AutismKB 2.0

Annotation Detail for HLA-DQA1


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Basic Information Top
Gene Symbol:HLA-DQA1 ( CD,CELIAC1,DQ-A1,FLJ27088,FLJ27328,GSE,HLA-DQA,MGC149527 )
Gene Full Name: major histocompatibility complex, class II, DQ alpha 1
Band: 6p21.32
Quick LinksEntrez ID:3117; OMIM: 146880; Uniprot ID:DQA1_HUMAN; ENSEMBL ID: ENSG00000196735; HGNC ID: 4942
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04672Intestinal immune network for IgA production
hsa05332Graft-versus-host disease
hsa04145Phagosome
hsa05310Asthma
hsa05416Viral myocarditis
hsa05140Leishmaniasis
hsa05145Toxoplasmosis
hsa05322Systemic lupus erythematosus
hsa05320Autoimmune thyroid disease
hsa05150Staphylococcus aureus infection
hsa05330Allograft rejection
hsa04612Antigen processing and presentation
hsa04514Cell adhesion molecules (CAMs)
hsa04940Type I diabetes mellitus
Pathway IDPathway Name
Signaling in Immune system
No data
Pathway IDPathway Name
P00053T cell activation
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Circulatory system diseases
H00082Graves' disease
H00080Systemic lupus erythematosus
H00081Hashimoto's thyroiditis
Metabolic diseases
Immune system diseases
Diabetes
Cardiac diseases
H00408Type I diabetes mellitus
H00294Dilated cardiomyopathy (DCM)
Allergies and autoimmune diseases
Desease IDDesease Name
1712Yersinia infection
1807Autoimmune disease
1810Common wart
1859Ovarian cancer
1863Aplastic anemia
1904Diabetes mellitus
1944Breast cancer
1964Primary biliary cirrhosis
1841Stomach cancer
2018Rheumatic fever
2022Liver cancer
2029Tuberculosis
2074Asthma
2171Celiac disease
2178Retinal disease
2230Alopecia
2256Aortic aneurysm
Desease Name
blood group incompatibility
rheumatoid arthritis
ovarian cancer
vitiligo
HLA-DQA1 differential expression
infertility, tubal factor
myasthenia gravis
tuberculosis
CARDIOVASCULAR
diabetes, type 1
endometriosis
cardiomyopathy
Celiac Disease
CANCER
stroke, lacunar
PSYCH
stomach cancer
Hepatitis B, Chronic
ulcerative colitis
cirrhosis, biliary primary
nasal polyposis
Asthma
adenomyosis
warts
hypertension
multiple sclerosis
allergy
sclerosis, systemic
allergic rhinitis
systemic lupus erythematosus
inflammatory bowel disease
IMMUNE
atherothrombotic brain infarction
Vogt-Koyanagi-Harada syndrome
kidney cancer
Graves' disease
juvenile dermatomyositis
pregnancy loss, recurrent
Arthritis, Rheumatoid
schizophrenia
METABOLIC
osteoarthritis
Graves disease
pemphigoid, bullous
autoimmune polyglandular syndrome
cholangitis, sclerosing
H. pylori infection
thyroid autoimmunity
psoriasis
HIV
hepatitis B
autoimmune response
carbamazepine hypersensitivity
REPRODUCTION
diabetes, type 2
cervical cancer
inflammatory myopathies
INFECTION
cytomegalovirus retinitis
measles antibody level
Desease Name
Rheumatoid arthritis
Celiac disease
Inflammatory bowel disease
Schizophrenia
Systemic lupus erythematosus
Desease Name
Celiac disease, susceptibility to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001151 Arsenic Arsenic affects the expression of HLA-DQA1 mRNAaffects expression 18414638
D003907 Dexamethasone Dexamethasone results in increased expression of HLA-DQA1 mRNAincreases expression 12732289
D003907 Dexamethasone Dexamethasone results in increased expression of HLA-DQA1 proteinincreases expression 12732289
C473384 lumiracoxib HLA-DQA1 gene SNP affects the susceptibility to lumiracoxibaffects response to substance 20639878
D008628 Mercury Mercury results in decreased expression of HLA-DQA1 mRNAdecreases expression 16823088
D011794 Quercetin Quercetin results in increased expression of HLA-DQA1 mRNAincreases expression 16455785
C004648 testosterone enanthate testosterone enanthate affects the expression of HLA-DQA1 mRNAaffects expression 17440010
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D018246 Adrenocortical Adenoma Arsenic 5.7317306315
MESH:D000743 Anemia, Hemolytic Quercetin 4.5717084956
MESH:D020261 Arsenic Poisoning Arsenic 2.9318414634 12569548 16835338 16251483
MESH:D001169 Arthritis, Experimental Dexamethasone 3.7217659584
MESH:D001249 Asthma marker/mechanism 10792356
MESH:D001260 Ataxia Telangiectasia Quercetin 5.4415336622
MESH:D050197 Atherosclerosis Arsenic 3.4212928151 19371607
MESH:D001321 Autistic Disorder Mercury 2.7617497416
MESH:D001327 Autoimmune Diseases Mercury 12.4416634805
MESH:D001327 Autoimmune Diseases Quercetin 12.4419761891
MESH:D001943 Breast Neoplasms Quercetin 2.6318628248
MESH:D002105 Cadmium Poisoning Quercetin 6.0716962696
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.7517687452 15504454
MESH:D006528 Carcinoma, Hepatocellular Arsenic 3.4616507464 17306315
MESH:D006528 Carcinoma, Hepatocellular Quercetin 3.4619519916 12508355
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 5.3717234771
MESH:D002294 Carcinoma, Squamous Cell Arsenic 2.7617687452 18922899 15504454
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.3818640142
MESH:D006332 Cardiomegaly Quercetin 3.4719794523
MESH:D002311 Cardiomyopathy, Dilated Mercury 3.5410334427
MESH:D002318 Cardiovascular Diseases Arsenic 3.6615738583 17938729 19152805
MESH:D002340 Carotid Artery Diseases Arsenic 4.6016973168 18022660
MESH:D002446 Celiac Disease marker/mechanism
MESH:D003110 Colonic Neoplasms Dexamethasone 4.1515824018
MESH:D003110 Colonic Neoplasms Quercetin 4.1515741050 11134977 17148506 19440933 17191121 19056647 16640504
MESH:D015179 Colorectal Neoplasms Quercetin 2.1918852136 18095365
MESH:D019465 Craniofacial Abnormalities Dexamethasone 2.2917728286
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 8.8212438553
MESH:D017449 Dermatitis, Allergic Contact Mercury 8.8216823706
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 4.0019496084
MESH:D003967 Diarrhea Dexamethasone 4.077237001
MESH:D056486 Drug-Induced Liver Injury lumiracoxib 4.5820639878
MESH:D004485 Eczema Dexamethasone 4.8412438553
MESH:D004487 Edema Dexamethasone 3.7219703484
MESH:D016603 Eosinophilia-Myalgia Syndrome marker/mechanism 19790128
MESH:D005355 Fibrosis Quercetin 4.3219474275
MESH:D005534 Foot Diseases Arsenic 6.086392382
MESH:D005909 Glioblastoma Quercetin 3.5819804834
MESH:D005910 Glioma Quercetin 3.1517643826
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 3.167520565
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 6.2717440010
MESH:D006943 Hyperglycemia Quercetin 4.3418262572 11834736
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.7617050553
MESH:D006973 Hypertension Arsenic 9.4111953799 9931084 16076760
MESH:D006973 Hypertension Dexamethasone 9.4117042910
MESH:D006973 Hypertension Quercetin 9.4118356687
MESH:D006987 Hypesthesia Arsenic 6.0816093927
MESH:D007249 Inflammation Dexamethasone 3.0211099482 8960868
MESH:D007251 Influenza, Human Quercetin 5.0316624496
MESH:D007627 Keloid Quercetin 5.3717086741
MESH:D007642 Keratosis Arsenic 5.4516930632 12749816
MESH:D007674 Kidney Diseases Mercury 7.1217934191
MESH:D007674 Kidney Diseases Quercetin 7.1216962696
MESH:D007938 Leukemia Quercetin 3.2917468513
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.7417339181
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 2.9016718785
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 2.9012741479
MESH:D008107 Liver Diseases Arsenic 2.6011134558
MESH:D008113 Liver Neoplasms Arsenic 5.2416368122
MESH:D008113 Liver Neoplasms Quercetin 5.2418980244
MESH:D008114 Liver Neoplasms, Experimental Quercetin 3.2419519916
MESH:D008175 Lung Neoplasms Arsenic 3.7817976673 17306315 19168569
MESH:D008175 Lung Neoplasms Dexamethasone 3.7815824018 11195469
MESH:D008175 Lung Neoplasms Quercetin 3.7816280456
MESH:D009101 Multiple Myeloma Dexamethasone 3.7216118317 15867202 15744524
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.709809623
MESH:D009203 Myocardial Infarction Quercetin 3.1019595682
MESH:D017202 Myocardial Ischemia Arsenic 4.2415371236
MESH:D015428 Myocardial Reperfusion Injury Quercetin 4.0319207477
MESH:D009369 Neoplasms Quercetin 2.9215185748
MESH:D009436 Neural Tube Defects Arsenic 3.6416620997
MESH:D020078 Neurogenic Inflammation Arsenic 11.8817056641
MESH:D020078 Neurogenic Inflammation Quercetin 11.8817929310
MESH:D010003 Osteoarthritis lumiracoxib 5.7020639878
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.5719495926
MESH:D010051 Ovarian Neoplasms Arsenic 5.4117306315
MESH:D010051 Ovarian Neoplasms Quercetin 5.4119005980
MESH:D010146 Pain lumiracoxib 5.5820639878
MESH:D010190 Pancreatic Neoplasms Quercetin 2.9416965848
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.5616093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.4516905509 6392382 15371236
MESH:D011230 Precancerous Conditions Quercetin 4.2719056647
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.7021297632
MESH:D011471 Prostatic Neoplasms Arsenic 3.4616140617
MESH:D011471 Prostatic Neoplasms Quercetin 3.4614715546 17292933
MESH:D011507 Proteinuria Arsenic 4.3521343184
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 4.3718379247 11700416
MESH:D012554 Schistosomiasis japonica Quercetin 6.0716862918
MESH:D012871 Skin Diseases Arsenic 2.8119834688 17453740 16353154 18709164 6392382 16702368 17548696 15952646 16759981 17050553 17938729
MESH:D012878 Skin Neoplasms Arsenic 3.1317976673 16251483 17029826 19538983 17050553 15504454
MESH:D013272 Stomach Diseases Dexamethasone 4.7815472012
MESH:D013276 Stomach Ulcer Dexamethasone 3.8115138204
MESH:D001749 Urinary Bladder Neoplasms Arsenic 5.7411144890 19429237 19322015 17306315 17976673 18640142 15987713
MESH:D001749 Urinary Bladder Neoplasms Quercetin 5.7416720314
MESH:D014605 Uveitis Dexamethasone 5.341336536
MESH:D014652 Vascular Diseases Arsenic 5.2017056641
Pathway ID Pathway Name
KEGG:05330 Allograft rejection
KEGG:04612 Antigen processing and presentation
KEGG:05310 Asthma
KEGG:05320 Autoimmune thyroid disease
KEGG:04514 Cell adhesion molecules (CAMs)
KEGG:05332 Graft-versus-host disease
KEGG:04672 Intestinal immune network for IgA production
KEGG:05140 Leishmaniasis
KEGG:04145 Phagosome
KEGG:05323 Rheumatoid arthritis
REACT:6900 Signaling in Immune system
KEGG:05150 Staphylococcus aureus infection
KEGG:05322 Systemic lupus erythematosus
KEGG:05145 Toxoplasmosis
KEGG:05152 Tuberculosis
KEGG:04940 Type I diabetes mellitus
KEGG:05416 Viral myocarditis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35066
    • No data
    Releated disease ID Related disease Name
    PA443888Diabetes Mellitus, Type 1
    PA443886Diabetes Mellitus
    PA443888Diabetes Mellitus, Type 1
    PA445174Osteoarthritis
    PA445208Pain
    Releated drug ID Related drug Name
    PA161748474ximelagatran
    PA164769031lumiracoxib
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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