AutismKB 2.0

Annotation Detail for HIVEP2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:HIVEP2 ( HIV-EP2,MBP-2,MIBP1,SHN2,ZAS2,ZNF40B )
Gene Full Name: human immunodeficiency virus type I enhancer binding protein 2
Band: 6q24.2
Quick LinksEntrez ID:3097; OMIM: 143054; Uniprot ID:ZEP2_HUMAN; ENSEMBL ID: ENSG00000010818; HGNC ID: 4921
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the expression of HIVEP2 mRNAaffects expression 19414516
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of HIVEP2 mRNA]affects expression|affects reaction 19414516
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of HIVEP2 mRNA]affects expression|affects reaction 19414516
C026114 2-xylene 2-xylene results in increased expression of HIVEP2 mRNAincreases expression 20359517
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of HIVEP2 mRNAdecreases expression 18648102
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of HIVEP2 mRNAdecreases expression 12419474
D000082 Acetaminophen Acetaminophen affects the expression of HIVEP2 mRNAaffects expression 17562736
D000242 Cyclic AMP 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of HIVEP2 mRNA]affects expression|affects reaction 19414516
D000643 Ammonium Chloride Ammonium Chloride affects the expression of HIVEP2 mRNAaffects expression 16483693
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of HIVEP2 mRNAincreases expression 18687144
D001554 Benzene Benzene results in increased expression of HIVEP2 mRNAincreases expression 20359517
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of HIVEP2 mRNAaffects cotreatment|increases expression 18164116
D016572 Cyclosporine Cyclosporine results in increased expression of HIVEP2 mRNAincreases expression 20106945
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of HIVEP2 mRNAaffects cotreatment|increases expression 18164116
D002117 Calcitriol Calcitriol results in increased expression of HIVEP2 mRNAincreases expression 16002434
C004912 ethylbenzene ethylbenzene results in increased expression of HIVEP2 mRNAincreases expression 20359517
D005419 Flavonoids Flavonoids results in increased expression of HIVEP2 mRNAincreases expression 18035473
D008752 Methylene Chloride Methylene Chloride results in increased expression of HIVEP2 mRNAincreases expression 20359517
D008770 Methylnitrosourea Methylnitrosourea results in increased expression of HIVEP2 mRNAincreases expression 17412507
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of HIVEP2 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of HIVEP2 mRNAincreases expression 12832660
C004648 testosterone enanthate testosterone enanthate affects the expression of HIVEP2 mRNAaffects expression 17440010
D014050 Toluene Toluene results in increased expression of HIVEP2 mRNAincreases expression 20359517
D014241 Trichloroethylene Trichloroethylene results in increased expression of HIVEP2 mRNAincreases expression 20359517
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.4518287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.0118653653
MESH:D000230 Adenocarcinoma Methylnitrosourea 3.0915113128 15688392
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 10.853712494
MESH:D000236 Adenoma beta-Naphthoflavone 10.8519389873
MESH:D000236 Adenoma Diethylnitrosamine 10.856695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.7318056438 19061943 17620307 19052882 17162532 16434500
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.7316434500
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 4.0310965797
MESH:D000741 Anemia, Aplastic Benzene 4.2817661222 11369114 14761424
MESH:D000799 Angioedema Acetaminophen 3.7410982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4318445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.911440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.0419483382
MESH:D001836 Body Weight Changes 2-xylene 5.817457028
MESH:D001855 Bone Marrow Diseases Benzene 5.1216183116
MESH:D001943 Breast Neoplasms Benzene 2.9417162533 11921183
MESH:D001943 Breast Neoplasms Calcitriol 2.9411237771
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.9417474063
MESH:D001943 Breast Neoplasms Methylene Chloride 2.9415986119
MESH:D001943 Breast Neoplasms Methylnitrosourea 2.9416253758 11306469 14633655
MESH:D001943 Breast Neoplasms Trichloroethylene 2.9415986119
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.427296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.423084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.4218785209 16569478 19394651 17138121 19519916 19919837 20084675 19208518 11831363 18506893 16807293 19052882 17428255 17761372 20935162 17173139 20512989 18788625 20007298 10672840 17162532 19539802 18494052 20727157 18978308 19171122 20524982 18210153 20101231 16502159 19107877 18393292 19383236 16288022 16698587 16328049 20432363 20214788 18056438 17055752 21159647 19701751 16681979 20514400 18691550 3084413 16540662 16935385 16779866 16878318 3581430 17978847 19335982 19822196 18971187 18665156 10737359 16830150 19418558
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.627296757
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 2.5911237771
MESH:D002386 Cataract Acetaminophen 7.3410977129
MESH:D002386 Cataract Methylnitrosourea 7.3412484553
