AutismKB 2.0

Annotation Detail for HINT1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:HINT1 ( FLJ30414,FLJ32340,HINT,PKCI-1,PRKCNH1 )
Gene Full Name: histidine triad nucleotide binding protein 1
Band: 5q23.3
Quick LinksEntrez ID:3094; OMIM: 601314; Uniprot ID:HINT1_HUMAN; ENSEMBL ID: ENSG00000169567; HGNC ID: 4912
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1983Down syndrome
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of HINT1 mRNAdecreases expression 18648102
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of HINT1 mRNAdecreases expression 12419474
D000082 Acetaminophen Acetaminophen affects the expression of HINT1 mRNAaffects expression 17562736
D000661 Amphetamine HINT1 protein affects the susceptibility to Amphetamineaffects response to substance 17203012
D001149 Arsenates [Atrazine co-treated with Arsenates] results in increased expression of HINT1 mRNAaffects cotreatment|increases expression 18585445
D001280 Atrazine [Atrazine co-treated with Arsenates] results in increased expression of HINT1 mRNAaffects cotreatment|increases expression 18585445
D001554 Benzene Benzene results in increased expression of HINT1 mRNAincreases expression 15122651
15120971
C007262 deoxynivalenol deoxynivalenol results in decreased expression of HINT1 mRNAdecreases expression 15371230
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of HINT1 mRNAincreases expression 15766595
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of HINT1 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of HINT1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HINT1 mRNAaffects cotreatment|increases expression 17942748
D005472 Fluorouracil Fluorouracil results in increased expression of HINT1 proteinincreases expression 16803524
15585135
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of HINT1 mRNAaffects cotreatment|increases expression 17183730
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased expression of HINT1 mRNAdecreases expression 12419474
D008464 Mecamylamine Mecamylamine inhibits the reaction [Nicotine results in increased expression of HINT1 protein]decreases reaction|increases expression 20514075
D009538 Nicotine Nicotine results in increased expression of HINT1 mRNAincreases expression 20514075
D009538 Nicotine Mecamylamine inhibits the reaction [Nicotine results in increased expression of HINT1 protein]decreases reaction|increases expression 20514075
D009538 Nicotine Nicotine results in increased expression of HINT1 proteinincreases expression 20514075
C017947 sodium arsenite sodium arsenite results in increased expression of HINT1 proteinincreases expression 19294697
D018038 Sodium Selenite Sodium Selenite results in increased expression of HINT1 mRNAincreases expression 18175754
C025463 sulindac sulfone sulindac sulfone results in increased expression of HINT1 mRNAincreases expression 18593937
C025463 sulindac sulfone sulindac sulfone results in increased expression of HINT1 proteinincreases expression 18593937
D013629 Tamoxifen Tamoxifen affects the expression of HINT1 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HINT1 mRNAaffects cotreatment|increases expression 17942748
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of HINT1 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.4414745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.9515322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 7.958875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.8319490988
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.8417505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.2514692618
MESH:D000230 Adenocarcinoma Fluorouracil 4.2517638652
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.693712494
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.2716835633
MESH:D011125 Adenomatous Polyposis Coli sulindac sulfone 5.1916150858
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.5915276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.8016712894 17306315
MESH:D000382 Agricultural Workers' Diseases Atrazine 4.1211874814
MESH:D000437 Alcoholism Mecamylamine 5.5520201817
MESH:D000544 Alzheimer Disease Nicotine 3.2616627626
MESH:D000550 Amblyopia Valproic Acid 5.1317688650
MESH:D019969 Amphetamine-Related Disorders Amphetamine 5.9518475255 15010207 16459022 16916582
MESH:D000686 Amyloidosis Diethylstilbestrol 4.3715469931
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 4.0310965797
MESH:D000740 Anemia Fluorouracil 8.3517963324 15504547 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.3511748828
MESH:D000741 Anemia, Aplastic Benzene 4.2817661222 11369114 14761424
MESH:D000799 Angioedema Acetaminophen 3.7410982225
MESH:D000855 Anorexia Amphetamine 4.9116084549 16101753 12005258 12183048
MESH:D001008 Anxiety Disorders Valproic Acid 3.4817497229
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.3611256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6015885639
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8515238991 18177632 20603192 17688650 18316065 16609825 17507914 18940202 18558336 18775368 18985861 17157402 19232924 19460635 18396377
