AutismKB 2.0

Annotation Detail for ACACA


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ACACA ( ACAC,ACC,ACC1,ACCA )
Gene Full Name: acetyl-CoA carboxylase alpha
Band: 17q12
Quick LinksEntrez ID:31; OMIM: 200350; Uniprot ID:ACACA_HUMAN; ENSEMBL ID: ENSG00000132142; HGNC ID: 84
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY0-1264biotin-carboxyl carrier protein assembly
Pathway IDPathway Name
hsa04910Insulin signaling pathway
hsa00640Propanoate metabolism
hsa01100Metabolic pathways
hsa00061Fatty acid biosynthesis
hsa00620Pyruvate metabolism
Pathway IDPathway Name
Metabolism of lipids and lipoproteins
Integration of energy metabolism
No data
No data
Pathway IDPathway Name
500801Fatty Acyl-CoA Biosynthesis
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1944Breast cancer
2066Lung cancer
Desease Name
CANCER
breast cancer
No data
Desease Name
Acetyl-CoA carboxylase deficiency
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ACACA mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in decreased expression of ACACA mRNAdecreases expression 20406850
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ACACA mRNAaffects expression 21346803
C438505 6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one 6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one results in increased phosphorylation of ACACA proteinincreases phosphorylation 16873680
C054931 9-oxononanoic acid 9-oxononanoic acid results in decreased activity of ACACA proteindecreases activity 2892534
D000082 Acetaminophen Acetaminophen affects the expression of ACACA mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of ACACA proteinaffects expression 20106945
C031143 AICA ribonucleotide AICA ribonucleotide results in increased phosphorylation of ACACA proteinincreases phosphorylation 16873680
15297373
C031143 AICA ribonucleotide AICA ribonucleotide results in increased phosphorylation of ACACA proteinincreases phosphorylation 16020477
D013196 Dihydrotestosterone Dihydrotestosterone results in decreased phosphorylation of ACACA proteindecreases phosphorylation 16990341
D000638 Amiodarone Amiodarone results in increased expression of ACACA mRNAincreases expression 19774075
D000638 Amiodarone Amiodarone affects the expression of ACACA mRNAaffects expression 19483382
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ACACA mRNAaffects expression 16483693
D001553 Benzbromarone Benzbromarone affects the expression of ACACA mRNAaffects expression 19483382
D001554 Benzene Benzene affects the expression of ACACA mRNAaffects expression 15878777
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ACACA mRNAdecreases expression 20106945
C006780 bisphenol A bisphenol A results in increased expression of ACACA mRNAincreases expression 20019905
D002994 Clofibrate Clofibrate affects the expression of ACACA mRNAaffects expression 19483382
D003314 Corn Oil Corn Oil results in increased expression of ACACA mRNAincreases expression 1973097
D003474 Curcumin Curcumin results in increased phosphorylation of ACACA proteinincreases phosphorylation 18790744
D003474 Curcumin Curcumin inhibits the reaction [Dietary Fats results in decreased phosphorylation of ACACA protein]decreases phosphorylation|decreases reaction 19297423
D003474 Curcumin Curcumin results in increased phosphorylation of ACACA proteinincreases phosphorylation 19297423
D016572 Cyclosporine Cyclosporine results in decreased expression of ACACA mRNAdecreases expression 20106945
D004041 Dietary Fats Curcumin inhibits the reaction [Dietary Fats results in decreased phosphorylation of ACACA protein]decreases phosphorylation|decreases reaction 19297423
D004041 Dietary Fats Dietary Fats results in decreased phosphorylation of ACACA proteindecreases phosphorylation 19297423
D004041 Dietary Fats Dietary Fats results in increased expression of ACACA mRNAincreases expression 17932310
D004041 Dietary Fats PPARGC1B protein promotes the reaction [Dietary Fats results in increased expression of ACACA mRNA]increases expression|increases reaction 17932310
D004958 Estradiol Estradiol results in increased phosphorylation of ACACA proteinincreases phosphorylation 15967841
D000431 Ethanol Ethanol inhibits the reaction [Fish Oils results in decreased expression of ACACA mRNA]decreases expression|decreases reaction 18620774
D000431 Ethanol Ethanol results in increased expression of ACACA mRNAincreases expression 18620774
D000431 Ethanol pirinixic acid inhibits the reaction [Ethanol results in increased expression of ACACA mRNA]decreases reaction|increases expression 18620774
D005001 Ethionine Ethionine affects the expression of ACACA mRNAaffects expression 19483382
D005395 Fish Oils Ethanol inhibits the reaction [Fish Oils results in decreased expression of ACACA mRNA]decreases expression|decreases reaction 18620774
D005395 Fish Oils Fish Oils results in decreased expression of ACACA mRNAdecreases expression 18620774
D005419 Flavonoids Flavonoids results in increased expression of ACACA mRNAincreases expression 18035473
D005576 Forskolin Forskolin results in increased phosphorylation of ACACA proteinincreases phosphorylation 18390901
D005632 Fructose Fructose results in increased expression of ACACA mRNAincreases expression 15066988
D005632 Fructose SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of ACACA mRNA]decreases reaction|increases expression 15066988
D005632 Fructose Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of ACACA mRNA]]decreases reaction|increases expression 15066988
D005632 Fructose Triolein promotes the reaction [Fructose results in increased expression of ACACA mRNA]increases expression|increases reaction 15066988