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 15.437505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 15.4312371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 15.432727394 7505956 17174075 21159647
MESH:D002471 Cell Transformation, Neoplastic Methylnitrosourea 15.437505956 2727394
MESH:D002547 Cerebral Palsy Toluene 5.749294310
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.5919052882
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 12.9019486331 9022650
MESH:D002779 Cholestasis Cyclosporine 12.9019486331
MESH:D002779 Cholestasis pirinixic acid 12.9019176532
MESH:D019465 Craniofacial Abnormalities Benzene 3.2415643154
MESH:D019465 Craniofacial Abnormalities Toluene 3.249294310
MESH:D003643 Death Toluene 5.566431079
MESH:D003872 Dermatitis Benzene 4.6615902427
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.7012868966 11298694 18759878 8970840 8156756 2524372 11906362 14531868
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3818249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.393621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.1620387270
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 8.767440962 18692083 6482804 9328219 16192314 18289764 6679447 18648102 1440618 9653073 9022650 8291058 11289319
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.7615968718 19085960 12153990 18071297 16485898 11461765 10663392 14725611 19370779 16109766 19420014 16781746 11743745 17522070 14550746 11421492 11739529 12705907 17562736 16081117 12594235 12958197 15619225 16177239 16393943 14986274 10774834 17906064 12392966 19739265 2444490 11834606 18713872 16227642 19923254 10915739 11529661 11287661 19164858 19416960 12540782
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 8.7619107877
MESH:D056486 Drug-Induced Liver Injury Trichloroethylene 8.767120509
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9919426721
MESH:D004487 Edema pirinixic acid 2.3812083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 3.8315138306
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.0116302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.083581430
MESH:D005234 Fatty Liver Cyclosporine 12.4619224547
MESH:D005234 Fatty Liver Diethylnitrosamine 12.4620387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 12.4619236843 20131406
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.916705139
MESH:D005354 Fibrosarcoma Methylnitrosourea 5.1211555667
MESH:D005355 Fibrosis Cyclosporine 3.0312639820 12168785
MESH:D005756 Gastritis Acetaminophen 3.5716983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.118708960
MESH:D005910 Glioma Methylnitrosourea 3.529825942
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.937505956
MESH:D006333 Heart Failure pirinixic acid 2.4720558911
MESH:D006402 Hematologic Diseases Benzene 4.5516183116
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3115720958
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.416705139
MESH:D006529 Hepatomegaly 2-xylene 8.687457028 7457013
MESH:D006529 Hepatomegaly pirinixic acid 8.6816221962 19176532 19772884 18467677
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.6417440010
MESH:D006930 Hyperalgesia Acetaminophen 2.6116870215
MESH:D006943 Hyperglycemia pirinixic acid 3.0820558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.8315034207
MESH:D006973 Hypertension Benzene 5.2417940673
MESH:D006973 Hypertension Cyclosporine 5.2410903974
MESH:D007248 Infertility, Male Methylnitrosourea 3.727193160
MESH:D007249 Inflammation Diethylnitrosamine 5.0018785209
MESH:D007249 Inflammation Flavonoids 5.0017296493
MESH:D007333 Insulin Resistance pirinixic acid 2.5616306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.918074119 9022650
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3415604871
MESH:D007674 Kidney Diseases Acetaminophen 5.5815629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 5.5818776723 10903974 8314463
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 6.976582329
MESH:D007680 Kidney Neoplasms Cyclosporine 6.9712371664
MESH:D007938 Leukemia Benzene 3.3414694614 15935818 18335105 17119257
MESH:D007951 Leukemia, Myeloid Benzene 4.2217506065
MESH:D015470 Leukemia, Myeloid, Acute Benzene 2.6819478238
MESH:D017880 Limb Deformities, Congenital Methylnitrosourea 4.1215526292
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.7618407596 18522880 19638242 18665156 20032147
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.139327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3415474484
MESH:D008107 Liver Diseases Acetaminophen 3.8119460945 11587558 12969438 16610002 19784758 12587719 19014921 16611625
MESH:D008107 Liver Diseases Diethylnitrosamine 3.8117034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.1416871587 17185352
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 7.2319389873 21295105
MESH:D008113 Liver Neoplasms Diethylnitrosamine 7.2319294768 21047994 21278145 15885732 19254457 16942905 20101389 19551842 18754104 20501860 20452335 19996281 12771043 19642983 18648771 20118626 19499222 18978307 15175105 21071580 19426721 20583210 19812893 19255062 18977376 19427195 12112319 19073162 19638242 2422723 20137499 19833225 19690152 21167192 18644402 19090486 20405173 20434301 19256749 2862719 9163691 19850985 10737359 20492335
MESH:D008113 Liver Neoplasms pirinixic acid 7.2316377806 20007298 15890375
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 17.963712494 598648 1399818 6587162
