AutismKB 2.0

Annotation Detail for HLA-B


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:HLA-B ( AS,HLA-B27,HLA-B73,HLAB,MGC111087,SPDA1 )
Gene Full Name: major histocompatibility complex, class I, B
Band: 6p21.33
Quick LinksEntrez ID:3106; OMIM: 142830; Uniprot ID:1B07_HUMAN; ENSEMBL ID: ENSG00000234745; HGNC ID: 4932
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05332Graft-versus-host disease
hsa04650Natural killer cell mediated cytotoxicity
hsa04145Phagosome
hsa04144Endocytosis
hsa05416Viral myocarditis
hsa05320Autoimmune thyroid disease
hsa05330Allograft rejection
hsa04612Antigen processing and presentation
hsa04514Cell adhesion molecules (CAMs)
hsa04940Type I diabetes mellitus
Pathway IDPathway Name
Signaling in Immune system
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1782Henoch-Schoenlein purpura
1779Cervical cancer
1803Periodontitis
1807Autoimmune disease
1845Psoriasis
1869Behcet syndrome
1901Endometriosis
1903Larynx cancer
1944Breast cancer
1970Virus disease
2018Rheumatic fever
2022Liver cancer
2028Nasopharyngeal cancer
2051Leukemia
2052Infection
2066Lung cancer
2069Schizophrenia
2075Heart failure
2076Spondylarthropathies
2093Viremia
2146Lupus erythematosus
2199Takayasu's arteritis
2219Mucocutaneous lymph node syndrome
2220Dermatitis
2230Alopecia
Desease Name
ankylosing spondylitis independent of HLA-B27
periodontitis
vitiligo
drug-induced liver injury (flucloxacillin)
leukemia, chronic lymphocytic
Spondylarthropathies
CARDIOVASCULAR
height
endometriosis
primary sclerosing cholangitis
Lambert-Eaton myasthenic syndrome
Celiac Disease
psoriatic arthritis
CANCER
hypertrophic cardiomyopathy
PHARMACOGENOMIC
multiple sclerosis
HIV-1 control
Chronic Hepatitis C
IMMUNE
Behcet's Disease
AIDS
pulmonary thromboembolism
ankylosing spondylitis
METABOLIC
Stevens-Johnson Syndrome
spondyloarthropathies
Chinese ankylosing spondylitis patients
complement C4 complotypes
Graves disease
acute anterior uveitis
lung cancer
HIV Infections
cholangitis, sclerosing
pemphigus
Haemophilia with Chronic synovitis
HIV
hepatitis B
hepatitis C
leukemia
DEVELOPMENTAL
thrombosis, deep vein
REPRODUCTION
INFECTION
pulmonary hypertension
Desease Name
Height
Nasopharyngeal carcinoma
Multiple sclerosis
CD4:CD8 lymphocyte ratio
HIV-1 control
Desease Name
Spondyloarthropathy, susceptibility to, 1
Drug-induced liver injury due to flucloxacillin
Synovitis, chronic, susceptibility to
Abacavir hypersensitivity, susceptibility to
Stevens-Johnson syndrome, carbamazepine-induced, susceptibility to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C106538 abacavir HLA-B protein affects the susceptibility to abacaviraffects response to substance 15024131
C006632 arsenic trioxide arsenic trioxide results in decreased expression of HLA-B mRNAdecreases expression 15725085
15761015
19128835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of HLA-B mRNAdecreases expression 20018196
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of HLA-B mRNAdecreases expression 15336504
D002220 Carbamazepine HLA-B gene polymorphism affects the susceptibility to Carbamazepineaffects response to substance 20485159
19915237
18855540
20235791
19694795
D002220 Carbamazepine HLA-B gene SNP affects the susceptibility to Carbamazepineaffects response to substance 16538176
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of HLA-B mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of HLA-B mRNAincreases expression 19619570
D005436 Floxacillin HLA-B protein polymorphism affects the susceptibility to Floxacillinaffects response to substance 19483685
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of HLA-B mRNAaffects cotreatment|increases expression 17183730
C051890 irinotecan irinotecan analog results in decreased expression of HLA-B mRNAdecreases expression 18927307
C047781 lamotrigine HLA-B gene polymorphism affects the susceptibility to lamotrigineaffects response to substance 20235791
20485159
C036006 oxcarbazepine HLA-B gene polymorphism affects the susceptibility to oxcarbazepineaffects response to substance 20235791
D010672 Phenytoin HLA-B gene polymorphism affects the susceptibility to Phenytoinaffects response to substance 20235791
D012643 Selenium Selenium results in increased expression of HLA-B mRNAincreases expression 19244175
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of HLA-B mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of HLA-B mRNAdecreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of HLA-B mRNAincreases expression 20106945
D014212 Tretinoin Tretinoin results in increased expression of HLA-B mRNAincreases expression 17218384
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of HLA-B mRNAaffects cotreatment|increases expression 17183730
D014635 Valproic Acid Valproic Acid results in increased expression of HLA-B mRNAincreases expression 19101580
D014810 Vitamin E Vitamin E results in increased expression of HLA-B mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Carbamazepine 20.398986270
MESH:D000014 Abnormalities, Drug-Induced Phenytoin 20.393425630 9118846 8986270 6195326 9677735 10563481
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 20.3915322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 20.398875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.9119490988
MESH:D000230 Adenocarcinoma arsenic trioxide 4.3819825857 11798837
MESH:D000230 Adenocarcinoma Estradiol 4.3811473722
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.3716835633
MESH:D000505 Alopecia Tretinoin 3.6015955085
MESH:D000550 Amblyopia Valproic Acid 5.2317688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9311748828
MESH:D001008 Anxiety Disorders Valproic Acid 3.5517497229
MESH:D001169 Arthritis, Experimental Tretinoin 3.0616412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2616292516
MESH:D001249 Asthma Tretinoin 2.3416456186
MESH:D050197 Atherosclerosis Phenytoin 3.9115136057
MESH:D001321 Autistic Disorder Valproic Acid 2.0118177632 18558336 19232924 15238991 16609825 18985861 18775368 20603192 18940202 17507914 19460635 18316065 18396377 17157402 17688650
MESH:D001471 Barrett Esophagus Tretinoin 4.3916935849
MESH:D001528 Behcet Syndrome marker/mechanism 20622878
MESH:D001714 Bipolar Disorder Carbamazepine 7.5117594078 20046352
MESH:D001714 Bipolar Disorder Valproic Acid 7.5120046352 17594078
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 15.2416206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 15.2412125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 15.2416206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.9815746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.988888407
MESH:D001943 Breast Neoplasms Estradiol 1.8212948864 17261762 17289903 16675129 19861407 18497071 17018787 14630087
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8220435547
MESH:D001943 Breast Neoplasms Tretinoin 1.8216166294 16873071 16443354
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.5816813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.3111589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4516111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.9216050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7816835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.1616168501
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.5815553829 16217749 15073043 14691202 11135700
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.5816924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.581917145
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.8719014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.1012490120
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.2816051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3518670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases abacavir 5.1118753925
MESH:D002386 Cataract Tretinoin 3.0817460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.6020889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.6018566989
MESH:D002493 Central Nervous System Diseases Phenytoin 5.284080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.5816129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7020734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1416835633
OMIM:601042 CHOREOATHETOSIS/SPASTICITY, EPISODIC Phenytoin 5.8611748493
MESH:D002822 Choriocarcinoma Tretinoin 5.1616461808
MESH:D002971 Cleft Lip Phenytoin 4.142227380
MESH:D002972 Cleft Palate Phenytoin 9.8710789828 6862529 2227380 3877104 6856622 1687470
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 9.8715668235 16354765 12621046 8697196 15340226
MESH:D002972 Cleft Palate Tretinoin 9.879407595
MESH:D003092 Colitis Selenium 9.4517936198
MESH:D003092 Colitis Tretinoin 9.4517035595
MESH:D003103 Coloboma Phenytoin 5.139212184
MESH:D003110 Colonic Neoplasms irinotecan 2.5917287894 17725105
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.6720501625
MESH:D015179 Colorectal Neoplasms irinotecan 2.6718259882 16391804 17159606 16303861 15273666 18509181 17454858
MESH:D000013 Congenital Abnormalities Phenytoin 9.3210627286
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 9.3214669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 4.1712609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 11.8010525206
MESH:D019465 Craniofacial Abnormalities Carbamazepine 11.809014606
MESH:D019465 Craniofacial Abnormalities Phenytoin 11.808986270 19952982 9212184
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 11.8015322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 11.8016925845 8800419 10589399 9125849 17551590 14991402 9664655 9211117 9142499 9224671
MESH:D019465 Craniofacial Abnormalities Valproic Acid 11.8016575769 8888407 17688650
MESH:D019465 Craniofacial Abnormalities Vitamin E 11.8019769572
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.0815213294
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6617107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.3919279558
OMIM:607208 DRAVET SYNDROME Carbamazepine 12.3611748493
OMIM:607208 DRAVET SYNDROME Phenytoin 12.3611748493
MESH:D003875 Drug Eruptions marker/mechanism 19712599
MESH:D003875 Drug Eruptions Phenytoin 5.4915024534
MESH:D004342 Drug Hypersensitivity marker/mechanism 15024131
MESH:D004342 Drug Hypersensitivity abacavir 9.1615024131 15867870
MESH:D004342 Drug Hypersensitivity Carbamazepine 9.1620216337 16538175 15057820 16538176
MESH:D056486 Drug-Induced Liver Injury marker/mechanism 19483685
MESH:D056486 Drug-Induced Liver Injury Carbamazepine 12.0417465707
MESH:D056486 Drug-Induced Liver Injury Floxacillin 12.0419483685
MESH:D056486 Drug-Induced Liver Injury Selenium 12.0415131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.0420420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 12.041733752 19641884
MESH:D004362 Drug Toxicity Carbamazepine 8.3520216337
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.3511462148
MESH:D004421 Dystonia Valproic Acid 4.031851702
MESH:C538011 Eales disease Vitamin E 4.709068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.3612711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.9515322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 11.9518230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Carbamazepine 9.8817654737
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Phenytoin 9.8817654737
MESH:D016889 Endometrial Neoplasms Estradiol 7.3719148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Tretinoin 7.3716569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.009294722 10568697
MESH:D004816 Epidermal Necrolysis, Toxic marker/mechanism 16538176 18855540 20235791 20485159
MESH:D004816 Epidermal Necrolysis, Toxic Carbamazepine 26.9516415921 20485159 19915237 18855540 16538176
MESH:D004816 Epidermal Necrolysis, Toxic lamotrigine 26.9520235791
MESH:D004816 Epidermal Necrolysis, Toxic oxcarbazepine 26.9520235791
MESH:D004816 Epidermal Necrolysis, Toxic Phenytoin 26.9520235791
MESH:D004820 Epidermolysis Bullosa Phenytoin 6.236251365 1399206
MESH:D004831 Epilepsies, Myoclonic Carbamazepine 18.6717275665
MESH:D004831 Epilepsies, Myoclonic lamotrigine 18.6717275665
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 18.673659116 17275665
MESH:D004828 Epilepsies, Partial Carbamazepine 24.2516628512 15008574 17116037
MESH:D004828 Epilepsies, Partial lamotrigine 24.2517116037
MESH:D004828 Epilepsies, Partial Phenytoin 24.2517116037 11558140
MESH:D004828 Epilepsies, Partial Valproic Acid 24.253922381 16628512
MESH:D004827 Epilepsy Carbamazepine 20.6817465707 18234410 20417680 7988514 19439326 17178248 19700373 19620853 9014606 821787
MESH:D004827 Epilepsy lamotrigine 20.6819668019
MESH:D004827 Epilepsy oxcarbazepine 20.6817516704 7988514
MESH:D004827 Epilepsy Phenytoin 20.68821787 11434505 20417680
MESH:D004827 Epilepsy Valproic Acid 20.6820417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.576426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Carbamazepine 19.507750514
MESH:D017029 Epilepsy, Complex Partial Phenytoin 19.507750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 19.507750514
MESH:D004833 Epilepsy, Temporal Lobe lamotrigine 6.8416499746
MESH:D004830 Epilepsy, Tonic-Clonic Carbamazepine 17.9915276670 3659116
MESH:D004830 Epilepsy, Tonic-Clonic Phenytoin 17.993659116
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 17.993659116
MESH:D004916 Erythromelalgia Carbamazepine 5.7119549232
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.4420426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.4412903497
MESH:D005076 Exanthema marker/mechanism 20485159
MESH:D005076 Exanthema Carbamazepine 5.4620485159
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.7811564622
MESH:D005124 Eye Abnormalities Tretinoin 8.7816938888 9664655
MESH:D005234 Fatty Liver arsenic trioxide 7.8615073043
MESH:D005234 Fatty Liver Valproic Acid 7.8619224547 14986274
MESH:D005313 Fetal Death Phenytoin 10.6910627286
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 10.6911858732
MESH:D005315 Fetal Diseases Valproic Acid 4.8916575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.118888407 18558336
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.5720067830
MESH:D005355 Fibrosis Tretinoin 8.5717994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.2416904648
MESH:D005885 Gingival Hyperplasia Phenytoin 5.669029455
MESH:D019214 Gingival Overgrowth Phenytoin 6.2316390469 14659971
MESH:D005909 Glioblastoma Tretinoin 2.9917312396
MESH:D005910 Glioma marker/mechanism 14511464
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5910696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.1716096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.1616084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.0710048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 11.079664655 14991402
MESH:D006330 Heart Defects, Congenital Vitamin E 11.0716080930
MESH:D006333 Heart Failure Selenium 3.0617162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.8815340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6916490937 16863852
MESH:D006558 Herpes Genitalis Estradiol 5.0315709030
MESH:D015658 HIV Infections marker/mechanism 17496894
MESH:D015658 HIV Infections abacavir 4.8717457083 11141242 12891065
MESH:D019584 Hot Flashes Estradiol 10.0517088409
MESH:D019584 Hot Flashes Vitamin E 10.0514716179
MESH:D006849 Hydrocephalus Valproic Acid 4.8617688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.058697196 18606429 15340226 16354765 16959395
MESH:D006930 Hyperalgesia Tretinoin 3.1916870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.5516778211
MESH:D020138 Hyperhomocysteinemia Carbamazepine 9.8510459572
MESH:D020138 Hyperhomocysteinemia Phenytoin 9.8510459572
MESH:D006965 Hyperplasia Carbamazepine 5.2018773962
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9018850075 18670907
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.6116612254
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8412878042 12200463
MESH:D007251 Influenza, Human Selenium 10.9616624496
MESH:D007251 Influenza, Human Vitamin E 10.9616624496
MESH:D007333 Insulin Resistance Estradiol 2.9516627594 16393666
MESH:D007410 Intestinal Diseases Tretinoin 3.7517994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.8716580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.8715992940 17551590
MESH:D007674 Kidney Diseases Estradiol 6.0715618244
MESH:D007674 Kidney Diseases Vitamin E 6.0712488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.8716518626
MESH:D007680 Kidney Neoplasms Estradiol 2.9615610895
MESH:D007938 Leukemia arsenic trioxide 6.3115070760
MESH:D007938 Leukemia Tretinoin 6.3117143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.7817077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.3016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.4114633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 9.4119077051
MESH:D007951 Leukemia, Myeloid Tretinoin 9.4116482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 6.1020471514 16467208 17050201 19850784 16968895
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 6.1019850784 16294345 17596541
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 6.1016294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.5917217047 17712046 19035177 17107899 16331271 12712474 15748426 16891316 12018890 16823087 19642359 15622746 19225113 9834237 16330433 17649720 12679006 17869043 11161223 19075265 15336539 16112521 16966277 15213294 11468182
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.5916935935 19035177 17301526 17294898 19029980 17339181 16140955 16823087 17506722 9834237 12679006 17107899 19225113 17712046 17217047 16891316 16331271 17361223 17368321 16788101 15748426 17649720 16766008 19642359 19075265
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.3416882451
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.299224671
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.9314659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.9312878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 4.9318397230 16248980
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 4.9316169303
MESH:D008107 Liver Diseases Phenytoin 3.2114986274
MESH:D008113 Liver Neoplasms arsenic trioxide 4.4114682389
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.4116984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 5.7620377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.7612151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.3315213294
MESH:D008171 Lung Diseases Vitamin E 3.1616863852
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.2617228818
MESH:D008175 Lung Neoplasms arsenic trioxide 3.3911798837 19825857
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.3919555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 3.3911062179
MESH:D008180 Lupus Erythematosus, Systemic Carbamazepine 3.5616628512
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.9711807958 17203775 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Selenium 5.9715318939
MESH:D020149 Manganese Poisoning Estradiol 4.4819453300
MESH:D008527 Medulloblastoma Tretinoin 2.7817453147
MESH:D008545 Melanoma Tretinoin 1.9416752155
MESH:D008591 Meningomyelocele Tretinoin 4.4116940565
MESH:D008607 Mental Retardation Carbamazepine 6.509014606
MESH:D008607 Mental Retardation Phenytoin 6.509212184
MESH:D008654 Mesothelioma Selenium 2.7815107826
MESH:D008881 Migraine Disorders Valproic Acid 3.1718765137 18803445
MESH:D052016 Mucositis irinotecan 5.0017159606
MESH:D009101 Multiple Myeloma arsenic trioxide 3.0919417148 14977855 19549372 11468182 15949261
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.018888407
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.6718349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 12.2416882451 16105982
MESH:D009190 Myelodysplastic Syndromes Tretinoin 12.2417596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 12.2417596541
MESH:D009203 Myocardial Infarction abacavir 4.6718753925
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0012213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.2616810080
MESH:D020191 Myoclonic Epilepsies, Progressive Phenytoin 5.5117484760
MESH:D009224 Myotonia Congenita Carbamazepine 12.4520399394
MESH:D009224 Myotonia Congenita Phenytoin 12.451896199
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.9416624393
MESH:D009362 Neoplasm Metastasis irinotecan 3.1618259882
MESH:D009369 Neoplasms Tretinoin 2.4016946489 16594593
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7217289903
MESH:D009421 Nervous System Malformations Carbamazepine 23.3616990009
MESH:D009421 Nervous System Malformations Estradiol 23.3616427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 23.3614600291
MESH:D009421 Nervous System Malformations Tretinoin 23.369125849
MESH:D009436 Neural Tube Defects arsenic trioxide 17.2710525206
MESH:D009436 Neural Tube Defects Phenytoin 17.279118846
MESH:D009436 Neural Tube Defects Tretinoin 17.279142499
MESH:D009436 Neural Tube Defects Valproic Acid 17.2716359493 8888407
MESH:D009447 Neuroblastoma irinotecan 3.478761367
MESH:D017599 Neuroectodermal Tumors irinotecan 4.728761367
MESH:D010018 Osteomalacia Carbamazepine 12.4517016548
MESH:D010018 Osteomalacia Phenytoin 12.4517016548
MESH:D010051 Ovarian Neoplasms arsenic trioxide 7.8319769630 16624393 12452020
MESH:D010051 Ovarian Neoplasms Estradiol 7.8319401270
MESH:D010051 Ovarian Neoplasms Tretinoin 7.8316936753
MESH:D010146 Pain Carbamazepine 11.4615215642
MESH:D010146 Pain Phenytoin 11.4615215642
MESH:D010146 Pain Tretinoin 11.4616870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.2615580305
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.2615976015
MESH:D010235 Paraganglioma arsenic trioxide 4.1419927285
MESH:D010267 Parapsoriasis Carbamazepine 5.6916538176
OMIM:167400 PAROXYSMAL EXTREME PAIN DISORDER Carbamazepine 5.9217145499 17679678
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2512520081
MESH:D010954 Plasmacytoma Selenium 4.8915087411
MESH:D017689 Polydactyly Phenytoin 5.029212184
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5418163543
MESH:D011248 Pregnancy Complications Carbamazepine 5.149014606
MESH:D011297 Prenatal Exposure Delayed Effects Carbamazepine 16.339014606
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 16.3311118676 11399792 11896295 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 16.3320603192
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8720887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.5719131511
MESH:D011471 Prostatic Neoplasms Estradiol 2.5716740699
MESH:D011471 Prostatic Neoplasms Vitamin E 2.5715084515
MESH:D011507 Proteinuria Tretinoin 3.5916636307
MESH:D019310 Pseudolymphoma Carbamazepine 21.339591791 12752131
MESH:D019310 Pseudolymphoma Phenytoin 21.338603615 1419762 12752131
MESH:D019310 Pseudolymphoma Valproic Acid 21.3311422049 12752131
MESH:D011625 Pterygium Tretinoin 4.7816723453
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8218990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 10.8016116481 16283617
