AutismKB 2.0

Annotation Detail for HLA-DRB4


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Basic Information Top
Gene Symbol:HLA-DRB4 ( DR-13,DR-14,DR13,DR14,DRB4,HLA-DR4B )
Gene Full Name: major histocompatibility complex, class II, DR beta 4
Band: 6p21.3 alternate reference locus
Quick LinksEntrez ID:3126; OMIM: NA; Uniprot ID:DRB4_HUMAN; ENSEMBL ID: ENSG00000227357; ENSG00000227826; ENSG00000231021; HGNC ID: 4952
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04672Intestinal immune network for IgA production
hsa04640Hematopoietic cell lineage
hsa05332Graft-versus-host disease
hsa04145Phagosome
hsa05310Asthma
hsa05416Viral myocarditis
hsa05140Leishmaniasis
hsa05145Toxoplasmosis
hsa05322Systemic lupus erythematosus
hsa05320Autoimmune thyroid disease
hsa05150Staphylococcus aureus infection
hsa05330Allograft rejection
hsa04612Antigen processing and presentation
hsa04514Cell adhesion molecules (CAMs)
hsa04940Type I diabetes mellitus
Pathway IDPathway Name
Signaling in Immune system
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
periodontitis
vitiligo
defective DR beta 4 chain expression to the HLA-DRB1 gene
thyroiditis, chronic lymphocytic
IMMUNE
NEUROLOGICAL
narcolepsy
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001151 Arsenic HLA-DRB4 mRNA results in decreased susceptibility to Arsenicdecreases response to substance 17976673
D004317 Doxorubicin HLA-DRB4 mRNA results in decreased susceptibility to Doxorubicindecreases response to substance 16322897
C051890 irinotecan irinotecan analog results in increased expression of HLA-DRB4 mRNAincreases expression 18927307
D008345 Manganese Manganese results in increased expression of HLA-DRB4 mRNAincreases expression 17175027
C025340 manganese chloride manganese chloride results in increased expression of HLA-DRB4 mRNAincreases expression 17175027
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of HLA-DRB4 mRNAdecreases expression 17101203
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3114514962 15322242 11752688
MESH:D000230 Adenocarcinoma Doxorubicin 2.6317418594
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.8416835633
MESH:D018246 Adrenocortical Adenoma Arsenic 5.7317306315
MESH:D000419 Albuminuria Doxorubicin 4.9321441931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2511748828
MESH:D000756 Anemia, Sideroblastic Manganese 12.1416910769
MESH:D000756 Anemia, Sideroblastic manganese chloride 12.1416910769
MESH:D020261 Arsenic Poisoning Arsenic 2.9312569548 16835338 16251483 18414634
MESH:D050197 Atherosclerosis Arsenic 3.4219371607 12928151
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9515746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 5.2214601052
MESH:D001932 Brain Neoplasms Doxorubicin 4.1117150277
MESH:D001943 Breast Neoplasms Doxorubicin 2.0816264153 11325840 15136595 15993339 15939500 15567936 18695136 16115903 16096432 16935488 18628466 15668708 19526202 17983394 15634643 16595493 17369602 15994142 16826403 16322301 17426702 18382427 18234424 15692762
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0820435547
MESH:D002276 Carcinoid Tumor Doxorubicin 5.3316051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.7517687452 15504454
MESH:D006528 Carcinoma, Hepatocellular Arsenic 3.4416507464 17306315
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 3.4418059187 16234567 16023760 17876044
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.281485588 16201981
MESH:D002294 Carcinoma, Squamous Cell Arsenic 5.1817687452 18922899 15504454
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 5.186189445
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.3818640142
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5218670907 16120746 18850075
MESH:D009202 Cardiomyopathies Doxorubicin 3.7217007740 15505089 16455267 17308081 17928571 15476868 16242529 18627295 16278810 16364871 16952015 17519947 17924179 17351982 17974986 16269455 16612575 17131338 15811867 17329180 17382496 16651473 15792986 16731534 16109756
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 3.0316243910 17334414
MESH:D002318 Cardiovascular Diseases Arsenic 3.6615738583 19152805 17938729
MESH:D002340 Carotid Artery Diseases Arsenic 4.6018022660 16973168
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4516835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2116354765 8697196 15668235 15340226 12621046
MESH:D003110 Colonic Neoplasms irinotecan 2.6317725105 17287894
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.8418259882 18802399
MESH:D015179 Colorectal Neoplasms irinotecan 2.8418509181 16391804 15273666 17159606 17454858 18259882 16303861
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3417141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 10048152 15322242
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 4.1217416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 4.1220420201
MESH:D004362 Drug Toxicity Doxorubicin 8.8918602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.8911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.4216714409 15322242 18230668
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.6417359293
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.339294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.6818037988
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2411564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8711858732
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 5.0519069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3620067830
MESH:D005534 Foot Diseases Arsenic 6.086392382
MESH:D005909 Glioblastoma Doxorubicin 8.2217150277
MESH:D005909 Glioblastoma Manganese 8.2217043766
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.1210696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.7315692506
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4711294989 10048152
MESH:D006331 Heart Diseases Doxorubicin 3.6912587719 18006777 16244371 16244372 16330681 18674790 17888722 17875725 16144979 16879835 14766674 16707910 16495754
MESH:D006333 Heart Failure Doxorubicin 3.5217481944
MESH:D006394 Hemangiosarcoma Doxorubicin 4.2315692506
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3115340226 12621046 16120746
MESH:D006689 Hodgkin Disease Doxorubicin 3.6918501091 15147373 17606976
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.5718606429 15340226 16959395 8697196 16354765
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.7617050553
MESH:D006973 Hypertension Arsenic 5.5616076760 9931084 11953799
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.5618850075 18670907
MESH:D006987 Hypesthesia Arsenic 6.0816093927
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9912200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6616580747
MESH:D007642 Keratosis Arsenic 5.4516930632 12749816
MESH:D007674 Kidney Diseases Doxorubicin 3.2116775033 15699352 15369732
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.4816707910
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.6816085563
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.7417339181
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 2.5116595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.5112878042
MESH:D008107 Liver Diseases Arsenic 2.6011134558
MESH:D008113 Liver Neoplasms Arsenic 4.8916368122
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.8916984957
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 6.5217085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.5212151625
MESH:D008175 Lung Neoplasms Arsenic 3.6417976673 17306315 19168569
MESH:D008175 Lung Neoplasms Doxorubicin 3.6417418594 6189445
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.6411884234 19555203
MESH:D008223 Lymphoma Doxorubicin 3.6816098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 4.0617654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.9815621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 3.2115458769
MESH:D020149 Manganese Poisoning Manganese 6.0419453300 16568477 16551646
MESH:D008545 Melanoma Doxorubicin 2.3216827129
MESH:D008654 Mesothelioma Doxorubicin 3.1617638057
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.8315792986
MESH:D009069 Movement Disorders Manganese 5.3616551646
MESH:D052016 Mucositis Doxorubicin 14.0117415656
MESH:D052016 Mucositis irinotecan 14.0117159606
MESH:D009203 Myocardial Infarction Doxorubicin 3.0519429709 15857846
MESH:D017202 Myocardial Ischemia Arsenic 9.8615371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.8612213967
MESH:D009362 Neoplasm Metastasis Doxorubicin 6.4518259882
MESH:D009362 Neoplasm Metastasis irinotecan 6.4518259882
MESH:D009401 Nephrosis Doxorubicin 5.1916899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.2915640375 16889571
MESH:D009410 Nerve Degeneration Manganese 4.5116551646
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5914600291
MESH:D009436 Neural Tube Defects Arsenic 3.6416620997
MESH:D009447 Neuroblastoma Doxorubicin 7.6315555623
MESH:D009447 Neuroblastoma irinotecan 7.638761367
MESH:D017599 Neuroectodermal Tumors irinotecan 5.198761367
MESH:D020078 Neurogenic Inflammation Arsenic 4.7317056641
MESH:D012516 Osteosarcoma Doxorubicin 4.3715930896
MESH:D010051 Ovarian Neoplasms Arsenic 2.8217306315
MESH:D010300 Parkinson Disease Manganese 3.4611181820
MESH:D020734 Parkinsonian Disorders Manganese 4.7716140633
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.7712520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.5616093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.4516905509 6392382 15371236
MESH:D003557 Phyllodes Tumor Doxorubicin 5.6817983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.6817638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.9418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.6511222880 11399792 11896295 11118676
MESH:D011471 Prostatic Neoplasms Arsenic 3.4516140617
MESH:D011471 Prostatic Neoplasms Doxorubicin 3.4516888761 18437689 16868541 16729912 15749863 15897917
MESH:D011507 Proteinuria Arsenic 4.3521343184
MESH:D051437 Renal Insufficiency Doxorubicin 4.6417922066
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2218990726
MESH:D012509 Sarcoma Doxorubicin 4.2916767912 15625365 17710206 18313854 17203757 15675481
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.6214601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 5.2517846226
MESH:D012871 Skin Diseases Arsenic 2.8119834688 18709164 17453740 17548696 16353154 17938729 17050553 15952646 6392382 16759981 16702368
MESH:D012878 Skin Neoplasms Arsenic 10.2717976673 16251483 17029826 15504454 17050553 19538983
MESH:D012878 Skin Neoplasms Doxorubicin 10.2715692506
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 10.2716192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.9815625365 17203757 16767912
MESH:D013274 Stomach Neoplasms irinotecan 2.3615723263
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.4212697716
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.6116010429 17909728
MESH:D001749 Urinary Bladder Neoplasms Arsenic 5.7311144890 17306315 19322015 15987713 17976673 18640142 19429237
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 5.7317653716
MESH:D014652 Vascular Diseases Arsenic 5.2017056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.1212125929
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.6417334414 16364871 17678736 17638931
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.7715886252
Pathway ID Pathway Name
KEGG:05330 Allograft rejection
KEGG:04612 Antigen processing and presentation
KEGG:05310 Asthma
KEGG:05320 Autoimmune thyroid disease
KEGG:04514 Cell adhesion molecules (CAMs)
KEGG:05332 Graft-versus-host disease
KEGG:04640 Hematopoietic cell lineage
KEGG:04672 Intestinal immune network for IgA production
KEGG:05140 Leishmaniasis
KEGG:04145 Phagosome
KEGG:05323 Rheumatoid arthritis
REACT:6900 Signaling in Immune system
KEGG:05150 Staphylococcus aureus infection
KEGG:05322 Systemic lupus erythematosus
KEGG:05145 Toxoplasmosis
KEGG:05152 Tuberculosis
KEGG:04940 Type I diabetes mellitus
KEGG:05416 Viral myocarditis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35075
    • No data
    Releated disease ID Related disease Name
    PA443297Agranulocytosis
    PA444620Inflammation
    Releated drug ID Related drug Name
    PA449061clozapine
    PA451096prednisolone
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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