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.911440618 11289319
MESH:D001714 Bipolar Disorder Valproic Acid 3.0217594078 20046352
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.9412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.7915746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.798888407
MESH:D001855 Bone Marrow Diseases Benzene 5.1216183116
MESH:D001943 Breast Neoplasms Benzene 2.3111921183 17162533
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.3117129689 15324884
MESH:D001943 Breast Neoplasms Fluorouracil 2.3115136595 18357371 19217205 16110121 16595493 18608205 16557594
MESH:D001943 Breast Neoplasms Tamoxifen 2.3119059307 19115204 18425577 19189212 16873071 19084267 18997820 20135344 19066611 19011961 20005174 15668708 16273361 19189210 18984771 18855134 20390343 19155303 19103187 11161223 17242785 19142967 19244106 18815881 21152245 19221464 17261762 18629630 19200415 18351453 20065188 20544844 19289846 17893378 18821012 16202921 17440819 17049068 16818667 21138602 20859285 19410462 15565566 19288272 19487384
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3120435547
MESH:D002276 Carcinoid Tumor Fluorouracil 4.5616051944
MESH:D002277 Carcinoma Fluorouracil 7.8917121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.8916835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.4019066611
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 11.167296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.163084413
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 11.1615948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 11.1616799960 18930000 16332177 17088986 17045692 17971768
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 11.1617306315 16507464 15276417
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 11.1616924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfone 4.0518758305
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.337296757
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.3318695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.6616280240 16757204 17066447 18986760
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.6618572023
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.5217572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3118850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.4416936243
MESH:D002386 Cataract Acetaminophen 2.5210977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.497505956
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 6.4919524636 20056578
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6720734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0716835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 7.5919486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 7.5917333356 16105132 11677210 17681005 15861022 16919318 17110522
MESH:D019457 Chromosome Breakage Sodium Selenite 4.6415894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0616354765 15340226 15668235 8697196 12621046
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2216510598 17018589 15001691 18772588 17725105 17016597 16340194 17287894 17169374 17172411
MESH:D015179 Colorectal Neoplasms Fluorouracil 3.0818802399 16282729 17255274 20501625 17094418 18509181 17016601 16303861 16391804 17454858 15289873 15148649 18448328 16524972 14970324 16331619 17594712 17401013 18288408 18383874 18949393 17695437
MESH:D015179 Colorectal Neoplasms sulindac sulfone 3.0811197048 18059344 10416599 10666051
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9614669216 17141729
MESH:D019465 Craniofacial Abnormalities Benzene 3.7815643154
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.7820055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.7817688650 16575769 8888407
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.4512952375 16002989
MESH:D007644 Darier Disease Fluorouracil 4.6816733453
MESH:D003711 Demyelinating Diseases Tamoxifen 4.2519031437
MESH:D003872 Dermatitis Benzene 4.6615902427
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.7012868966 14531868 18759878 11906362 8156756 2524372 11298694 8970840
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.392952479 3621924
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.6816285004
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6417107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.3819279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 11.6618692083 9653073 18289764 11289319 7440962 9022650 16192314 6482804 18648102 9328219 1440618 8291058 6679447
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 11.6611461765 19739265 11743745 11834606 18071297 16177239 14550746 11421492 19416960 12705907 11739529 14725611 12540782 19085960 19370779 14986274 16485898 17906064 19923254 17522070 16393943 15968718 17562736 16781746 15619225 16227642 11529661 16109766 12392966 10915739 19420014 12958197 18713872 11287661 12594235 16081117 10663392 10774834 19164858 12153990 2444490
