AutismKB 2.0

Annotation Detail for UBE2K


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Basic Information Top
Gene Symbol:UBE2K ( DKFZp564C1216,DKFZp686J24237,E2-25K,HIP2,HYPG,LIG )
Gene Full Name: ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast)
Band: 4p14
Quick LinksEntrez ID:3093; OMIM: 602846; Uniprot ID:UBE2K_HUMAN; ENSEMBL ID: ENSG00000078140; HGNC ID: 4914
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04120Ubiquitin mediated proteolysis
No data
No data
Pathway IDPathway Name
P00060Ubiquitin proteasome pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C049325 1,2-dithiol-3-thione 1,2-dithiol-3-thione results in increased expression of UBE2K mRNAincreases expression 15375163
D001241 Aspirin Aspirin results in increased expression of UBE2K mRNAincreases expression 11906190
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of UBE2K mRNAdecreases expression 20064835
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of UBE2K mRNAincreases expression 15336504
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of UBE2K mRNAincreases expression 17555576
D008466 Mechlorethamine Mechlorethamine results in increased expression of UBE2K mRNAincreases expression 17107856
C006253 pirinixic acid pirinixic acid results in increased expression of UBE2K mRNAincreases expression 15375163
C017947 sodium arsenite TP53 protein affects the reaction [sodium arsenite results in increased expression of UBE2K mRNA]affects reaction|increases expression 16966095
D013629 Tamoxifen Tamoxifen affects the expression of UBE2K mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of UBE2K mRNAincreases expression 19465110
D014028 Tobacco Smoke Pollution Tobacco Smoke Pollution results in increased expression of UBE2K mRNAincreases expression 18087596
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.7614745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0415322242 11752688 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1617505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.2718653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.2820127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.2814692618
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Tobacco Smoke Pollution 5.7515814487
MESH:D000236 Adenoma Benzo(a)pyrene 2.736695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.5616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.5616835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.9215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.1216712894 17306315
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2519183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7415885639
MESH:D001172 Arthritis, Rheumatoid Tobacco Smoke Pollution 3.2119898480
MESH:D055963 Asthma, Aspirin-Induced Aspirin 4.8120485159 12372130
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.2419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.2412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001932 Brain Neoplasms Aspirin 4.5515481559
MESH:D001943 Breast Neoplasms Aspirin 1.9915161893
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9920146248 17474063
MESH:D001943 Breast Neoplasms Tamoxifen 1.9919155303 21138602 18351453 19200415 16273361 18855134 19066611 16202921 18984771 18815881 20005174 19487384 19244106 11161223 18997820 19288272 20065188 17049068 18425577 19084267 19103187 17261762 16818667 19142967 19289846 17440819 19059307 18629630 17242785 20135344 18821012 19115204 15668708 17893378 19011961 15565566 19189210 16873071 19189212 20859285 21152245 20544844 19221464 20390343 19410462
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9920435547
MESH:D002057 Burns, Chemical Mechlorethamine 6.459625245
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.6819066611
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 3.1217306315 16507464 15276417
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 3.1216924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung Tobacco Smoke Pollution 3.4711212258
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.8520419170
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 7.8518572023
MESH:D002294 Carcinoma, Squamous Cell Tobacco Smoke Pollution 7.8511212258
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.7517572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4418850075 18670907 16120746
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 3.0819524636 20056578
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002779 Cholestasis Ethinyl Estradiol 8.0916105132 15861022 16919318 17333356 11677210 17110522 17681005
MESH:D002779 Cholestasis pirinixic acid 8.0919176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1515668235 15340226 12621046 16354765 8697196
MESH:D003110 Colonic Neoplasms Aspirin 3.0012411196
MESH:D015179 Colorectal Neoplasms Aspirin 2.7517047198
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1817141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 10048152 15322242
MESH:D003711 Demyelinating Diseases Tamoxifen 4.5419031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.6019279558
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5720420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D004487 Edema Aspirin 12.3317259670
MESH:D004487 Edema pirinixic acid 12.3312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 12.3312711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1218230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.4912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.4919031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1317893378 19155303 20544844 16202921
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.159294722 10568697
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0416530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.8715345470
MESH:D005234 Fatty Liver pirinixic acid 13.8719236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 13.8714986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3116709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.7214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.3819069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.1220067830
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.8716452187
MESH:D005909 Glioblastoma Aspirin 4.0412870263
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006261 Headache Aspirin 5.1815240983
