AutismKB 2.0

Annotation Detail for HLA-DPB1


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Basic Information Top
Gene Symbol:HLA-DPB1 ( DPB1,HLA-DP1B )
Gene Full Name: major histocompatibility complex, class II, DP beta 1
Band: 6p21.32
Quick LinksEntrez ID:3115; OMIM: 142858; Uniprot ID:DPB1_HUMAN; ENSEMBL ID: ENSG00000223865; HGNC ID: 4940
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04672Intestinal immune network for IgA production
hsa05332Graft-versus-host disease
hsa04145Phagosome
hsa05310Asthma
hsa05416Viral myocarditis
hsa05140Leishmaniasis
hsa05145Toxoplasmosis
hsa05322Systemic lupus erythematosus
hsa05320Autoimmune thyroid disease
hsa05150Staphylococcus aureus infection
hsa05330Allograft rejection
hsa04612Antigen processing and presentation
hsa04514Cell adhesion molecules (CAMs)
hsa04940Type I diabetes mellitus
Pathway IDPathway Name
Signaling in Immune system
No data
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Circulatory system diseases
Cardiac diseases
H00294Dilated cardiomyopathy (DCM)
Desease IDDesease Name
1904Diabetes mellitus
2025Polyarthritis
2051Leukemia
2179Mycosis fungoides
Desease Name
leukemia, myeloid
pathological myopia
CARDIOVASCULAR
diabetes, type 1
endometriosis
bone marrow transplant
cardiomyopathy
graft-versus-host disease
asthma, aspirin-intolerant
Celiac Disease
silicosis
CANCER
primary biliary cirrhosis
Asthma
nephropathy in other diseases
RENAL
leukemia, acute lymphoblastic
multiple sclerosis
Urticaria
IMMUNE
pulmonary thromboembolism
atopy
METABOLIC
VISION
hepatitis B
thrombosis, deep vein
REPRODUCTION
INFECTION
pulmonary hypertension
Desease Name
Hepatitis B
Desease Name
Beryllium disease, chronic, susceptibility to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000638 Amiodarone Amiodarone results in increased expression of HLA-DPB1 mRNAincreases expression 19774075
D001608 Beryllium HLA-DPB1 gene polymorphism results in increased susceptibility to Berylliumincreases response to substance 11551429
D001608 Beryllium HLA-DPB1 gene SNP results in increased susceptibility to Berylliumincreases response to substance 17956852
D001608 Beryllium HLA-DPB1 protein mutant form binds to Berylliumaffects binding 17956852
D001608 Beryllium HLA-DPB1 protein mutant form results in increased susceptibility to Berylliumincreases response to substance 15273960
C020711 beryllium sulfate beryllium sulfate binds to HLA-DPB1 proteinaffects binding 11423174
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of HLA-DPB1 mRNAincreases expression 15336504
D003907 Dexamethasone Dexamethasone results in increased expression of HLA-DPB1 mRNAincreases expression 12732289
C013038 hydroxyhydroquinone hydroxyhydroquinone results in decreased expression of HLA-DPB1 mRNAdecreases expression 17572062
D014635 Valproic Acid Valproic Acid results in increased expression of HLA-DPB1 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.888875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.2119490988
MESH:D000550 Amblyopia Valproic Acid 5.6817688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.7917497229
MESH:D001145 Arrhythmias, Cardiac Amiodarone 4.0720041841 18218290 18057881
MESH:D001169 Arthritis, Experimental Dexamethasone 3.6917659584
MESH:D001172 Arthritis, Rheumatoid marker/mechanism 17956852
MESH:D001249 Asthma marker/mechanism 16792590 17956852
MESH:D001281 Atrial Fibrillation Amiodarone 4.1119698954 18651412
MESH:D001321 Autistic Disorder Valproic Acid 1.9918396377 20603192 18177632 18558336 19232924 18985861 17688650 18316065 18775368 15238991 16609825 17157402 17507914 19460635 18940202
MESH:D001607 Berylliosis marker/mechanism 8105536 11551429 14662898 15273960 17927685 17956852
MESH:D001607 Berylliosis Beryllium 6.2119589099
MESH:D001714 Bipolar Disorder Valproic Acid 3.2017594078 20046352
MESH:D001778 Blood Coagulation Disorders Amiodarone 4.1819483382
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.578888407
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9719225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.4818974383
MESH:D002446 Celiac Disease marker/mechanism 17956852
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7920734317
MESH:D003110 Colonic Neoplasms Dexamethasone 2.5315824018
MESH:D019465 Craniofacial Abnormalities Dexamethasone 2.9217728286
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.9216575769 17688650 8888407
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.7612438553
MESH:D003967 Diarrhea Dexamethasone 4.027237001
MESH:D056486 Drug-Induced Liver Injury Amiodarone 4.3118218290 15265979
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 4.311733752 19641884
MESH:D004421 Dystonia Valproic Acid 4.351851702
MESH:D004485 Eczema Dexamethasone 4.7912438553
MESH:D004487 Edema Dexamethasone 3.6819703484