D005632 Fructose Fructose inhibits the reaction [Streptozocin results in decreased activity of ACACA protein]decreases activity|decreases reaction 1973097
D005632 Fructose Fructose inhibits the reaction [Streptozocin results in decreased expression of ACACA mRNA]decreases expression|decreases reaction 1973097
D005947 Glucose Glucose results in increased expression of ACACA mRNAincreases expression 15066988
D006861 Hydrogen Peroxide Hydrogen Peroxide results in increased expression of and results in increased phosphorylation of and results in increased activity of ACACA proteinincreases activity|increases expression|increases phosphorylation 15297373
C051890 irinotecan irinotecan analog results in decreased expression of ACACA mRNAdecreases expression 18927307
D015056 1-Methyl-3-isobutylxanthine 1-Methyl-3-isobutylxanthine results in increased phosphorylation of ACACA proteinincreases phosphorylation 18390901
D007545 Isoproterenol Isoproterenol results in increased phosphorylation of ACACA proteinincreases phosphorylation 18390901
D007545 Isoproterenol triacsin C inhibits the reaction [Isoproterenol results in increased phosphorylation of ACACA protein]decreases reaction|increases phosphorylation 18390901
D007657 Ketone Bodies Ketone Bodies results in decreased expression of ACACA mRNAdecreases expression 16807920
D008687 Metformin Metformin results in increased phosphorylation of ACACA proteinincreases phosphorylation 16873680
D008687 Metformin Metformin results in increased phosphorylation of ACACA proteinincreases phosphorylation 16760380
D009853 Omeprazole Omeprazole affects the expression of ACACA mRNAaffects expression 19483382
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of ACACA mRNAincreases expression 17681415
C006253 pirinixic acid ACAA1B protein inhibits the reaction [pirinixic acid results in increased expression of ACACA mRNA]decreases reaction|increases expression 19772884
C006253 pirinixic acid pirinixic acid inhibits the reaction [Ethanol results in increased expression of ACACA mRNA]decreases reaction|increases expression 18620774
C006253 pirinixic acid pirinixic acid results in decreased expression of ACACA mRNAdecreases expression 18620774
C006253 pirinixic acid pirinixic acid results in increased expression of ACACA mRNAincreases expression 19772884
18301758
C006253 pirinixic acid pirinixic acid affects the expression of ACACA mRNAaffects expression 19483382
D011441 Propylthiouracil Propylthiouracil affects the expression of ACACA mRNAaffects expression 19483382
C059514 resveratrol resveratrol results in increased phosphorylation of ACACA proteinincreases phosphorylation 17464184
17438283
C059514 resveratrol STK11 protein promotes the reaction [resveratrol results in increased phosphorylation of ACACA protein]increases phosphorylation|increases reaction 17438283
D013311 Streptozocin Fructose inhibits the reaction [Streptozocin results in decreased activity of ACACA protein]decreases activity|decreases reaction 1973097
D013311 Streptozocin Fructose inhibits the reaction [Streptozocin results in decreased expression of ACACA mRNA]decreases expression|decreases reaction 1973097
D013311 Streptozocin Streptozocin results in decreased activity of ACACA proteindecreases activity 1973097
D013311 Streptozocin Streptozocin results in decreased expression of ACACA mRNAdecreases expression 1973097
D013311 Streptozocin Triiodothyronine inhibits the reaction [Streptozocin results in decreased activity of ACACA protein]decreases activity|decreases reaction 1973097
D013311 Streptozocin Triiodothyronine inhibits the reaction [Streptozocin results in decreased expression of ACACA mRNA]decreases expression|decreases reaction 1973097
D014284 Triiodothyronine Triiodothyronine inhibits the reaction [Streptozocin results in decreased activity of ACACA protein]decreases activity|decreases reaction 1973097
D014284 Triiodothyronine Triiodothyronine inhibits the reaction [Streptozocin results in decreased expression of ACACA mRNA]decreases expression|decreases reaction 1973097
D014284 Triiodothyronine Triiodothyronine results in increased activity of ACACA proteinincreases activity 1973097
D014284 Triiodothyronine Triiodothyronine results in increased expression of ACACA mRNAincreases expression 1973097
D013739 Testosterone Testosterone results in increased expression of ACACA mRNAincreases expression 16579987
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ACACA mRNAdecreases expression 18336851
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ACACA proteindecreases expression 18336851
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ACACA mRNAincreases expression 16267337
D013853 Thioacetamide Thioacetamide results in increased expression of ACACA mRNAincreases expression 16456712
D013853 Thioacetamide Thioacetamide affects the expression of ACACA mRNAaffects expression 19483382
C034613 triacsin C triacsin C inhibits the reaction [Isoproterenol results in increased phosphorylation of ACACA protein]decreases reaction|increases phosphorylation 18390901
D014304 Triolein Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of ACACA mRNA]]decreases reaction|increases expression 15066988
D014304 Triolein Triolein promotes the reaction [Fructose results in increased expression of ACACA mRNA]increases expression|increases reaction 15066988
D014638 Vanadates Vanadates results in increased phosphorylation of ACACA proteinincreases phosphorylation 15297373
C025643 vinclozolin vinclozolin results in increased methylation of ACACA promoterincreases methylation 16973722
D015215 Zidovudine Zidovudine affects the expression of ACACA mRNAaffects expression 20032539
D015032 Zinc Zinc affects the expression of ACACA mRNAaffects expression 17181878
