Annotation Detail for HLA-DRB5
Basic Information Top
| Gene Symbol: | HLA-DRB5 ( FLJ76359,HLA-DRB ) |
|---|---|
| Gene Full Name: | major histocompatibility complex, class II, DR beta 5 |
| Band: | 6p21.32 |
| Quick Links | Entrez ID:3127; OMIM: 604776; Uniprot ID:DRB5_HUMAN; ENSEMBL ID: ENSG00000198502; HGNC ID: 4953 |
| Relate to Another Database: | SFARIGene; denovo-db |
| No data |
| Pathway ID | Pathway Name |
|---|---|
| hsa04672 | Intestinal immune network for IgA production |
| hsa04640 | Hematopoietic cell lineage |
| hsa05332 | Graft-versus-host disease |
| hsa04145 | Phagosome |
| hsa05310 | Asthma |
| hsa05416 | Viral myocarditis |
| hsa05140 | Leishmaniasis |
| hsa05145 | Toxoplasmosis |
| hsa05322 | Systemic lupus erythematosus |
| hsa05320 | Autoimmune thyroid disease |
| hsa05150 | Staphylococcus aureus infection |
| hsa05330 | Allograft rejection |
| hsa04612 | Antigen processing and presentation |
| hsa04514 | Cell adhesion molecules (CAMs) |
| hsa04940 | Type I diabetes mellitus |
| No data |
| No data |
| No data |
| No data |
| No data |
| No data |
| Desease Name |
|---|
| periodontitis |
| tuberculosis |
| echinococcosis |
| malaria |
| IMMUNE |
| schistosomiasis |
| INFECTION |
| No data |
| No data |
| Chemical ID | Chemical Name | Interaction | Interaction Action | Publication |
|---|---|---|---|---|
| C061133 | Am 80 | Am 80 results in increased expression of HLA-DRB5 mRNA | increases expression | 17229644 |
| C473384 | lumiracoxib | HLA-DRB5 gene SNP affects the susceptibility to lumiracoxib | affects response to substance | 20639878 |
| D008942 | Mitoxantrone | HLA-DRB5 protein affects the susceptibility to Mitoxantrone | affects response to substance | 16217747 |
| Disease ID | Disease Name | Direct Evidence | Inference Chemical Name | Inference Score | Publication |
|---|---|---|---|---|---|
| MESH:D001172 | Arthritis, Rheumatoid | Am 80 | 3.83 | 16819260 | |
| MESH:D050197 | Atherosclerosis | Am 80 | 4.57 | 16484594 | |
| MESH:D056486 | Drug-Induced Liver Injury | lumiracoxib | 4.61 | 20639878 | |
| MESH:D004681 | Encephalomyelitis, Autoimmune, Experimental | Am 80 | 5.67 | 16819260 | |
| MESH:D006331 | Heart Diseases | Mitoxantrone | 4.44 | 16019553 | |
| MESH:D015451 | Leukemia, Lymphocytic, Chronic, B-Cell | Mitoxantrone | 3.93 | 18172266 | |
| MESH:D015473 | Leukemia, Promyelocytic, Acute | Am 80 | 4.91 | 16819260 16531727 | |
| MESH:D009101 | Multiple Myeloma | Am 80 | 4.84 | 17229644 | |
| MESH:D009369 | Neoplasms | Mitoxantrone | 3.60 | 16640825 | |
| MESH:D010003 | Osteoarthritis | lumiracoxib | 5.76 | 20639878 | |
| MESH:D010146 | Pain | lumiracoxib | 5.70 | 20639878 | |
| MESH:D011471 | Prostatic Neoplasms | Am 80 | 4.63 | 16289102 | |
| MESH:D011565 | Psoriasis | Am 80 | 4.20 | 16819260 |
| Pathway ID | Pathway Name |
|---|---|
| KEGG:05330 | Allograft rejection |
| KEGG:04612 | Antigen processing and presentation |
| KEGG:05310 | Asthma |
| KEGG:05320 | Autoimmune thyroid disease |
| KEGG:04514 | Cell adhesion molecules (CAMs) |
| KEGG:05332 | Graft-versus-host disease |
| KEGG:04640 | Hematopoietic cell lineage |
| KEGG:04672 | Intestinal immune network for IgA production |
| KEGG:05140 | Leishmaniasis |
| KEGG:04145 | Phagosome |
| KEGG:05323 | Rheumatoid arthritis |
| KEGG:05150 | Staphylococcus aureus infection |
| KEGG:05322 | Systemic lupus erythematosus |
| KEGG:05145 | Toxoplasmosis |
| KEGG:05152 | Tuberculosis |
| KEGG:04940 | Type I diabetes mellitus |
| KEGG:05416 | Viral myocarditis |
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