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 11.6615131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.6620420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 11.661733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9919426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6811462148
MESH:D004421 Dystonia Valproic Acid 3.941851702
MESH:D020821 Dystonic Disorders Nicotine 5.8217881519
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.2811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8016714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.5912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.5919031437
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.5816402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 7.3316804899 15700306
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.3319155303 17893378 16202921 20544844
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9210568697 9294722
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.043659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.8116628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.8818234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.496426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.197750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.963659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.433581430
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.4316481741 16337965 16785472 15173087 17638652
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9311564622
MESH:D005221 Fatigue Amphetamine 5.4919890266
MESH:D005234 Fatty Liver Ethinyl Estradiol 12.5215345470
MESH:D005234 Fatty Liver Tamoxifen 12.5214986274 19224547
MESH:D005234 Fatty Liver Valproic Acid 12.5219224547 14986274
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 7.9916534752 16513791 15751030 16611131 16002989
MESH:D052776 Female Urogenital Diseases Tamoxifen 7.9916709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3511858732
MESH:D005315 Fetal Diseases Valproic Acid 4.7816575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.028888407 18558336
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.916705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.4214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.0719069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.8420067830
MESH:D005756 Gastritis Acetaminophen 3.5716983495
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 12.4516452187
MESH:D005833 Genital Neoplasms, Female sodium arsenite 12.4516452187
MESH:D005910 Glioma Fluorouracil 2.8316145905
MESH:D005922 Glomerulonephritis, IGA deoxynivalenol 4.9216524712 15173396
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.937505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4910696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.3118337622 15162350 15102660
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2710048152 11294989
MESH:D006402 Hematologic Diseases Benzene 4.5516183116
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2311000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.416705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.7815340226 12621046 16120746
MESH:D006689 Hodgkin Disease sodium arsenite 3.0612676792
MESH:D006849 Hydrocephalus Valproic Acid 4.7617688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9415340226 18606429 8697196 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.6116870215
MESH:D006948 Hyperkinesis Amphetamine 5.3214960337 1977408
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 10.4715034207
MESH:D006965 Hyperplasia Diethylstilbestrol 10.4712960047 14722030
MESH:D006973 Hypertension Benzene 5.1717940673
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1718670907 18850075
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.5216612254
MESH:D007021 Hypospadias Diethylstilbestrol 10.8816002989
MESH:D007021 Hypospadias Ethinyl Estradiol 10.8816945680 16569931
MESH:D007246 Infertility Diethylstilbestrol 4.2515036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3612013081
MESH:D007248 Infertility, Male Atrazine 10.8712948887
MESH:D007248 Infertility, Male Ethinyl Estradiol 10.8717937319
MESH:D007248 Infertility, Male sodium arsenite 10.8712646999 15346721
MESH:D007249 Inflammation Tamoxifen 4.7019457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.7012200463 12878042
MESH:D007333 Insulin Resistance Sodium Selenite 3.2014714311
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.918074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2316580747
MESH:D007674 Kidney Diseases Acetaminophen 5.7515629191 12587719
MESH:D007674 Kidney Diseases sodium arsenite 5.7520008137
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 4.1716518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 17.046582329
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 17.0416762066 15003126 14681315
MESH:D007680 Kidney Neoplasms Fluorouracil 17.0416985049
MESH:D007680 Kidney Neoplasms Tamoxifen 17.0418625569
