AutismKB 2.0

Annotation Detail for HLA-A


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Basic Information Top
Gene Symbol:HLA-A ( FLJ26655,HLAA )
Gene Full Name: major histocompatibility complex, class I, A
Band: 6p22.1
Quick LinksEntrez ID:3105; OMIM: 142800; Uniprot ID:1A03_HUMAN; ENSEMBL ID: ENSG00000206503; HGNC ID: 4931
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05332Graft-versus-host disease
hsa04650Natural killer cell mediated cytotoxicity
hsa04145Phagosome
hsa04144Endocytosis
hsa05416Viral myocarditis
hsa05320Autoimmune thyroid disease
hsa05330Allograft rejection
hsa04612Antigen processing and presentation
hsa04514Cell adhesion molecules (CAMs)
hsa04940Type I diabetes mellitus
Pathway IDPathway Name
Signaling in Immune system
Pathway IDPathway Name
200034IL12-mediated signaling events
200184Downstream signaling in naive CD8+ T cells
200062TCR signaling in naive CD8+ T cells
200118AP-1 transcription factor network
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1707Multiple myeloma
1725Severe acute respiratory syndrome
1782Henoch-Schoenlein purpura
1770Melanoma
1779Cervical cancer
1803Periodontitis
1809HIV infection
1831Prostate cancer
1845Psoriasis
1848Embryoma
1850Herpes
1877Multiple sclerosis
1894Abortion
1901Endometriosis
1904Diabetes mellitus
1930Graves' disease
1964Primary biliary cirrhosis
2022Liver cancer
2028Nasopharyngeal cancer
2051Leukemia
2053Colon cancer
2069Schizophrenia
2083IGA glomerulonephritis
2094Ulcerative colitis
2099Hepatitis B
2106Pancreas cancer
2110Leprosy
2124Autistic disorder
2125Bladder cancer
2130Autoimmune thyroiditis
2146Lupus erythematosus
2161Hodgkin's disease
2189Ankylosing spondylitis
2199Takayasu's arteritis
2219Mucocutaneous lymph node syndrome
2230Alopecia
2191Meningioma
Desease Name
Sjogren's syndrome
periodontitis
vitiligo
hepatitis, fulminant non-A, nonB
AGING
Spondylarthropathies
CARDIOVASCULAR
diabetes, type 1
endometriosis
prostate cancer
pancreatitis, autoimmune
graft-versus-host disease
Alzheimer's disease
CANCER
PSYCH
Dermatitis, Atopic
nasopharyngeal cancer
multiple sclerosis
HIV-1 control
alopecia areata
IMMUNE
NEUROLOGICAL
pulmonary thromboembolism
Enterovirus Infections
ANCA positive patients
schizophrenia
nasopharyngeal carcinoma
age
psoriasis
HIV
leukemia
thrombosis, deep vein
REPRODUCTION
Hepatitis C, Chronic
INFECTION
pancreatitis, chronic calcifying
pulmonary hypertension
Desease Name
Nasopharyngeal carcinoma
Vitiligo
Desease Name
Severe cutaneous adverse reaction, susceptibiliyt to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C006632 arsenic trioxide arsenic trioxide results in decreased expression of HLA-A mRNAdecreases expression 19128835
C020711 beryllium sulfate beryllium sulfate results in increased expression of HLA-A mRNAincreases expression 16314022
D002220 Carbamazepine HLA-A gene SNP affects the susceptibility to Carbamazepineaffects response to substance 16538176
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of HLA-A mRNAincreases expression 15963578
D002945 Cisplatin HLA-A protein affects the susceptibility to Cisplatinaffects response to substance 16217747
D004391 Dust Dust results in increased expression of HLA-A mRNAincreases expression 17805423
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of HLA-A mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of HLA-A mRNAincreases expression 19619570
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of HLA-A mRNAaffects cotreatment|increases expression 17183730
D008727 Methotrexate HLA-A protein affects the susceptibility to Methotrexateaffects response to substance 16217747
C030984 pyrene pyrene results in decreased expression of HLA-A mRNAdecreases expression 15963578
D018038 Sodium Selenite Sodium Selenite results in increased expression of HLA-A mRNAincreases expression 18175754
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of HLA-A mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of HLA-A mRNAdecreases expression 19619570
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of HLA-A mRNAaffects cotreatment|increases expression 17183730
D014635 Valproic Acid Valproic Acid results in increased expression of HLA-A mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Carbamazepine 21.468986270
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 21.4612039119
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 21.4614514962 15322242 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 21.468875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.0119490988
MESH:D058186 Acute Kidney Injury Cisplatin 4.0412690470 15814532 17670903
MESH:D000230 Adenocarcinoma arsenic trioxide 7.2811798837 19825857
MESH:D000230 Adenocarcinoma Cisplatin 7.2811798837 17638652
MESH:D000230 Adenocarcinoma Estradiol 7.2811473722
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4916835633
MESH:D000550 Amblyopia Valproic Acid 5.3717688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D001008 Anxiety Disorders Valproic Acid 3.6417497229
MESH:D001172 Arthritis, Rheumatoid Methotrexate 3.1117286800
MESH:D001321 Autistic Disorder marker/mechanism 16720216
MESH:D001321 Autistic Disorder Valproic Acid 2.0017157402 18985861 18396377 20603192 18775368 18316065 19460635 18558336 16609825 15238991 19232924 17507914 18177632 18940202 17688650
MESH:D001714 Bipolar Disorder Carbamazepine 7.6817594078 20046352
MESH:D001714 Bipolar Disorder Valproic Acid 7.6820046352 17594078
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.2316206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.2312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.1915746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.198888407
MESH:D019046 Bone Marrow Neoplasms Cisplatin 5.0214601052
MESH:D001943 Breast Neoplasms Cisplatin 2.0118382427 19526202
MESH:D001943 Breast Neoplasms Estradiol 2.0119861407 17289903 14630087 12948864 18497071 17261762 16675129 17018787
MESH:D001943 Breast Neoplasms Methotrexate 2.0116978400
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0120435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.4211589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5816111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.8816050911 16011737 15700767 15673190 18705752 15721981 16192424 16227642 16124888 16097048 3786805 10355542
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 6.7116217749 11135700 14691202 15553829 15073043
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.7118788625
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 6.7117982673
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.7116924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.0616685392 12023789
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.0119014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.1912490120
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 2.8418337622 17066447 6189445
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4118850075 18670907 16120746
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.8218566989
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7320734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2316835633
MESH:D019457 Chromosome Breakage Sodium Selenite 4.8615894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1316354765 12621046 15668235 8697196 15340226
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.6820501625
MESH:D015179 Colorectal Neoplasms Cisplatin 2.6815273666
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1314669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 4.2812609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 7.4610525206
MESH:D019465 Craniofacial Abnormalities Carbamazepine 7.469014606
MESH:D019465 Craniofacial Abnormalities Methotrexate 7.4612039119 9562676
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 7.4615322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Valproic Acid 7.468888407 16575769 17688650
MESH:D003550 Cystic Fibrosis Methotrexate 4.3119747007
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.1815213294
MESH:D003882 Dermatomyositis Methotrexate 5.2220191521
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.8516285004
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.4819279558
OMIM:607208 DRAVET SYNDROME Carbamazepine 5.5511748493
MESH:D004342 Drug Hypersensitivity Carbamazepine 4.4516538176 16538175 15057820 20216337
MESH:D056486 Drug-Induced Liver Injury Carbamazepine 12.2917465707
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 12.2919085960 6884620 15968718 10092053 2869522 15027814 16177239 7179309 9327722 7120509 21278145 11566570 16227642 19336974 4309450 6623471 17522070 3732212 7440962 3786805 10915739 15998439
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 12.2915131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.2920420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 12.291733752 19641884
MESH:D004362 Drug Toxicity Carbamazepine 14.2420216337
MESH:D004362 Drug Toxicity Cisplatin 14.2419839026 12649298 15033597 12231392
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 14.2411462148
MESH:D004421 Dystonia Valproic Acid 4.141851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4612711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0415322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Carbamazepine 4.8317654737
MESH:D016889 Endometrial Neoplasms Estradiol 3.0319148513 11473722 18566989
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1010568697 9294722
MESH:D004816 Epidermal Necrolysis, Toxic Carbamazepine 5.3519915237 16538176 18855540 20485159 16415921
MESH:D004831 Epilepsies, Myoclonic Carbamazepine 11.5517275665
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 11.553659116 17275665
MESH:D004828 Epilepsies, Partial Carbamazepine 10.8316628512 17116037 15008574
MESH:D004828 Epilepsies, Partial Valproic Acid 10.8316628512 3922381
MESH:D004827 Epilepsy Carbamazepine 7.2017178248 9014606 19620853 20417680 19700373 821787 7988514 17465707 18234410 19439326
MESH:D004827 Epilepsy Valproic Acid 7.2020417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.666426943 6254150 7562514
MESH:D017029 Epilepsy, Complex Partial Carbamazepine 12.067750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 12.067750514
MESH:D004830 Epilepsy, Tonic-Clonic Carbamazepine 11.2815276670 3659116
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 11.283659116
MESH:D004916 Erythromelalgia Carbamazepine 5.8419549232
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.7812903497
MESH:D004938 Esophageal Neoplasms Cisplatin 4.7815173087 16785472 15464296 17638652 16481741
MESH:D005076 Exanthema Carbamazepine 5.5820485159
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver arsenic trioxide 13.6615073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 13.6615959796 16045604 12631006 17595544 12795759 19224547 16239168 61145
MESH:D005234 Fatty Liver Valproic Acid 13.6619224547 14986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005315 Fetal Diseases Valproic Acid 5.0216575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.238888407 18558336
MESH:D005355 Fibrosis Carbon Tetrachloride 8.9518705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.9520067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.3616904648
MESH:D005910 Glioma marker/mechanism 14511464
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006086 Graft vs Host Disease Methotrexate 5.2516518429
MESH:D006258 Head and Neck Neoplasms Cisplatin 3.7715464296 15102660
MESH:D034381 Hearing Loss Cisplatin 4.3719898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.4915464296
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3710048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.6919900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0015340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.1715709030
MESH:D006689 Hodgkin Disease Cisplatin 3.6616200630 16170182
MESH:D019584 Hot Flashes Estradiol 3.8917088409
MESH:D006849 Hydrocephalus Valproic Acid 4.9817688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.188697196 16959395 15340226 18606429 16354765
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6516899240
MESH:D020138 Hyperhomocysteinemia Carbamazepine 4.8010459572
MESH:D006965 Hyperplasia Carbamazepine 5.3118773962
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9318850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1915338365
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.7316612254
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8912200463 12878042
MESH:D007333 Insulin Resistance Estradiol 7.6116627594 16393666
MESH:D007333 Insulin Resistance Sodium Selenite 7.6114714311
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.2715464296
MESH:D007674 Kidney Diseases Cisplatin 6.4219839026 12649298 12231392 18289764 15190930
MESH:D007674 Kidney Diseases Estradiol 6.4215618244
MESH:D007680 Kidney Neoplasms Estradiol 3.0515610895
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.9311231351
MESH:D007805 Language Development Disorders Methotrexate 5.199562676
MESH:D007938 Leukemia arsenic trioxide 2.8715070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.8812560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.4216972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.4914633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.8419077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.9516467208 17050201 20471514 16968895 19850784
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.9517596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.2612712474 16331271 16891316 17869043 16112521 11161223 19075265 16966277 15213294 12679006 17649720 16330433 19642359 19225113 16823087 17217047 17107899 12018890 11468182 15748426 17712046 15622746 9834237 15336539 19035177
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.4516882451