MESH:D008114 Liver Neoplasms, Experimental Benzene 17.9612562636
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 17.9618164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 17.962563599 18544905 16842330 19539802 3124819 19009564 19519916 18079962 9362446 16267830 19126423 17942915 17174075 18775883 21159647 18093689 18164116 18253720 18282651 19004024 17854601 18308698
MESH:D008114 Liver Neoplasms, Experimental Trichloroethylene 17.967955063
MESH:D038061 Lower Extremity Deformities, Congenital Methylnitrosourea 5.3516080182
MESH:D017563 Lung Diseases, Interstitial Benzene 4.7014698565
MESH:D055370 Lung Injury Asbestos, Crocidolite 3.9117365036
MESH:D008175 Lung Neoplasms Benzene 4.9112562636
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.9120512841 20970405 6695378 21163286
MESH:D008175 Lung Neoplasms Methylene Chloride 4.9115172992
MESH:D008175 Lung Neoplasms Methylnitrosourea 4.9118062963
MESH:D008223 Lymphoma Benzene 7.7817584886 17119257
MESH:D008223 Lymphoma Methylnitrosourea 7.7816257854 11418001
MESH:D016393 Lymphoma, B-Cell Methylnitrosourea 4.6714633661
MESH:D015674 Mammary Neoplasms, Animal Benzene 4.3312562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 6.3611921183
MESH:D008325 Mammary Neoplasms, Experimental Methylnitrosourea 6.3615113128 14633655 15313902 12931682 16619500 19196723 11807958 17020996 11751437 16827153 10767621 17131329 10838139 16051031 15688392 14999141 16944150
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4619513568
MESH:D008607 Mental Retardation Toluene 3.619294310
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.1416966607 18303189 16166281
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6816801185
MESH:D020326 Migraine without Aura Cyclic AMP 5.0511304026
MESH:D019957 Motor Skills Disorders Toluene 5.139294310
MESH:D009101 Multiple Myeloma Benzene 3.5817119195
MESH:D009135 Muscular Diseases pirinixic acid 3.4016239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1019151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8616411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.563581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.563581430 9029167
MESH:D009369 Neoplasms Methylnitrosourea 8.1815533788
MESH:D009369 Neoplasms pirinixic acid 8.1817405874
MESH:D009369 Neoplasms Trichloroethylene 8.1811911487
MESH:D009374 Neoplasms, Experimental Methylnitrosourea 4.3612696579
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1918481113 19348381
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.226679447
MESH:D009436 Neural Tube Defects Benzene 7.2215643154
MESH:D009442 Neurilemmoma Methylnitrosourea 5.3811555667
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.8818514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.8820387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.0120387270
MESH:D009765 Obesity pirinixic acid 1.7920558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 8.834026338 6482804
MESH:D009784 Occupational Diseases Benzene 8.8315576619 17479406 15935809 17119257 16737584 17178637 15913788 15727169 15612468
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.913988306
MESH:D010051 Ovarian Neoplasms Benzene 2.9312562636
MESH:D010146 Pain Acetaminophen 2.3016870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.4516540662
MESH:D010190 Pancreatic Neoplasms Methylnitrosourea 5.4516965848
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.387296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 12.646228378
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 12.6411550810
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.7810923243
MESH:D011230 Precancerous Conditions Cyclosporine 8.6312371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.632563599
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.6715572423
MESH:D011471 Prostatic Neoplasms Calcitriol 3.7315754350 12479363 18247401 16289102 16644109
MESH:D011471 Prostatic Neoplasms Methylnitrosourea 3.7315682402 12376480
MESH:D011565 Psoriasis Cyclosporine 2.1916882103
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 2.9917365031 17975199 17322281 15814490
MESH:D015427 Reperfusion Injury pirinixic acid 2.3319058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 8.843692021
MESH:D012162 Retinal Degeneration Methylnitrosourea 8.8418172121 18155124
MESH:D012175 Retinoblastoma Methylnitrosourea 5.3811555667
MESH:D012640 Seizures Toluene 3.659294310 6431079
MESH:D013274 Stomach Neoplasms Benzene 3.5112562636
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.5118456281
MESH:D013274 Stomach Neoplasms Methylnitrosourea 3.5115930296 16257854 18593901
MESH:D013733 Testicular Diseases Toluene 4.8510048760 10514026
MESH:D013953 Thymus Neoplasms Benzene 11.8610850423
MESH:D013953 Thymus Neoplasms Methylnitrosourea 11.8611418001
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 11.587505956 6582329 6587162 1399818 3712494
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 11.587505956
MESH:D013964 Thyroid Neoplasms Methylnitrosourea 11.587505956 3078959
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.248074119
MESH:D014581 Urticaria Acetaminophen 2.8710982225
MESH:D014594 Uterine Neoplasms Benzene 4.2312562636
MESH:D014605 Uveitis Cyclosporine 3.881336536
MESH:D014985 Xerophthalmia Cyclosporine 4.3417120751
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved