AutismKB 2.0

Annotation Detail for HK1


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Basic Information Top
Gene Symbol:HK1 ( HK1-ta,HK1-tb,HK1-tc,HKI,HXK1 )
Gene Full Name: hexokinase 1
Band: 10q22.1
Quick LinksEntrez ID:3098; OMIM: 142600; Uniprot ID:HXK1_HUMAN; ENSEMBL ID: ENSG00000156515; HGNC ID: 4922
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-842starch degradation
Pathway IDPathway Name
hsa04973Carbohydrate digestion and absorption
hsa04910Insulin signaling pathway
hsa00010Glycolysis / Gluconeogenesis
hsa00524Butirosin and neomycin biosynthesis
hsa00520Amino sugar and nucleotide sugar metabolism
hsa01100Metabolic pathways
hsa00052Galactose metabolism
hsa00051Fructose and mannose metabolism
hsa00500Starch and sucrose metabolism
hsa04930Type II diabetes mellitus
Pathway IDPathway Name
Metabolism of carbohydrates
Transmembrane transport of small molecules
Pathway IDPathway Name
200172HIF-1-alpha transcription factor network
Pathway IDPathway Name
P00024Glycolysis
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1856Obesity
2064Spinal dysraphism
Desease Name
HEMATOLOGICAL
hemoglobin
glycated hemoglobin levels
METABOLIC
hematocrit
obesity
Diabetes Mellitus, Type 2
Desease Name
Hemoglobin
Hematocrit
Glycated hemoglobin levels
Desease Name
Hemolytic anemia due to hexokinase deficiency
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in decreased expression of HK1 mRNAdecreases expression 20406850
C021296 2-ethoxyethanol 2-ethoxyethanol results in increased expression of HK1 mRNAincreases expression 19643169
D000535 Aluminum Aluminum results in decreased activity of HK1 proteindecreases activity 16969689
D000535 Aluminum Meclofenoxate inhibits the reaction [Aluminum results in decreased activity of HK1 protein]decreases activity|decreases reaction 16969689
D000643 Ammonium Chloride Ammonium Chloride affects the expression of HK1 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of HK1 mRNAincreases expression 15761015
D001205 Ascorbic Acid [Tretinoin co-treated with Ascorbic Acid] results in increased expression of HK1 mRNAaffects cotreatment|increases expression 16443354
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of HK1 mRNAincreases expression 15336504
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of HK1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HK1 mRNAaffects cotreatment|increases expression 17942748
D005485 Flutamide Flutamide results in increased expression of HK1 mRNAincreases expression 17702527
C010176 halofuginone halofuginone results in increased expression of HK1 mRNAincreases expression 17180598
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of HK1 mRNAaffects cotreatment|increases expression 17183730
D002504 Meclofenoxate Meclofenoxate inhibits the reaction [Aluminum results in decreased activity of HK1 protein]decreases activity|decreases reaction 16969689
C005219 methyl cellosolve methyl cellosolve results in increased expression of HK1 mRNAincreases expression 19643169
D009151 Mustard Gas Mustard Gas affects the expression of HK1 mRNAaffects expression 15651846
C002741 N-nitrosomorpholine N-nitrosomorpholine results in increased expression of HK1 proteinincreases expression 7921415
D010665 Phenylpropanolamine Phenylpropanolamine results in decreased expression of HK1 mRNAdecreases expression 16465460
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of HK1 mRNAaffects binding|increases activity|increases expression 19710929
D020849 Raloxifene [Raloxifene co-treated with ESR1 protein] results in increased expression of HK1 mRNAaffects cotreatment|increases expression 19059307
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in decreased expression of HK1 mRNAaffects cotreatment|decreases expression 19059307
D012402 Rotenone Rotenone results in increased expression of HK1 mRNAincreases expression 17702527
D013629 Tamoxifen [Tamoxifen co-treated with ESR1 protein] results in increased expression of HK1 mRNAaffects cotreatment|increases expression 19059307
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in decreased expression of HK1 mRNAaffects cotreatment|decreases expression 19059307
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HK1 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of HK1 mRNAdecreases expression 15667827
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of HK1 proteindecreases expression 16548065
D014212 Tretinoin [Tretinoin co-treated with Ascorbic Acid] results in increased expression of HK1 mRNAaffects cotreatment|increases expression 16443354
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of HK1 mRNAaffects cotreatment|increases expression 17183730
C025643 vinclozolin vinclozolin affects the expression of HK1 mRNAaffects expression 19015723
C025643 vinclozolin vinclozolin results in decreased expression of HK1 mRNAdecreases expression 18042343
D015032 Zinc Zinc results in decreased expression of HK1 mRNAdecreases expression 17074742
D019287 Zinc Sulfate Zinc Sulfate results in decreased expression of HK1 mRNAdecreases expression 17074742
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3414745880
MESH:D000014 Abnormalities, Drug-Induced 2-ethoxyethanol 18.717151721 6499820 6499796 6499812 6499823
MESH:D000014 Abnormalities, Drug-Induced methyl cellosolve 18.716499812 3652986 6474471
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 18.7115322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 18.718875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.7419490988
MESH:D000138 Acidosis Ammonium Chloride 9.9218287403
MESH:D000138 Acidosis Zinc Sulfate 9.927265320
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7317505938
MESH:D000169 Acrodermatitis Zinc 5.1917202136 17190629 16889938
MESH:D055371 Acute Lung Injury pirinixic acid 2.9218653653
MESH:D000230 Adenocarcinoma arsenic trioxide 4.1111798837 19825857
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.1114692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.2016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.2016835633
MESH:D000419 Albuminuria Raloxifene 4.3917308373 17451421
MESH:D000505 Alopecia Tretinoin 3.4515955085
MESH:D000544 Alzheimer Disease Aluminum 6.6317662457 10721010
MESH:D000544 Alzheimer Disease Raloxifene 6.6315800139
MESH:D000544 Alzheimer Disease Zinc 6.6316580781 17119284 16410023 16325427
MESH:D000550 Amblyopia Valproic Acid 5.0217688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7611748828
MESH:D000748 Anemia, Macrocytic methyl cellosolve 6.143699323
MESH:D000755 Anemia, Sickle Cell Zinc 4.7016916123
MESH:D000855 Anorexia Phenylpropanolamine 5.5417684035
MESH:D000860 Anoxia Zinc Sulfate 4.817265320
MESH:D001008 Anxiety Disorders Valproic Acid 8.3117497229
MESH:D001008 Anxiety Disorders vinclozolin 8.3119015723
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2611256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.7815885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.7816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2216292516
MESH:D053627 Asthenozoospermia 2-ethoxyethanol 11.906499807 10689203 6499823
MESH:D053627 Asthenozoospermia methyl cellosolve 11.903987992
MESH:D001249 Asthma Mustard Gas 7.6110378619
MESH:D001249 Asthma Tretinoin 7.6116456186
MESH:D001249 Asthma Zinc 7.6117085522
MESH:D001259 Ataxia 2-ethoxyethanol 5.267151721
MESH:D001284 Atrophy 2-ethoxyethanol 10.7415850284 6499799
MESH:D001284 Atrophy methyl cellosolve 10.743699323 2626667 6705890
MESH:D001321 Autistic Disorder Valproic Acid 2.0218940202 17157402 19232924 15238991 19460635 17507914 17688650 20603192 18396377 18985861 18177632 18558336 16609825 18316065 18775368
MESH:D053713 Azoospermia 2-ethoxyethanol 5.376492198 6499807
MESH:D001471 Barrett Esophagus Tretinoin 4.2016935849
MESH:D001714 Bipolar Disorder Valproic Acid 2.9717594078 20046352
MESH:D001724 Birth Weight 2-ethoxyethanol 6.302884743 6499823
MESH:D001768 Blister Mustard Gas 4.9519167455
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 20.3916206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 20.3919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 20.3912125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 20.3916206674 16197459
MESH:D001836 Body Weight Changes 2-ethoxyethanol 11.327151721 6499796
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 11.3215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.5815746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.588888407
MESH:D001930 Brain Injuries Raloxifene 10.4316580743
MESH:D001930 Brain Injuries Zinc 10.4317109824
MESH:D001943 Breast Neoplasms Ascorbic Acid 2.2816443354
MESH:D001943 Breast Neoplasms Raloxifene 2.2817952589 16912660 17261762 15758505 15775269 17893378 17242785 15572757 17049068 17440819 17595753 16837676
MESH:D001943 Breast Neoplasms Tamoxifen 2.2819200415 19189212 19289846 17893378 19410462 20135344 21138602 18629630 19288272 15565566 20065188 18351453 17440819 19084267 20859285 19011961 19487384 19115204 18425577 18855134 20005174 19155303 18984771 16202921 19066611 20544844 16818667 11161223 17049068 19189210 17242785 19142967 20390343 19221464 16873071 15668708 18821012 18815881 18997820 19059307 21152245 19244106 17261762 19103187 16273361
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.2820435547
MESH:D001943 Breast Neoplasms Tretinoin 2.2816873071 16443354 16166294
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.9515286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.7617687719 10378619
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.3816813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.1311589617
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6316835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.3019066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9516168501
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 8.5316705839
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 8.5316217749 15073043 14691202 15553829 11135700
MESH:D006528 Carcinoma, Hepatocellular N-nitrosomorpholine 8.538364915 9029167 9311599 15543204 1701930 16935385 10629087 15010824 11509945 19335982 9466558 1917145 19383236 1967229 2885971
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 8.5316924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 8.531917145
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.6619014326
MESH:D002292 Carcinoma, Renal Cell N-nitrosomorpholine 4.601429202 7921415
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.9312490120
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.6716096774 16051514
MESH:D002294 Carcinoma, Squamous Cell Zinc 4.6716543248
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 8.8917572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 8.8917572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2518670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Raloxifene 7.1615775269
MESH:D002318 Cardiovascular Diseases Zinc 7.1616936243
MESH:D002386 Cataract Tretinoin 2.9717460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.636135515
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.3816129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6320734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D002764 Cholecystitis 2-ethoxyethanol 12.946499794
MESH:D002764 Cholecystitis methyl cellosolve 12.946499794
MESH:D002779 Cholestasis Ethinyl Estradiol 7.2317681005 17110522 16919318 15861022 16105132 11677210 17333356
MESH:D002779 Cholestasis pirinixic acid 7.2319176532
MESH:D002822 Choriocarcinoma Tretinoin 4.9516461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.4716354765 8697196 12621046 15340226 15668235
MESH:D002972 Cleft Palate Tretinoin 5.479407595
MESH:D003072 Cognition Disorders Raloxifene 4.4115800139
MESH:D003092 Colitis Tretinoin 3.5017035595
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D003139 Common Cold Ascorbic Acid 5.2617323712
MESH:D000013 Congenital Abnormalities methyl cellosolve 8.846499821 12530607
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 8.8414669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 3.9812609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 7.0710525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 7.0710048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 7.0716925845 9142499 17551590 9211117 10589399 9224671 8800419 14991402 9125849 9664655
MESH:D019465 Craniofacial Abnormalities Valproic Acid 7.078888407 17688650 16575769
MESH:D019465 Craniofacial Abnormalities Zinc 7.0719302082
MESH:D003456 Cryptorchidism vinclozolin 4.1414966744
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.8118551238
MESH:D003643 Death 2-ethoxyethanol 5.756499796
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.9015213294
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1519031437
MESH:D003865 Depressive Disorder, Major Raloxifene 3.9817474826
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3318249437
MESH:D003920 Diabetes Mellitus Zinc 4.0316479319
MESH:D003924 Diabetes Mellitus, Type 2 Ascorbic Acid 4.3816506275
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3817107852
MESH:D003928 Diabetic Nephropathies Raloxifene 8.4517451421 17308373 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.4519279558
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 5.8218551238 21346803
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.8220420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 5.821733752 19641884
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6111462148
MESH:D004421 Dystonia Valproic Acid 3.851851702
MESH:C538011 Eales disease Ascorbic Acid 5.269068938
MESH:D004487 Edema Mustard Gas 14.9011428647 11428631 11402378 9260866
MESH:D004487 Edema pirinixic acid 14.9012083418
MESH:D004487 Edema Raloxifene 14.9015860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 14.9012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.2315322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 11.2318230668
MESH:D020964 Embryo Loss 2-ethoxyethanol 6.306499796