MESH:D012208 Rhabdomyosarcoma Valproic Acid 10.8019155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.9416646077
MESH:D012559 Schizophrenia Valproic Acid 2.0719110320 15737665
MESH:D012640 Seizures Carbamazepine 14.189046859 15946322 9844417 19414003 16876388 16938433 16180713
MESH:D012640 Seizures lamotrigine 14.189844417 16499746
MESH:D012640 Seizures Phenytoin 14.1819919933 10029267 3691417 3137016 9844417 11044598 16876388 15946322
MESH:D012640 Seizures Valproic Acid 14.1811044598 15475178 3137016 11738929 14763951 17978042 1511512 16876388
OMIM:608579 SEVERE CUTANEOUS ADVERSE REACTION, SUSCEPTIBILITY TO marker/mechanism 20485159
OMIM:608579 SEVERE CUTANEOUS ADVERSE REACTION, SUSCEPTIBILITY TO lamotrigine 6.5819668019 20485159
MESH:D012871 Skin Diseases Vitamin E 2.4418709164
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.378532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.3716192470
MESH:D012878 Skin Neoplasms Tretinoin 9.3716467112
MESH:D012893 Sleep Disorders Carbamazepine 5.1119414003
MESH:D016135 Spinal Dysraphism Valproic Acid 3.7619490988
MESH:D013167 Spondylitis, Ankylosing marker/mechanism
OMIM:106300 SPONDYLOARTHROPATHY, SUSCEPTIBILITY TO, 1 marker/mechanism
MESH:D013226 Status Epilepticus Valproic Acid 4.5412833885
MESH:D013262 Stevens-Johnson Syndrome marker/mechanism 15057820 18855540 19694795 19915237 20235791 20485159
MESH:D013262 Stevens-Johnson Syndrome Carbamazepine 26.4918855540 16538176 15057820 19694795 16415921 19915237 20485159
MESH:D013262 Stevens-Johnson Syndrome lamotrigine 26.4920235791
MESH:D013262 Stevens-Johnson Syndrome oxcarbazepine 26.4920235791
MESH:D013262 Stevens-Johnson Syndrome Phenytoin 26.4920235791
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.4417007042
MESH:D013274 Stomach Neoplasms irinotecan 3.4415723263
MESH:D013274 Stomach Neoplasms Tretinoin 3.4417261132
MESH:D020521 Stroke Vitamin E 3.5016517955
MESH:D013585 Synovitis marker/mechanism
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9012697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.1519014326
MESH:D013964 Thyroid Neoplasms Tretinoin 7.1516026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.6919048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.7716051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.9515213294
MESH:D014178 Translocation, Genetic Valproic Acid 5.2317262798
MESH:D014376 Tuberculosis Tretinoin 3.2116040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.513119515
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.4712845720 20435036 12973940 11780464
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.638888407
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.6616129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.6116752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5912125929
MESH:D014820 Vitiligo Tretinoin 4.0416761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2515886252
MESH:D009396 Wilms Tumor Tretinoin 3.9516287080
Pathway ID Pathway Name
KEGG:05330 Allograft rejection
KEGG:04612 Antigen processing and presentation
KEGG:05320 Autoimmune thyroid disease
KEGG:04514 Cell adhesion molecules (CAMs)
KEGG:04144 Endocytosis
KEGG:05332 Graft-versus-host disease
KEGG:04650 Natural killer cell mediated cytotoxicity
KEGG:04145 Phagosome
REACT:6900 Signaling in Immune system
KEGG:04940 Type I diabetes mellitus
KEGG:05416 Viral myocarditis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35056
    • No data
    Releated disease ID Related disease Name
    PA444859Malaria
    PA443888Diabetes Mellitus, Type 1
    PA444750Leukemia
    PA447163Spondylarthropathies
    PA134850558Macular Degeneration
    PA445532Retinal Diseases
    PA446010Uveitis
    PA443750Colitis, Ulcerative
    PA446023Vasculitis
    PA443557Brain Neoplasms
    PA445451Psoriasis
    PA447025Muscular Dystrophy, Duchenne
    PA444546Hypersensitivity
    PA445738Stevens-Johnson Syndrome
    PA446213HIV Infections
    PA447230HIV
    PA443937Drug Toxicity
    PA444059Epidermal Necrolysis, Toxic
    PA443936Drug Hypersensitivity
    PA443224Abnormalities, Drug-Induced
    PA164925725Toxic liver disease
    Releated drug ID Related drug Name
    PA450616nevirapine
    PA448004abacavir
    PA448785carbamazepine
    PA448320allopurinol
    PA450164lamotrigine
    PA451544sulfamethoxazole
    PA451686ticlopidine
    PA450732oxcarbazepine
    PA450947phenytoin
    PA164746820fosphenytoin
    PA164781042flucloxacillin
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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