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 6.7618926900 17676605
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 6.7614514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 8.7518287403
MESH:D000138 Acidosis Ethanol 8.7511192467
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.329612607
MESH:D000169 Acrodermatitis Zinc 4.8816889938 17190629 17202136
MESH:D058186 Acute Kidney Injury resveratrol 3.3916538975
MESH:D055371 Acute Lung Injury pirinixic acid 2.6418653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 3.7620127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 3.7611473722
MESH:D000236 Adenoma Benzo(a)pyrene 5.746695378
MESH:D000236 Adenoma resveratrol 5.7415688382
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.1816434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.1816835633
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 4.7915451040 15451039
MESH:D019973 Alcohol-Related Disorders Curcumin 4.5517887948
MESH:D000544 Alzheimer Disease Curcumin 5.9015590663
MESH:D000544 Alzheimer Disease resveratrol 5.9016162502 16183991
MESH:D000544 Alzheimer Disease Zinc 5.9016410023 16325427 16580781 17119284
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.5011748828
MESH:D000741 Anemia, Aplastic Benzene 3.9711369114 17661222 14761424
MESH:D000755 Anemia, Sickle Cell Zinc 4.4116916123
MESH:D000799 Angioedema Acetaminophen 3.3210982225
MESH:D000853 Anophthalmos Ethanol 4.3115513904
MESH:D000987 Antisocial Personality Disorder Testosterone 5.337506515
MESH:D001008 Anxiety Disorders Ethanol 7.6411141031
MESH:D001008 Anxiety Disorders vinclozolin 7.6419015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.5719183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.3518057881 18218290 20041841
MESH:D001161 Arteriosclerosis Dietary Fats 3.3915238619
MESH:D001169 Arthritis, Experimental resveratrol 3.1717115116
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.6016807698
MESH:D001249 Asthma Zinc 2.7817085522
MESH:D050197 Atherosclerosis Curcumin 5.8418704882
MESH:D050197 Atherosclerosis resveratrol 5.8417967414 16873680
MESH:D001281 Atrial Fibrillation Amiodarone 3.5118651412 19698954
MESH:D001321 Autistic Disorder Acetaminophen 1.4818445737
MESH:D001327 Autoimmune Diseases Curcumin 3.9919761891
MESH:D001778 Blood Coagulation Disorders Amiodarone 49.0619483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 49.0619483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 49.0619483382
MESH:D001778 Blood Coagulation Disorders Ethionine 49.0619483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 49.0619483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 49.0619483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 49.0619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 49.0612125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 49.0619483382
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.2615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.4215746008
MESH:D001855 Bone Marrow Diseases Benzene 4.7016183116
MESH:D001862 Bone Resorption bisphenol A 3.4011985600
MESH:D001919 Bradycardia Isoproterenol 4.676740701
MESH:D001930 Brain Injuries Zinc 4.1817109824
MESH:D002545 Brain Ischemia Curcumin 8.6116770732
MESH:D002545 Brain Ischemia resveratrol 8.6117600658
MESH:D001932 Brain Neoplasms Curcumin 3.4917596214
MESH:D001943 Breast Neoplasms Benzene 5.1611921183 17162533
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 5.1617474063 20146248
MESH:D001943 Breast Neoplasms bisphenol A 5.1617123778
MESH:D001943 Breast Neoplasms Curcumin 5.1618593918 18462866 19250217 16243823
MESH:D001943 Breast Neoplasms Dietary Fats 5.1620435547
MESH:D001943 Breast Neoplasms Estradiol 5.1616675129 12948864 17018787 17261762 19861407 17289903 18497071 14630087
MESH:D001943 Breast Neoplasms resveratrol 5.1617534123 17651959 16393696
MESH:D001943 Breast Neoplasms Testosterone 5.1617261762
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 5.1620435547
MESH:D002056 Burns Ethanol 4.1516374292
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.9416111702
MESH:D002276 Carcinoid Tumor Streptozocin 5.0716051944
MESH:D002277 Carcinoma Curcumin 6.9118593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 6.9116835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 17.7216705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 17.7216705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 17.723084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 17.7212907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 17.721701930
MESH:D006528 Carcinoma, Hepatocellular Estradiol 17.7216924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 17.7215289165 15763234 18788625
MESH:D006528 Carcinoma, Hepatocellular resveratrol 17.7219321006 16227395
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 17.7217997003
MESH:D002278 Carcinoma in Situ bisphenol A 4.4717123778
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.0716675471
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.7818414057
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 9.3520419170
MESH:D002294 Carcinoma, Squamous Cell Curcumin 9.3518462866
MESH:D002294 Carcinoma, Squamous Cell resveratrol 9.3516227395
MESH:D002294 Carcinoma, Squamous Cell Zinc 9.3516543248
MESH:D006332 Cardiomegaly Ethanol 9.8019332462
MESH:D006332 Cardiomegaly Isoproterenol 9.807544033 11179087
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 9.8018670907 18850075 16120746
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.6919225199 15710769
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 10.1816936243
MESH:D002318 Cardiovascular Diseases resveratrol 10.1815458977