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 14.1812538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 14.1815845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 14.1819031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 6.9916202921 17893378 19155303 20544844
MESH:D016889 Endometrial Neoplasms Tretinoin 6.9916569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8410568697 9294722
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.953659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.7116628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.8318234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.416426943 6254150 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.097750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.853659116
MESH:D004890 Erythema Mustard Gas 4.959357497
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.5612903497
MESH:D004938 Esophageal Neoplasms Zinc 4.5616543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.3211564622
MESH:D005124 Eye Abnormalities Tretinoin 8.329664655 16938888
MESH:D005234 Fatty Liver arsenic trioxide 28.2515073043
MESH:D005234 Fatty Liver Ethinyl Estradiol 28.2515345470
MESH:D005234 Fatty Liver pirinixic acid 28.2519236843 20131406
MESH:D005234 Fatty Liver Raloxifene 28.2517473493
MESH:D005234 Fatty Liver Tamoxifen 28.2514986274 19224547
MESH:D005234 Fatty Liver Valproic Acid 28.2519224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1116709447
MESH:D005313 Fetal Death 2-ethoxyethanol 10.157198755 6499823 7151721 6499820 2884743
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 10.1511858732
MESH:D005315 Fetal Diseases Valproic Acid 4.6716575769
MESH:D005317 Fetal Growth Retardation 2-ethoxyethanol 10.536499796
MESH:D005317 Fetal Growth Retardation Valproic Acid 10.538888407 18558336
MESH:D005327 Fetal Resorption 2-ethoxyethanol 11.966499820 6499812
MESH:D005327 Fetal Resorption methyl cellosolve 11.963987992 6499821 6499812 6474471
MESH:D020567 Fetal Weight 2-ethoxyethanol 12.946499820 7151721 2884743
MESH:D020567 Fetal Weight methyl cellosolve 12.946474471 6499812 6499821
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.3214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.9719069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.9320067830
MESH:D005355 Fibrosis Tretinoin 7.9317994277
MESH:D005532 Foot Deformities, Congenital methyl cellosolve 5.283652986
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.0616904648
MESH:D005756 Gastritis Zinc 4.5917241300
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.7216973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.0916417039
MESH:D005909 Glioblastoma Tretinoin 2.8717312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3810696789
MESH:D006130 Growth Disorders Zinc 3.8317217573
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.0516096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9516084493
MESH:D006330 Heart Defects, Congenital Ascorbic Acid 10.6016080930
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.6010048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 10.609664655 14991402
MESH:D006331 Heart Diseases Raloxifene 3.3911110106
MESH:D006333 Heart Failure pirinixic acid 6.7220558911
MESH:D006333 Heart Failure Zinc 6.7217162251
MESH:D006335 Heart Injuries Zinc 5.5617074742
MESH:D006345 Heart Septal Defects, Ventricular methyl cellosolve 5.576499821
MESH:D016481 Helicobacter Infections Zinc 4.3417241300
MESH:D006402 Hematologic Diseases 2-ethoxyethanol 5.1920172899 10514026
MESH:D006461 Hemolysis 2-ethoxyethanol 11.6319051582 17874071
MESH:D006461 Hemolysis methyl cellosolve 11.6317874071
OMIM:235700 HEMOLYTIC ANEMIA, NONSPHEROCYTIC, DUE TO HEXOKINASE DEFICIENCY marker/mechanism
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1511000095
MESH:D006527 Hepatolenticular Degeneration Zinc 10.6317276780
MESH:D006527 Hepatolenticular Degeneration Zinc Sulfate 10.6317063115
MESH:D006529 Hepatomegaly pirinixic acid 7.5719176532 16221962 18467677 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.5715340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Ascorbic Acid 3.4016490937 16863852
MESH:D006849 Hydrocephalus Valproic Acid 4.6617688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8315340226 18606429 8697196 16959395 16354765
MESH:D006930 Hyperalgesia Tretinoin 3.0516870215
MESH:D017588 Hyperandrogenism Flutamide 5.2515356085
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3616778211
MESH:D006943 Hyperglycemia pirinixic acid 3.0020558911
MESH:D006965 Hyperplasia halofuginone 5.0411874485
MESH:D006973 Hypertension Raloxifene 4.9617577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.9618850075 18670907
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.4216612254
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6016569931 16945680
MESH:D007022 Hypotension Zinc Sulfate 4.287265320
MESH:D007247 Infertility, Female 2-ethoxyethanol 9.756499823
MESH:D007247 Infertility, Female Ethinyl Estradiol 9.7512013081
MESH:D007248 Infertility, Male 2-ethoxyethanol 15.026499823
MESH:D007248 Infertility, Male Ethinyl Estradiol 15.0217937319
MESH:D007248 Infertility, Male methyl cellosolve 15.023987992
MESH:D007248 Infertility, Male vinclozolin 15.0216467254
MESH:D007249 Inflammation Aluminum 11.1416052892
MESH:D007249 Inflammation Mustard Gas 11.1417524151 11402378 9260866 11428631 8975870 9357497 11428620 11428647 16001271
MESH:D007249 Inflammation Tamoxifen 11.1419457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.1412878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.5016306350
MESH:D007410 Intestinal Diseases Tretinoin 3.5617994277
MESH:D007511 Ischemia Zinc 4.4216584753
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.3016580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.3015992940 17551590
MESH:D007674 Kidney Diseases Zinc 3.2016960431
MESH:D007676 Kidney Failure, Chronic Zinc 4.2316518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 6.8216705839
MESH:D007680 Kidney Neoplasms Tamoxifen 6.8218625569
MESH:D007889 Leiomyoma Raloxifene 4.3016973256
MESH:D016773 Leishmaniasis, Cutaneous Zinc Sulfate 4.0915237267
MESH:D007938 Leukemia arsenic trioxide 6.0015070760
MESH:D007938 Leukemia Tretinoin 6.0017143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.6117077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.1016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.2714633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 8.8419077051
MESH:D007951 Leukemia, Myeloid Tretinoin 8.8416482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 5.8816467208 20471514 17050201 16968895 19850784
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 5.8816294345 17596541 19850784
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 5.8816294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.1815336539 16112521 12018890 15213294 17217047 11468182 15748426 17712046 16331271 16823087 16966277 17649720 17869043 19642359 19225113 9834237 16330433 19035177 15622746 12679006 11161223 12712474 16891316 19075265 17107899
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.1816935935 17361223 19029980 17339181 17217047 17712046 17506722 19035177 17301526 9834237 12679006 17294898 19225113 17649720 16140955 19075265 15748426 16788101 16331271 19642359 17368321 16891316 16766008 17107899 16823087
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.1516882451
MESH:D007984 Leydig Cell Tumor vinclozolin 4.5216417039
MESH:D017880 Limb Deformities, Congenital methyl cellosolve 8.076499821
MESH:D017880 Limb Deformities, Congenital Tretinoin 8.079224671
MESH:D008064 Lipidoses Tamoxifen 3.0117567588 15342952
MESH:D008103 Liver Cirrhosis halofuginone 3.9217180598
MESH:D008106 Liver Cirrhosis, Experimental halofuginone 6.4512175628 18458672 14739098 11172339 16489207
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.4515474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.4518564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.4512878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.4516248980 18397230
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 13.377678174
MESH:D008113 Liver Neoplasms arsenic trioxide 13.3714682389
MESH:D008113 Liver Neoplasms pirinixic acid 13.3720007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tamoxifen 13.3716684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.3716984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 13.082876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 13.0820377131
MESH:D008114 Liver Neoplasms, Experimental Ascorbic Acid 13.0818544905
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 13.0812151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.1915213294
MESH:D008171 Lung Diseases Aluminum 11.8716052892
MESH:D008171 Lung Diseases Ascorbic Acid 11.8716863852
MESH:D008171 Lung Diseases Mustard Gas 11.8718702808 18161513
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.0517228818
MESH:D008175 Lung Neoplasms arsenic trioxide 6.3211798837 19825857
MESH:D008175 Lung Neoplasms Ascorbic Acid 6.3216401635
MESH:D008175 Lung Neoplasms Mustard Gas 6.323148597 8781369
MESH:D008175 Lung Neoplasms Tamoxifen 6.3218625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.3211884234 19555203
MESH:D008231 Lymphopenia methyl cellosolve 5.573699323
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.5519428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 5.8014580682 19196722 11731420 16827153 19196723
MESH:D008325 Mammary Neoplasms, Experimental Zinc 5.8012773700
MESH:D020149 Manganese Poisoning Tamoxifen 4.3419453300
MESH:D008527 Medulloblastoma Tretinoin 2.7017453147
MESH:D008545 Melanoma Tamoxifen 3.1612393984 19393235
MESH:D008545 Melanoma Tretinoin 3.1616752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9715990972
MESH:D008591 Meningomyelocele Tretinoin 4.2216940565
MESH:D008881 Migraine Disorders Valproic Acid 3.0418803445 18765137
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.3415863610
MESH:D009101 Multiple Myeloma arsenic trioxide 6.9219549372 19417148 11468182 14977855 15949261
MESH:D009101 Multiple Myeloma Raloxifene 6.9216497877
MESH:D020528 Multiple Sclerosis, Chronic Progressive Aluminum 6.1617086897
MESH:D020529 Multiple Sclerosis, Relapsing-Remitting Aluminum 6.1617086897
MESH:D009135 Muscular Diseases pirinixic acid 3.3016239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.848888407
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.4618349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 11.6216882451 16105982
MESH:D009190 Myelodysplastic Syndromes Tretinoin 11.6217596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 11.6217596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.0619151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8512213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.7916411023
MESH:D009232 Myxoma Raloxifene 5.3416343187
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.197678174 18551238
MESH:D009336 Necrosis 2-ethoxyethanol 10.1920172899
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.7616624393
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.4619393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4519410462
MESH:D009369 Neoplasms pirinixic acid 4.5717405874
MESH:D009369 Neoplasms Tretinoin 4.5716946489 16594593
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.7919200415 19189210 19196722
MESH:D009410 Nerve Degeneration Rotenone 3.7218619942 15790535 17356569
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.8414600291
MESH:D009421 Nervous System Malformations Tretinoin 8.849125849
MESH:D009436 Neural Tube Defects arsenic trioxide 11.3710525206
MESH:D009436 Neural Tube Defects Tretinoin 11.379142499
MESH:D009436 Neural Tube Defects Valproic Acid 11.3716359493 8888407
MESH:D009503 Neutropenia Mustard Gas 3.787688884 16761898
MESH:D009765 Obesity Ascorbic Acid 4.5717217161
MESH:D009765 Obesity pirinixic acid 4.5720558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.2516049721
MESH:D009845 Oligospermia 2-ethoxyethanol 10.6720172899
MESH:D009845 Oligospermia methyl cellosolve 10.673987992
MESH:D010024 Osteoporosis Raloxifene 3.2717882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.0317823083 15579764 17893378 15758505
MESH:D010051 Ovarian Neoplasms arsenic trioxide 4.6516624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms Tretinoin 4.6516936753
MESH:D010146 Pain Tretinoin 2.7416870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.0415580305
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.0415976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4911578682
MESH:D010235 Paraganglioma arsenic trioxide 3.9719927285
MESH:D010300 Parkinson Disease Rotenone 2.9011445065 19114014 15451049 19232380 11535288 18619942 16412576 18191903 16140633
MESH:D020734 Parkinsonian Disorders Rotenone 3.8915927086 15795934 15574749 18197244
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0412520081
MESH:D011041 Poisoning Mustard Gas 3.6015727166
MESH:D011085 Polycystic Ovary Syndrome Flutamide 4.8215356085
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3618163543
MESH:D011225 Pre-Eclampsia Zinc 4.0117114810
MESH:D011297 Prenatal Exposure Delayed Effects 2-ethoxyethanol 28.246499817 7198755 2884743
MESH:D011297 Prenatal Exposure Delayed Effects methyl cellosolve 28.247974496 12530607 6499817
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 28.2411896295 11399792 11222880 11118676
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 28.2420603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 28.2418220299 18042343 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.7218220299
MESH:D011471 Prostatic Neoplasms arsenic trioxide 1.9119131511
MESH:D011471 Prostatic Neoplasms Flutamide 1.913169114
MESH:D011471 Prostatic Neoplasms Raloxifene 1.9116536755 16220300 15731164
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.9115067354
MESH:D011471 Prostatic Neoplasms Zinc 1.9116517595 16700911 12429649 16606632
MESH:D011472 Prostatitis vinclozolin 4.7218629315
MESH:D011507 Proteinuria Tretinoin 3.4116636307
MESH:D011537 Pruritus Ethinyl Estradiol 8.8215861022 16919318
MESH:D011537 Pruritus Mustard Gas 8.8218058305
MESH:D019310 Pseudolymphoma Valproic Acid 4.3311422049 12752131
MESH:D011625 Pterygium Tretinoin 4.5816723453
MESH:D011657 Pulmonary Eosinophilia Ascorbic Acid 5.1214606601
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.8517620002 17266442 17894541 17720292 10334151
MESH:D011693 Purpura Raloxifene 5.3415770314
MESH:D015427 Reperfusion Injury pirinixic acid 2.2919058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6418990726
MESH:D012162 Retinal Degeneration Zinc 3.9716584753
MESH:D012174 Retinitis Pigmentosa Ascorbic Acid 3.2516849425
MESH:D012208 Rhabdomyosarcoma Tretinoin 10.2116116481 16283617
MESH:D012208 Rhabdomyosarcoma Valproic Acid 10.2119155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.7616646077
MESH:D012559 Schizophrenia Valproic Acid 2.0415737665 19110320
MESH:D012640 Seizures 2,6-dinitrotoluene 5.4818551238
MESH:D012640 Seizures Valproic Acid 5.481511512 15475178 11044598 16876388 3137016 17978042 14763951 11738929
MESH:D012871 Skin Diseases Ascorbic Acid 7.8918709164
MESH:D012871 Skin Diseases halofuginone 7.8911874485
MESH:D012871 Skin Diseases Mustard Gas 7.8912880345 16961503 15451306
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 8.868532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.8616192470
MESH:D012878 Skin Neoplasms Tretinoin 8.8616467112
MESH:D013088 Spermatocele Ethinyl Estradiol 10.8516709447
MESH:D013088 Spermatocele Tamoxifen 10.8516709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.8319457130
MESH:D016135 Spinal Dysraphism Valproic Acid 3.6219490988
MESH:D013226 Status Epilepticus Valproic Acid 4.3312833885
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.4017007042
MESH:D013274 Stomach Neoplasms Tretinoin 2.4017261132
MESH:D013276 Stomach Ulcer 2-ethoxyethanol 7.396499799
MESH:D013276 Stomach Ulcer Ascorbic Acid 7.3918726076
MESH:D020521 Stroke Ascorbic Acid 8.4516403987 16517955
MESH:D020521 Stroke Raloxifene 8.4516837676
MESH:D013733 Testicular Diseases 2-ethoxyethanol 10.366499806 10048760 10514026
MESH:D013733 Testicular Diseases methyl cellosolve 10.366499806
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6912697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 6.6819014326
MESH:D013964 Thyroid Neoplasms Tretinoin 6.6817045167 16026305
MESH:D013978 Tibial Fractures Raloxifene 5.0019048282
MESH:D014062 Tongue Neoplasms Tretinoin 9.3716051514
MESH:D014062 Tongue Neoplasms Zinc 9.3716543248
MESH:D016171 Torsades de Pointes arsenic trioxide 3.7515213294
MESH:D014178 Translocation, Genetic Valproic Acid 5.0217262798
MESH:D014376 Tuberculosis Tretinoin 3.1016040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.313119515
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 11.2616049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 11.2611780464 20435036 12845720 12973940
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 11.2617572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 11.2616712894 17572228 8653321
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.448888407
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.1110091137
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.4916129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1014692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.4016752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3812125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.0016837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3514671159 15869587
MESH:D014820 Vitiligo Tretinoin 3.8516761959
MESH:D014846 Vulvar Neoplasms Raloxifene 5.3416343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0415886252
MESH:D009396 Wilms Tumor Tretinoin 3.7916287080
Pathway ID Pathway Name
KEGG:00520 Amino sugar and nucleotide sugar metabolism
KEGG:00524 Butirosin and neomycin biosynthesis
KEGG:04973 Carbohydrate digestion and absorption
KEGG:00051 Fructose and mannose metabolism
KEGG:00052 Galactose metabolism
KEGG:00010 Glycolysis / Gluconeogenesis
KEGG:04910 Insulin signaling pathway
KEGG:01100 Metabolic pathways
REACT:474 Metabolism of carbohydrates
KEGG:00500 Starch and sucrose metabolism
REACT:15518 Transmembrane transport of small molecules
KEGG:04930 Type II diabetes mellitus
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB02007 - Alpha-D-Glucose-6-Phosphate Mol_Id: 1
DB02379 - Beta-D-Glucose Sweetening Agents
DB03431 - Adenosine-5'-Diphosphate
DB04395 - Phosphoaminophosphonic Acid-Adenylate Ester
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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