AutismKB 2.0

Annotation Detail for HLA-DMA


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:HLA-DMA ( D6S222E,DMA,HLADM,RING6 )
Gene Full Name: major histocompatibility complex, class II, DM alpha
Band: 6p21.32
Quick LinksEntrez ID:3108; OMIM: 142855; Uniprot ID:Q31604_HUMAN; ENSEMBL ID: ENSG00000204257; HGNC ID: 4934
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04672Intestinal immune network for IgA production
hsa05332Graft-versus-host disease
hsa04145Phagosome
hsa05310Asthma
hsa05416Viral myocarditis
hsa05140Leishmaniasis
hsa05145Toxoplasmosis
hsa05322Systemic lupus erythematosus
hsa05320Autoimmune thyroid disease
hsa05150Staphylococcus aureus infection
hsa05330Allograft rejection
hsa04612Antigen processing and presentation
hsa04514Cell adhesion molecules (CAMs)
hsa04940Type I diabetes mellitus
No data
No data
Pathway IDPathway Name
P00053T cell activation
No data
Related Diseases/Disorders Top
Desease IDDesease Name
H00083Allograft rejection
Immune system diseases
Allergies and autoimmune diseases
Desease IDDesease Name
1781Rheumatoid arthritis
1904Diabetes mellitus
2146Lupus erythematosus
Desease Name
rheumatoid arthritis
systemic lupus erythematosus
IMMUNE
lupus erythematosus
antiphospholipid syndrome
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C000188 alachlor alachlor results in increased expression of HLA-DMA mRNAincreases expression 12419858
C061133 Am 80 Am 80 results in increased expression of HLA-DMA mRNAincreases expression 17229644
D001151 Arsenic HLA-DMA mRNA results in decreased susceptibility to Arsenicdecreases response to substance 17976673
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of HLA-DMA mRNAaffects expression 20382639
C030123 coumarin coumarin results in increased expression of HLA-DMA mRNAincreases expression 18480146
D016572 Cyclosporine Cyclosporine results in decreased expression of HLA-DMA mRNAdecreases expression 20106945
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of HLA-DMA mRNAincreases expression 19638242
D006581 Hexachlorobenzene Hexachlorobenzene results in decreased expression of HLA-DMA mRNAdecreases expression 15159207
D007657 Ketone Bodies Ketone Bodies results in decreased expression of HLA-DMA mRNAdecreases expression 16807920
C029938 nickel sulfate nickel sulfate results in decreased expression of HLA-DMA mRNAdecreases expression 16780908
D011794 Quercetin Quercetin results in increased expression of HLA-DMA mRNAincreases expression 16455785
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of HLA-DMA mRNAincreases expression 19684285
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0015322242 14514962 11752688
MESH:D055371 Acute Lung Injury nickel sulfate 4.4211954676 12718980 19131640 16100012
MESH:D000236 Adenoma Diethylnitrosamine 2.916695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.5819052882 19061943 17620307 18056438 17162532 16434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.5816835633
MESH:D018246 Adrenocortical Adenoma Arsenic 5.3917306315
MESH:D000382 Agricultural Workers' Diseases alachlor 4.8114769641 11874814
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D000743 Anemia, Hemolytic Quercetin 4.3517084956
MESH:D020261 Arsenic Poisoning Arsenic 2.8916251483 12569548 18414634 16835338
MESH:D001172 Arthritis, Rheumatoid Am 80 3.7716819260
MESH:D001260 Ataxia Telangiectasia Quercetin 5.1315336622
MESH:D050197 Atherosclerosis Am 80 7.4916484594
MESH:D050197 Atherosclerosis Arsenic 7.4919371607 12928151
MESH:D001327 Autoimmune Diseases Quercetin 4.5519761891
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.0217474063
MESH:D001943 Breast Neoplasms Hexachlorobenzene 2.0212709520 15061365
MESH:D001943 Breast Neoplasms Quercetin 2.0218628248
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0220435547
MESH:D002105 Cadmium Poisoning Quercetin 5.7216962696
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.6515504454 17687452
MESH:D006528 Carcinoma, Hepatocellular Arsenic 4.8016507464 17306315
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.8020727157 18665156 16502159 21159647 17055752 19519916 19539802 20101231 17978847 20524982 16328049 20084675 19171122 19107877 17138121 19822196 16878318 20432363 20514400 19335982 17173139 16698587 10672840 16830150 18788625 16779866 16288022 20512989 18393292 18785209 19701751 18978308 3084413 16681979 18506893 19383236 17761372 3581430 16569478 18494052 19208518 16540662 16935385 19418558 19919837 18210153 20214788 18056438 19052882 16807293 18971187 18691550 11831363 20007298 20935162 17162532 19394651 17428255 10737359
MESH:D006528 Carcinoma, Hepatocellular Quercetin 4.8019519916 12508355
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 5.0917234771
MESH:D002294 Carcinoma, Squamous Cell Arsenic 2.7218922899 17687452 15504454
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.1818640142
MESH:D006332 Cardiomegaly Quercetin 6.9919794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.9918670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Arsenic 3.5215738583 19152805 17938729
MESH:D002340 Carotid Artery Diseases Arsenic 4.4116973168 18022660
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.5920889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.5912371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 11.5921159647 7505956 2727394 17174075
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.6519052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.6516835633
MESH:D002779 Cholestasis Cyclosporine 3.0019486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1415340226 16354765 8697196 12621046 15668235
MESH:D003110 Colonic Neoplasms Quercetin 2.4311134977 19440933 16640504 17148506 15741050 17191121 19056647
MESH:D015179 Colorectal Neoplasms Quercetin 2.1918852136 18095365
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1614669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D017449 Dermatitis, Allergic Contact alachlor 8.118428444
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 8.1116780908 16823706 11298694
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.8219496084
MESH:D003924 Diabetes Mellitus, Type 2 coumarin 7.3519647726
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 7.3520387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 7.3517107852
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 3.8219107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0816714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Am 80 5.2216819260
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.129294722 10568697
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2916302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1020426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0911564622
MESH:D005234 Fatty Liver Cyclosporine 8.0819224547
MESH:D005234 Fatty Liver Diethylnitrosamine 8.0821071580 20387270
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D005355 Fibrosis Cyclosporine 15.6112168785 12639820
MESH:D005355 Fibrosis Quercetin 15.6119474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 15.6120067830
MESH:D005534 Foot Diseases Arsenic 5.736392382
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.378708960
MESH:D005909 Glioblastoma Quercetin 3.4619804834
MESH:D005910 Glioma Quercetin 3.0917643826
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3811294989 10048152
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5815720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0312621046 16120746 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2218606429 8697196 16354765 15340226 16959395
MESH:D006943 Hyperglycemia Quercetin 4.1311834736 18262572
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.5617050553
MESH:D006973 Hypertension Arsenic 12.7016076760 11953799 9931084
MESH:D006973 Hypertension Cyclosporine 12.7010903974
MESH:D006973 Hypertension Quercetin 12.7018356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 12.7018850075 18670907
MESH:D006987 Hypesthesia Arsenic 5.7316093927
MESH:D007248 Infertility, Male alachlor 4.2112948887 16466525 17049205
MESH:D007249 Inflammation Diethylnitrosamine 5.0718785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.0712878042 12200463
MESH:D007251 Influenza, Human Quercetin 4.6816624496
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4416580747
MESH:D007627 Keloid Quercetin 5.0917086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6215604871
MESH:D007642 Keratosis Arsenic 5.1412749816 16930632
MESH:D007674 Kidney Diseases Cyclosporine 6.328314463 10903974 18776723
MESH:D007674 Kidney Diseases Quercetin 6.3216962696
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8212371664
MESH:D007938 Leukemia alachlor 7.0914769641
MESH:D007938 Leukemia Quercetin 7.0917468513
MESH:D015473 Leukemia, Promyelocytic, Acute Am 80 8.5416531727 16819260
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 8.5417339181
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8820032147 18407596 18522880 19638242 18665156
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 2.4812741479
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.4812878042
MESH:D008107 Liver Diseases Arsenic 4.3211134558
MESH:D008107 Liver Diseases Diethylnitrosamine 4.3217034775
MESH:D008113 Liver Neoplasms Arsenic 11.0616368122
MESH:D008113 Liver Neoplasms Diethylnitrosamine 11.0612112319 15885732 20452335 19642983 19690152 21047994 12771043 19833225 18754104 21167192 19294768 20118626 20137499 20434301 19638242 19256749 19499222 20501860 19812893 9163691 21278145 19850985 19426721 19551842 18644402 19090486 15175105 19996281 20101389 19073162 18648771 19427195 19254457 19255062 18977376 2862719 18978307 20405173 16942905 10737359 20583210 21071580 20492335 2422723
