AutismKB 2.0

Annotation Detail for HIP1


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Basic Information Top
Gene Symbol:HIP1 ( ILWEQ,MGC126506 )
Gene Full Name: huntingtin interacting protein 1
Band: 7q11.23
Quick LinksEntrez ID:3092; OMIM: 601767; Uniprot ID:HIP1_HUMAN; ENSEMBL ID: ENSG00000127946; HGNC ID: 4913
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05016Huntington's disease
No data
Pathway IDPathway Name
200038Coregulation of Androgen receptor activity
Pathway IDPathway Name
P00029Huntington disease
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2053Colon cancer
No data
No data
Desease Name
Prostate cancer, progression of
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of HIP1 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of HIP1 mRNAdecreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of HIP1 mRNAdecreases expression 17555576
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HIP1 mRNAaffects cotreatment|increases expression 17942748
C011890 kojic acid kojic acid results in increased expression of HIP1 mRNAincreases expression 16595896
D009151 Mustard Gas Mustard Gas affects the expression of HIP1 mRNAaffects expression 15651846
C029938 nickel sulfate nickel sulfate results in increased expression of HIP1 mRNAincreases expression 16780908
D013629 Tamoxifen Tamoxifen results in increased expression of HIP1 mRNAincreases expression 15590111
C020806 tetrabromobisphenol A tetrabromobisphenol A affects the expression of HIP1 mRNAaffects expression 18976794
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of HIP1 mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HIP1 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of HIP1 mRNAincreases expression 15800033
15328365
C025643 vinclozolin vinclozolin affects the expression of HIP1 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.8114745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0811752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2117505938
MESH:D055371 Acute Lung Injury nickel sulfate 4.4911954676 12718980 19131640 16100012
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.3020127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3014692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.746695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D001008 Anxiety Disorders vinclozolin 3.7819015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2919183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7615885639
MESH:D001249 Asthma Mustard Gas 2.7510378619
MESH:D001768 Blister Mustard Gas 5.4019167455
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.7920146248 17474063
MESH:D001943 Breast Neoplasms Tamoxifen 1.7918821012 18629630 19410462 20135344 19103187 19142967 20065188 17893378 17261762 19189210 21152245 18351453 19200415 11161223 21138602 19084267 16273361 19115204 18997820 19155303 18984771 19221464 17242785 15668708 20005174 16202921 19066611 18855134 20390343 18815881 19059307 19011961 17049068 15565566 19288272 19189212 18425577 20859285 19244106 16873071 19289846 17440819 16818667 20544844 19487384
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.7920435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.4015286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.2417687719 10378619
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.7219066611
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 1.8416924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0920419170
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.7817572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4518670907 18850075 16120746
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0011677210 16105132 17333356 16919318 17110522 15861022 17681005
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1615668235 15340226 12621046 8697196 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003456 Cryptorchidism vinclozolin 4.5414966744
MESH:D003711 Demyelinating Diseases Tamoxifen 4.5819031437
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 3.8816780908 16823706 11298694
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.6319279558
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5720420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D004487 Edema Mustard Gas 7.4111402378 9260866 11428631 11428647
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.4111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1718230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.6212538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.6219031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1520544844 16202921 17893378 19155303
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1810568697 9294722
MESH:D004890 Erythema Mustard Gas 5.409357497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0416530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.2715345470
MESH:D005234 Fatty Liver Tamoxifen 8.2714986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3316709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.7614745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.4219069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.1620067830
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.1716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.5716417039
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.7220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7211294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1115340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3118606429 8697196 16354765 15340226 16959395
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9618850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.0317937319
MESH:D007248 Infertility, Male vinclozolin 7.0316467254
MESH:D007249 Inflammation Mustard Gas 8.8111428631 8975870 9357497 11428620 16001271 9260866 11402378 17524151 11428647
MESH:D007249 Inflammation Tamoxifen 8.8119457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.8112200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007680 Kidney Neoplasms Tamoxifen 3.1918625569
MESH:D007984 Leydig Cell Tumor vinclozolin 4.9716417039
MESH:D008064 Lipidoses Tamoxifen 3.2717567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.3318564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3312878042
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.7020195826 21137059
MESH:D008113 Liver Neoplasms Tamoxifen 7.7016684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.7016984957
MESH:D008114 Liver Neoplasms, Experimental kojic acid 6.3618544905
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.3612151625
MESH:D008171 Lung Diseases Mustard Gas 3.5618702808 18161513
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.9817053015 20464547 18520028 18569708 18816296 20064080 20869020 20135361 6695378
MESH:D008175 Lung Neoplasms Mustard Gas 4.983148597 8781369
MESH:D008175 Lung Neoplasms Tamoxifen 4.9818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9811884234 19555203
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.0019428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7319196723 14580682 16827153 19196722 11731420
MESH:D020149 Manganese Poisoning Tamoxifen 4.8119453300
MESH:D008545 Melanoma Tamoxifen 1.9019393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.4215990972
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3216381670
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6019393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5619410462
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2411141357
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.2619189210 19200415 19196722
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4114600291
MESH:D009503 Neutropenia Mustard Gas 4.157688884 16761898
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D011041 Poisoning Mustard Gas 3.9815727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.2911896295 11222880 11118676 11399792
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 10.2919015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 5.1718220299
MESH:D011471 Prostatic Neoplasms marker/mechanism
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.0917292933
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.0915067354
MESH:D011472 Prostatitis vinclozolin 5.1718629315
MESH:D011537 Pruritus Ethinyl Estradiol 10.3316919318 15861022
MESH:D011537 Pruritus Mustard Gas 10.3318058305
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9817720292 17894541 17620002 17266442 10334151
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012871 Skin Diseases Mustard Gas 2.7512880345 15451306 16961503
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.7219755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7216192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.4616709447
MESH:D013088 Spermatocele Tamoxifen 12.4616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.2819457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.1917053015
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.1916712894 17572228 8653321
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5014692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7114671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
Pathway ID Pathway Name
KEGG:05016 Huntington's disease
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29289
    • No data
    Releated disease ID Related disease Name
    PA446794Williams Syndrome
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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