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 7.0717157831 16943688 16221502 11408273 21278145 16239168 17174718 17334410 11903743
MESH:D008103 Liver Cirrhosis Methotrexate 7.0714986274
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.4817525996 12546737 18187930 15931870 16033810 17708605 18418968 15730626 16097048 15338365 15996030 17869086 13678700 18251166 17900296 15818738 18205269 17714472 12741479 12389079 15893842 15925388 18279442 15370692 17721639 16248980 18263696 14748882 10355542 17698563 15650968 14716496 15052691 15123356 15959796 17823541 17631135 17761835 12586293 16638106 17565644 18412020 18156304 12898905 18429990 18376398 15362042 17557913 18317297 18054572 12958196 16136751 18339082 17922224 17976157 18210741 12632512 18472094 16027843 12666154 16011737 18006644 16116963 17805973 15876570 12649538 17640975 14620537 12445421 15673190 16192424 14512876 12667390 12632514 18166357 17481882 15057751 18472332 14716833 18395914 12445418 17766677 11481614 18277467 17944888 20821823 16015684 18481824 18420326 12609069 18395095 14724832 18705752
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.4814716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4812878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1017285989 16964402 15720792 16246199 15830285
MESH:D017093 Liver Failure Carbon Tetrachloride 4.2715123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.7716899240 14706259
MESH:D008113 Liver Neoplasms arsenic trioxide 7.5714682389
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.5719294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.5716984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 10.1020377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.1012014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.1012151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4115213294
MESH:D017563 Lung Diseases, Interstitial Methotrexate 11.9218516814
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 11.9217228818
MESH:D008175 Lung Neoplasms arsenic trioxide 3.5111798837 19825857
MESH:D008175 Lung Neoplasms Cisplatin 3.5111798837 6189445 17225452
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5111884234 19555203
MESH:D008180 Lupus Erythematosus, Systemic Carbamazepine 3.5916628512
MESH:D008223 Lymphoma Methotrexate 4.0117352296
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.1514737004
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6116891317 11408345 17203775 11807958
MESH:D020149 Manganese Poisoning Estradiol 4.6219453300
MESH:D008545 Melanoma Cisplatin 2.4812374674 17023156 18332650 16809738 18176117 15577323 12393984 16432458 11135225 18505091 12883367 16248763 17761969
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.8915990972
MESH:D008607 Mental Retardation Carbamazepine 3.759014606
MESH:D008654 Mesothelioma Cisplatin 3.2717638057
MESH:D008881 Migraine Disorders Valproic Acid 3.2518765137 18803445
MESH:D052016 Mucositis Methotrexate 5.4017488658
MESH:D009101 Multiple Myeloma arsenic trioxide 3.1619417148 11468182 19549372 14977855 15949261
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.118888407
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.8118349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.5616105982 16882451
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.5617596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3416810080
MESH:D009224 Myotonia Congenita Carbamazepine 5.5820399394
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.0516624393
MESH:D009369 Neoplasms Cisplatin 2.9716773208
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8517289903
MESH:D009395 Nephritis, Interstitial Cisplatin 4.6315464296
MESH:D009421 Nervous System Malformations Carbamazepine 17.0616990009
MESH:D009421 Nervous System Malformations Estradiol 17.0616427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 17.0614600291
MESH:D009436 Neural Tube Defects arsenic trioxide 7.5010525206
MESH:D009436 Neural Tube Defects Valproic Acid 7.508888407 16359493
MESH:D009447 Neuroblastoma Cisplatin 3.498761367
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.818761367
MESH:D010018 Osteomalacia Carbamazepine 5.5817016548
MESH:D010051 Ovarian Neoplasms arsenic trioxide 8.0812452020 19769630 16624393
MESH:D010051 Ovarian Neoplasms Cisplatin 8.0815464296 19769630 17225452 6897625
MESH:D010051 Ovarian Neoplasms Estradiol 8.0819401270
MESH:D010146 Pain Carbamazepine 4.1015215642
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.5715580305
MESH:D010190 Pancreatic Neoplasms Cisplatin 5.5719003803