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.6720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6710048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6220558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006529 Hepatomegaly pirinixic acid 8.8516221962 18467677 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.8512621046 15340226 16120746
MESH:D006689 Hodgkin Disease sodium arsenite 3.2712676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2616354765 15340226 8697196 18606429 16959395
MESH:D012001 Hyperacusis Aspirin 5.9815240983
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9518670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9816569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.9517937319
MESH:D007248 Infertility, Male sodium arsenite 6.9515346721 12646999
MESH:D007249 Inflammation Tamoxifen 8.8019457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.8012878042 12200463
MESH:D007249 Inflammation Tobacco Smoke Pollution 8.8018590791
MESH:D007333 Insulin Resistance pirinixic acid 2.7216306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007674 Kidney Diseases sodium arsenite 2.8720008137
MESH:D007680 Kidney Neoplasms Tamoxifen 3.1618625569
MESH:D008064 Lipidoses Tamoxifen 3.2515342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4615474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.4618564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4612878042
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.7520195826 21137059
MESH:D008113 Liver Neoplasms pirinixic acid 14.7520007298 16377806 15890375
MESH:D008113 Liver Neoplasms sodium arsenite 14.7516712894 15276417
MESH:D008113 Liver Neoplasms Tamoxifen 14.7516684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.7516984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1912151625
MESH:D008171 Lung Diseases sodium arsenite 3.2619095001
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.7520064080 18520028 20135361 20464547 6695378 17053015 20869020 18569708 18816296
MESH:D008175 Lung Neoplasms sodium arsenite 6.7519931552 16712894 17077188 17306315 15276417
MESH:D008175 Lung Neoplasms Tamoxifen 6.7518625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.7511884234 19555203
MESH:D008175 Lung Neoplasms Tobacco Smoke Pollution 6.7511091918 3440675 16288123 12111688
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.9519428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7111731420 16827153 14580682 19196723 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.7619453300
MESH:D008545 Melanoma sodium arsenite 3.3919082730 16487513
MESH:D008545 Melanoma Tamoxifen 3.3919393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.3815990972
MESH:D008881 Migraine Disorders Aspirin 4.1615240983
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 9.1516381670
MESH:D009062 Mouth Neoplasms Tobacco Smoke Pollution 9.1515006635
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009203 Myocardial Infarction Aspirin 6.1112692751
MESH:D009203 Myocardial Infarction pirinixic acid 6.1119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0516411023
MESH:D009325 Nausea Aspirin 5.4315240983
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5919393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5519410462
MESH:D009369 Neoplasms Benzo(a)pyrene 8.5811141357
MESH:D009369 Neoplasms pirinixic acid 8.5817405874
MESH:D009369 Neoplasms sodium arsenite 8.5811559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.8420056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.2219196722 19189210 19200415
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3714600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.2312854658
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D010003 Osteoarthritis Aspirin 4.147009135
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.4717306315 15276417
MESH:D010146 Pain Aspirin 3.976363464 6995502
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8411578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D010438 Peptic Ulcer Hemorrhage Aspirin 5.7311156591
MESH:D020795 Photophobia Aspirin 5.9815240983
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3811222880 11896295 11118676 11399792
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5117292933
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.5116039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.5115067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.5116919318 15861022
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D012135 Respiratory Sounds Tobacco Smoke Pollution 4.8018410779
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012220 Rhinitis Aspirin 4.5012372130
MESH:D012851 Sinus Thrombosis, Intracranial Aspirin 5.4412269725
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 18.5910029692 19755658
MESH:D012878 Skin Neoplasms sodium arsenite 18.5918572023 19524636
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 18.598532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 18.5916192470
MESH:D012878 Skin Neoplasms Tobacco Smoke Pollution 18.5918590791
MESH:D013088 Spermatocele Ethinyl Estradiol 12.3016709447
MESH:D013088 Spermatocele Tamoxifen 12.3016709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.2319457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.9012854658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D020521 Stroke Aspirin 4.4916403987
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7711994571
MESH:D013927 Thrombosis Aspirin 9.6217672075
MESH:D013927 Thrombosis Ethinyl Estradiol 9.6215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 12.3917053015
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 12.3916452187 16712894 17306315 11723127
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 12.398653321 16712894 17572228
MESH:D001749 Urinary Bladder Neoplasms Tobacco Smoke Pollution 12.3912846360
MESH:D014581 Urticaria Aspirin 4.5910982225 20485159
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.9011813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4614692618
MESH:D014652 Vascular Diseases sodium arsenite 4.6217056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6814671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
Pathway ID Pathway Name
REACT:25177 RNF125 mediated ubiquitination of RIG-I, MDA5 and IPS-1
REACT:6900 Signaling in Immune system
KEGG:04120 Ubiquitin mediated proteolysis
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB03131 - Beta-Mercaptoethanol
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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