AutismKB 2.0

Annotation Detail for HMBS


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:HMBS ( PBG-D,PBGD,PORC,UPS )
Gene Full Name: hydroxymethylbilane synthase
Band: 11q23.3
Quick LinksEntrez ID:3145; OMIM: 609806; Uniprot ID:HEM3_HUMAN; ENSEMBL ID: ENSG00000149397; HGNC ID: 4982
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-5920heme biosynthesis II
PWY-5189tetrapyrrole biosynthesis II
Pathway IDPathway Name
hsa00860Porphyrin and chlorophyll metabolism
hsa01100Metabolic pathways
Pathway IDPathway Name
Metabolism of porphyrins
No data
Pathway IDPathway Name
P02746Heme biosynthesis
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Inherited disorders of cofactor/vitamin metabolism
H00202Hepatic porphyria
Genetic disorders
No data
Desease Name
PSYCH
schizophrenia
No data
Desease Name
Porphyria, acute intermittent
Porphyria, acute intermittent, nonerythroid variant
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of HMBS mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of HMBS mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of HMBS mRNAaffects expression 17562736
D000111 Acetylcysteine Acetylcysteine inhibits the reaction [Aclarubicin results in increased expression of HMBS mRNA]decreases reaction|increases expression 10656287
D000111 Acetylcysteine Acetylcysteine inhibits the reaction [Butyric Acid results in increased expression of HMBS mRNA]decreases reaction|increases expression 10656287
D015250 Aclarubicin Acetylcysteine inhibits the reaction [Aclarubicin results in increased expression of HMBS mRNA]decreases reaction|increases expression 10656287
D015250 Aclarubicin Aclarubicin results in increased expression of HMBS mRNAincreases expression 10656287
D015250 Aclarubicin pyrrolidine dithiocarbamic acid inhibits the reaction [Aclarubicin results in increased expression of HMBS mRNA]decreases reaction|increases expression 10656287
D015250 Aclarubicin Quercetin inhibits the reaction [Aclarubicin results in increased expression of HMBS mRNA]decreases reaction|increases expression 10656287
D000643 Ammonium Chloride Ammonium Chloride affects the expression of HMBS mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of HMBS mRNAdecreases expression 20064835
D020148 Butyric Acid Acetylcysteine inhibits the reaction [Butyric Acid results in increased expression of HMBS mRNA]decreases reaction|increases expression 10656287
D020148 Butyric Acid Butyric Acid results in increased expression of HMBS mRNAincreases expression 10656287
14757314
D020148 Butyric Acid chebulinic acid inhibits the reaction [Butyric Acid results in increased expression of HMBS mRNA]decreases reaction|increases expression 14769215
D020148 Butyric Acid pyrrolidine dithiocarbamic acid inhibits the reaction [Butyric Acid results in increased expression of HMBS mRNA]decreases reaction|increases expression 10656287
D020148 Butyric Acid Quercetin inhibits the reaction [Butyric Acid results in increased expression of HMBS mRNA]decreases reaction|increases expression 10656287
D020148 Butyric Acid tellimagrandin I inhibits the reaction [Butyric Acid results in increased expression of HMBS mRNA]decreases reaction|increases expression 14757314
C103481 chebulinic acid chebulinic acid inhibits the reaction [Butyric Acid results in increased expression of HMBS mRNA]decreases reaction|increases expression 14769215
C103481 chebulinic acid chebulinic acid results in decreased expression of HMBS mRNAdecreases expression 14769215
D003300 Copper Copper results in decreased activity of HMBS proteindecreases activity 19888908
D004958 Estradiol Estradiol affects the expression of HMBS mRNAaffects expression 16684588
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of HMBS mRNAincreases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased activity of HMBS proteindecreases activity 10416826
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of HMBS mRNAincreases expression 16940010
D005419 Flavonoids Flavonoids results in decreased expression of HMBS mRNAdecreases expression 18035473
D006581 Hexachlorobenzene Hexachlorobenzene results in increased expression of HMBS mRNAincreases expression 15159207
D007099 Imipramine Imipramine results in decreased activity of HMBS proteindecreases activity 10416826
C008261 lead acetate lead acetate results in increased activity of HMBS proteinincreases activity 10416826
C029891 lead chloride lead chloride results in decreased activity of HMBS proteindecreases activity 10416826
D017239 Paclitaxel Paclitaxel results in decreased expression of HMBS mRNAdecreases expression 15585946
C020972 pyrrolidine dithiocarbamic acid pyrrolidine dithiocarbamic acid inhibits the reaction [Aclarubicin results in increased expression of HMBS mRNA]decreases reaction|increases expression 10656287
C020972 pyrrolidine dithiocarbamic acid pyrrolidine dithiocarbamic acid inhibits the reaction [Butyric Acid results in increased expression of HMBS mRNA]decreases reaction|increases expression 10656287
D011794 Quercetin Quercetin inhibits the reaction [Aclarubicin results in increased expression of HMBS mRNA]decreases reaction|increases expression 10656287
D011794 Quercetin Quercetin inhibits the reaction [Butyric Acid results in increased expression of HMBS mRNA]decreases reaction|increases expression 10656287
D012643 Selenium Selenium results in increased expression of HMBS mRNAincreases expression 19244175
D013629 Tamoxifen Tamoxifen results in decreased expression of HMBS mRNAdecreases expression 15849065
C087926 tellimagrandin I tellimagrandin I inhibits the reaction [Butyric Acid results in increased expression of HMBS mRNA]decreases reaction|increases expression 14757314
C087926 tellimagrandin I tellimagrandin I results in decreased expression of HMBS mRNAdecreases expression 14757314
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of HMBS mRNAdecreases expression 18163543
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of HMBS mRNAincreases expression 19465110
D014303 Trinitrotoluene Trinitrotoluene affects the expression of HMBS mRNAaffects expression 21346803
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3514745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.9315322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 7.937525203
MESH:D000138 Acidosis Ammonium Chloride 3.3718287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7517505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.7120127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 6.7111473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.7114692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.233712494
MESH:D000236 Adenoma Benzo(a)pyrene 6.236695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.1916835633
MESH:D000544 Alzheimer Disease Copper 3.1917119284 16410023 16325427 16886094 16866297 16962711
MESH:D000690 Amyotrophic Lateral Sclerosis Copper 4.1810694572
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7811748828
MESH:D000743 Anemia, Hemolytic Quercetin 4.0717084956
MESH:D018798 Anemia, Iron-Deficiency Copper 4.7116614410
MESH:D000799 Angioedema Acetaminophen 3.6510982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8819183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5515885639
MESH:D001260 Ataxia Telangiectasia Quercetin 4.7815336622
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001327 Autoimmune Diseases Quercetin 4.2219761891
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.8311289319 1440618
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.8712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6415746008
MESH:D001859 Bone Neoplasms Paclitaxel 4.3915867366
MESH:D001932 Brain Neoplasms Copper 4.3917079463
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 4.5820146248 17474063
MESH:D001943 Breast Neoplasms Copper 4.5815986119 17079463
MESH:D001943 Breast Neoplasms Estradiol 4.5812948864 18497071 17289903 17018787 14630087 17261762 19861407 16675129
MESH:D001943 Breast Neoplasms Hexachlorobenzene 4.5812709520 15061365
MESH:D001943 Breast Neoplasms Paclitaxel 4.5816115903 15136595 11325840 18323546 18234424 16273361 18223236 16244791
MESH:D001943 Breast Neoplasms Quercetin 4.5818628248
MESH:D001943 Breast Neoplasms Tamoxifen 4.5819155303 18425577 20135344 18821012 11161223 20005174 19059307 19103187 19189210 19289846 18815881 19244106 19115204 20859285 17893378 16273361 18855134 17261762 19221464 20390343 18629630 17440819 15668708 16873071 16202921 21152245 19011961 16818667 19142967 17242785 19084267 18984771 15565566 21138602 20544844 19066611 19189212 19200415 18351453 19487384 19288272 19410462 20065188 17049068 18997820
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.5820435547
MESH:D002105 Cadmium Poisoning Quercetin 5.3516962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2716111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6516835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.3219066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 13.6016705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 13.603581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.603084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 13.6016924424
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 13.6016313753
MESH:D006528 Carcinoma, Hepatocellular Quercetin 13.6012508355 19519916
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 13.6016924424
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.7717234771
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.597296757
MESH:D002294 Carcinoma, Squamous Cell Acetylcysteine 4.7417015178
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.7420419170
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.4517572228
MESH:D006332 Cardiomegaly Copper 10.9317327471
MESH:D006332 Cardiomegaly Quercetin 10.9319794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 10.9318670907 18850075 16120746
MESH:D002386 Cataract Acetaminophen 7.1410977129
MESH:D002386 Cataract Trinitrotoluene 7.1415817613 14694615
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 10.577505956
MESH:D002471 Cell Transformation, Neoplastic Acetylcysteine 10.5718226522
MESH:D002471 Cell Transformation, Neoplastic Estradiol 10.5718566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0016835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 7.3919486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 7.3917681005 16105132 11677210 16919318 17333356 15861022 17110522
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0315340226 15668235 8697196 16354765 12621046
MESH:D003092 Colitis Selenium 3.5917936198
MESH:D003110 Colonic Neoplasms Quercetin 2.3916640504 11134977 19440933 19056647 17148506 17191121 15741050
MESH:D015179 Colorectal Neoplasms Paclitaxel 2.7818802399
MESH:D015179 Colorectal Neoplasms Quercetin 2.7818852136 18095365
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 8.7414669216 17141729
MESH:D000013 Congenital Abnormalities Trinitrotoluene 8.7415095906
MESH:D019465 Craniofacial Abnormalities lead acetate 2.8819769572
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.8810048152 15322242 20055451
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.6018551238
MESH:D003490 Cyanosis Trinitrotoluene 10.6018551238
MESH:D003550 Cystic Fibrosis Acetylcysteine 4.2119747007
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1719031437
MESH:D003866 Depressive Disorder Imipramine 4.6420305041
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.6218759878 14531868 8156756 2524372 12868966 11298694 11906362 8970840
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.312952479 3621924
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.5819496084
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6217107852
MESH:D003928 Diabetic Nephropathies Estradiol 8.3019279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.3019279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 17.8021346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 17.8018289764 6679447 18692083 9653073 11289319 7440962 9022650 16192314 6482804 8291058 1440618 18648102 9328219
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 17.8014986274 14725611 16227642 12705907 11834606 17906064 12958197 16781746 2444490 19085960 16109766 15968718 16081117 17522070 19923254 11421492 12153990 16177239 15619225 19416960 10774834 10915739 11529661 19739265 18713872 11287661 19164858 11461765 19370779 18071297 10663392 11743745 19420014 16485898 11739529 16393943 12594235 14550746 12392966 17562736 12540782
MESH:D056486 Drug-Induced Liver Injury Acetylcysteine 17.8011287661
MESH:D056486 Drug-Induced Liver Injury Selenium 17.8015131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 17.8020420201
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 17.8018551238 21346803
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9119426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6211462148
MESH:D004487 Edema Imipramine 6.7312798668
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.7311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7116714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.3312538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.3319031437
MESH:D016889 Endometrial Neoplasms Estradiol 6.9818566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 6.9817893378 19155303 20544844 16202921
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.869294722 10568697
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.003581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.0016530937
MESH:D004938 Esophageal Neoplasms Paclitaxel 7.0016481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8711564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.1215345470
MESH:D005234 Fatty Liver Tamoxifen 7.1219224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1216709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2711858732
MESH:D005317 Fetal Growth Retardation lead acetate 5.2019769572
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.836705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.3414745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.9919069698
MESH:D005355 Fibrosis Quercetin 8.1319474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.1320067830
MESH:D005756 Gastritis Acetaminophen 3.4816983495
MESH:D005909 Glioblastoma Quercetin 3.2719804834
MESH:D005910 Glioma Quercetin 2.9817643826
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.867505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4010696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.1220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.1210048152 11294989
MESH:D006333 Heart Failure Selenium 2.9617162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1611000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.336705139
MESH:D006521 Hepatitis, Chronic Copper 5.0817338147
MESH:D006527 Hepatolenticular Degeneration Copper 4.9817182432 19888908 16607473 17109627 17276780
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.0915340226 12621046 16120746
MESH:D006529 Hepatomegaly Trinitrotoluene 8.0915817613
MESH:D006558 Herpes Genitalis Estradiol 4.8415709030
MESH:D019584 Hot Flashes Estradiol 3.5617088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8515340226 16959395 8697196 16354765 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.5516870215
MESH:D006943 Hyperglycemia Quercetin 3.8611834736 18262572
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.7515034207
MESH:D006973 Hypertension Quercetin 4.9818356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.9818850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.4817937319
MESH:D007248 Infertility, Male Trinitrotoluene 6.4812150543
MESH:D007249 Inflammation Flavonoids 11.2217296493
MESH:D007249 Inflammation Imipramine 11.2212798668
MESH:D007249 Inflammation Tamoxifen 11.2219457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.2212878042 12200463
MESH:D007251 Influenza, Human pyrrolidine dithiocarbamic acid 17.6818473937
MESH:D007251 Influenza, Human Quercetin 17.6816624496
MESH:D007251 Influenza, Human Selenium 17.6816624496
MESH:D007333 Insulin Resistance Estradiol 2.8416393666 16627594
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.839022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1616580747
MESH:D007627 Keloid Quercetin 4.7717086741
MESH:D007674 Kidney Diseases Acetaminophen 9.4415629191 12587719
MESH:D007674 Kidney Diseases Estradiol 9.4415618244
MESH:D007674 Kidney Diseases Quercetin 9.4416962696
MESH:D007676 Kidney Failure, Chronic Copper 9.6816518626
MESH:D007676 Kidney Failure, Chronic Selenium 9.6816518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 16.4816705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 16.486582329
MESH:D007680 Kidney Neoplasms Estradiol 16.4815610895
MESH:D007680 Kidney Neoplasms Tamoxifen 16.4818625569
MESH:D007859 Learning Disorders Copper 4.6017134702
MESH:D007938 Leukemia Quercetin 3.0617468513
MESH:D008064 Lipidoses Imipramine 7.9515342952 17567588
MESH:D008064 Lipidoses Tamoxifen 7.9517567588 15342952
MESH:D008080 Liposarcoma Paclitaxel 4.6417353645
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.0815034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.5014659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pyrrolidine dithiocarbamic acid 6.5015078482
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 6.5012741479
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.5018564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.5012878042
MESH:D008107 Liver Diseases Acetaminophen 1.5919784758 16610002 19460945 16611625 19014921 11587558 12969438 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 3.0717185352 16871587
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 13.4821137059 20195826
MESH:D008113 Liver Neoplasms Copper 13.4820302851
MESH:D008113 Liver Neoplasms Quercetin 13.4818980244
MESH:D008113 Liver Neoplasms Tamoxifen 13.4816684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.4816984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 13.21598648 6587162 1399818 3712494
MESH:D008114 Liver Neoplasms, Experimental Hexachlorobenzene 13.211423854
MESH:D008114 Liver Neoplasms, Experimental Quercetin 13.2119519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 13.2112151625
MESH:D008171 Lung Diseases Acetylcysteine 3.9312815614
MESH:D055370 Lung Injury pyrrolidine dithiocarbamic acid 4.8016129981
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.6518816296 17053015 20464547 20869020 18569708 20064080 20135361 6695378 18520028
MESH:D008175 Lung Neoplasms Quercetin 4.6516280456
MESH:D008175 Lung Neoplasms Tamoxifen 4.6518625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.6511884234 19555203
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 3.9314749477
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.5719428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.2517203775 11807958 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Selenium 9.2515318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 9.2511731420 19196723 14580682 19196722 16827153
MESH:D020149 Manganese Poisoning Estradiol 12.0019453300
MESH:D020149 Manganese Poisoning Tamoxifen 12.0019453300
MESH:D008545 Melanoma Paclitaxel 3.4112025231 16342250 12040289
MESH:D008545 Melanoma Tamoxifen 3.4119393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9915990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3819513568
MESH:D007706 Menkes Kinky Hair Syndrome Copper 5.6917268249 17109627
MESH:D001523 Mental Disorders Imipramine 4.6216856516
MESH:D008654 Mesothelioma Selenium 2.7215107826
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0416381670
MESH:D009101 Multiple Myeloma Paclitaxel 3.5514749477
MESH:D009203 Myocardial Infarction Quercetin 2.9119595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8712213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.0816810080
MESH:D015428 Myocardial Reperfusion Injury Quercetin 8.0819207477
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.0418551238
MESH:D009336 Necrosis Trinitrotoluene 10.0418551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 13.023581430
MESH:D009362 Neoplasm Metastasis Acetylcysteine 13.0214720322
MESH:D009362 Neoplasm Metastasis Paclitaxel 13.0215867366
MESH:D009362 Neoplasm Metastasis Tamoxifen 13.0219393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4519410462