MESH:D007859 Learning Disorders Diethylstilbestrol 3.9517184923
MESH:D007938 Leukemia Benzene 3.3417119257 14694614 15935818 18335105
MESH:D007951 Leukemia, Myeloid Benzene 4.2217506065
MESH:D015470 Leukemia, Myeloid, Acute Benzene 4.0519478238
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 4.0517596541 16294345
MESH:D008064 Lipidoses Tamoxifen 3.0815342952 17567588
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.139327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.2518564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.2512878042
MESH:D008107 Liver Diseases Acetaminophen 1.6016611625 19014921 12587719 12969438 11587558 19784758 16610002 19460945
MESH:D017114 Liver Failure, Acute Acetaminophen 3.1416871587 17185352
MESH:D008113 Liver Neoplasms Diethylstilbestrol 13.8115890375 16712894
MESH:D008113 Liver Neoplasms Fluorouracil 13.8115113037 17045692 18383874 16603448
MESH:D008113 Liver Neoplasms sodium arsenite 13.8115276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 13.8116684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.8116984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 9.47598648 6587162 3712494 1399818
MESH:D008114 Liver Neoplasms, Experimental Benzene 9.4712562636
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.4712151625
MESH:D008171 Lung Diseases sodium arsenite 3.1019095001
MESH:D017563 Lung Diseases, Interstitial Benzene 11.0314698565
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 11.0317228818
MESH:D008175 Lung Neoplasms Benzene 6.4512562636
MESH:D008175 Lung Neoplasms Fluorouracil 6.4515246190
MESH:D008175 Lung Neoplasms sodium arsenite 6.4516712894 17077188 17306315 19931552 15276417
MESH:D008175 Lung Neoplasms Tamoxifen 6.4518625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.4519555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.6815086387
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.0415166399
MESH:D008223 Lymphoma Benzene 7.5817584886 17119257
MESH:D008223 Lymphoma Diethylstilbestrol 7.5815700306
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 3.9514737004
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.4116002989
MESH:D015674 Mammary Neoplasms, Animal Benzene 9.7112562636
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 9.7119428831
MESH:D008325 Mammary Neoplasms, Experimental Benzene 6.0111921183
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.0119196723 14580682 19196722 11731420 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 4.4419453300
MESH:D008545 Melanoma sodium arsenite 3.2616487513 19082730
MESH:D008545 Melanoma Tamoxifen 3.2612393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.0715990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4619513568
MESH:D008654 Mesothelioma Atrazine 3.481916698
MESH:D008881 Migraine Disorders Valproic Acid 3.1118803445 18765137
MESH:D009062 Mouth Neoplasms Fluorouracil 3.5518986760 16757204
MESH:D009101 Multiple Myeloma Benzene 3.5817119195
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.928888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.0917596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9312213967
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.553581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.5519393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4819410462
MESH:D009369 Neoplasms Diethylstilbestrol 11.5215313581
MESH:D009369 Neoplasms Fluorouracil 11.5218239605 18600527 16928823
MESH:D009369 Neoplasms Nicotine 11.5216365874
MESH:D009369 Neoplasms sodium arsenite 11.5211559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.5620056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.8919196722 19200415 19189210
MESH:D009389 Neovascularization, Pathologic Nicotine 4.8916365874
MESH:D009421 Nervous System Malformations Diethylstilbestrol 9.2811399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.2814600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 16.776679447
MESH:D009436 Neural Tube Defects Benzene 16.7715643154
MESH:D009436 Neural Tube Defects sodium arsenite 16.7712854658
MESH:D009436 Neural Tube Defects Valproic Acid 16.7716359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.3618514411
MESH:D019636 Neurodegenerative Diseases Amphetamine 8.3615183010
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.3616436463
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 8.834026338 6482804
MESH:D009784 Occupational Diseases Benzene 8.8316737584 17479406 15913788 17119257 15727169 17178637 15935809 15576619 15612468
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.913988306
MESH:D010051 Ovarian Neoplasms Benzene 5.0012562636
MESH:D010051 Ovarian Neoplasms sodium arsenite 5.0017306315 15276417
MESH:D010146 Pain Acetaminophen 2.3016870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.6315113037 16929163 19003803 16500647
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5811578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 8.957296757
MESH:D010212 Papilloma Hydrogen Peroxide 8.9512065085
MESH:D010300 Parkinson Disease Atrazine 3.2317218051