MESH:D010235 Paraganglioma arsenic trioxide 4.2519927285
MESH:D010267 Parapsoriasis marker/mechanism 16538176
MESH:D010267 Parapsoriasis Carbamazepine 5.8016538176
OMIM:167400 PAROXYSMAL EXTREME PAIN DISORDER Carbamazepine 6.0417145499 17679678
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.4015464296
MESH:D010997 Pleural Neoplasms Cisplatin 5.4817638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011248 Pregnancy Complications Carbamazepine 5.269014606
MESH:D011297 Prenatal Exposure Delayed Effects Carbamazepine 17.099014606
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 17.0911222880 11896295 11118676 11399792
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 17.0920603192
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9720887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.5619131511
MESH:D011471 Prostatic Neoplasms Estradiol 2.5616740699
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.5618760546
MESH:D019310 Pseudolymphoma Carbamazepine 13.059591791 12752131
MESH:D019310 Pseudolymphoma Valproic Acid 13.0512752131 11422049
MESH:D011565 Psoriasis Methotrexate 3.4617410198
MESH:D051437 Renal Insufficiency Cisplatin 10.9115464296
MESH:D051437 Renal Insufficiency Methotrexate 10.9117352296
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.2619155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 10.6716646077
MESH:D012512 Sarcoma, Ewing's Cisplatin 10.6714601052
MESH:D012559 Schizophrenia Valproic Acid 2.0815737665 19110320
MESH:D012640 Seizures Carbamazepine 6.5916876388 16938433 9844417 16180713 9046859 15946322 19414003
MESH:D012640 Seizures Valproic Acid 6.591511512 17978042 14763951 15475178 11044598 11738929 3137016 16876388
OMIM:608579 SEVERE CUTANEOUS ADVERSE REACTION, SUSCEPTIBILITY TO marker/mechanism
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0816192470
MESH:D012893 Sleep Disorders Carbamazepine 5.2419414003
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.4815464296
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8419490988
OMIM:106300 SPONDYLOARTHROPATHY, SUSCEPTIBILITY TO, 1 marker/mechanism
MESH:D013226 Status Epilepticus Valproic Acid 4.6712833885
MESH:D013262 Stevens-Johnson Syndrome Carbamazepine 5.3119694795 15057820 16538176 18855540 19915237 16415921 20485159
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.6717007042
MESH:D013274 Stomach Neoplasms Cisplatin 2.6715958060 18396642 17522103
MESH:D013576 Syndactyly Methotrexate 5.139562676
MESH:D013736 Testicular Neoplasms Cisplatin 4.7217225452 15464296
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.1519014326
MESH:D013978 Tibial Fractures Estradiol 4.8219048282
MESH:D016171 Torsades de Pointes arsenic trioxide 4.0815213294
MESH:D014178 Translocation, Genetic Valproic Acid 5.3717262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.643119515
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.4211780464 20435036 12973940 12845720
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 5.4215464296 12973940 17225452
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.758888407
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 4.2816803524
MESH:D014625 Vaginal Neoplasms Cisplatin 4.7115577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D014839 Vomiting Cisplatin 4.8511897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
Pathway ID Pathway Name
KEGG:05330 Allograft rejection
KEGG:04612 Antigen processing and presentation
KEGG:05320 Autoimmune thyroid disease
KEGG:04514 Cell adhesion molecules (CAMs)
KEGG:04144 Endocytosis
KEGG:05332 Graft-versus-host disease
KEGG:04650 Natural killer cell mediated cytotoxicity
KEGG:04145 Phagosome
REACT:6900 Signaling in Immune system
KEGG:04940 Type I diabetes mellitus
KEGG:05416 Viral myocarditis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35055
    • No data
    Releated disease ID Related disease Name
    PA445532Retinal Diseases
    PA446010Uveitis
    PA443888Diabetes Mellitus, Type 1
    PA444750Leukemia
    PA446023Vasculitis
    PA444859Malaria
    PA443557Brain Neoplasms
    PA447025Muscular Dystrophy, Duchenne
    PA444546Hypersensitivity
    PA162316739Maculopapular Exanthema
    PA445738Stevens-Johnson Syndrome
    PA443936Drug Hypersensitivity
    PA443937Drug Toxicity
    PA444059Epidermal Necrolysis, Toxic
    PA444065Epilepsy
    PA443224Abnormalities, Drug-Induced
    PA164925725Toxic liver disease
    Releated drug ID Related drug Name
    PA449167cyclosporine
    PA164764446daclizumab
    PA448785carbamazepine
    PA451686ticlopidine
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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