MESH:D004715 Endometriosis marker/mechanism 17956852
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.513659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.3616628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0618234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.846426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.667750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.463659116
MESH:D005234 Fatty Liver Amiodarone 8.9514986274
MESH:D005234 Fatty Liver Valproic Acid 8.9514986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 5.3316575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.468888407 18558336
MESH:D006099 Granuloma Beryllium 7.9719070257
MESH:D019694 Hepatitis B, Chronic marker/mechanism 19349983
MESH:D006529 Hepatomegaly Amiodarone 4.1115265979
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 3.157520565
MESH:D006849 Hydrocephalus Valproic Acid 5.2617688650
MESH:D006937 Hypercholesterolemia Amiodarone 4.159751232 8137927
MESH:D006973 Hypertension Dexamethasone 3.0217042910
MESH:D007037 Hypothyroidism Amiodarone 4.8717991464 18020914
MESH:D007249 Inflammation Dexamethasone 3.008960868 11099482
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1917596541 16294345
MESH:D008064 Lipidoses Amiodarone 3.7015342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 2.2716718785
MESH:D008133 Long QT Syndrome Amiodarone 3.7917391786 15350150 11989578
MESH:D008171 Lung Diseases Amiodarone 3.5512587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 12.7918516814
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 12.7917228818
MESH:D008175 Lung Neoplasms Beryllium 3.589715507 7545909 8933044 9255578
MESH:D008175 Lung Neoplasms Dexamethasone 3.5815824018 11195469
MESH:D008881 Migraine Disorders Valproic Acid 3.3818803445 18765137
MESH:D009101 Multiple Myeloma Dexamethasone 3.6915867202 16118317 15744524
MESH:D009103 Multiple Sclerosis marker/mechanism 17956852
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.318888407
MESH:D009157 Myasthenia Gravis marker/mechanism 17956852
MESH:D009181 Mycoses Amiodarone 5.3417974566 12754197
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 8.049809623
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 8.0417596541
MESH:D009436 Neural Tube Defects Valproic Acid 3.3016359493 8888407
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.6821297632
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.2320603192
MESH:D019310 Pseudolymphoma Valproic Acid 4.9812752131 11422049
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.9412490602 11597910 12832656
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 4.3218379247 11700416
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.4819155313
MESH:D012507 Sarcoidosis marker/mechanism 8909942 14508706 17956852
MESH:D012559 Schizophrenia Valproic Acid 2.0915737665 19110320
MESH:D012640 Seizures Valproic Acid 2.9111044598 17978042 14763951 16876388 3137016 15475178 1511512 11738929
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.4818724381
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.808532709
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9919490988
MESH:D013226 Status Epilepticus Valproic Acid 4.9812833885
MESH:D013272 Stomach Diseases Dexamethasone 4.7215472012
MESH:D013276 Stomach Ulcer Amiodarone 8.4218087811
MESH:D013276 Stomach Ulcer Dexamethasone 8.4215138204
MESH:D013610 Tachycardia Amiodarone 4.6211238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.5219225199
MESH:D013959 Thyroid Diseases Amiodarone 5.2019731979
MESH:D013971 Thyrotoxicosis Amiodarone 5.2218020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 4.5917467628 11989578
MESH:D014178 Translocation, Genetic Valproic Acid 5.6817262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.923119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.008888407
MESH:D014605 Uveitis Dexamethasone 5.261336536
Pathway ID Pathway Name
KEGG:05330 Allograft rejection
KEGG:04612 Antigen processing and presentation
KEGG:05310 Asthma
KEGG:05320 Autoimmune thyroid disease
KEGG:04514 Cell adhesion molecules (CAMs)
KEGG:05332 Graft-versus-host disease
KEGG:04672 Intestinal immune network for IgA production
KEGG:05140 Leishmaniasis
KEGG:04145 Phagosome
KEGG:05323 Rheumatoid arthritis
REACT:6900 Signaling in Immune system
KEGG:05150 Staphylococcus aureus infection
KEGG:05322 Systemic lupus erythematosus
KEGG:05145 Toxoplasmosis
KEGG:05152 Tuberculosis
KEGG:04940 Type I diabetes mellitus
KEGG:05416 Viral myocarditis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35064
    • No data
    Releated disease ID Related disease Name
    PA443888Diabetes Mellitus, Type 1
    PA444859Malaria
    PA444437Hepatitis B
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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