AutismKB 2.0

Annotation Detail for HLX


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Basic Information Top
Gene Symbol:HLX ( HB24,HLX1 )
Gene Full Name: H2.0-like homeobox
Band: 1q41
Quick LinksEntrez ID:3142; OMIM: 142995; Uniprot ID:HLX_HUMAN; ENSEMBL ID: ENSG00000136630; HGNC ID: 4978
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200034IL12-mediated signaling events
No data
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C068073 Am 580 Am 580 results in decreased expression of HLX mRNAdecreases expression 16982809
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of HLX mRNAaffects binding|increases activity|increases expression 19710929
C089730 rosiglitazone rosiglitazone results in decreased expression of HLX mRNAdecreases expression 16982809
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.6418653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.2216434500
MESH:D000544 Alzheimer Disease rosiglitazone 2.9219621015
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.6319483382
MESH:D002386 Cataract Am 580 4.5817460283
MESH:D002779 Cholestasis pirinixic acid 3.1519176532
MESH:D003092 Colitis Am 580 5.6117035595
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5918249437
MESH:D003920 Diabetes Mellitus rosiglitazone 4.7217446233
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 3.0112642470
MESH:D004487 Edema pirinixic acid 8.6512083418
MESH:D004487 Edema rosiglitazone 8.6512083418
MESH:D005234 Fatty Liver pirinixic acid 9.6120131406 19236843
MESH:D005234 Fatty Liver rosiglitazone 9.6119196556
MESH:D006333 Heart Failure pirinixic acid 2.7820558911
MESH:D006529 Hepatomegaly pirinixic acid 3.6418467677 16221962 19772884 19176532
MESH:D006930 Hyperalgesia rosiglitazone 4.2812083418
MESH:D006943 Hyperglycemia pirinixic acid 3.6320558911
MESH:D007249 Inflammation rosiglitazone 3.3212083418
MESH:D007333 Insulin Resistance pirinixic acid 8.4116306350
MESH:D007333 Insulin Resistance rosiglitazone 8.4116306350
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.7015474484
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 2.7015980055 17347453
MESH:D008113 Liver Neoplasms pirinixic acid 1.9416377806 20007298 15890375
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 3.6516827153
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.7717261469
MESH:D009135 Muscular Diseases pirinixic acid 4.1616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2919151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2916411023
MESH:D009369 Neoplasms pirinixic acid 2.1217405874
MESH:D009765 Obesity pirinixic acid 1.8920558911
MESH:D015427 Reperfusion Injury pirinixic acid 2.5619058328
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA162391017
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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