MESH:D008113 Liver Neoplasms Quercetin 11.0618980244
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.0616984957
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 14.7417942915 18544905 19519916 18079962 18164116 19539802 19004024 18775883 2563599 16267830 3124819 19009564 21159647 18253720 18282651 18093689 17174075 19126423 17854601 18308698 16842330 9362446
MESH:D008114 Liver Neoplasms, Experimental Hexachlorobenzene 14.741423854
MESH:D008114 Liver Neoplasms, Experimental Quercetin 14.7419519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.7412151625
MESH:D008175 Lung Neoplasms Arsenic 4.9717976673 17306315 19168569
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.9720970405 6695378 20512841 21163286
MESH:D008175 Lung Neoplasms Quercetin 4.9716280456
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9719555203 11884234
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9616801185
MESH:D009101 Multiple Myeloma alachlor 8.5114769641
MESH:D009101 Multiple Myeloma Am 80 8.5117229644
MESH:D009203 Myocardial Infarction Quercetin 3.0319595682
MESH:D017202 Myocardial Ischemia Arsenic 9.3015371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.3012213967
MESH:D015428 Myocardial Reperfusion Injury Quercetin 3.8819207477
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.609029167 3581430
MESH:D009369 Neoplasms Quercetin 2.8415185748
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3818481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3414600291
MESH:D009436 Neural Tube Defects Arsenic 3.5216620997
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.4320387270
MESH:D020078 Neurogenic Inflammation Arsenic 11.0817056641
MESH:D020078 Neurogenic Inflammation Quercetin 11.0817929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2920387270
MESH:D009669 Nose Neoplasms alachlor 4.9711127290 16178123 16698726 15580706 14563481
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.3419495926
MESH:D010051 Ovarian Neoplasms Arsenic 5.2417306315
MESH:D010051 Ovarian Neoplasms Quercetin 5.2419005980
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.5116540662
MESH:D010190 Pancreatic Neoplasms Quercetin 5.5116965848
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.3016093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.1416905509 6392382 15371236
MESH:D017119 Porphyria Cutanea Tarda Hexachlorobenzene 11.539918132
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 11.5318163543
MESH:D011230 Precancerous Conditions Cyclosporine 15.9012371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 15.902563599
MESH:D011230 Precancerous Conditions Quercetin 15.9019056647
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3411222880 11118676 11896295 11399792
MESH:D011471 Prostatic Neoplasms Am 80 2.8516289102
MESH:D011471 Prostatic Neoplasms Arsenic 2.8516140617
MESH:D011471 Prostatic Neoplasms Quercetin 2.8514715546 17292933
MESH:D011507 Proteinuria Arsenic 4.1221343184
MESH:D011565 Psoriasis Am 80 6.2616819260
MESH:D011565 Psoriasis Cyclosporine 6.2616882103
MESH:D012135 Respiratory Sounds alachlor 5.0911874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012554 Schistosomiasis japonica Quercetin 5.7216862918
MESH:D012871 Skin Diseases Arsenic 2.7719834688 16702368 16759981 17938729 16353154 17548696 6392382 18709164 17050553 15952646 17453740
MESH:D012878 Skin Neoplasms Arsenic 5.8717029826 15504454 17976673 16251483 17050553 19538983
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.8716192470
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D013964 Thyroid Neoplasms alachlor 7.918812207
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.917505956
MESH:D001749 Urinary Bladder Neoplasms Arsenic 5.5315987713 17976673 18640142 19322015 19429237 11144890 17306315
MESH:D001749 Urinary Bladder Neoplasms Quercetin 5.5316720314
MESH:D014605 Uveitis Cyclosporine 4.161336536
MESH:D014652 Vascular Diseases Arsenic 4.8917056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D014689 Venous Insufficiency coumarin 5.9512708602
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.6217120751
Pathway ID Pathway Name
KEGG:05330 Allograft rejection
KEGG:04612 Antigen processing and presentation
KEGG:05310 Asthma
KEGG:05320 Autoimmune thyroid disease
KEGG:04514 Cell adhesion molecules (CAMs)
KEGG:05332 Graft-versus-host disease
KEGG:04672 Intestinal immune network for IgA production
KEGG:05140 Leishmaniasis
KEGG:04145 Phagosome
KEGG:05323 Rheumatoid arthritis
KEGG:05150 Staphylococcus aureus infection
KEGG:05322 Systemic lupus erythematosus
KEGG:05145 Toxoplasmosis
KEGG:05152 Tuberculosis
KEGG:04940 Type I diabetes mellitus
KEGG:05416 Viral myocarditis
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved