AutismKB 2.0

Annotation Detail for HLA-G


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Basic Information Top
Gene Symbol:HLA-G ( MHC-G )
Gene Full Name: major histocompatibility complex, class I, G
Band: 6p22.1
Quick LinksEntrez ID:3135; OMIM: 142871; Uniprot ID:HLAG_HUMAN; ENSEMBL ID: ENSG00000204632; HGNC ID: 4964
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05332Graft-versus-host disease
hsa04650Natural killer cell mediated cytotoxicity
hsa04145Phagosome
hsa04144Endocytosis
hsa05416Viral myocarditis
hsa05320Autoimmune thyroid disease
hsa05330Allograft rejection
hsa04612Antigen processing and presentation
hsa04514Cell adhesion molecules (CAMs)
hsa04940Type I diabetes mellitus
Pathway IDPathway Name
Signaling in Immune system
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
placental weight
in vitro fertilization success
Pre-Eclampsia
Birth Weight
IMMUNE
pregnancy loss, recurrent
preeclampsia
HIV
REPRODUCTION
Crohn's disease ulcerative colitis
INFECTION
sarcoidosis
No data
Desease Name
Asthma, susceptibility to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C006632 arsenic trioxide arsenic trioxide results in decreased expression of HLA-G mRNAdecreases expression 15725085
19128835
15761015
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of HLA-G mRNAincreases expression 19150397
C014347 decitabine [decitabine affects the methylation of HLA-G promoter] which affects the expression of HLA-G mRNAaffects expression|affects methylation 18498645
18823661
C014347 decitabine [decitabine affects the methylation of HLA-G promoter] which affects the expression of HLA-G proteinaffects expression|affects methylation 18823661
C014347 decitabine decitabine results in increased expression of HLA-G mRNAincreases expression 17949227
C014347 decitabine decitabine results in increased expression of HLA-G proteinincreases expression 17949227
D002945 Cisplatin HLA-G protein affects the susceptibility to Cisplatinaffects response to substance 16217747
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of HLA-G mRNAaffects cotreatment|increases expression 19619570
D004958 Estradiol Estradiol results in increased expression of HLA-G mRNAincreases expression 19619570
D005472 Fluorouracil Fluorouracil results in increased expression of HLA-G mRNAincreases expression 16101138
D015735 Mifepristone Mifepristone inhibits the reaction [Progesterone results in increased expression of HLA-G mRNA]decreases reaction|increases expression 16210391
D015735 Mifepristone Mifepristone inhibits the reaction [Progesterone results in increased expression of HLA-G protein]decreases reaction|increases expression 16210391
D011374 Progesterone Mifepristone inhibits the reaction [Progesterone results in increased expression of HLA-G mRNA]decreases reaction|increases expression 16210391
D011374 Progesterone Mifepristone inhibits the reaction [Progesterone results in increased expression of HLA-G protein]decreases reaction|increases expression 16210391
D011374 Progesterone Progesterone results in increased expression of HLA-G mRNAincreases expression 16210391
D011374 Progesterone Progesterone results in increased expression of HLA-G proteinincreases expression 16210391
D012643 Selenium Selenium results in increased expression of HLA-G mRNAincreases expression 19244175
D018038 Sodium Selenite Sodium Selenite results in increased expression of HLA-G mRNAincreases expression 18175754
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of HLA-G mRNAaffects cotreatment|increases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of HLA-G mRNAincreases expression 19619570
D014635 Valproic Acid Valproic Acid results in increased expression of HLA-G mRNAincreases expression 19101580
D014810 Vitamin E Vitamin E results in increased expression of HLA-G mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.7011752688 15322242 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 8.708875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.0119490988
MESH:D058186 Acute Kidney Injury Cisplatin 4.0412690470 17670903 15814532
MESH:D000230 Adenocarcinoma arsenic trioxide 10.3919825857 11798837
MESH:D000230 Adenocarcinoma Cisplatin 10.3917638652 11798837
MESH:D000230 Adenocarcinoma Estradiol 10.3911473722
MESH:D000230 Adenocarcinoma Fluorouracil 10.3917638652
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4916835633
MESH:D000550 Amblyopia Valproic Acid 5.3717688650
MESH:D000740 Anemia Fluorouracil 8.9416511603 17963324 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.9411748828
MESH:D001008 Anxiety Disorders Valproic Acid 3.6417497229
MESH:D001249 Asthma marker/mechanism
MESH:D001321 Autistic Disorder Valproic Acid 2.0015238991 18396377 17507914 18775368 18985861 17688650 18316065 16609825 18558336 18940202 20603192 18177632 19232924 17157402 19460635
MESH:D001714 Bipolar Disorder Valproic Acid 3.1120046352 17594078
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.2316206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.2312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.1915746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.198888407
MESH:D019046 Bone Marrow Neoplasms Cisplatin 5.0214601052
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.4717868700
MESH:D001930 Brain Injuries Progesterone 4.3615665606 15380490 15845082
MESH:D001943 Breast Neoplasms Cisplatin 3.0019526202 18382427
MESH:D001943 Breast Neoplasms decitabine 3.0019208741 18320071
MESH:D001943 Breast Neoplasms Estradiol 3.0012948864 16675129 17289903 17018787 19861407 18497071 14630087 17261762
MESH:D001943 Breast Neoplasms Fluorouracil 3.0015136595 18357371 18608205 16110121 16595493 16557594 19217205
MESH:D001943 Breast Neoplasms Progesterone 3.0017614352 15562024 16175315
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.0020435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.4211589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5816111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.0316050911
MESH:D002276 Carcinoid Tumor Fluorouracil 4.8016051944
MESH:D002277 Carcinoma Fluorouracil 8.4017121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.4016835633
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 6.7214691202 15073043 16217749 11135700 15553829
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 6.7217982673
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.7216924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 6.7216799960 17045692 17971768 16332177 17088986 18930000
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.0612023789 16685392
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.0119014326
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0518695887
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.1912490120
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 7.8018337622 17066447 6189445
MESH:D002294 Carcinoma, Squamous Cell decitabine 7.8019215824
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 7.8018986760 16757204 17066447 16280240
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4116120746 18670907 18850075
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.8320889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.8318566989
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7320734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2316835633
MESH:D019457 Chromosome Breakage Sodium Selenite 4.8615894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1316354765 8697196 12621046 15340226 15668235
MESH:D003092 Colitis Selenium 3.8817936198
MESH:D003110 Colonic Neoplasms decitabine 3.9117616700
MESH:D003110 Colonic Neoplasms Fluorouracil 3.9115001691 16340194 16510598 17016597 18772588 17018589 17725105 17169374 17287894 17172411
MESH:D015179 Colorectal Neoplasms arsenic trioxide 4.8820501625
MESH:D015179 Colorectal Neoplasms Cisplatin 4.8815273666
MESH:D015179 Colorectal Neoplasms decitabine 4.8818981723
MESH:D015179 Colorectal Neoplasms Fluorouracil 4.8816524972 17016601 15148649 16303861 17454858 18448328 18383874 17094418 16282729 17255274 17401013 18288408 17695437 14970324 16331619 15289873 18802399 18509181 20501625 18949393 16391804 17594712
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1317141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.2812609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 5.4710525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.4710048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Valproic Acid 5.478888407 16575769 17688650
MESH:D019465 Craniofacial Abnormalities Vitamin E 5.4719769572
MESH:D007644 Darier Disease Fluorouracil 4.9116733453
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.1815213294
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.8516285004
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.4819279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.6017187935
MESH:D056486 Drug-Induced Liver Injury Selenium 9.1815131321
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 9.1815131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.1820420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 9.181733752 19641884
MESH:D004362 Drug Toxicity Cisplatin 8.3812649298 12231392 15033597 19839026
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.3811462148
MESH:D004421 Dystonia Valproic Acid 4.141851702
MESH:C538011 Eales disease Vitamin E 4.849068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4612711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0415322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.8717692515
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.2519294695
MESH:D016889 Endometrial Neoplasms Estradiol 3.0311473722 19148513 18566989
MESH:D004715 Endometriosis Mifepristone 15.7916134523
MESH:D004715 Endometriosis Progesterone 15.7916134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 15.799294722 10568697
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.263659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.0516628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.9720417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.666426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.407750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.183659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.6020426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 10.6012903497
MESH:D004938 Esophageal Neoplasms Cisplatin 10.6015173087 16481741 15464296 17638652 16785472
MESH:D004938 Esophageal Neoplasms Fluorouracil 10.6017638652 15173087 16785472 16337965 16481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver arsenic trioxide 8.1915073043
MESH:D005234 Fatty Liver Valproic Acid 8.1919224547 14986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005315 Fetal Diseases Valproic Acid 5.0216575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.238888407 18558336
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.0520067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.3616904648
MESH:D005910 Glioma Fluorouracil 2.9016145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 13.3615102660 15464296
MESH:D006258 Head and Neck Neoplasms decitabine 13.3619215824
MESH:D006258 Head and Neck Neoplasms Fluorouracil 13.3615102660 15162350 18337622
