AutismKB 2.0

Annotation Detail for HIVEP1


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Basic Information Top
Gene Symbol:HIVEP1 ( CIRIP,CRYBP1,MBP-1,PRDII-BF1,Schnurri-1,ZAS1,ZNF40,ZNF40A )
Gene Full Name: human immunodeficiency virus type I enhancer binding protein 1
Band: 6p24.1
Quick LinksEntrez ID:3096; OMIM: 194540; Uniprot ID:ZEP1_HUMAN; ENSEMBL ID: ENSG00000095951; HGNC ID: 4920
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the expression of HIVEP1 mRNAaffects expression 19414516
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of HIVEP1 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of HIVEP1 mRNAincreases expression 18648102
D000643 Ammonium Chloride Ammonium Chloride results in increased expression of HIVEP1 mRNAincreases expression 12420312
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of HIVEP1 mRNAincreases expression 18687144
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of HIVEP1 mRNAdecreases expression 19150397
C006780 bisphenol A bisphenol A results in increased expression of HIVEP1 mRNAincreases expression 19371625
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of HIVEP1 mRNAdecreases expression 15003993
D015025 Zearalenone Zearalenone results in increased expression of HIVEP1 mRNAincreases expression 19371625
D019833 Genistein Genistein results in increased expression of HIVEP1 mRNAincreases expression 19371625
C029938 nickel sulfate nickel sulfate results in increased expression of HIVEP1 mRNAincreases expression 16780908
C016340 o,p'-DDT o,p'-DDT results in increased expression of HIVEP1 mRNAincreases expression 19371625
C081489 valsartan valsartan inhibits the reaction [AGT protein results in increased expression of HIVEP1 mRNA]decreases reaction|increases expression 19225232
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.6818287403
MESH:D055371 Acute Lung Injury nickel sulfate 4.3911954676 16100012 19131640 12718980
MESH:D000230 Adenocarcinoma Genistein 2.5011473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.803712494
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.151440618 11289319
MESH:D001862 Bone Resorption bisphenol A 3.9411985600
MESH:D001943 Breast Neoplasms bisphenol A 2.3517123778
MESH:D001943 Breast Neoplasms Genistein 2.3517200150 16873071 16541309
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.6816705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.683581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Genistein 4.6816924424
MESH:D002278 Carcinoma in Situ bisphenol A 5.1117123778
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.717296757
MESH:D006332 Cardiomegaly valsartan 4.2219597038
MESH:D009202 Cardiomyopathies valsartan 4.4916247790
MESH:D002318 Cardiovascular Diseases Genistein 8.0016332659
MESH:D002318 Cardiovascular Diseases valsartan 8.0011230374
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.837505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.8320889678
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.219022650 19486331
MESH:D003110 Colonic Neoplasms Genistein 2.3017182828
MESH:D003324 Coronary Artery Disease valsartan 3.9217719468
MESH:D003384 Coxsackievirus Infections valsartan 5.9620392896
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.1218551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 7.498970840 18759878 14531868 8156756 11298694 12868966 2524372 11906362
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 7.4916780908 16823706 11298694
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.583621924 2952479
MESH:D003921 Diabetes Mellitus, Experimental valsartan 4.6611508273
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.5016647724
MESH:D003928 Diabetic Nephropathies valsartan 4.8611427623 18630688
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 3.9221346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 3.9218648102 9022650 8291058 6679447 7440962 9653073 18289764 11289319 18692083 6482804 9328219 16192314 1440618
MESH:D004714 Endometrial Hyperplasia Genistein 4.7116402032
MESH:D016889 Endometrial Neoplasms Genistein 3.4111473722
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.453581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.4520426865
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.156705139
MESH:D005355 Fibrosis valsartan 4.8716893502
MESH:D005909 Glioblastoma Genistein 3.3116598420
MESH:D015432 Glomerulonephritis, Membranoproliferative valsartan 5.6416928621
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.127505956
MESH:D006333 Heart Failure valsartan 4.3019027736
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.616705139
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0415034207
MESH:D006973 Hypertension valsartan 3.7518344623 11427623 20102058 12692753 16475468 12850387 10903974 18390891
MESH:D006974 Hypertension, Malignant valsartan 6.5411560862
MESH:D007333 Insulin Resistance bisphenol A 3.3416393666
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.159022650 8074119
MESH:D007674 Kidney Diseases valsartan 4.0010903974 12164870 16893502
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.5816705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.586582329
MESH:D007938 Leukemia Genistein 3.0617468513 18980019
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2415034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Genistein 3.0917823541
MESH:D008106 Liver Cirrhosis, Experimental valsartan 3.0916872305 15619341 15504291
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.58598648 3712494 1399818 6587162
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.1317365036
MESH:D008325 Mammary Neoplasms, Experimental Genistein 2.9912929590 14578162
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.2118303189 16966607 16166281
MESH:D009203 Myocardial Infarction Genistein 2.8917141266
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.7217141266
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.9718551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.503581430
MESH:D009421 Nervous System Malformations bisphenol A 10.2011399458 16427766
MESH:D009421 Nervous System Malformations Genistein 10.2016427766
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.966679447
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.1412819281 16049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.144026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.153988306
MESH:D010024 Osteoporosis Genistein 3.3019401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.1716169203
MESH:D010049 Ovarian Diseases bisphenol A 5.1111985600
MESH:D010051 Ovarian Neoplasms Genistein 2.6219005980
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.597296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.606228378
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 5.0010923243
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 4.0710548101
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.2920887781
MESH:D011471 Prostatic Neoplasms bisphenol A 3.3916740699
MESH:D011471 Prostatic Neoplasms Genistein 3.3915256057 16925846 15378649
MESH:D011507 Proteinuria valsartan 4.9417664856 18344623 12164870
MESH:D011629 Puberty, Precocious bisphenol A 4.9010548101
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 6.3317322281 17365031 15814490 17975199
MESH:D011658 Pulmonary Fibrosis valsartan 6.3317241526
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.433692021
MESH:D012640 Seizures 2,4-dinitrotoluene 2.5818551238
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.728532709
MESH:D019966 Substance-Related Disorders bisphenol A 4.1016684133 16045194
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.956582329 1399818 6587162 3712494 7505956
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.1016049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.108074119
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.4310091137
MESH:D014591 Uterine Diseases bisphenol A 5.1414652134
MESH:D020257 Ventricular Remodeling valsartan 5.8219027736
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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