MESH:D009369 Neoplasms Benzo(a)pyrene 4.8211141357
MESH:D009369 Neoplasms Quercetin 4.8215185748
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.8119189210 19196722 19200415
MESH:D009389 Neovascularization, Pathologic Copper 9.7117308104
MESH:D009389 Neovascularization, Pathologic Estradiol 9.7117289903
MESH:D009421 Nervous System Malformations Estradiol 8.8516427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.8514600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.176679447
MESH:D009436 Neural Tube Defects Acetylcysteine 7.1719446573
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.7218514411
MESH:D020078 Neurogenic Inflammation Quercetin 4.1817929310
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 14.2212819281 16049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 14.224026338 6482804
MESH:D009784 Occupational Diseases Trinitrotoluene 14.2212819281 17852074 14694615
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.833988306
MESH:D010014 Osteolysis Paclitaxel 4.7915867366
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.0419495926
MESH:D010051 Ovarian Neoplasms Estradiol 7.6519401270
MESH:D010051 Ovarian Neoplasms Paclitaxel 7.6511161223
MESH:D010051 Ovarian Neoplasms Quercetin 7.6519005980
MESH:D010146 Pain Acetaminophen 6.6716870215
MESH:D010146 Pain Imipramine 6.6712798668
MESH:D010190 Pancreatic Neoplasms Quercetin 2.7816965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5111578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.307296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0612520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.286228378
MESH:D010954 Plasmacytoma Selenium 4.7015087411
MESH:D017118 Porphyria, Acute Intermittent marker/mechanism
MESH:D017119 Porphyria Cutanea Tarda Hexachlorobenzene 10.499918132
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 10.4918163543
MESH:D011230 Precancerous Conditions Quercetin 3.8219056647
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.0011118676 11399792 11222880 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.7120887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0817292933
MESH:D011471 Prostatic Neoplasms Copper 2.0817308104 17079463
MESH:D011471 Prostatic Neoplasms Estradiol 2.0816740699
MESH:D011471 Prostatic Neoplasms Paclitaxel 2.0817172428 16356831 16729912 17136230
MESH:D011471 Prostatic Neoplasms pyrrolidine dithiocarbamic acid 2.0816139439
MESH:D011471 Prostatic Neoplasms Quercetin 2.0817292933 14715546
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0815067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.1215861022 16919318
MESH:D012128 Respiratory Distress Syndrome, Adult Acetylcysteine 9.2512210543
MESH:D012128 Respiratory Distress Syndrome, Adult pyrrolidine dithiocarbamic acid 9.2516129981
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6518990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.233692021
MESH:D012554 Schistosomiasis japonica Quercetin 5.3516862918
MESH:D012559 Schizophrenia Copper 3.0616842975
MESH:D012640 Seizures 2,4-dinitrotoluene 5.7718551238
MESH:D012640 Seizures Trinitrotoluene 5.7718551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.1819755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.1816192470
MESH:D012892 Sleep Deprivation Imipramine 6.0019798453
MESH:D013088 Spermatocele Ethinyl Estradiol 10.9216709447
MESH:D013088 Spermatocele Tamoxifen 10.9216709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.8519457130
MESH:D013163 Splenomegaly Trinitrotoluene 5.0115817613
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.542093021 20155912
MESH:D013274 Stomach Neoplasms Paclitaxel 2.5418506536 18396642
MESH:D013276 Stomach Ulcer Acetylcysteine 3.8317918041
MESH:D024801 Tauopathies Paclitaxel 4.6216930453
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9915669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7112697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.741399818 6582329 6587162 3712494 7505956
MESH:D013978 Tibial Fractures Estradiol 4.4919048282
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 15.0016049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 15.008074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 15.0017053015
MESH:D001749 Urinary Bladder Neoplasms Quercetin 15.0016720314
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 15.0017572228 16712894 8653321
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.1210091137
MESH:D014581 Urticaria Acetaminophen 2.8010982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1214692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4012125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3714671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0615886252
Pathway ID Pathway Name
KEGG:01100 Metabolic pathways
REACT:9431 Metabolism of porphyrins
KEGG:00860 Porphyrin and chlorophyll metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29317
    • No data
    No data
    Releated drug ID Related drug Name
    PA449789glycine
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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