AutismKB 2.0

Annotation Detail for ANXA11


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Basic Information Top
Gene Symbol:ANXA11 ( ANX11,CAP50 )
Gene Full Name: annexin A11
Band: 10q22.3
Quick LinksEntrez ID:311; OMIM: 602572; Uniprot ID:ANX11_HUMAN; ENSEMBL ID: ENSG00000122359; HGNC ID: 535
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ANXA11 mRNAaffects expression 21346803
C430898 AGN 194204 AGN 194204 results in increased expression of ANXA11 mRNAincreases expression 16339527
D016572 Cyclosporine Cyclosporine results in decreased expression of ANXA11 mRNAdecreases expression 20106945
D008727 Methotrexate ANXA11 protein affects the susceptibility to Methotrexateaffects response to substance 16217747
D018038 Sodium Selenite Sodium Selenite results in increased expression of ANXA11 mRNAincreases expression 18175754
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ANXA11 mRNAincreases expression 20106945
D014212 Tretinoin Tretinoin results in increased expression of ANXA11 mRNAincreases expression 16249480
D014635 Valproic Acid Valproic Acid results in increased expression of ANXA11 mRNAincreases expression 15345369
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 16.3812039119
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 16.3815322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 16.388875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1719490988
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7116835633
MESH:D000505 Alopecia Tretinoin 3.8115955085
MESH:D000550 Amblyopia Valproic Acid 5.6117688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D001008 Anxiety Disorders Valproic Acid 3.7617497229
MESH:D001169 Arthritis, Experimental Tretinoin 3.2116412693
MESH:D001172 Arthritis, Rheumatoid Methotrexate 5.0317286800
MESH:D001172 Arthritis, Rheumatoid Tretinoin 5.0316292516
MESH:D001249 Asthma Tretinoin 2.4016456186
MESH:D001321 Autistic Disorder Valproic Acid 1.9915238991 18985861 20603192 19460635 17507914 18558336 18316065 19232924 17157402 18396377 18940202 18177632 18775368 17688650 16609825
MESH:D001471 Barrett Esophagus Tretinoin 4.6816935849
MESH:D001714 Bipolar Disorder Valproic Acid 3.1820046352 17594078
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.7612125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.7616206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.5015746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.508888407
MESH:D001943 Breast Neoplasms Methotrexate 1.9516978400
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9520435547
MESH:D001943 Breast Neoplasms Tretinoin 1.9516873071 16166294 16443354
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.9316813970
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.5416168501
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 3.1016705839
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.101917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3416051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4918850075 18670907 16120746
MESH:D002386 Cataract Tretinoin 3.2217460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.116135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.1112371664
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.9316129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7820734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002779 Cholestasis Cyclosporine 3.0919486331
MESH:D002822 Choriocarcinoma Tretinoin 5.5416461808
MESH:D019457 Chromosome Breakage Sodium Selenite 5.0615894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.058697196 15668235 12621046 15340226 16354765
MESH:D002972 Cleft Palate Tretinoin 6.059407595
MESH:D003092 Colitis Tretinoin 4.0117035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2717141729 14669216
MESH:D019465 Craniofacial Abnormalities Methotrexate 5.6212039119 9562676
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.6210048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 5.6216925845 10589399 9211117 17551590 9142499 9664655 9224671 9125849 14991402 8800419
MESH:D019465 Craniofacial Abnormalities Valproic Acid 5.6216575769 17688650 8888407
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.3218551238
MESH:D003550 Cystic Fibrosis Methotrexate 4.4719747007
MESH:D003882 Dermatomyositis Methotrexate 5.4120191521
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9916285004
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.5021346803 18551238
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 9.5015131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.5020420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 9.5019641884 1733752
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D004421 Dystonia Valproic Acid 4.311851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 13.2315322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 13.2318230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.2516569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.259294722 10568697
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.463659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.293922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0420417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.806254150 7562514 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.607750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.403659116
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.4311564622
MESH:D005124 Eye Abnormalities Tretinoin 9.439664655 16938888
MESH:D005234 Fatty Liver Cyclosporine 8.5719224547
MESH:D005234 Fatty Liver Valproic Acid 8.5719224547 14986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D005315 Fetal Diseases Valproic Acid 5.2616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.418888407 18558336
MESH:D005355 Fibrosis Cyclosporine 16.5912639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 16.5920067830
MESH:D005355 Fibrosis Tretinoin 16.5917994277
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D005909 Glioblastoma Tretinoin 3.1517312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006086 Graft vs Host Disease Methotrexate 5.4516518429
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.3416096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.5416084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.9110048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 6.919664655 14991402
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2016120746 15340226 12621046
MESH:D006849 Hydrocephalus Valproic Acid 5.2017688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4218606429 16959395 15340226 8697196 16354765
MESH:D006930 Hyperalgesia Tretinoin 3.4016870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.8816778211
MESH:D006973 Hypertension Cyclosporine 5.2110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2118850075 18670907
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9612200463 12878042
MESH:D007333 Insulin Resistance Sodium Selenite 3.4214714311
MESH:D007410 Intestinal Diseases Tretinoin 4.0717994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.7616580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.7615992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Cyclosporine 2.468314463 18776723 10903974
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.9516705839
MESH:D007680 Kidney Neoplasms Cyclosporine 7.9512371664
MESH:D007805 Language Development Disorders Methotrexate 5.369562676
MESH:D007938 Leukemia Tretinoin 2.8717143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.9419285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 4.0119850784 17596541 16294345
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 4.0116294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3017649720 15748426 16788101 19642359 16891316 17712046 17294898 9834237 19029980 19075265 19225113 17368321 16823087 17339181 17361223 19035177 17217047 16331271 16140955 16766008 12679006 17107899 17506722 17301526 16935935
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.479224671
MESH:D008103 Liver Cirrhosis Methotrexate 3.8214986274
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3612878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.3616248980 18397230
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.637678174
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.6316984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.202876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.2012151625
MESH:D017563 Lung Diseases, Interstitial Methotrexate 12.7518516814
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 12.7517228818
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D008223 Lymphoma Methotrexate 4.1217352296
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.3214737004
MESH:D008527 Medulloblastoma Tretinoin 2.8617453147
MESH:D008545 Melanoma Tretinoin 1.9716752155
MESH:D008591 Meningomyelocele Tretinoin 4.7316940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D008881 Migraine Disorders Valproic Acid 3.3618765137 18803445
MESH:D052016 Mucositis Methotrexate 5.6217488658
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.278888407
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.8117596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.8117596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.2018551238 7678174
MESH:D009369 Neoplasms Tretinoin 2.5116594593 16946489
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5019348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.4714600291
MESH:D009421 Nervous System Malformations Tretinoin 10.479125849
MESH:D009436 Neural Tube Defects Tretinoin 7.809142499
MESH:D009436 Neural Tube Defects Valproic Acid 7.808888407 16359493
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.6616049721
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4016936753
MESH:D010146 Pain Tretinoin 3.1016870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5315976015
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.4412371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.6111222880 11118676 11399792 11896295
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 10.6120603192
MESH:D011471 Prostatic Neoplasms AGN 194204 3.6516000583
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.6518760546
MESH:D011507 Proteinuria Tretinoin 3.8616636307
MESH:D019310 Pseudolymphoma Valproic Acid 4.9212752131 11422049
MESH:D011565 Psoriasis Cyclosporine 6.1416882103
MESH:D011565 Psoriasis Methotrexate 6.1417410198
MESH:D011625 Pterygium Tretinoin 5.1316723453
MESH:D051437 Renal Insufficiency Methotrexate 5.0217352296
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 11.7516283617 16116481
MESH:D012208 Rhabdomyosarcoma Valproic Acid 11.7519155313
MESH:D012507 Sarcoidosis marker/mechanism 18690218
MESH:D012559 Schizophrenia Valproic Acid 2.0919110320 15737665
MESH:D012640 Seizures 2,6-dinitrotoluene 6.4718551238
MESH:D012640 Seizures Valproic Acid 6.4717978042 16876388 15475178 11738929 11044598 3137016 1511512 14763951
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.8916192470
MESH:D012878 Skin Neoplasms Tretinoin 5.8916467112
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9619490988
MESH:D013226 Status Epilepticus Valproic Acid 4.9212833885
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013576 Syndactyly Methotrexate 5.329562676
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D013964 Thyroid Neoplasms Tretinoin 3.2116026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 4.0216051514
MESH:D014178 Translocation, Genetic Valproic Acid 5.6117262798
MESH:D014376 Tuberculosis Tretinoin 3.3616040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.863119515
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.3716049721
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.958888407
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.6610091137
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.9016129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.9916752155
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D014820 Vitiligo Tretinoin 4.3416761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
MESH:D009396 Wilms Tumor Tretinoin 4.1816287080
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24825
    • No data
    Releated disease ID Related disease Name
    PA445593Sarcoidosis
    PA443756Colonic Neoplasms
    PA443560Breast Neoplasms
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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