MESH:D002318 Cardiovascular Diseases Zinc 10.1816936243
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.5618974383
MESH:D002386 Cataract Acetaminophen 2.2610977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 13.036135515
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 13.031399818
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 13.0312371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 13.0318566989
MESH:D002637 Chest Pain Omeprazole 4.5815447763
MESH:D002659 Child Development Disorders, Pervasive Testosterone 3.4720678186
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.0916835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 8.0918291259
MESH:D002779 Cholestasis Cyclosporine 6.4619486331
MESH:D002779 Cholestasis pirinixic acid 6.4619176532
MESH:D002971 Cleft Lip Ethanol 3.3015513904
MESH:D002972 Cleft Palate Ethanol 5.1415513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.1416354765 8697196 15668235 15340226 12621046
MESH:D003092 Colitis Curcumin 8.1218200517 16804969 16782535
MESH:D003092 Colitis resveratrol 8.1216474422
MESH:D003103 Coloboma Curcumin 4.0818809619
MESH:D003110 Colonic Neoplasms Curcumin 5.2519359593 16340194
MESH:D003110 Colonic Neoplasms irinotecan 5.2517725105 17287894
MESH:D003110 Colonic Neoplasms resveratrol 5.2516338953
MESH:D015179 Colorectal Neoplasms irinotecan 2.6616391804 18259882 15273666 17159606 18509181 16303861 17454858
MESH:D015179 Colorectal Neoplasms resveratrol 2.6616550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.6214669216 17141729
MESH:D016510 Corneal Neovascularization Curcumin 4.3918497527
MESH:D003327 Coronary Disease Fructose 7.6318504504
MESH:D003327 Coronary Disease resveratrol 7.6316507316
MESH:D019465 Craniofacial Abnormalities Benzene 4.8615643154
MESH:D019465 Craniofacial Abnormalities Ethanol 4.8615513904 19302082 15451040 11198716 11873399 15451039 10194807
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 4.8620055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Zinc 4.8619302082
MESH:D003456 Cryptorchidism vinclozolin 3.8514966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 9.2118551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 9.2118551238
MESH:D003872 Dermatitis Benzene 4.2615902427
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.1718249437
MESH:D003920 Diabetes Mellitus Metformin 13.2617446233
MESH:D003920 Diabetes Mellitus Streptozocin 13.2616285004
MESH:D003920 Diabetes Mellitus Zinc 13.2616479319
MESH:D003921 Diabetes Mellitus, Experimental Fructose 11.7618603373
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 11.7616873680
MESH:D003921 Diabetes Mellitus, Experimental Streptozocin 11.762177838 16684804 12446591 12644472 7637645 17442507 19496084 15298345 18603373 8740154 15862027 1374869 11260395 6379147 16286809 19298542 12083368 19960420 18715473 12093613 17874149 11055810 15831366 19586609
MESH:D003922 Diabetes Mellitus, Type 1 Streptozocin 3.4518603373
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 12.0118403477
MESH:D003924 Diabetes Mellitus, Type 2 Fructose 12.0118603373
MESH:D003924 Diabetes Mellitus, Type 2 Metformin 12.0121186350
MESH:D003924 Diabetes Mellitus, Type 2 Streptozocin 12.0119586609 19647726
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 12.0117107852
MESH:D003925 Diabetic Angiopathies Metformin 5.5316385087
MESH:D058065 Diabetic Cardiomyopathies Streptozocin 5.2116025228
MESH:D003928 Diabetic Nephropathies Curcumin 17.9118204486
MESH:D003928 Diabetic Nephropathies Estradiol 17.9119279558
MESH:D003928 Diabetic Nephropathies resveratrol 17.9116286809
MESH:D003928 Diabetic Nephropathies Streptozocin 17.9119960420 19682444
MESH:D003930 Diabetic Retinopathy Streptozocin 4.9317662242
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 15.8318551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 15.8321346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 15.8311743745 17522070 10663392 11421492 11529661 19416960 11287661 11834606 12705907 16227642 12153990 18071297 12540782 11461765 10915739 14986274 17906064 14725611 14550746 16781746 2444490 12958197 19085960 19739265 19370779 19420014 16393943 17562736 16081117 15619225 16109766 12392966 15968718 19923254 18713872 11739529 16177239 19164858 16485898 10774834 12594235
MESH:D056486 Drug-Induced Liver Injury Amiodarone 15.8318218290 15265979
MESH:D056486 Drug-Induced Liver Injury Ethanol 15.8311566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 15.8320420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 15.8312963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.5719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 6.9411462148
MESH:D004362 Drug Toxicity Zidovudine 6.9415040536
MESH:D004381 Duodenal Ulcer Curcumin 7.8617351913
MESH:D004381 Duodenal Ulcer Omeprazole 7.8621218061 17151854 15991576 16613094
MESH:D050171 Dyslipidemias Clofibrate 7.5516707586
MESH:D050171 Dyslipidemias Dietary Fats 7.5518367378
MESH:D004487 Edema perfluorooctanoic acid 12.7017259670 12083418
MESH:D004487 Edema pirinixic acid 12.7012083418
MESH:D004487 Edema resveratrol 12.708985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 12.7011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.3718230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 3.5417872969
MESH:D016889 Endometrial Neoplasms Estradiol 2.6311473722 18566989 19148513
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.5710568697 9294722
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.3417923197
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 6.4216530937
MESH:D004938 Esophageal Neoplasms Ethanol 6.4216704527
MESH:D004938 Esophageal Neoplasms Zinc 6.4216543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.6211564622
MESH:D005218 Fat Necrosis Thioacetamide 5.1916456712
MESH:D005234 Fatty Liver Amiodarone 46.3614986274
MESH:D005234 Fatty Liver Clofibrate 46.3619224547
MESH:D005234 Fatty Liver Curcumin 46.3619297423
MESH:D005234 Fatty Liver Cyclosporine 46.3619224547
MESH:D005234 Fatty Liver Dietary Fats 46.3619551842 19004024 18296743 17967931
MESH:D005234 Fatty Liver Ethanol 46.3619236843 18620774 16409862
MESH:D005234 Fatty Liver Fish Oils 46.3618620774
MESH:D005234 Fatty Liver Fructose 46.3619196556 18395287 18641190
MESH:D005234 Fatty Liver pirinixic acid 46.3620131406 19236843
MESH:D005234 Fatty Liver Zidovudine 46.3618299183
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.1417920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.7816946407 15451040 10194807 15513904
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.9511858732
MESH:D005355 Fibrosis Curcumin 22.4118705752
MESH:D005355 Fibrosis Cyclosporine 22.4112168785 12639820
MESH:D005355 Fibrosis Dietary Fats 22.4118296743
MESH:D005355 Fibrosis Fructose 22.4118504504
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 22.4120067830
MESH:D005391 Firesetting Behavior Testosterone 5.337506515
MESH:D005756 Gastritis Acetaminophen 16.0116983495
MESH:D005756 Gastritis Ethanol 16.0115046732
MESH:D005756 Gastritis Zinc 16.0117241300
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.1918462866
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.4216973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.7716417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.708708960
MESH:D005909 Glioblastoma Curcumin 6.5117596214
MESH:D005909 Glioblastoma Testosterone 6.5117162496
MESH:D018149 Glucose Intolerance Fructose 4.8419165636
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.0710696789
MESH:D006130 Growth Disorders Zinc 3.6217217573
MESH:D006258 Head and Neck Neoplasms Curcumin 3.3018462866 18829502
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 5.4720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.4710048152 11294989
MESH:D006331 Heart Diseases Streptozocin 3.9112093613
MESH:D006333 Heart Failure Isoproterenol 10.0618097624
MESH:D006333 Heart Failure pirinixic acid 10.0620558911
MESH:D006333 Heart Failure Zinc 10.0617162251
MESH:D006335 Heart Injuries Zinc 5.2417074742
MESH:D016481 Helicobacter Infections Zinc 4.0617241300
MESH:D006402 Hematologic Diseases Benzene 9.4916183116
MESH:D006402 Hematologic Diseases Zidovudine 9.4912579204
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.9015720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.8711000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.1117276928 18665440 15929193
MESH:D006505 Hepatitis Thioacetamide 3.7316456712
MESH:D006527 Hepatolenticular Degeneration Zinc 4.1817276780
MESH:D006529 Hepatomegaly Amiodarone 16.5715265979
MESH:D006529 Hepatomegaly perfluorooctanoic acid 16.573609246
MESH:D006529 Hepatomegaly pirinixic acid 16.5716221962 18467677 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 16.5715340226 12621046 16120746
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.5317701891
MESH:D006558 Herpes Genitalis Estradiol 4.5015709030
MESH:D006561 Herpes Simplex resveratrol 3.6716876885
MESH:D006628 Hirsutism Testosterone 5.1217019078
MESH:D015658 HIV Infections Zidovudine 3.2111363243 17358032 20032539 11141242 11698656
MESH:D019584 Hot Flashes Estradiol 3.2317088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.5216354765 15340226 16959395 18606429 8697196
MESH:D006930 Hyperalgesia Acetaminophen 10.7716870215
MESH:D006930 Hyperalgesia Ethanol 10.7718783367
MESH:D006930 Hyperalgesia perfluorooctanoic acid 10.7712083418
MESH:D017588 Hyperandrogenism Metformin 10.6717062894 15356085
MESH:D017588 Hyperandrogenism Testosterone 10.6717019078
MESH:D006937 Hypercholesterolemia Amiodarone 18.029751232 8137927
MESH:D006937 Hypercholesterolemia Curcumin 18.0218704882
MESH:D006937 Hypercholesterolemia Dietary Fats 18.0221332399
MESH:D006937 Hypercholesterolemia resveratrol 18.0217188708
MESH:D006943 Hyperglycemia pirinixic acid 2.7320558911
MESH:D006946 Hyperinsulinism Fructose 4.4714757778 15752949 18360027 19008412 18563319
MESH:D006949 Hyperlipidemias Dietary Fats 18.1721332399
MESH:D006949 Hyperlipidemias Fish Oils 18.1715752949
MESH:D006949 Hyperlipidemias Fructose 18.1715752949
MESH:D006949 Hyperlipidemias resveratrol 18.1716873680
MESH:D006968 Hypersensitivity, Delayed Corn Oil 10.9411484837
MESH:D006968 Hypersensitivity, Delayed Fish Oils 10.9411484837
MESH:D006973 Hypertension Benzene 10.5717940673
MESH:D006973 Hypertension Cyclosporine 10.5710903974
MESH:D006973 Hypertension Fructose 10.5714568997 16843071 19008412 14573337 14633139
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 10.5718850075 18670907
MESH:D015228 Hypertriglyceridemia Fructose 4.6319799862 19342510
MESH:D006984 Hypertrophy Isoproterenol 4.7312791704
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 3.8517488730
MESH:D007006 Hypogonadism Testosterone 4.2112002444
MESH:D007018 Hypopituitarism Testosterone 5.6717426086
MESH:D007022 Hypotension Isoproterenol 4.326740701
MESH:D007037 Hypothyroidism Amiodarone 9.9317991464 18020914
MESH:D007037 Hypothyroidism Propylthiouracil 9.9318031379 8137927
MESH:D007077 Ileal Diseases 1-Methyl-3-isobutylxanthine 4.9118306037
MESH:D007174 Impulse Control Disorders Testosterone 5.337506515
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.1417600658
MESH:D007248 Infertility, Male vinclozolin 2.6916467254
MESH:D007249 Inflammation Curcumin 16.1817151092 16956363 18403477
MESH:D007249 Inflammation Dietary Fats 16.1820412841
MESH:D007249 Inflammation Flavonoids 16.1817296493
MESH:D007249 Inflammation perfluorooctanoic acid 16.1812083418
MESH:D007249 Inflammation resveratrol 16.1816366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 16.1812878042 12200463
MESH:D015212 Inflammatory Bowel Diseases Curcumin 2.9818200517 18596194
MESH:D007251 Influenza, Human resveratrol 4.0216624496
MESH:D007333 Insulin Resistance bisphenol A 24.3816393666
MESH:D007333 Insulin Resistance Dietary Fats 24.3818457598 11836018
MESH:D007333 Insulin Resistance Estradiol 24.3816627594 16393666
MESH:D007333 Insulin Resistance Fructose 24.3817133782 14633139 19342510 18563319 14757778 18981581 19799862 19586609 14573337 18057795 19008412
MESH:D007333 Insulin Resistance Metformin 24.3817062894
MESH:D007333 Insulin Resistance pirinixic acid 24.3816306350
MESH:D007414 Intestinal Neoplasms Curcumin 3.7710783313
MESH:D007511 Ischemia Zinc 4.1316584753
MESH:D007569 Jaw Abnormalities Ethanol 8.5715513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.5716580747
MESH:D007579 Jejunal Diseases 1-Methyl-3-isobutylxanthine 4.9118306037
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.9115604871
MESH:D007674 Kidney Diseases Acetaminophen 15.7112587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 15.718314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 15.7115618244
MESH:D007674 Kidney Diseases Streptozocin 15.7112093613
MESH:D007674 Kidney Diseases Zinc 15.7116960431
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 8.6816518626
MESH:D007676 Kidney Failure, Chronic Zinc 8.6816518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 18.8716705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 18.8716705839
MESH:D007680 Kidney Neoplasms Cyclosporine 18.8712371664
MESH:D007680 Kidney Neoplasms Estradiol 18.8715610895
MESH:D007680 Kidney Neoplasms Zidovudine 18.8712579204
MESH:D007859 Learning Disorders Ethanol 3.7115451040
MESH:D007889 Leiomyoma Curcumin 4.0918555241
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 3.6819248655
MESH:D007938 Leukemia Benzene 5.7918335105 14694614 15935818 17119257
MESH:D007938 Leukemia Curcumin 5.7918462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 8.4516106398
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 8.4520370541
MESH:D007951 Leukemia, Myeloid Benzene 3.8617506065
MESH:D015470 Leukemia, Myeloid, Acute Benzene 2.6019478238
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.2316087638
MESH:D015458 Leukemia, T-Cell Curcumin 4.2716106398
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 11.218812269
MESH:D007984 Leydig Cell Tumor vinclozolin 11.2116417039
MESH:D017880 Limb Deformities, Congenital Ethanol 3.4417676605
MESH:D008064 Lipidoses Amiodarone 3.1317567588 15342952
MESH:D008103 Liver Cirrhosis Dietary Fats 5.8218296743
MESH:D008103 Liver Cirrhosis Ethanol 5.8215289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.5818295389
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 7.6417355460 18705752 18006644
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 7.6414716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 7.6418166357
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 7.6415474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 7.6412878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 7.6415288472 18416461 17292413 12679928 12175628 11682029 16248980 18295389 16489207 15078482 17355460 15716488 15465738 18032466 16343077 11172339 18380797 15288473 18458672 16126171 15362042 15095483 17050028 18031379 18395095 16098781 12891558 15316131 18263696 15334695 10677585 12531686 12085344 11481614 18615449 17629604 17127702 15075984 14739098 15474484 12557150 15158331 16511523 18606216 16097051
MESH:D008107 Liver Diseases Acetaminophen 5.6716610002 12969438 16611625 19460945 11587558 19014921 12587719 19784758
MESH:D008107 Liver Diseases Curcumin 5.6716956363
MESH:D008107 Liver Diseases Thioacetamide 5.6715158337 16337175 18374380
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.1517347304 17207112
MESH:D017114 Liver Failure, Acute Acetaminophen 8.1416871587 17185352
MESH:D017114 Liver Failure, Acute Thioacetamide 8.1415633222 15313186 12479984 17276928
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 18.447678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 18.449163691 15890375 2125692 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 18.4421137059 20195826
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 18.4418709148 14757943
MESH:D008113 Liver Neoplasms pirinixic acid 18.4415890375 16377806 20007298
MESH:D008113 Liver Neoplasms resveratrol 18.4419321006 19812893 20405173 19073162
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 18.4416984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 11.362876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 11.368603461
MESH:D008114 Liver Neoplasms, Experimental Benzene 11.3612562636
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 11.3612151625
MESH:D008133 Long QT Syndrome Amiodarone 3.1811989578 15350150 17391786
MESH:D008171 Lung Diseases Amiodarone 3.0212587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 9.7118516814
MESH:D017563 Lung Diseases, Interstitial Benzene 9.7114698565
MESH:D008175 Lung Neoplasms Aflatoxin B1 7.4814755239
MESH:D008175 Lung Neoplasms Benzene 7.4812562636
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 7.486695378 18569708 18520028 18816296 20135361 20869020 20464547 20064080 17053015
MESH:D008175 Lung Neoplasms Curcumin 7.4819359593 18462866 16243823
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 7.4819555203 11884234
MESH:D008175 Lung Neoplasms Zidovudine 7.4818800350
MESH:D008223 Lymphoma Benzene 6.6317584886 17119257
MESH:D008223 Lymphoma Curcumin 6.6318462866
MESH:D016393 Lymphoma, B-Cell resveratrol 3.8217088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.4514749477
MESH:D016399 Lymphoma, T-Cell Curcumin 4.1916173963
MESH:D015674 Mammary Neoplasms, Animal Benzene 8.5412562636
MESH:D015674 Mammary Neoplasms, Animal resveratrol 8.5415688416
MESH:D008325 Mammary Neoplasms, Experimental Benzene 11.5011921183
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 11.5011807958 17203775 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 11.5011606380 8985016
MESH:D008325 Mammary Neoplasms, Experimental Zinc 11.5012773700
MESH:D020149 Manganese Poisoning Estradiol 3.9519453300
MESH:D008545 Melanoma Curcumin 4.6918462866 17885582
MESH:D008545 Melanoma Glucose 4.6914993021
MESH:D008545 Melanoma resveratrol 4.6917992120
MESH:D008546 Melanoma, Experimental Acetaminophen 3.0619513568
MESH:D008569 Memory Disorders Curcumin 8.1217263510
MESH:D008569 Memory Disorders Ethanol 8.1218411066 15451040
MESH:D008659 Metabolic Diseases resveratrol 3.9117112576
MESH:D024821 Metabolic Syndrome X Fructose 4.3918497449 17098227 19165636 17261469 16815490
MESH:D008661 Metabolism, Inborn Errors marker/mechanism
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.2616801185
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.3117358032
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.7916381670
MESH:D052016 Mucositis irinotecan 4.4917159606
MESH:D009101 Multiple Myeloma Benzene 10.0917119195
MESH:D009101 Multiple Myeloma Curcumin 10.0919372569
MESH:D009101 Multiple Myeloma resveratrol 10.0917049120 16267019 16490592 17164350 14749477 17935668
MESH:D009134 Muscular Atrophy, Spinal Curcumin 10.6917962980
MESH:D009134 Muscular Atrophy, Spinal resveratrol 10.6917962980
MESH:D009135 Muscular Diseases pirinixic acid 3.0016239165
MESH:D009181 Mycoses Amiodarone 4.3717974566 12754197
MESH:D009203 Myocardial Infarction Isoproterenol 8.2216584858 16697266 17052832 15740881 19595682 16538859 19172585
MESH:D009203 Myocardial Infarction pirinixic acid 8.2219151258
MESH:D009203 Myocardial Infarction resveratrol 8.2216525036 16456233 17188708 17015251 17125593 16317513
MESH:D017202 Myocardial Ischemia resveratrol 7.6317125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 7.6312213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 6.9116810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 6.9116411023
MESH:D009205 Myocarditis resveratrol 4.2417322642
MESH:D009336 Necrosis 2,4-dinitrotoluene 8.6318551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 8.637678174 18551238
MESH:D009361 Neoplasm Invasiveness Curcumin 3.8818495463
MESH:D009362 Neoplasm Metastasis irinotecan 2.9518259882
MESH:D009369 Neoplasms Benzo(a)pyrene 3.9111141357
MESH:D009369 Neoplasms pirinixic acid 3.9117405874
MESH:D009374 Neoplasms, Experimental resveratrol 3.508985016
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.0112497104
MESH:D009389 Neovascularization, Pathologic Estradiol 3.2217289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.9117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.8518481113 19348381
MESH:D009421 Nervous System Malformations bisphenol A 13.5116427766 11399458
MESH:D009421 Nervous System Malformations Estradiol 13.5116427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 13.5114600291
MESH:D009423 Nervous System Neoplasms Curcumin 5.1018462866
MESH:D009436 Neural Tube Defects Benzene 3.3315643154
MESH:D009447 Neuroblastoma irinotecan 3.208761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 6.9418514411
MESH:D019636 Neurodegenerative Diseases resveratrol 6.9417652729
MESH:D017599 Neuroectodermal Tumors irinotecan 4.218761367
MESH:D020078 Neurogenic Inflammation resveratrol 3.9217929310
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 10.389802331
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 10.389802331
MESH:D009765 Obesity Curcumin 9.3919297423
MESH:D009765 Obesity Dietary Fats 9.3919632207 11836018 21332399 16723640 18674790 18457598 17217161 20132043 20518802
MESH:D009765 Obesity Fructose 9.3917707055 18585860
MESH:D009765 Obesity pirinixic acid 9.3920558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 12.5612819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 12.5616049721
MESH:D009784 Occupational Diseases Benzene 12.5615935809 15727169 15612468 17119257 15913788 17479406 15576619 17178637 16737584
MESH:D010024 Osteoporosis Curcumin 3.1418719352
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 3.7817513867
MESH:D010049 Ovarian Diseases bisphenol A 4.4711985600
MESH:D010051 Ovarian Neoplasms Benzene 6.8912562636
MESH:D010051 Ovarian Neoplasms Curcumin 6.8919020741 18462866
MESH:D010051 Ovarian Neoplasms Estradiol 6.8919401270
MESH:D010146 Pain Acetaminophen 1.9916870215
MESH:D010190 Pancreatic Neoplasms Curcumin 4.9219196508 17440100 19401701
MESH:D010190 Pancreatic Neoplasms Ethanol 4.9212384795
MESH:D010212 Papilloma Hydrogen Peroxide 3.5912065085
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.7212520081
MESH:D011085 Polycystic Ovary Syndrome Metformin 5.0815356085 17062894
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.0718163543
MESH:D011230 Precancerous Conditions Corn Oil 8.0414668109
MESH:D011230 Precancerous Conditions Cyclosporine 8.0412371664
MESH:D011225 Pre-Eclampsia Zinc 3.7717114810
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 24.9810548101
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 24.9817132714
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 24.9816679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 24.9811118676 11896295 11222880 11399792
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 24.9818042343 19015723 18220299
MESH:D011469 Prostatic Diseases vinclozolin 4.4218220299
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 15.3620887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 15.3620887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Testosterone 15.3620887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8717292933
MESH:D011471 Prostatic Neoplasms bisphenol A 1.8716740699
MESH:D011471 Prostatic Neoplasms Curcumin 1.8718769126 18226269 12497104 15129424 18156803 11398177 10851300
MESH:D011471 Prostatic Neoplasms Estradiol 1.8716740699
MESH:D011471 Prostatic Neoplasms resveratrol 1.8716731767 17804756 17675339 17636462 15767336 17718901
MESH:D011471 Prostatic Neoplasms Zinc 1.8716700911 16517595 12429649 16606632
MESH:D011472 Prostatitis vinclozolin 4.4218629315
MESH:D011565 Psoriasis Cyclosporine 2.0316882103
MESH:D011629 Puberty, Precocious bisphenol A 4.2710548101
MESH:D011654 Pulmonary Edema Isoproterenol 4.7210903255
MESH:D011656 Pulmonary Emphysema Curcumin 4.0719168576
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.6411597910 12832656 12490602
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.0516325855
MESH:D015427 Reperfusion Injury pirinixic acid 5.6519058328
MESH:D015427 Reperfusion Injury resveratrol 5.6516317513 16314181 17058453 15827377 17520802
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.5510666014 18379247
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.3418990726
MESH:D012162 Retinal Degeneration Zinc 3.7316584753
MESH:D012509 Sarcoma Curcumin 3.6718462866
MESH:D012640 Seizures 2,4-dinitrotoluene 7.7818551238
MESH:D012640 Seizures 2,6-dinitrotoluene 7.7818551238
MESH:D012640 Seizures Ethanol 7.789754883
MESH:D018805 Sepsis Curcumin 3.6518389075
MESH:D012735 Sexual Dysfunction, Physiological Testosterone 5.6716631401
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.5618724381
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 15.1019755658 10029692
MESH:D012878 Skin Neoplasms Glucose 15.1014993021
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 15.1012065085
MESH:D012878 Skin Neoplasms resveratrol 15.108985016 15837718
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 15.1016192470
MESH:D013272 Stomach Diseases Omeprazole 4.1018545984
MESH:D013274 Stomach Neoplasms Benzene 5.6912562636
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 5.692093021 20155912
MESH:D013274 Stomach Neoplasms Ethanol 5.6918456281
MESH:D013274 Stomach Neoplasms irinotecan 5.6915723263
MESH:D013274 Stomach Neoplasms Zidovudine 5.6917696246
MESH:D013276 Stomach Ulcer Amiodarone 13.4718087811
MESH:D013276 Stomach Ulcer Curcumin 13.4719188055 16631530
MESH:D013276 Stomach Ulcer Ethanol 13.4717189318 17918041 16755016 11906479 9211565 9562338
MESH:D013276 Stomach Ulcer Omeprazole 13.4715991576 18237397 17977527 10750652 11906479 16755016
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.0316321402
MESH:D019966 Substance-Related Disorders bisphenol A 3.4716045194 16684133
MESH:D013375 Substance Withdrawal Syndrome Ethanol 3.809754883
MESH:D013610 Tachycardia Amiodarone 3.8011238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.7019225199
MESH:D013953 Thymus Neoplasms Benzene 4.4410850423
MESH:D013959 Thyroid Diseases Amiodarone 10.2919731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 10.2912697716
MESH:D013964 Thyroid Neoplasms Propylthiouracil 3.2915710170
MESH:D013971 Thyrotoxicosis Amiodarone 4.3519584973 18020914
MESH:D013978 Tibial Fractures Estradiol 4.1619048282
MESH:D014062 Tongue Neoplasms resveratrol 8.6416227395
MESH:D014062 Tongue Neoplasms Zinc 8.6416543248
MESH:D016171 Torsades de Pointes Amiodarone 3.6817467628 11989578
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 10.0216049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 10.0216049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 10.0217053015
MESH:D001749 Urinary Bladder Neoplasms Curcumin 10.0218593936
MESH:D014565 Urogenital Neoplasms Curcumin 4.7418462866
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 10.2610091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 10.2610091137
MESH:D014581 Urticaria Acetaminophen 2.5010982225
MESH:D002583 Uterine Cervical Neoplasms resveratrol 3.6517473185
MESH:D014591 Uterine Diseases bisphenol A 4.4814652134
MESH:D014594 Uterine Neoplasms Benzene 8.2512562636
MESH:D014594 Uterine Neoplasms resveratrol 8.2517044934
MESH:D014605 Uveitis Cyclosporine 3.461336536
MESH:D014625 Vaginal Neoplasms Zidovudine 4.2512579204
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.0712125929
MESH:D018487 Ventricular Dysfunction, Left Isoproterenol 8.9918097624
MESH:D018487 Ventricular Dysfunction, Left resveratrol 8.9917488730
MESH:D020257 Ventricular Remodeling Isoproterenol 5.1718097624
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.7215886252
MESH:D015430 Weight Gain Dietary Fats 3.3016723640
MESH:D014985 Xerophthalmia Cyclosporine 3.9117120751
Pathway ID Pathway Name
KEGG:00061 Fatty acid biosynthesis
KEGG:04910 Insulin signaling pathway
REACT:1505 Integration of energy metabolism
KEGG:01100 Metabolic pathways
REACT:22258 Metabolism of lipids and lipoproteins
KEGG:00640 Propanoate metabolism
KEGG:00620 Pyruvate metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24421
    • No data
    Releated disease ID Related disease Name
    PA443890Diabetes Mellitus, Type 2
    PA445131Obesity
    PA446120Hypertriglyceridemia
    Releated drug ID Related drug Name
    PA450970pioglitazone
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00121 - Biotin Dietary supplement;Micronutrient;Vitamins (Vitamin B Complex);Vitamin B Complex
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved