 | |
| MESH:D007938 | Leukemia | decitabine | 22.90 | 19235587 18980019 | |
| MESH:D007938 | Leukemia | Genistein | 22.90 | 17468513 18980019 | |
| MESH:D007938 | Leukemia | Quercetin | 22.90 | 17468513 | |
| MESH:D007938 | Leukemia | Tretinoin | 22.90 | 17143497 | |
| MESH:D004915 | Leukemia, Erythroblastic, Acute | Doxorubicin | 4.06 | 16085563 | |
| MESH:D015451 | Leukemia, Lymphocytic, Chronic, B-Cell | Cyclophosphamide | 5.19 | 17008537 17802794 18172266 17658394 17296974 18587576 | |
| MESH:D015451 | Leukemia, Lymphocytic, Chronic, B-Cell | fludarabine | 5.19 | 18172266 17802794 17658394 18587576 17296974 | |
| MESH:D015459 | Leukemia-Lymphoma, Adult T-Cell | arsenic trioxide | 10.71 | 17077332 12560223 | |
| MESH:D015459 | Leukemia-Lymphoma, Adult T-Cell | bortezomib | 10.71 | 18089816 | |
| MESH:D015459 | Leukemia-Lymphoma, Adult T-Cell | Curcumin | 10.71 | 16106398 | |
| MESH:D007948 | Leukemia, Monocytic, Acute | arsenic trioxide | 13.48 | 16972261 | |
| MESH:D007948 | Leukemia, Monocytic, Acute | PD 98059 | 13.48 | 16972261 | |
| MESH:D007948 | Leukemia, Monocytic, Acute | U 0126 | 13.48 | 16972261 | |
| MESH:D015464 | Leukemia, Myelogenous, Chronic, BCR-ABL Positive | arsenic trioxide | 5.71 | 14633726 | |
| MESH:D015464 | Leukemia, Myelogenous, Chronic, BCR-ABL Positive | Cyclophosphamide | 5.71 | 10373061 | |
| MESH:D007951 | Leukemia, Myeloid | arsenic trioxide | 10.29 | 19077051 | |
| MESH:D007951 | Leukemia, Myeloid | decitabine | 10.29 | 17236224 19117987 18454857 | |
| MESH:D007951 | Leukemia, Myeloid | Tretinoin | 10.29 | 16932348 16482212 19285840 | |
| MESH:D015470 | Leukemia, Myeloid, Acute | arsenic trioxide | 9.99 | 16467208 16968895 19850784 17050201 20471514 | |
| MESH:D015470 | Leukemia, Myeloid, Acute | bortezomib | 9.99 | 20471514 | |
| MESH:D015470 | Leukemia, Myeloid, Acute | decitabine | 9.99 | 18460780 17679729 19010910 18704418 18206229 19387464 | |
| MESH:D015470 | Leukemia, Myeloid, Acute | Deferoxamine | 9.99 | 20368581 | |
| MESH:D015470 | Leukemia, Myeloid, Acute | SU 5416 | 9.99 | 12649163 | |
| MESH:D015470 | Leukemia, Myeloid, Acute | Tretinoin | 9.99 | 17596541 16294345 19850784 | |
| MESH:D015477 | Leukemia, Myelomonocytic, Chronic | decitabine | 4.36 | 18055864 | |
| MESH:D015473 | Leukemia, Promyelocytic, Acute | Arsenic | 11.53 | 17339181 | |
| MESH:D015473 | Leukemia, Promyelocytic, Acute | arsenic trioxide | 11.53 | 17712046 12679006 19642359 17217047 16112521 12018890 17649720 16330433 16823087 19225113 12712474 16966277 11468182 15622746 17107899 11161223 9834237 17869043 19035177 15748426 15213294 15336539 19075265 16331271 16891316 | |
| MESH:D015473 | Leukemia, Promyelocytic, Acute | resveratrol | 11.53 | 16087638 | |
| MESH:D015473 | Leukemia, Promyelocytic, Acute | Tretinoin | 11.53 | 17361223 17368321 19075265 16935935 16891316 19225113 16823087 15748426 17294898 17217047 19035177 16331271 19642359 19029980 17712046 16140955 16788101 17506722 17107899 12679006 9834237 16766008 17339181 17301526 17649720 | |
| MESH:D015458 | Leukemia, T-Cell | arsenic trioxide | 8.27 | 16882451 | |
| MESH:D015458 | Leukemia, T-Cell | Curcumin | 8.27 | 16106398 | |
| MESH:D007970 | Leukopenia | Cyclophosphamide | 8.20 | 10052129 11830472 | |
| MESH:D007970 | Leukopenia | Lipopolysaccharides | 8.20 | 15821434 | |
| MESH:D020961 | Lewy Body Disease | Iron | 4.36 | 16563566 | |
| MESH:D017880 | Limb Deformities, Congenital | Tretinoin | 2.46 | 9224671 | |
| MESH:D008064 | Lipidoses | Tamoxifen | 2.32 | 17567588 15342952 | |
| MESH:D008103 | Liver Cirrhosis | arsenite | 9.80 | 18296743 | |
| MESH:D008103 | Liver Cirrhosis | Carbon Tetrachloride | 9.80 | 17157831 11408273 16239168 16943688 16221502 21278145 11903743 17334410 17174718 | |
| MESH:D008103 | Liver Cirrhosis | Diethylnitrosamine | 9.80 | 18522880 19638242 18665156 18407596 20032147 | |
| MESH:D008103 | Liver Cirrhosis | Iron | 9.80 | 16640825 | |
| MESH:D008105 | Liver Cirrhosis, Biliary | Sulindac | 3.44 | 12468960 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Carbon Tetrachloride | 22.80 | 12445418 18317297 12898905 15057751 17823541 18705752 18251166 15052691 15925388 16116963 14716496 14724832 12389079 18429990 12632514 12958196 18376398 15996030 16638106 18420326 12666154 14716833 18472332 17721639 18277467 15893842 16136751 15650968 18054572 11481614 15730626 18205269 14620537 16027843 18472094 20821823 15818738 12741479 17557913 10355542 17869086 16097048 17481882 18339082 15673190 12586293 17761835 15362042 16015684 16011737 16248980 15123356 18210741 18395095 14748882 16033810 17698563 18166357 17714472 18481824 17708605 18279442 12546737 12609069 12649538 17976157 15959796 18263696 15370692 17565644 17922224 17944888 14512876 17900296 18006644 18156304 15931870 15876570 18395914 15338365 18412020 18418968 13678700 17805973 17631135 18187930 12667390 16192424 17525996 12632512 17640975 17766677 12445421 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Curcumin | 22.80 | 18006644 18705752 17355460 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Doxorubicin | 22.80 | 16595196 16439617 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | epigallocatechin gallate | 22.80 | 17481882 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Estradiol | 22.80 | 14716833 14659978 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Fenofibrate | 22.80 | 15474484 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Genistein | 22.80 | 17823541 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Lipopolysaccharides | 22.80 | 12878042 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | pirinixic acid | 22.80 | 15474484 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Quercetin | 22.80 | 12741479 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Sirolimus | 22.80 | 17050028 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Tamoxifen | 22.80 | 18564211 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Tetrachlorodibenzodioxin | 22.80 | 12878042 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Tretinoin | 22.80 | 18397230 16248980 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Y 27632 | 22.80 | 13678700 | |
| MESH:D008107 | Liver Diseases | Acetaminophen | 14.82 | 19784758 16611625 19460945 12587719 19014921 16610002 11587558 12969438 | |
| MESH:D008107 | Liver Diseases | Arsenic | 14.82 | 11134558 | |
| MESH:D008107 | Liver Diseases | Carbon Tetrachloride | 14.82 | 15830285 17285989 16246199 16964402 15720792 | |
| MESH:D008107 | Liver Diseases | Curcumin | 14.82 | 16956363 | |
| MESH:D008107 | Liver Diseases | Diclofenac | 14.82 | 16867024 14566034 | |
| MESH:D008107 | Liver Diseases | Diethylnitrosamine | 14.82 | 17034775 | |
| MESH:D008107 | Liver Diseases | Nitrofurantoin | 14.82 | 14966256 | |
| MESH:D008107 | Liver Diseases | Sulindac | 14.82 | 14986274 16867024 | |
| MESH:D008108 | Liver Diseases, Alcoholic | Iron | 3.95 | 17207112 16737972 | |
| MESH:D017093 | Liver Failure | Carbon Tetrachloride | 3.11 | 15123358 | |
| MESH:D017114 | Liver Failure, Acute | Acetaminophen | 6.18 | 16871587 17185352 | |
| MESH:D017114 | Liver Failure, Acute | Carbon Tetrachloride | 6.18 | 16899240 14706259 | |
| MESH:D008113 | Liver Neoplasms | 2,4,5,2',4',5'-hexachlorobiphenyl | 48.33 | 18644402 16835634 | |
| MESH:D008113 | Liver Neoplasms | Aflatoxin B1 | 48.33 | 2125692 18177683 9163691 15890375 | |
| MESH:D008113 | Liver Neoplasms | Arsenic | 48.33 | 16368122 | |
| MESH:D008113 | Liver Neoplasms | arsenic trioxide | 48.33 | 14682389 | |
| MESH:D008113 | Liver Neoplasms | Benzo(a)pyrene | 48.33 | 21137059 20195826 | |
| MESH:D008113 | Liver Neoplasms | Carbon Tetrachloride | 48.33 | 19294768 | |
| MESH:D008113 | Liver Neoplasms | Copper | 48.33 | 20302851 | |
| MESH:D008113 | Liver Neoplasms | Diethylnitrosamine | 48.33 | 19073162 18977376 20492335 20137499 10737359 15175105 20583210 12112319 19996281 18644402 19256749 12771043 9163691 19499222 19833225 20452335 19255062 19690152 16942905 21278145 21167192 18648771 15885732 19294768 19850985 19812893 21047994 19254457 20434301 18754104 19427195 20101389 20405173 19426721 2422723 19638242 20501860 20118626 18978307 19642983 2862719 19551842 19090486 21071580 | |
| MESH:D008113 | Liver Neoplasms | Ethylenethiourea | 48.33 | 11940454 | |
| MESH:D008113 | Liver Neoplasms | Fenofibrate | 48.33 | 18978307 | |
| MESH:D008113 | Liver Neoplasms | Fluorouracil | 48.33 | 18383874 17045692 15113037 16603448 | |
| MESH:D008113 | Liver Neoplasms | Iron | 48.33 | 16640825 20302851 | |
| MESH:D008113 | Liver Neoplasms | pirinixic acid | 48.33 | 20007298 15890375 16377806 | |
| MESH:D008113 | Liver Neoplasms | Quercetin | 48.33 | 18980244 | |
| MESH:D008113 | Liver Neoplasms | resveratrol | 48.33 | 20405173 19812893 19321006 19073162 | |
| MESH:D008113 | Liver Neoplasms | sodium arsenite | 48.33 | 15276417 16712894 | |
| MESH:D008113 | Liver Neoplasms | Tamoxifen | 48.33 | 16684651 | |
| MESH:D008113 | Liver Neoplasms | Tetrachlorodibenzodioxin | 48.33 | 16984957 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Aflatoxin B1 | 26.43 | 8603461 | |
| MESH:D008114 | Liver Neoplasms, Experimental | arsenic trioxide | 26.43 | 20377131 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Ascorbic Acid | 26.43 | 18544905 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Carbon Tetrachloride | 26.43 | 15583823 12014681 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Diethylnitrosamine | 26.43 | 18775883 18093689 19539802 18253720 18079962 18282651 16267830 18164116 18544905 19519916 19009564 21159647 9362446 18308698 2563599 19126423 19004024 16842330 17174075 3124819 17854601 17942915 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Doxorubicin | 26.43 | 16842330 17085340 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Fenofibrate | 26.43 | 18775883 18253720 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Quercetin | 26.43 | 19519916 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Tetrachlorodibenzodioxin | 26.43 | 12151625 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Vanadium | 26.43 | 17174075 | |
| MESH:D008133 | Long QT Syndrome | arsenic trioxide | 2.48 | 15213294 | |
| MESH:D008171 | Lung Diseases | Acetylcysteine | 22.17 | 12815614 | |
| MESH:D008171 | Lung Diseases | Aluminum | 22.17 | 16052892 | |
| MESH:D008171 | Lung Diseases | Ascorbic Acid | 22.17 | 16863852 | |
| MESH:D008171 | Lung Diseases | chromium hexavalent ion | 22.17 | 16775837 | |
| MESH:D008171 | Lung Diseases | Mustard Gas | 22.17 | 18161513 18702808 | |
| MESH:D008171 | Lung Diseases | Nitrofurantoin | 22.17 | 14966256 9429087 | |
| MESH:D008171 | Lung Diseases | sodium arsenite | 22.17 | 19095001 | |
| MESH:D017563 | Lung Diseases, Interstitial | Nitrofurantoin | 4.88 | 18516814 | |
| MESH:D008173 | Lung Diseases, Obstructive | Cobalt | 4.80 | 6434250 | |
| MESH:D055370 | Lung Injury | Asbestos, Crocidolite | 17.31 | 17365036 | |
| MESH:D055370 | Lung Injury | Lipopolysaccharides | 17.31 | 21114838 | |
| MESH:D055370 | Lung Injury | Nitric Oxide | 17.31 | 11395602 | |
| MESH:D055370 | Lung Injury | Nitrofurantoin | 17.31 | 1313237 | |
| MESH:D055370 | Lung Injury | Oxygen | 17.31 | 18339021 | |
| MESH:D008175 | Lung Neoplasms | Aflatoxin B1 | 37.52 | 14755239 | |
| MESH:D008175 | Lung Neoplasms | Arsenic | 37.52 | 17306315 17976673 19168569 | |
| MESH:D008175 | Lung Neoplasms | arsenic trioxide | 37.52 | 19825857 11798837 | |
| MESH:D008175 | Lung Neoplasms | arsenite | 37.52 | 16809336 | |
| MESH:D008175 | Lung Neoplasms | Ascorbic Acid | 37.52 | 16401635 | |
| MESH:D008175 | Lung Neoplasms | Benzo(a)pyrene | 37.52 | 20064080 20464547 6695378 18569708 20869020 18816296 17053015 18520028 20135361 | |
| MESH:D008175 | Lung Neoplasms | chromium hexavalent ion | 37.52 | 16570259 16876463 | |
| MESH:D008175 | Lung Neoplasms | Cisplatin | 37.52 | 6189445 11798837 17225452 | |
| MESH:D008175 | Lung Neoplasms | Curcumin | 37.52 | 19359593 18462866 16243823 | |
| MESH:D008175 | Lung Neoplasms | deguelin | 37.52 | 19336726 16288123 | |
| MESH:D008175 | Lung Neoplasms | Diethylnitrosamine | 37.52 | 21163286 20970405 6695378 20512841 | |
| MESH:D008175 | Lung Neoplasms | Doxorubicin | 37.52 | 17418594 6189445 | |
| MESH:D008175 | Lung Neoplasms | Fluorouracil | 37.52 | 15246190 | |
| MESH:D008175 | Lung Neoplasms | Iron | 37.52 | 16640825 | |
| MESH:D008175 | Lung Neoplasms | Mustard Gas | 37.52 | 8781369 3148597 | |
| MESH:D008175 | Lung Neoplasms | Quercetin | 37.52 | 16280456 | |
| MESH:D008175 | Lung Neoplasms | sodium arsenite | 37.52 | 17306315 17077188 16712894 19931552 15276417 | |
| MESH:D008175 | Lung Neoplasms | Sulindac | 37.52 | 15713900 19359593 | |
| MESH:D008175 | Lung Neoplasms | Tamoxifen | 37.52 | 18625569 | |
| MESH:D008175 | Lung Neoplasms | Tetrachlorodibenzodioxin | 37.52 | 19555203 11884234 | |
| MESH:D008175 | Lung Neoplasms | Tetradecanoylphorbol Acetate | 37.52 | 11807781 | |
| MESH:D008178 | Lupus Erythematosus, Cutaneous | Fluorouracil | 3.71 | 15086387 | |
| MESH:D008223 | Lymphoma | bortezomib | 18.27 | 16098063 | |
| MESH:D008223 | Lymphoma | Curcumin | 18.27 | 18462866 | |
| MESH:D008223 | Lymphoma | Cyclophosphamide | 18.27 | 12854902 | |
| MESH:D008223 | Lymphoma | decitabine | 18.27 | 19470736 | |
| MESH:D008223 | Lymphoma | Doxorubicin | 18.27 | 16098063 | |
| MESH:D008223 | Lymphoma | Nitric Oxide | 18.27 | 16166326 | |
| MESH:D016393 | Lymphoma, B-Cell | bortezomib | 11.54 | 16675587 | |
| MESH:D016393 | Lymphoma, B-Cell | Cyclophosphamide | 11.54 | 16675587 | |
| MESH:D016393 | Lymphoma, B-Cell | resveratrol | 11.54 | 17088997 | |
| MESH:D008228 | Lymphoma, Non-Hodgkin | Cyclophosphamide | 9.28 | 11911406 | |
| MESH:D008228 | Lymphoma, Non-Hodgkin | Doxorubicin | 9.28 | 17654614 | |
| MESH:D008228 | Lymphoma, Non-Hodgkin | resveratrol | 9.28 | 14749477 | |
| MESH:D016399 | Lymphoma, T-Cell | Curcumin | 8.06 | 16173963 | |
| MESH:D016399 | Lymphoma, T-Cell | Doxorubicin | 8.06 | 15621674 | |
| MESH:D008268 | Macular Degeneration | Iron | 3.26 | 16640825 | |
| MESH:D015674 | Mammary Neoplasms, Animal | resveratrol | 6.45 | 15688416 | |
| MESH:D015674 | Mammary Neoplasms, Animal | Tamoxifen | 6.45 | 19428831 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | Doxorubicin | 26.48 | 15458769 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | Estradiol | 26.48 | 11807958 16891317 11408345 17203775 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | Genistein | 26.48 | 12929590 14578162 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | Ibuprofen | 26.48 | 10697514 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | Progesterone | 26.48 | 11408345 17203775 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | resveratrol | 26.48 | 11606380 8985016 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | salinomycin | 26.48 | 19682730 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | Tamoxifen | 26.48 | 11731420 16827153 14580682 19196722 19196723 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | Tetradecanoylphorbol Acetate | 26.48 | 8985016 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | Zinc | 26.48 | 12773700 | |
| MESH:D020149 | Manganese Poisoning | Estradiol | 16.09 | 19453300 | |
| MESH:D020149 | Manganese Poisoning | Manganese | 16.09 | 19453300 16568477 16551646 | |
| MESH:D020149 | Manganese Poisoning | Tamoxifen | 16.09 | 19453300 | |
| MESH:D008527 | Medulloblastoma | bortezomib | 4.91 | 19213072 | |
| MESH:D008527 | Medulloblastoma | Tretinoin | 4.91 | 17453147 | |
| MESH:D008545 | Melanoma | Cisplatin | 21.89 | 11135225 17761969 12374674 17023156 18176117 15577323 12393984 16432458 18332650 16248763 12883367 16809738 18505091 | |
| MESH:D008545 | Melanoma | Curcumin | 21.89 | 18462866 17885582 | |
| MESH:D008545 | Melanoma | decitabine | 21.89 | 17785578 16505122 | |
| MESH:D008545 | Melanoma | Doxorubicin | 21.89 | 16827129 | |
| MESH:D008545 | Melanoma | epigallocatechin gallate | 21.89 | 11746506 17992120 | |
| MESH:D008545 | Melanoma | Reactive Oxygen Species | 21.89 | 17992120 | |
| MESH:D008545 | Melanoma | resveratrol | 21.89 | 17992120 | |
| MESH:D008545 | Melanoma | Sirolimus | 21.89 | 19282848 | |
| MESH:D008545 | Melanoma | sodium arsenite | 21.89 | 19082730 16487513 | |
| MESH:D008545 | Melanoma | Sulindac | 21.89 | 16642371 | |
| MESH:D008545 | Melanoma | Tamoxifen | 21.89 | 12393984 19393235 | |
| MESH:D008545 | Melanoma | Tretinoin | 21.89 | 16752155 | |
| MESH:D018328 | Melanoma, Amelanotic | Cisplatin | 7.94 | 15990972 | |
| MESH:D018328 | Melanoma, Amelanotic | Tamoxifen | 7.94 | 15990972 | |
| MESH:D008546 | Melanoma, Experimental | Acetaminophen | 7.33 | 19513568 | |
| MESH:D008546 | Melanoma, Experimental | Cyclophosphamide | 7.33 | 16388313 | |
| MESH:D008569 | Memory Disorders | Curcumin | 3.13 | 17263510 | |
| MESH:D008591 | Meningomyelocele | Tretinoin | 3.36 | 16940565 | |
| MESH:D007706 | Menkes Kinky Hair Syndrome | Copper | 4.80 | 17268249 17109627 | |
| MESH:D008654 | Mesothelioma | Asbestos, Crocidolite | 6.80 | 18303189 16966607 16166281 | |
| MESH:D008654 | Mesothelioma | Cisplatin | 6.80 | 17638057 | |
| MESH:D008654 | Mesothelioma | Doxorubicin | 6.80 | 17638057 | |
| MESH:D008659 | Metabolic Diseases | phenylmethylpyrazolone | 7.74 | 16301206 | |
| MESH:D008659 | Metabolic Diseases | resveratrol | 7.74 | 17112576 | |
| MESH:D008664 | Metal Metabolism, Inborn Errors | Cyclosporine | 3.69 | 16801185 | |
| MESH:D008881 | Migraine Disorders | Nitric Oxide | 3.46 | 11701602 | |
| MESH:D020326 | Migraine without Aura | Nitric Oxide | 4.08 | 11304026 14659530 | |
| MESH:D028361 | Mitochondrial Diseases | Doxorubicin | 3.50 | 15792986 | |
| MESH:D009062 | Mouth Neoplasms | Benzo(a)pyrene | 9.35 | 16381670 | |
| MESH:D009062 | Mouth Neoplasms | Fluorouracil | 9.35 | 16757204 18986760 | |
| MESH:D009062 | Mouth Neoplasms | Sirolimus | 9.35 | 19435901 | |
| MESH:D009069 | Movement Disorders | Manganese | 3.99 | 16551646 | |
| MESH:D052016 | Mucositis | Doxorubicin | 3.71 | 17415656 | |
| MESH:D009101 | Multiple Myeloma | arsenic trioxide | 13.73 | 11468182 19417148 14977855 15949261 19549372 | |
| MESH:D009101 | Multiple Myeloma | bortezomib | 13.73 | 19112201 19372569 19112817 | |
| MESH:D009101 | Multiple Myeloma | Curcumin | 13.73 | 19372569 | |
| MESH:D009101 | Multiple Myeloma | decitabine | 13.73 | 18172295 | |
| MESH:D009101 | Multiple Myeloma | resveratrol | 13.73 | 16267019 17049120 17935668 16490592 17164350 14749477 | |
| MESH:D020528 | Multiple Sclerosis, Chronic Progressive | Aluminum | 10.86 | 17086897 | |
| MESH:D020528 | Multiple Sclerosis, Chronic Progressive | Iron | 10.86 | 17086897 | |
| MESH:D020529 | Multiple Sclerosis, Relapsing-Remitting | Aluminum | 5.28 | 17086897 | |
| MESH:D009134 | Muscular Atrophy, Spinal | Curcumin | 14.95 | 17962980 | |
| MESH:D009134 | Muscular Atrophy, Spinal | epigallocatechin gallate | 14.95 | 17962980 | |
| MESH:D009134 | Muscular Atrophy, Spinal | resveratrol | 14.95 | 17962980 | |
| MESH:D009135 | Muscular Diseases | pirinixic acid | 2.46 | 16239165 | |
| MESH:D009137 | Muscular Dystrophy, Animal | Gentamicins | 5.17 | 18694830 | |
| MESH:D009139 | Musculoskeletal Abnormalities | sodium arsenate | 3.86 | 18186108 | |
| MESH:D009181 | Mycoses | Iron | 4.37 | 16640825 | |
| MESH:D009182 | Mycosis Fungoides | arsenic trioxide | 3.57 | 18349030 | |
| MESH:D009190 | Myelodysplastic Syndromes | arsenic trioxide | 11.50 | 16105982 16882451 | |
| MESH:D009190 | Myelodysplastic Syndromes | decitabine | 11.50 | 19157545 16882708 19010910 18608210 | |
| MESH:D009190 | Myelodysplastic Syndromes | SU 5416 | 11.50 | 12649163 | |
| MESH:D009190 | Myelodysplastic Syndromes | Tretinoin | 11.50 | 17596541 | |
| MESH:D009203 | Myocardial Infarction | Doxorubicin | 11.32 | 19429709 15857846 | |
| MESH:D009203 | Myocardial Infarction | Genistein | 11.32 | 17141266 | |
| MESH:D009203 | Myocardial Infarction | pirinixic acid | 11.32 | 19151258 | |
| MESH:D009203 | Myocardial Infarction | Quercetin | 11.32 | 19595682 | |
| MESH:D009203 | Myocardial Infarction | resveratrol | 11.32 | 17015251 17188708 16456233 16525036 16317513 17125593 | |
| MESH:D017202 | Myocardial Ischemia | Arsenic | 14.40 | 15371236 | |
| MESH:D017202 | Myocardial Ischemia | Iron | 14.40 | 16604332 | |
| MESH:D017202 | Myocardial Ischemia | resveratrol | 14.40 | 17015251 17125593 | |
| MESH:D017202 | Myocardial Ischemia | Tetrachlorodibenzodioxin | 14.40 | 12213967 | |
| MESH:D015428 | Myocardial Reperfusion Injury | Estradiol | 17.23 | 16810080 | |
| MESH:D015428 | Myocardial Reperfusion Injury | Genistein | 17.23 | 17141266 | |
| MESH:D015428 | Myocardial Reperfusion Injury | Iron | 17.23 | 16604332 | |
| MESH:D015428 | Myocardial Reperfusion Injury | pirinixic acid | 17.23 | 16411023 | |
| MESH:D015428 | Myocardial Reperfusion Injury | Quercetin | 17.23 | 19207477 | |
| MESH:D009205 | Myocarditis | resveratrol | 3.68 | 17322642 | |
| MESH:D009361 | Neoplasm Invasiveness | arsenic trioxide | 6.90 | 16624393 | |
| MESH:D009361 | Neoplasm Invasiveness | Curcumin | 6.90 | 18495463 | |
| MESH:D009362 | Neoplasm Metastasis | Acetylcysteine | 11.54 | 14720322 | |
| MESH:D009362 | Neoplasm Metastasis | capecitabine | 11.54 | 12972520 | |
| MESH:D009362 | Neoplasm Metastasis | Diethylnitrosamine | 11.54 | 9029167 3581430 | |
| MESH:D009362 | Neoplasm Metastasis | Doxorubicin | 11.54 | 18259882 | |
| MESH:D009362 | Neoplasm Metastasis | Tamoxifen | 11.54 | 19393235 | |
| MESH:D009364 | Neoplasm Recurrence, Local | Tamoxifen | 2.03 | 19410462 | |
| MESH:D009369 | Neoplasms | 2,4,5,2',4',5'-hexachlorobiphenyl | 32.15 | 8820588 | |
| MESH:D009369 | Neoplasms | Benzo(a)pyrene | 32.15 | 11141357 | |
| MESH:D009369 | Neoplasms | capecitabine | 32.15 | 16374040 | |
| MESH:D009369 | Neoplasms | Cisplatin | 32.15 | 16773208 | |
| MESH:D009369 | Neoplasms | Cyclophosphamide | 32.15 | 18854779 | |
| MESH:D009369 | Neoplasms | decitabine | 32.15 | 19470736 19116145 17925555 | |
| MESH:D009369 | Neoplasms | deguelin | 32.15 | 17764071 | |
| MESH:D009369 | Neoplasms | Fluorouracil | 32.15 | 18239605 18600527 16928823 | |
| MESH:D009369 | Neoplasms | pirinixic acid | 32.15 | 17405874 | |
| MESH:D009369 | Neoplasms | Quercetin | 32.15 | 15185748 | |
| MESH:D009369 | Neoplasms | sodium arsenite | 32.15 | 11559025 | |
| MESH:D009369 | Neoplasms | SU 5416 | 32.15 | 17264769 | |
| MESH:D009369 | Neoplasms | Tretinoin | 32.15 | 16594593 16946489 | |
| MESH:D009374 | Neoplasms, Experimental | resveratrol | 5.77 | 8985016 | |
| MESH:D009374 | Neoplasms, Experimental | sodium arsenite | 5.77 | 20056578 | |
| MESH:D009376 | Neoplasms, Hormone-Dependent | Curcumin | 7.22 | 12497104 | |
| MESH:D009376 | Neoplasms, Hormone-Dependent | Tamoxifen | 7.22 | 19189210 19196722 19200415 | |
| MESH:D009389 | Neovascularization, Pathologic | arsenite | 10.94 | 15738583 | |
| MESH:D009389 | Neovascularization, Pathologic | Copper | 10.94 | 17308104 | |
| MESH:D009389 | Neovascularization, Pathologic | Estradiol | 10.94 | 17289903 | |
| MESH:D009395 | Nephritis, Interstitial | Cisplatin | 11.71 | 15464296 | |
| MESH:D009395 | Nephritis, Interstitial | Ibuprofen | 11.71 | 6375363 | |
| MESH:D009395 | Nephritis, Interstitial | Nitrofurantoin | 11.71 | 19214031 | |
| MESH:D009401 | Nephrosis | Doxorubicin | 3.71 | 16899518 16636307 | |
| MESH:D009402 | Nephrosis, Lipoid | Cyclosporine | 3.34 | 17954296 | |
| MESH:D009404 | Nephrotic Syndrome | Cyclosporine | 10.32 | 18481113 19348381 | |
| MESH:D009404 | Nephrotic Syndrome | Doxorubicin | 10.32 | 16889571 15640375 | |
| MESH:D009404 | Nephrotic Syndrome | Iron | 10.32 | 17178036 | |
| MESH:D009410 | Nerve Degeneration | 1-Methyl-4-phenylpyridinium | 12.84 | 17433543 | |
| MESH:D009410 | Nerve Degeneration | Ibuprofen | 12.84 | 10961664 | |
| MESH:D009410 | Nerve Degeneration | Manganese | 12.84 | 16551646 | |
| MESH:D009410 | Nerve Degeneration | Rotenone | 12.84 | 15790535 18619942 17356569 | |
| MESH:D009421 | Nervous System Malformations | bisphenol A | 19.95 | 16427766 11399458 | |
| MESH:D009421 | Nervous System Malformations | Estradiol | 19.95 | 16427766 11399458 | |
| MESH:D009421 | Nervous System Malformations | Genistein | 19.95 | 16427766 | |
| MESH:D009421 | Nervous System Malformations | Tetrachlorodibenzodioxin | 19.95 | 14600291 | |
| MESH:D009421 | Nervous System Malformations | Tretinoin | 19.95 | 9125849 | |
| MESH:D009423 | Nervous System Neoplasms | Curcumin | 4.53 | 18462866 | |
| MESH:D009436 | Neural Tube Defects | Acetylcysteine | 17.99 | 19446573 | |
| MESH:D009436 | Neural Tube Defects | Arsenic | 17.99 | 16620997 | |
| MESH:D009436 | Neural Tube Defects | arsenic trioxide | 17.99 | 10525206 | |
| MESH:D009436 | Neural Tube Defects | sodium arsenate | 17.99 | 10525206 18186108 19446573 11749123 | |
| MESH:D009436 | Neural Tube Defects | sodium arsenite | 17.99 | 12854658 | |
| MESH:D009436 | Neural Tube Defects | Tretinoin | 17.99 | 9142499 | |
| MESH:D019954 | Neurobehavioral Manifestations | 2,3',4,4',5-pentachlorobiphenyl | 5.45 | 19647017 | |
| MESH:D009447 | Neuroblastoma | Cisplatin | 10.51 | 8761367 | |
| MESH:D009447 | Neuroblastoma | Cyclophosphamide | 10.51 | 15176712 8761367 16115947 | |
| MESH:D009447 | Neuroblastoma | Doxorubicin | 10.51 | 15555623 | |
| MESH:D009447 | Neuroblastoma | Topotecan | 10.51 | 15176712 | |
| MESH:D019636 | Neurodegenerative Diseases | 1-Methyl-4-phenylpyridinium | 20.93 | 16353238 | |
| MESH:D019636 | Neurodegenerative Diseases | Acetaminophen | 20.93 | 18514411 | |
| MESH:D019636 | Neurodegenerative Diseases | Diethylnitrosamine | 20.93 | 20387270 | |
| MESH:D019636 | Neurodegenerative Diseases | Iron | 20.93 | 17296847 16604332 | |
| MESH:D019636 | Neurodegenerative Diseases | resveratrol | 20.93 | 17652729 | |
| MESH:D019636 | Neurodegenerative Diseases | Sulindac | 20.93 | 16850258 17266991 | |
| MESH:D017599 | Neuroectodermal Tumors | Cisplatin | 7.96 | 8761367 | |
| MESH:D017599 | Neuroectodermal Tumors | Cyclophosphamide | 7.96 | 8761367 12837982 | |
| MESH:D020078 | Neurogenic Inflammation | Arsenic | 11.98 | 17056641 | |
| MESH:D020078 | Neurogenic Inflammation | Quercetin | 11.98 | 17929310 | |
| MESH:D020078 | Neurogenic Inflammation | resveratrol | 11.98 | 17929310 | |
| MESH:D009461 | Neurologic Manifestations | Diethylnitrosamine | 4.02 | 20387270 | |
| MESH:D020258 | Neurotoxicity Syndromes | Fluorouracil | 2.62 | 16436463 | |
| MESH:D009503 | Neutropenia | Cyclophosphamide | 6.19 | 8291058 | |
| MESH:D009503 | Neutropenia | Mustard Gas | 6.19 | 7688884 16761898 | |
| MESH:D009669 | Nose Neoplasms | chromium hexavalent ion | 4.07 | 16876463 | |
| MESH:D009765 | Obesity | Ascorbic Acid | 4.95 | 17217161 | |
| MESH:D009765 | Obesity | Curcumin | 4.95 | 19297423 | |
| MESH:D009765 | Obesity | pirinixic acid | 4.95 | 20558911 | |
| MESH:D009845 | Oligospermia | Cyclophosphamide | 3.64 | 16517039 | |
| MESH:D010003 | Osteoarthritis | Diclofenac | 8.41 | 18287210 | |
| MESH:D010003 | Osteoarthritis | Ibuprofen | 8.41 | 7009135 | |
| MESH:D010003 | Osteoarthritis | Iron | 8.41 | 16640825 | |
| MESH:D010024 | Osteoporosis | Curcumin | 7.49 | 18719352 | |
| MESH:D010024 | Osteoporosis | Genistein | 7.49 | 19401787 | |
| MESH:D010024 | Osteoporosis | Iron | 7.49 | 16640825 16648989 | |
| MESH:D015663 | Osteoporosis, Postmenopausal | Genistein | 11.07 | 16169203 | |
| MESH:D015663 | Osteoporosis, Postmenopausal | Quercetin | 11.07 | 19495926 | |
| MESH:D015663 | Osteoporosis, Postmenopausal | resveratrol | 11.07 | 17513867 | |
| MESH:D012516 | Osteosarcoma | Doxorubicin | 3.19 | 15930896 | |
| MESH:D010049 | Ovarian Diseases | bisphenol A | 3.90 | 11985600 | |
| MESH:D010051 | Ovarian Neoplasms | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one | 34.70 | 16211241 | |
| MESH:D010051 | Ovarian Neoplasms | Arsenic | 34.70 | 17306315 | |
| MESH:D010051 | Ovarian Neoplasms | arsenic trioxide | 34.70 | 12452020 19769630 16624393 | |
| MESH:D010051 | Ovarian Neoplasms | Cisplatin | 34.70 | 15464296 19769630 17225452 6897625 | |
| MESH:D010051 | Ovarian Neoplasms | Curcumin | 34.70 | 18462866 19020741 | |
| MESH:D010051 | Ovarian Neoplasms | decitabine | 34.70 | 19259094 19331143 | |
| MESH:D010051 | Ovarian Neoplasms | Estradiol | 34.70 | 19401270 | |
| MESH:D010051 | Ovarian Neoplasms | Genistein | 34.70 | 19005980 | |
| MESH:D010051 | Ovarian Neoplasms | Progesterone | 34.70 | 17393432 16525653 | |
| MESH:D010051 | Ovarian Neoplasms | Quercetin | 34.70 | 19005980 | |
| MESH:D010051 | Ovarian Neoplasms | sodium arsenite | 34.70 | 15276417 17306315 | |
| MESH:D010051 | Ovarian Neoplasms | Tretinoin | 34.70 | 16936753 | |
| MESH:D010051 | Ovarian Neoplasms | U 0126 | 34.70 | 16211241 | |
| MESH:D010146 | Pain | Acetaminophen | 14.79 | 16870215 | |
| MESH:D010146 | Pain | Cyclophosphamide | 14.79 | 18093676 12161096 | |
| MESH:D010146 | Pain | Diclofenac | 14.79 | 13679232 | |
| MESH:D010146 | Pain | Ibuprofen | 14.79 | 3291741 | |
| MESH:D010146 | Pain | Sulindac | 14.79 | 3291741 | |
| MESH:D010146 | Pain | Tretinoin | 14.79 | 16870215 | |
| MESH:D010149 | Pain, Postoperative | Ibuprofen | 4.05 | 16678543 | |
| MESH:D010190 | Pancreatic Neoplasms | marker/mechanism | 16628086 | ||
| MESH:D010190 | Pancreatic Neoplasms | arsenic trioxide | 41.10 | 15580305 | |
| MESH:D010190 | Pancreatic Neoplasms | Cisplatin | 41.10 | 19003803 | |
| MESH:D010190 | Pancreatic Neoplasms | Curcumin | 41.10 | 19401701 17440100 19196508 | |
| MESH:D010190 | Pancreatic Neoplasms | Cyclophosphamide | 41.10 | 11332152 | |
| MESH:D010190 | Pancreatic Neoplasms | decitabine | 41.10 | 19294695 | |
| MESH:D010190 | Pancreatic Neoplasms | Diethylnitrosamine | 41.10 | 16540662 | |
| MESH:D010190 | Pancreatic Neoplasms | Fluorouracil | 41.10 | 19003803 16929163 15113037 16500647 | |
| MESH:D010190 | Pancreatic Neoplasms | gemcitabine | 41.10 | 11504793 18383843 18992248 16929163 17440100 | |
| MESH:D010190 | Pancreatic Neoplasms | Ibuprofen | 41.10 | 12384795 | |
| MESH:D010190 | Pancreatic Neoplasms | Quercetin | 41.10 | 16965848 | |
| MESH:D010190 | Pancreatic Neoplasms | Reactive Oxygen Species | 41.10 | 15580305 | |
| MESH:D010190 | Pancreatic Neoplasms | Sulindac | 41.10 | 11504793 16820089 | |
| MESH:D010190 | Pancreatic Neoplasms | Tetradecanoylphorbol Acetate | 41.10 | 15976015 | |
| MESH:D010190 | Pancreatic Neoplasms | Tretinoin | 41.10 | 15976015 | |
| MESH:D010195 | Pancreatitis | phenylmethylpyrazolone | 3.91 | 20035747 | |
| MESH:D010212 | Papilloma | Hydrogen Peroxide | 9.73 | 12065085 | |
| MESH:D010212 | Papilloma | Iron | 9.73 | 12065085 | |
| MESH:D010212 | Papilloma | Tetradecanoylphorbol Acetate | 9.73 | 18404319 8330346 12065085 18922899 | |
| MESH:D010235 | Paraganglioma | arsenic trioxide | 3.15 | 19927285 | |
| MESH:D020447 | Parasomnias | Iron | 4.92 | 17352947 | |
| MESH:D010300 | Parkinson Disease | 1-Methyl-4-phenylpyridinium | 10.24 | 17433543 | |
| MESH:D010300 | Parkinson Disease | Iron | 10.24 | 16640825 16563566 | |
| MESH:D010300 | Parkinson Disease | Manganese | 10.24 | 11181820 | |
| MESH:D010300 | Parkinson Disease | Rotenone | 10.24 | 11535288 19232380 19114014 16412576 15451049 18191903 11445065 16140633 18619942 | |
| MESH:D010300 | Parkinson Disease | Sirolimus | 10.24 | 19682553 | |
| MESH:D020734 | Parkinsonian Disorders | Manganese | 6.30 | 16140633 | |
| MESH:D020734 | Parkinsonian Disorders | Rotenone | 6.30 | 15795934 18197244 15927086 15574749 | |
| MESH:D010382 | Peliosis Hepatis | Tetrachlorodibenzodioxin | 3.15 | 12520081 | |
| MESH:D010523 | Peripheral Nervous System Diseases | Arsenic | 6.64 | 16093927 | |
| MESH:D010523 | Peripheral Nervous System Diseases | Cisplatin | 6.64 | 15464296 | |
| MESH:D016491 | Peripheral Vascular Diseases | Arsenic | 3.91 | 16905509 6392382 15371236 | |
| MESH:D003557 | Phyllodes Tumor | Doxorubicin | 4.06 | 17983394 | |
| MESH:D010900 | Pituitary Diseases | Iron | 4.57 | 16604332 | |
| MESH:D010995 | Pleural Diseases | Asbestos, Crocidolite | 3.83 | 10923243 | |
| MESH:D010997 | Pleural Neoplasms | Cisplatin | 10.30 | 17638057 | |
| MESH:D010997 | Pleural Neoplasms | Doxorubicin | 10.30 | 17638057 | |
| MESH:D011014 | Pneumonia | Lipopolysaccharides | 3.48 | 12224865 11605937 | |
| MESH:D011015 | Pneumonia, Aspiration | Nitric Oxide | 4.26 | 18573544 | |
| MESH:D011041 | Poisoning | Iron | 5.68 | 16604332 | |
| MESH:D011041 | Poisoning | Mustard Gas | 5.68 | 15727166 | |
| MESH:D017119 | Porphyria Cutanea Tarda | Iron | 7.58 | 16640825 | |
| MESH:D017119 | Porphyria Cutanea Tarda | Tetrachlorodibenzodioxin | 7.58 | 18163543 | |
| MESH:D011230 | Precancerous Conditions | Cyclosporine | 9.84 | 12371664 | |
| MESH:D011230 | Precancerous Conditions | Diethylnitrosamine | 9.84 | 2563599 | |
| MESH:D011230 | Precancerous Conditions | Quercetin | 9.84 | 19056647 | |
| MESH:D054198 | Precursor Cell Lymphoblastic Leukemia-Lymphoma | Cyclophosphamide | 3.08 | 21297632 | |
| MESH:D011225 | Pre-Eclampsia | Iron | 6.55 | 16640825 | |
| MESH:D011225 | Pre-Eclampsia | Zinc | 6.55 | 17114810 | |
| MESH:D011248 | Pregnancy Complications | Nitrofurantoin | 4.75 | 19789166 | |
| MESH:D011297 | Prenatal Exposure Delayed Effects | bisphenol A | 10.13 | 10548101 | |
| MESH:D011297 | Prenatal Exposure Delayed Effects | resveratrol | 10.13 | 16679765 | |
| MESH:D011297 | Prenatal Exposure Delayed Effects | Tetrachlorodibenzodioxin | 10.13 | 11222880 11399792 11896295 11118676 | |
| MESH:D055728 | Primary Myelofibrosis | decitabine | 3.67 | 17616702 | |
| MESH:D019048 | Prostatic Intraepithelial Neoplasia | bisphenol A | 7.25 | 20887781 | |
| MESH:D019048 | Prostatic Intraepithelial Neoplasia | Estradiol | 7.25 | 20887781 | |
| MESH:D011471 | Prostatic Neoplasms | marker/mechanism | 16205110 | ||
| MESH:D011471 | Prostatic Neoplasms | Apigenin | 10.08 | 17132221 | |
| MESH:D011471 | Prostatic Neoplasms | Arsenic | 10.08 | 16140617 | |
| MESH:D011471 | Prostatic Neoplasms | arsenic trioxide | 10.08 | 19131511 | |
| MESH:D011471 | Prostatic Neoplasms | Benzo(a)pyrene | 10.08 | 17292933 | |
| MESH:D011471 | Prostatic Neoplasms | bisphenol A | 10.08 | 16740699 | |
| MESH:D011471 | Prostatic Neoplasms | Cholecalciferol | 10.08 | 17024972 | |
| MESH:D011471 | Prostatic Neoplasms | Clioquinol | 10.08 | 17308104 | |
| MESH:D011471 | Prostatic Neoplasms | Copper | 10.08 | 17308104 17079463 | |
| MESH:D011471 | Prostatic Neoplasms | Curcumin | 10.08 | 18769126 12497104 15129424 11398177 18226269 10851300 18156803 | |
| MESH:D011471 | Prostatic Neoplasms | Cyclophosphamide | 10.08 | 17136230 | |
| MESH:D011471 | Prostatic Neoplasms | Doxorubicin | 10.08 | 15897917 16888761 18437689 15749863 16729912 16868541 | |
| MESH:D011471 | Prostatic Neoplasms | Estradiol | 10.08 | 16740699 | |
| MESH:D011471 | Prostatic Neoplasms | Fluorouracil | 10.08 | 19082440 18626508 | |
| MESH:D011471 | Prostatic Neoplasms | Genistein | 10.08 | 15256057 15378649 16925846 | |
| MESH:D011471 | Prostatic Neoplasms | Ibuprofen | 10.08 | 17409433 | |
| MESH:D011471 | Prostatic Neoplasms | Quercetin | 10.08 | 17292933 14715546 | |
| MESH:D011471 | Prostatic Neoplasms | resveratrol | 10.08 | 16731767 17804756 17718901 17675339 15767336 17636462 | |
| MESH:D011471 | Prostatic Neoplasms | sodium arsenite | 10.08 | 16039940 | |
| MESH:D011471 | Prostatic Neoplasms | Tamoxifen | 10.08 | 15067354 | |
| MESH:D011471 | Prostatic Neoplasms | Zinc | 10.08 | 16517595 16606632 12429649 16700911 | |
| MESH:D011507 | Proteinuria | Arsenic | 13.87 | 21343184 | |
| MESH:D011507 | Proteinuria | Gentamicins | 13.87 | 15033597 | |
| MESH:D011507 | Proteinuria | Ibuprofen | 13.87 | 6375363 | |
| MESH:D011507 | Proteinuria | Tretinoin | 13.87 | 16636307 | |
| MESH:D011528 | Protozoan Infections | Iron | 4.92 | 16640825 | |
| MESH:D011537 | Pruritus | Mustard Gas | 3.04 | 18058305 | |
| MESH:D011565 | Psoriasis | Cyclosporine | 1.72 | 16882103 | |
| MESH:D011625 | Pterygium | Tretinoin | 3.71 | 16723453 | |
| MESH:D011629 | Puberty, Precocious | bisphenol A | 3.70 | 10548101 | |
| MESH:D011654 | Pulmonary Edema | Nitrofurantoin | 4.70 | 9429087 | |
| MESH:D011656 | Pulmonary Emphysema | Curcumin | 3.55 | 19168576 | |
| MESH:D011657 | Pulmonary Eosinophilia | Ascorbic Acid | 4.24 | 14606601 | |
| MESH:D011658 | Pulmonary Fibrosis | Asbestos, Crocidolite | 11.21 | 17975199 17365031 17322281 15814490 | |
| MESH:D011658 | Pulmonary Fibrosis | Cobalt | 11.21 | 6434250 | |
| MESH:D011658 | Pulmonary Fibrosis | Cyclophosphamide | 11.21 | 16636934 | |
| MESH:D011658 | Pulmonary Fibrosis | Mustard Gas | 11.21 | 17620002 10334151 17894541 17720292 17266442 | |
| MESH:D011658 | Pulmonary Fibrosis | Nitrofurantoin | 11.21 | 1551546 | |
| MESH:D012004 | Rectal Neoplasms | Fluorouracil | 3.06 | 18286688 16160472 18722050 15538739 | |
| MESH:D051437 | Renal Insufficiency | Cisplatin | 11.23 | 15464296 | |
| MESH:D051437 | Renal Insufficiency | Doxorubicin | 11.23 | 17922066 | |
| MESH:D051437 | Renal Insufficiency | Gentamicins | 11.23 | 17132701 15728788 | |
| MESH:D051436 | Renal Insufficiency, Chronic | resveratrol | 4.48 | 16325855 | |
| MESH:D015427 | Reperfusion Injury | phenylmethylpyrazolone | 7.14 | 15086910 14654979 16041266 15629865 15948865 16753835 | |
| MESH:D015427 | Reperfusion Injury | pirinixic acid | 7.14 | 19058328 | |
| MESH:D015427 | Reperfusion Injury | resveratrol | 7.14 | 17520802 16314181 15827377 17058453 16317513 | |
| MESH:D012128 | Respiratory Distress Syndrome, Adult | Acetylcysteine | 9.61 | 12210543 | |
| MESH:D012128 | Respiratory Distress Syndrome, Adult | Curcumin | 9.61 | 18379247 10666014 | |
| MESH:D012128 | Respiratory Distress Syndrome, Adult | Oxygen | 9.61 | 17627322 18339021 | |
| MESH:D012130 | Respiratory Hypersensitivity | Lipopolysaccharides | 2.93 | 10835634 | |
| MESH:D015619 | Respiratory System Abnormalities | Tetrachlorodibenzodioxin | 2.80 | 18990726 | |
| MESH:D012148 | Restless Legs Syndrome | Iron | 3.66 | 16930377 | |
| MESH:D012162 | Retinal Degeneration | Zinc | 3.25 | 16584753 | |
| MESH:D012173 | Retinitis | Gentamicins | 5.17 | 18644591 | |
| MESH:D012174 | Retinitis Pigmentosa | Ascorbic Acid | 2.88 | 16849425 | |
| MESH:D012208 | Rhabdomyosarcoma | decitabine | 7.57 | 19155313 | |
| MESH:D012208 | Rhabdomyosarcoma | Tretinoin | 7.57 | 16283617 16116481 | |
| MESH:D012468 | Salivary Gland Neoplasms | Progesterone | 2.33 | 18045962 | |
| MESH:D012509 | Sarcoma | Curcumin | 6.35 | 18462866 | |
| MESH:D012509 | Sarcoma | Doxorubicin | 6.35 | 15625365 17203757 16767912 15675481 17710206 18313854 | |
| MESH:D012512 | Sarcoma, Ewing's | arsenic trioxide | 11.34 | 16646077 | |
| MESH:D012512 | Sarcoma, Ewing's | Cisplatin | 11.34 | 14601052 | |
| MESH:D012512 | Sarcoma, Ewing's | Doxorubicin | 11.34 | 14601052 16326096 | |
| MESH:D012514 | Sarcoma, Kaposi | Doxorubicin | 3.71 | 17846226 | |
| MESH:D012554 | Schistosomiasis japonica | Quercetin | 4.44 | 16862918 | |
| MESH:D012555 | Schistosomiasis mansoni | Nitric Oxide | 4.41 | 9673227 | |
| MESH:D012559 | Schizophrenia | Copper | 2.90 | 16842975 | |
| MESH:D012595 | Scleroderma, Systemic | Cyclophosphamide | 3.80 | 16636934 | |
| MESH:D018805 | Sepsis | Curcumin | 3.15 | 18389075 | |
| MESH:D012871 | Skin Diseases | Arsenic | 5.42 | 17050553 19834688 17548696 18709164 6392382 17453740 16759981 16353154 16702368 15952646 17938729 | |
| MESH:D012871 | Skin Diseases | Ascorbic Acid | 5.42 | 18709164 | |
| MESH:D012871 | Skin Diseases | Mustard Gas | 5.42 | 15451306 12880345 16961503 | |
| MESH:D012878 | Skin Neoplasms | marker/mechanism | 19276359 | ||
| MESH:D012878 | Skin Neoplasms | Arsenic | 34.98 | 17976673 15504454 17029826 19538983 16251483 17050553 | |
| MESH:D012878 | Skin Neoplasms | Benzo(a)pyrene | 34.98 | 19755658 10029692 | |
| MESH:D012878 | Skin Neoplasms | deguelin | 34.98 | 16041863 | |
| MESH:D012878 | Skin Neoplasms | Doxorubicin | 34.98 | 15692506 | |
| MESH:D012878 | Skin Neoplasms | Hydrogen Peroxide | 34.98 | 12065085 | |
| MESH:D012878 | Skin Neoplasms | Iron | 34.98 | 12065085 | |
| MESH:D012878 | Skin Neoplasms | resveratrol | 34.98 | 15837718 8985016 | |
| MESH:D012878 | Skin Neoplasms | sodium arsenite | 34.98 | 19524636 18572023 | |
| MESH:D012878 | Skin Neoplasms | tert-Butylhydroperoxide | 34.98 | 8532709 | |
| MESH:D012878 | Skin Neoplasms | Tetrachlorodibenzodioxin | 34.98 | 16192470 | |
| MESH:D012878 | Skin Neoplasms | Tetradecanoylphorbol Acetate | 34.98 | 8330346 12065085 18404319 8985016 11807781 | |
| MESH:D012878 | Skin Neoplasms | Tretinoin | 34.98 | 16467112 | |
| MESH:D055752 | Small Cell Lung Carcinoma | Cisplatin | 4.24 | 15464296 | |
| MESH:D012983 | Soft Tissue Neoplasms | Doxorubicin | 3.51 | 17203757 15625365 16767912 | |
| MESH:D013088 | Spermatocele | Tamoxifen | 3.20 | 16709447 | |
| OMIM:102530 | SPERMATOGENIC FAILURE 6 | Cyclophosphamide | 4.43 | 16517039 | |
| MESH:D013119 | Spinal Cord Injuries | Progesterone | 7.31 | 16503802 15862959 | |
| MESH:D013119 | Spinal Cord Injuries | Tamoxifen | 7.31 | 19457130 | |
| MESH:D016135 | Spinal Dysraphism | sodium arsenite | 2.90 | 12854658 | |
| MESH:D013274 | Stomach Neoplasms | arsenic trioxide | 8.43 | 17007042 | |
| MESH:D013274 | Stomach Neoplasms | Benzo(a)pyrene | 8.43 | 2093021 20155912 | |
| MESH:D013274 | Stomach Neoplasms | Cisplatin | 8.43 | 15958060 17522103 18396642 | |
| MESH:D013274 | Stomach Neoplasms | decitabine | 8.43 | 19037991 | |
| MESH:D013274 | Stomach Neoplasms | Diethylnitrosamine | 8.43 | 18456281 | |
| MESH:D013274 | Stomach Neoplasms | Fluorouracil | 8.43 | 19084572 16424979 15786421 17522103 16951190 18396642 17172411 18567086 17498489 19015929 | |
| MESH:D013274 | Stomach Neoplasms | nitrosobenzylmethylamine | 8.43 | 12958204 17575124 | |
| MESH:D013274 | Stomach Neoplasms | Tretinoin | 8.43 | 17261132 | |
| MESH:D013276 | Stomach Ulcer | Acetylcysteine | 9.40 | 17918041 | |
| MESH:D013276 | Stomach Ulcer | Ascorbic Acid | 9.40 | 18726076 | |
| MESH:D013276 | Stomach Ulcer | Curcumin | 9.40 | 16631530 19188055 | |
| MESH:D013276 | Stomach Ulcer | Nitric Oxide | 9.40 | 15138204 | |
| MESH:D020521 | Stroke | Ascorbic Acid | 3.39 | 16517955 16403987 | |
| OMIM:601367 | STROKE, ISCHEMIC | resveratrol | 3.50 | 16321402 | |
| MESH:D019966 | Substance-Related Disorders | bisphenol A | 2.92 | 16684133 16045194 | |
| MESH:D013398 | Sudden Infant Death | Iron | 9.74 | 16640825 | |
| MESH:D013398 | Sudden Infant Death | Oxygen | 9.74 | 12563064 | |
| MESH:D015173 | Supratentorial Neoplasms | Cyclophosphamide | 3.98 | 12837982 | |
| MESH:D013610 | Tachycardia | Nitroprusside | 4.58 | 15306635 | |
| MESH:D013736 | Testicular Neoplasms | Cisplatin | 3.61 | 17225452 15464296 | |
| MESH:D013921 | Thrombocytopenia | Lipopolysaccharides | 3.20 | 15821434 | |
| MESH:D013927 | Thrombosis | SU 5416 | 4.67 | 12649163 | |
| MESH:D013959 | Thyroid Diseases | Tetrachlorodibenzodioxin | 2.81 | 12697716 | |
| MESH:D013964 | Thyroid Neoplasms | 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine | 20.41 | 16940797 | |
| MESH:D013964 | Thyroid Neoplasms | arsenic trioxide | 20.41 | 19014326 | |
| MESH:D013964 | Thyroid Neoplasms | decitabine | 20.41 | 17967635 | |
| MESH:D013964 | Thyroid Neoplasms | Diethylnitrosamine | 20.41 | 7505956 | |
| MESH:D013964 | Thyroid Neoplasms | Doxorubicin | 20.41 | 17909728 16010429 | |
| MESH:D013964 | Thyroid Neoplasms | Ethylenethiourea | 20.41 | 11940454 | |
| MESH:D013964 | Thyroid Neoplasms | Tretinoin | 20.41 | 17045167 16026305 | |
| MESH:D013978 | Tibial Fractures | Estradiol | 3.59 | 19048282 | |
| MESH:D014062 | Tongue Neoplasms | Fluorouracil | 15.73 | 16280240 | |
| MESH:D014062 | Tongue Neoplasms | resveratrol | 15.73 | 16227395 | |
| MESH:D014062 | Tongue Neoplasms | Tretinoin | 15.73 | 16051514 | |
| MESH:D014062 | Tongue Neoplasms | Zinc | 15.73 | 16543248 | |
| MESH:D016171 | Torsades de Pointes | arsenic trioxide | 2.90 | 15213294 | |
| MESH:D014376 | Tuberculosis | Iron | 5.55 | 16597321 | |
| MESH:D014376 | Tuberculosis | Tretinoin | 5.55 | 16040207 | |
| MESH:D014402 | Tuberous Sclerosis | Sirolimus | 4.53 | 21115397 18495876 | |
| MESH:D001749 | Urinary Bladder Neoplasms | Arsenic | 31.30 | 19429237 11144890 15987713 17976673 17306315 19322015 18640142 | |
| MESH:D001749 | Urinary Bladder Neoplasms | arsenic trioxide | 31.30 | 12845720 20435036 11780464 12973940 | |
| MESH:D001749 | Urinary Bladder Neoplasms | Benzo(a)pyrene | 31.30 | 17053015 | |
| MESH:D001749 | Urinary Bladder Neoplasms | Cisplatin | 31.30 | 17225452 12973940 15464296 | |
| MESH:D001749 | Urinary Bladder Neoplasms | Curcumin | 31.30 | 18593936 | |
| MESH:D001749 | Urinary Bladder Neoplasms | Cyclophosphamide | 31.30 | 14692829 | |
| MESH:D001749 | Urinary Bladder Neoplasms | decitabine | 31.30 | 19087683 17616700 | |
| MESH:D001749 | Urinary Bladder Neoplasms | Doxorubicin | 31.30 | 17653716 | |
| MESH:D001749 | Urinary Bladder Neoplasms | Nitrofurantoin | 31.30 | 15028437 | |
| MESH:D001749 | Urinary Bladder Neoplasms | Quercetin | 31.30 | 16720314 | |
| MESH:D001749 | Urinary Bladder Neoplasms | sodium arsenite | 31.30 | 16452187 17306315 11723127 16712894 | |
| MESH:D001749 | Urinary Bladder Neoplasms | Tamoxifen | 31.30 | 17572228 16712894 8653321 | |
| MESH:D014552 | Urinary Tract Infections | Nitrofurantoin | 5.49 | 1551546 | |
| MESH:D014565 | Urogenital Neoplasms | Curcumin | 4.18 | 18462866 | |
| MESH:D014581 | Urticaria | Acetaminophen | 1.99 | 10982225 | |
| MESH:D002583 | Uterine Cervical Neoplasms | Cisplatin | 19.49 | 16803524 | |
| MESH:D002583 | Uterine Cervical Neoplasms | Fluorouracil | 19.49 | 16803524 | |
| MESH:D002583 | Uterine Cervical Neoplasms | resveratrol | 19.49 | 17473185 | |
| MESH:D002583 | Uterine Cervical Neoplasms | sodium arsenite | 19.49 | 11813266 | |
| MESH:D002583 | Uterine Cervical Neoplasms | Tretinoin | 19.49 | 16129372 | |
| MESH:D014591 | Uterine Diseases | bisphenol A | 3.91 | 14652134 | |
| MESH:D014594 | Uterine Neoplasms | resveratrol | 6.56 | 17044934 | |
| MESH:D014594 | Uterine Neoplasms | Sulindac | 6.56 | 18645019 | |
| MESH:D014604 | Uveal Neoplasms | decitabine | 9.19 | 17785578 | |
| MESH:D014604 | Uveal Neoplasms | Tretinoin | 9.19 | 16752155 | |
| MESH:D014605 | Uveitis | Cyclosporine | 8.44 | 1336536 | |
| MESH:D014605 | Uveitis | Sirolimus | 8.44 | 1336536 | |
| MESH:D014625 | Vaginal Neoplasms | Cisplatin | 3.56 | 15577323 | |
| MESH:D014652 | Vascular Diseases | Arsenic | 8.27 | 17056641 | |
| MESH:D014652 | Vascular Diseases | sodium arsenite | 8.27 | 17056641 | |
| MESH:D054079 | Vascular Malformations | Tetrachlorodibenzodioxin | 3.49 | 12125929 | |
| MESH:D020301 | Vasospasm, Intracranial | Ibuprofen | 4.12 | 19057314 | |
| MESH:D018487 | Ventricular Dysfunction, Left | Doxorubicin | 6.85 | 17334414 17638931 17678736 16364871 | |
| MESH:D018487 | Ventricular Dysfunction, Left | resveratrol | 6.85 | 17488730 | |
| MESH:D015837 | Vestibular Diseases | Gentamicins | 4.48 | 18776599 | |
| MESH:D014820 | Vitiligo | Tretinoin | 3.02 | 16761959 | |
| MESH:D014839 | Vomiting | Cisplatin | 3.63 | 11897121 | |
| MESH:D019282 | Wasting Syndrome | Tetrachlorodibenzodioxin | 3.15 | 15886252 | |
| MESH:D009396 | Wilms Tumor | Tretinoin | 3.01 | 16287080 | |
| MESH:D014947 | Wounds and Injuries | lysophosphatidic acid | 4.39 | 15541073 | |
| MESH:D014985 | Xerophthalmia | Cyclosporine | 3.34 | 17120751 |
| Pathway ID | Pathway Name |
|---|---|
| KEGG:04150 | mTOR signaling pathway |
| KEGG:05200 | Pathways in cancer |
| KEGG:05211 | Renal cell carcinoma |
| Releated gene ID | Related gene Name |
|---|---|
| PA31266 | MT-ND6 |
| Releated disease ID | Related disease Name |
|---|---|
| PA165111675 | Drug Resistance |
| PA446155 | Precursor Cell Lymphoblastic Leukemia-Lymphoma |
| PA445062 | Neoplasms |
| Releated drug ID | Related drug Name |
|---|---|
| PA164743471 | adenosine triphosphate |
| PA449773 | glucose |
| PA164778686 | pyruvic acid |
| PA130232992 | bevacizumab |
| PA449212 | daunorubicin |
| PA449412 | doxorubicin |
| PA449552 | etoposide |
| PA450526 | mitoxantrone |
| PA164747225 | l-citrulline |
| PA134967247 | 2-methoxyestradiol |
| PA448478 | l-arginine |
| PA450635 | nitric oxide |
| Drugbank ID | Action | Drug Name | Description |
|---|---|---|---|
| DB08687 | - | N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE |
| No data |
| No data |
| No data |