MESH:D034381 Hearing Loss Cisplatin 4.3719898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.4915464296
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7010048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 6.7016080930
MESH:D006333 Heart Failure Selenium 3.1217162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0016120746 12621046 15340226
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7316863852 16490937
MESH:D006558 Herpes Genitalis Estradiol 5.1715709030
MESH:D006689 Hodgkin Disease Cisplatin 3.6616170182 16200630
MESH:D019584 Hot Flashes Estradiol 10.5017088409
MESH:D019584 Hot Flashes Vitamin E 10.5014716179
MESH:D006849 Hydrocephalus Valproic Acid 4.9817688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1815340226 16959395 8697196 16354765 18606429
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9318670907 18850075
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.5115869954
MESH:D007248 Infertility, Male decitabine 3.2517581917
MESH:D007249 Inflammation Progesterone 5.1115869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.1112200463 12878042
MESH:D007251 Influenza, Human Selenium 11.4116624496
MESH:D007251 Influenza, Human Vitamin E 11.4116624496
MESH:D007333 Insulin Resistance Estradiol 7.6116627594 16393666
MESH:D007333 Insulin Resistance Sodium Selenite 7.6114714311
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.2715464296
MESH:D007674 Kidney Diseases Cisplatin 10.4419839026 12649298 15190930 12231392 18289764
MESH:D007674 Kidney Diseases Estradiol 10.4415618244
MESH:D007674 Kidney Diseases Vitamin E 10.4412488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.9716518626
MESH:D007680 Kidney Neoplasms Estradiol 7.7115610895
MESH:D007680 Kidney Neoplasms Fluorouracil 7.7116985049
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.9311231351
MESH:D007938 Leukemia arsenic trioxide 6.5815070760
MESH:D007938 Leukemia decitabine 6.5818980019 19235587
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.8817077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.4216972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.4914633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 9.8619077051
MESH:D007951 Leukemia, Myeloid decitabine 9.8617236224 19117987 18454857
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 6.2419850784 16467208 17050201 20471514 16968895
MESH:D015470 Leukemia, Myeloid, Acute decitabine 6.2418460780 18206229 17679729 18704418 19010910 19387464
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 6.2417596541 16294345
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.6018055864
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.2612712474 17869043 19642359 15622746 11468182 16331271 19035177 12018890 9834237 16330433 16112521 15748426 16823087 17217047 17107899 16966277 16891316 19225113 15213294 11161223 19075265 12679006 15336539 17712046 17649720
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.4516882451
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.5014716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5012878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.5016169303
MESH:D008113 Liver Neoplasms arsenic trioxide 7.6114682389
MESH:D008113 Liver Neoplasms Fluorouracil 7.6118383874 17045692 16603448 15113037
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.6116984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 5.9720377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.9712151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4115213294
MESH:D008171 Lung Diseases Vitamin E 3.2316863852
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.4017228818
MESH:D008175 Lung Neoplasms arsenic trioxide 6.6919825857 11798837
MESH:D008175 Lung Neoplasms Cisplatin 6.6911798837 17225452 6189445
MESH:D008175 Lung Neoplasms Fluorouracil 6.6915246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.6911884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 6.6911062179
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.9115086387
MESH:D008223 Lymphoma decitabine 3.4719470736
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.1514737004
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 10.2917203775 11807958 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 10.2917203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Selenium 10.2915318939
MESH:D020149 Manganese Poisoning Estradiol 4.6219453300
MESH:D008545 Melanoma Cisplatin 3.6618332650 16248763 12393984 16432458 12883367 17023156 18176117 16809738 12374674 18505091 11135225 17761969 15577323
MESH:D008545 Melanoma decitabine 3.6616505122 17785578
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.8915990972
MESH:D008654 Mesothelioma Cisplatin 6.4617638057
MESH:D008654 Mesothelioma Selenium 6.4615107826
MESH:D008881 Migraine Disorders Valproic Acid 3.2518803445 18765137
MESH:D009062 Mouth Neoplasms Fluorouracil 3.6918986760 16757204
MESH:D009101 Multiple Myeloma arsenic trioxide 7.5715949261 19417148 19549372 11468182 14977855
MESH:D009101 Multiple Myeloma decitabine 7.5718172295
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.118888407
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.8118349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 12.6116105982 16882451
MESH:D009190 Myelodysplastic Syndromes decitabine 12.6119010910 18608210 19157545 16882708
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 12.6117596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3416810080
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.0516624393
MESH:D009369 Neoplasms Cisplatin 8.6516773208
MESH:D009369 Neoplasms decitabine 8.6519116145 17925555 19470736
MESH:D009369 Neoplasms Fluorouracil 8.6516928823 18600527 18239605
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8517289903
MESH:D009395 Nephritis, Interstitial Cisplatin 4.6315464296
MESH:D009421 Nervous System Malformations Estradiol 9.7811399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.7814600291
MESH:D009436 Neural Tube Defects arsenic trioxide 7.5010525206
MESH:D009436 Neural Tube Defects Valproic Acid 7.5016359493 8888407
MESH:D009447 Neuroblastoma Cisplatin 3.498761367
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.818761367
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.4916436463
MESH:D010051 Ovarian Neoplasms arsenic trioxide 19.2016624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms Cisplatin 19.206897625 19769630 17225452 15464296
MESH:D010051 Ovarian Neoplasms decitabine 19.2019259094 19331143
MESH:D010051 Ovarian Neoplasms Estradiol 19.2019401270
MESH:D010051 Ovarian Neoplasms Mifepristone 19.2016525653
MESH:D010051 Ovarian Neoplasms Progesterone 19.2016525653 17393432
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 12.6115580305
MESH:D010190 Pancreatic Neoplasms Cisplatin 12.6119003803
MESH:D010190 Pancreatic Neoplasms decitabine 12.6119294695
MESH:D010190 Pancreatic Neoplasms Fluorouracil 12.6115113037 16929163 16500647 19003803
MESH:D010235 Paraganglioma arsenic trioxide 4.2519927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.4015464296
MESH:D010954 Plasmacytoma Selenium 5.0215087411
MESH:D010997 Pleural Neoplasms Cisplatin 5.4817638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.8611399792 11222880 11896295 11118676
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 9.8620603192
MESH:D055728 Primary Myelofibrosis decitabine 4.8317616702
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9720887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 1.8619131511
MESH:D011471 Prostatic Neoplasms Estradiol 1.8616740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.8618626508 19082440
MESH:D011471 Prostatic Neoplasms Sodium Selenite 1.8618760546
MESH:D011471 Prostatic Neoplasms Vitamin E 1.8615084515
MESH:D019310 Pseudolymphoma Valproic Acid 4.6712752131 11422049
MESH:D012004 Rectal Neoplasms Fluorouracil 4.0818722050 15538739 16160472 18286688
MESH:D051437 Renal Insufficiency Cisplatin 4.5115464296
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012208 Rhabdomyosarcoma decitabine 11.2719155313
MESH:D012208 Rhabdomyosarcoma Valproic Acid 11.2719155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8818045962
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 10.6716646077
MESH:D012512 Sarcoma, Ewing's Cisplatin 10.6714601052
MESH:D012559 Schizophrenia Valproic Acid 2.0815737665 19110320
MESH:D012640 Seizures Valproic Acid 2.793137016 15475178 14763951 17978042 11044598 11738929 1511512 16876388
MESH:D012871 Skin Diseases Vitamin E 2.4618709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0816192470
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.4815464296
MESH:D013119 Spinal Cord Injuries Progesterone 4.4015862959 16503802
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8419490988
MESH:D013226 Status Epilepticus Valproic Acid 4.6712833885
MESH:D013274 Stomach Neoplasms arsenic trioxide 4.8317007042
MESH:D013274 Stomach Neoplasms Cisplatin 4.8317522103 15958060 18396642
MESH:D013274 Stomach Neoplasms decitabine 4.8319037991
MESH:D013274 Stomach Neoplasms Fluorouracil 4.8316424979 19084572 18396642 18567086 16951190 17172411 19015929 17498489 17522103 15786421
MESH:D020521 Stroke Vitamin E 3.5816517955
MESH:D013736 Testicular Neoplasms Cisplatin 4.7217225452 15464296
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.5319014326
MESH:D013964 Thyroid Neoplasms decitabine 7.5317967635
MESH:D013978 Tibial Fractures Estradiol 4.8219048282
MESH:D014062 Tongue Neoplasms Fluorouracil 4.0616280240
MESH:D016171 Torsades de Pointes arsenic trioxide 4.0815213294
MESH:D014178 Translocation, Genetic Valproic Acid 5.3717262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.643119515
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.6311780464 20435036 12973940 12845720
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 8.6317225452 12973940 15464296
MESH:D001749 Urinary Bladder Neoplasms decitabine 8.6317616700 19087683
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.758888407
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 9.9016803524
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 9.9016803524
MESH:D014604 Uveal Neoplasms decitabine 5.0517785578
MESH:D014625 Vaginal Neoplasms Cisplatin 4.7115577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D014839 Vomiting Cisplatin 4.8511897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
Pathway ID Pathway Name
KEGG:05330 Allograft rejection
KEGG:04612 Antigen processing and presentation
KEGG:05320 Autoimmune thyroid disease
KEGG:04514 Cell adhesion molecules (CAMs)
KEGG:04144 Endocytosis
KEGG:05332 Graft-versus-host disease
KEGG:04650 Natural killer cell mediated cytotoxicity
KEGG:04145 Phagosome
REACT:6900 Signaling in Immune system
KEGG:04940 Type I diabetes mellitus
KEGG:05416 Viral myocarditis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35083
    • No data
    Releated disease ID Related disease Name
    PA444602Immune System Diseases
    PA443450Asthma
    PA443434Arthritis, Rheumatoid
    Releated drug ID Related drug Name
    PA450428methotrexate
    PA449692folic acid
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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