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1412520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 12.646228378
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 12.6411550810
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.0614722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.5615687265 16977796
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4518163543
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 15.6417184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 15.6411222880 11399792 11896295 11118676
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 15.6420603192
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 1.8915046698 17136230 15846301
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.8918626508 19082440
MESH:D011471 Prostatic Neoplasms sodium arsenite 1.8916039940
MESH:D011471 Prostatic Neoplasms Sodium Selenite 1.8918760546
MESH:D011471 Prostatic Neoplasms sulindac sulfone 1.8915570007 17908994
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8915067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.2015861022 16919318
MESH:D019310 Pseudolymphoma Valproic Acid 4.4412752131 11422049
MESH:D012004 Rectal Neoplasms Fluorouracil 3.9215538739 16160472 18286688 18722050
MESH:D012135 Respiratory Sounds Atrazine 4.4111874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7318990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.293692021
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.0719155313
MESH:D012559 Schizophrenia marker/mechanism 17203012 20514075
MESH:D012559 Schizophrenia Valproic Acid 2.0519110320 15737665
MESH:D012640 Seizures Mecamylamine 9.8512660363
MESH:D012640 Seizures Nicotine 9.8517873105
MESH:D012640 Seizures Valproic Acid 9.8517978042 3137016 11738929 14763951 15475178 1511512 16876388 11044598
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 9.1912065085
MESH:D012878 Skin Neoplasms sodium arsenite 9.1919524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.1916192470
MESH:D013088 Spermatocele Diethylstilbestrol 19.5316002989 16709447
MESH:D013088 Spermatocele Ethinyl Estradiol 19.5316709447
MESH:D013088 Spermatocele Tamoxifen 19.5316709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.9319457130
MESH:D016135 Spinal Dysraphism sodium arsenite 9.2612854658
MESH:D016135 Spinal Dysraphism Valproic Acid 9.2619490988
MESH:D013226 Status Epilepticus Valproic Acid 4.4412833885
MESH:D019956 Stereotypic Movement Disorder Amphetamine 6.321977408
MESH:D013274 Stomach Neoplasms Benzene 2.7112562636
MESH:D013274 Stomach Neoplasms Fluorouracil 2.7118396642 19084572 17522103 18567086 16424979 17172411 15786421 17498489 19015929 16951190
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0615669648
MESH:D013953 Thymus Neoplasms Benzene 4.8510850423
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8012697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.801399818 6582329 7505956 6587162 3712494
OMIM:188890 TOBACCO ADDICTION, SUSCEPTIBILITY TO marker/mechanism 20514075
OMIM:188890 TOBACCO ADDICTION, SUSCEPTIBILITY TO Nicotine 4.6516785264 16720336 11259349
MESH:D014029 Tobacco Use Disorder Nicotine 5.3417979512 18041664 15735609 18305452
MESH:D014062 Tongue Neoplasms Fluorouracil 3.8916280240
MESH:D014178 Translocation, Genetic Valproic Acid 5.1317262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.413119515
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 11.598074119
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 11.5917306315 16452187 16712894
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 11.5916712894 16452187 17306315 11723127
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 11.5916712894 8653321 17572228
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.538888407
MESH:D014581 Urticaria Acetaminophen 2.8710982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 15.3416175088
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 15.3416803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 15.3411813266
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.0614652134
MESH:D014594 Uterine Neoplasms Benzene 15.4812562636
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 15.4815809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 15.4814692618
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.3316002989 16513791
MESH:D014652 Vascular Diseases sodium arsenite 4.3217056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4414671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1415886252
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29286
    • No data
    Releated disease ID Related disease Name
    PA445876Tobacco Use Disorder
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00131 - Adenosine monophosphate Dietary supplement;Micronutrient
    DB01972 - Guanosine-5'-Monophosphate
    DB02162 - 5'-O-(N-Ethyl-Sulfamoyl)Adenosine
    DB02183 - Adenosine-5'-Ditungstate
    DB03349 - 8-Bromo-Adenosine-5'-Monophosphate
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved