AutismKB 2.0

Annotation Detail for HMGB1


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Basic Information Top
Gene Symbol:HMGB1 ( DKFZp686A04236,HMG1,HMG3,SBP-1 )
Gene Full Name: high-mobility group box 1
Band: 13q12.3
Quick LinksEntrez ID:3146; OMIM: 163905; Uniprot ID:HMGB1_HUMAN; ENSEMBL ID: ENSG00000189403; HGNC ID: 4983
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03410Base excision repair
Pathway IDPathway Name
Apoptosis
Pathway IDPathway Name
200177Endogenous TLR signaling
200108amb2 Integrin signaling
Pathway IDPathway Name
P00059p53 pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of HMGB1 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of HMGB1 mRNAincreases expression 18648102
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of HMGB1 mRNAaffects expression 21346803
C016601 4-hydroxytamoxifen 4-hydroxytamoxifen results in decreased expression of HMGB1 mRNAdecreases expression 16514628
D019386 Alendronate Alendronate affects the expression of HMGB1 mRNAaffects expression 16079270
D000643 Ammonium Chloride Ammonium Chloride affects the expression of HMGB1 mRNAaffects expression 16483693
C044613 angelicae sinensis extract angelicae sinensis extract inhibits the reaction [endotoxin, Escherichia coli affects the localization of and results in increased secretion of HMGB1 protein]affects localization|decreases reaction|increases secretion 16424112
C044613 angelicae sinensis extract angelicae sinensis extract inhibits the reaction [lipopolysaccharide, Escherichia coli 0111 B4 affects the localization of and results in increased secretion of HMGB1 protein]affects localization|decreases reaction|increases secretion 16424112
C005948 astaxanthine astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of HMGB1 mRNA]decreases reaction|increases expression 16964424
C099555 CD 437 CD 437 results in decreased expression of HMGB1 mRNAdecreases expression 12958071
C097256 CNI 1493 CNI 1493 results in decreased expression of HMGB1 proteindecreases expression 15947118
C014347 decitabine decitabine results in decreased expression of HMGB1 mRNAdecreases expression 19363521
C014347 decitabine TP53 protein affects the reaction [decitabine results in decreased expression of HMGB1 mRNA]affects reaction|decreases expression 19363521
C109695 dong quai dong quai inhibits the reaction [endotoxin, Escherichia coli affects the localization of and results in increased secretion of HMGB1 protein]affects localization|decreases reaction|increases secretion 16424112
C109695 dong quai dong quai inhibits the reaction [lipopolysaccharide, Escherichia coli 0111 B4 affects the localization of and results in increased secretion of HMGB1 protein]affects localization|decreases reaction|increases secretion 16424112
C044101 endotoxin, Escherichia coli angelicae sinensis extract inhibits the reaction [endotoxin, Escherichia coli affects the localization of and results in increased secretion of HMGB1 protein]affects localization|decreases reaction|increases secretion 16424112
C044101 endotoxin, Escherichia coli dong quai inhibits the reaction [endotoxin, Escherichia coli affects the localization of and results in increased secretion of HMGB1 protein]affects localization|decreases reaction|increases secretion 16424112
C044101 endotoxin, Escherichia coli endotoxin, Escherichia coli affects the localization of and results in increased secretion of HMGB1 proteinaffects localization|increases secretion 16424112
D004958 Estradiol Estradiol results in increased expression of HMGB1 mRNAincreases expression 16514628
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of HMGB1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HMGB1 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of HMGB1 mRNAaffects expression 16079270
C070081 fulvestrant fulvestrant results in decreased expression of HMGB1 mRNAdecreases expression 16514628
D006861 Hydrogen Peroxide Hydrogen Peroxide promotes the reaction [HSPA1A protein binds to HMGB1 protein]affects binding|increases reaction 17513788
D006861 Hydrogen Peroxide HSPA1A protein inhibits the reaction [Hydrogen Peroxide affects the localization of HMGB1 protein]affects localization|decreases reaction 17513788
D006861 Hydrogen Peroxide HSPA1A protein inhibits the reaction [Hydrogen Peroxide results in increased secretion of HMGB1 protein]decreases reaction|increases secretion 17513788
D006861 Hydrogen Peroxide Hydrogen Peroxide affects the localization of HMGB1 proteinaffects localization 17513788
D006861 Hydrogen Peroxide Hydrogen Peroxide promotes the reaction [HSPA1A protein binds to HMGB1 protein]affects binding|increases reaction 17513788
D006861 Hydrogen Peroxide Hydrogen Peroxide results in increased secretion of HMGB1 proteinincreases secretion 17513788
D006861 Hydrogen Peroxide Quercetin inhibits the reaction [Hydrogen Peroxide promotes the reaction [HSPA1A protein binds to HMGB1 protein]]affects binding|decreases reaction|increases reaction 17513788
C440499 lipopolysaccharide, Escherichia coli 0111 B4 angelicae sinensis extract inhibits the reaction [lipopolysaccharide, Escherichia coli 0111 B4 affects the localization of and results in increased secretion of HMGB1 protein]affects localization|decreases reaction|increases secretion 16424112
C440499 lipopolysaccharide, Escherichia coli 0111 B4 dong quai inhibits the reaction [lipopolysaccharide, Escherichia coli 0111 B4 affects the localization of and results in increased secretion of HMGB1 protein]affects localization|decreases reaction|increases secretion 16424112
C440499 lipopolysaccharide, Escherichia coli 0111 B4 lipopolysaccharide, Escherichia coli 0111 B4 affects the localization of and results in increased secretion of HMGB1 proteinaffects localization|increases secretion 16424112
D008769 Methylnitronitrosoguanidine Methylnitronitrosoguanidine results in increased expression of HMGB1 mRNAincreases expression 12634122
D015741 Metribolone Metribolone results in decreased expression of HMGB1 proteindecreases expression 17152098
D017239 Paclitaxel HMGB1 protein affects the susceptibility to Paclitaxelaffects response to substance 16217747
C023844 potassium nitrate potassium nitrate results in increased expression of HMGB1 mRNAincreases expression 15878651
D011794 Quercetin Quercetin inhibits the reaction [Hydrogen Peroxide promotes the reaction [HSPA1A protein binds to HMGB1 protein]]affects binding|decreases reaction|increases reaction 17513788
D020849 Raloxifene Raloxifene results in decreased expression of HMGB1 mRNAdecreases expression 16514628
D020849 Raloxifene Raloxifene affects the expression of HMGB1 mRNAaffects expression 16079270
D012643 Selenium [Selenium co-treated with Vitamin E] results in decreased expression of HMGB1 mRNAaffects cotreatment|decreases expression 19244175
D013974 Thyroxine Thyroxine affects the expression of HMGB1 mRNAaffects expression 17403546
D013654 Taurine Taurine results in decreased expression of HMGB1 mRNAdecreases expression 16579726
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HMGB1 mRNAaffects cotreatment|increases expression 17942748
D019772 Topotecan HMGB1 protein affects the susceptibility to Topotecanaffects response to substance 16217747
D014501 Uranium Uranium affects the expression of HMGB1 mRNAaffects expression 15672453
D014501 Uranium Uranium affects the expression of HMGB1 proteinaffects expression 15672453
C005460 uranyl acetate uranyl acetate affects the expression of HMGB1 mRNAaffects expression 15672453
C005460 uranyl acetate uranyl acetate affects the expression of HMGB1 proteinaffects expression 15672453
D014747 Vinblastine HMGB1 protein affects the susceptibility to Vinblastineaffects response to substance 16217747
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in decreased expression of HMGB1 mRNAaffects cotreatment|decreases expression 19244175
D014810 Vitamin E Vitamin E results in decreased expression of HMGB1 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 7.407525203
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.4011752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.2318287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6117505938
MESH:D000230 Adenocarcinoma Estradiol 3.9211473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 3.9214692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.563712494
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.0516835633
MESH:D000419 Albuminuria Raloxifene 4.2917308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.4715800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6711748828
MESH:D000743 Anemia, Hemolytic Quercetin 3.9517084956
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.1511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.4615885639
MESH:D001260 Ataxia Telangiectasia Quercetin 4.6515336622
MESH:D001284 Atrophy fulvestrant 4.5411514358
MESH:D001327 Autoimmune Diseases Quercetin 4.0919761891
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.6911289319 1440618
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.7612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5615746008
MESH:D001859 Bone Neoplasms Paclitaxel 4.2715867366
MESH:D001930 Brain Injuries Raloxifene 4.1616580743
MESH:D001943 Breast Neoplasms decitabine 3.5419208741 18320071
MESH:D001943 Breast Neoplasms Estradiol 3.5417289903 18497071 12948864 19861407 17261762 17018787 14630087 16675129
MESH:D001943 Breast Neoplasms fulvestrant 3.5418984771
MESH:D001943 Breast Neoplasms Paclitaxel 3.5416244791 18223236 16273361 18234424 15136595 11325840 18323546 16115903
MESH:D001943 Breast Neoplasms Quercetin 3.5418628248
MESH:D001943 Breast Neoplasms Raloxifene 3.5417261762 17242785 16837676 16912660 17595753 15572757 17440819 15758505 15775269 17893378 17952589 17049068
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.5420435547
MESH:D002105 Cadmium Poisoning Quercetin 5.2116962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1416111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.6116050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5516835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 8.2616705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 8.267296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.2616924424
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 8.2616313753
MESH:D006528 Carcinoma, Hepatocellular Quercetin 8.2612508355 19519916
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.6417234771
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.267296757
MESH:D002292 Carcinoma, Renal Cell Vinblastine 6.261485588
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.5019215824
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 3.7917572228
MESH:D006332 Cardiomegaly Quercetin 10.4919794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 10.4918670907 18850075 16120746
MESH:D006332 Cardiomegaly Thyroxine 10.4918093424
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 6.8416936243
MESH:D002318 Cardiovascular Diseases Raloxifene 6.8415775269
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 3.4414694615
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 14.246135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 14.247505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 14.2418566989
MESH:D002471 Cell Transformation, Neoplastic Methylnitronitrosoguanidine 14.242727394
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 7.0719486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 7.0717333356 16919318 17110522 17681005 11677210 16105132 15861022
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9715340226 12621046 8697196 16354765 15668235
MESH:D003072 Cognition Disorders Raloxifene 4.3015800139
MESH:D003092 Colitis Selenium 3.4617936198
MESH:D003110 Colonic Neoplasms decitabine 3.7217616700
MESH:D003110 Colonic Neoplasms Quercetin 3.7211134977 19056647 17148506 19440933 16640504 17191121 15741050
MESH:D015179 Colorectal Neoplasms decitabine 4.5918981723
MESH:D015179 Colorectal Neoplasms Paclitaxel 4.5918802399
MESH:D015179 Colorectal Neoplasms Quercetin 4.5918852136 18095365
MESH:D015179 Colorectal Neoplasms Vinblastine 4.5918802399
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 8.2815095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 8.2814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.3710048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.3719769572
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.7018551238
MESH:D003865 Depressive Disorder, Major Raloxifene 3.8917474826
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.508156756 2524372 12868966 8970840 18759878 11906362 11298694 14531868
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.192952479 3621924
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.4719496084
MESH:D003924 Diabetes Mellitus, Type 2 astaxanthine 4.5916964424
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.5917107852
MESH:D058065 Diabetic Cardiomyopathies Taurine 5.7316025228
MESH:D003928 Diabetic Nephropathies Estradiol 8.1119279558
MESH:D003928 Diabetic Nephropathies Raloxifene 8.1117451421 15920148 17308373
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 13.9121346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 13.9118289764 9022650 18692083 6482804 1440618 11289319 9328219 16192314 6679447 7440962 8291058 9653073 18648102
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 13.9121346803
MESH:D056486 Drug-Induced Liver Injury Selenium 13.9115131321
MESH:D056486 Drug-Induced Liver Injury Taurine 13.919328219
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 13.9120420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5211462148
MESH:C538011 Eales disease Vitamin E 4.379068938
MESH:D004487 Edema Raloxifene 5.9115860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.9112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5715322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.0912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 8.0915845917
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.7819294695
MESH:D016889 Endometrial Neoplasms 4-hydroxytamoxifen 7.0819148513
MESH:D016889 Endometrial Neoplasms Estradiol 7.0811473722 18566989 19148513
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.749294722 10568697
MESH:D019446 Endotoxemia angelicae sinensis extract 22.6316424112
MESH:D019446 Endotoxemia dong quai 22.6316424112
MESH:D019446 Endotoxemia endotoxin, Escherichia coli 22.6317637181 18509659
MESH:D019446 Endotoxemia lipopolysaccharide, Escherichia coli 0111 B4 22.6312954792
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.393581430
MESH:D004938 Esophageal Neoplasms Paclitaxel 4.3916481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7711564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 6.9015345470
MESH:D005234 Fatty Liver Raloxifene 6.9017473493
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1411858732
MESH:D005334 Fever endotoxin, Escherichia coli 9.2616997862
MESH:D005334 Fever lipopolysaccharide, Escherichia coli 0111 B4 9.2616997862
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.696705139
MESH:D005355 Fibrosis Quercetin 7.7119474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.7120067830
MESH:D005909 Glioblastoma Quercetin 3.1819804834
MESH:D005910 Glioma Quercetin 2.9217643826
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.747505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2610696789
MESH:D006177 Gynecomastia dong quai 6.7011405562
MESH:D006258 Head and Neck Neoplasms decitabine 3.2719215824
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.9911294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 5.9916080930
MESH:D006331 Heart Diseases Raloxifene 3.3111110106
MESH:D006333 Heart Failure Selenium 2.8817162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0511000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.216705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.5815340226 16120746 12621046
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.5916490937 16863852
MESH:D006558 Herpes Genitalis Estradiol 4.7015709030
MESH:D006689 Hodgkin Disease Vinblastine 3.7718180244 18501091
MESH:D019584 Hot Flashes dong quai 15.4018568789
MESH:D019584 Hot Flashes Estradiol 15.4017088409
MESH:D019584 Hot Flashes Vitamin E 15.4014716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7118606429 8697196 16354765 15340226 16959395
MESH:D006930 Hyperalgesia Alendronate 4.4616769263
MESH:D006943 Hyperglycemia Quercetin 3.7511834736 18262572
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.6215034207
MESH:D006973 Hypertension Quercetin 7.9318356687
MESH:D006973 Hypertension Raloxifene 7.9317577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 7.9318850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.4916945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1612013081
MESH:D007248 Infertility, Male decitabine 10.0817581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 10.0817937319
MESH:D007248 Infertility, Male fulvestrant 10.0811514358
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.7012878042 12200463
MESH:D007251 Influenza, Human Quercetin 16.7016624496
MESH:D007251 Influenza, Human Selenium 16.7016624496
MESH:D007251 Influenza, Human Vitamin E 16.7016624496
MESH:D007333 Insulin Resistance Estradiol 2.7616627594 16393666
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.698074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0516580747
MESH:D007627 Keloid Quercetin 4.6417086741
MESH:D007674 Kidney Diseases Estradiol 9.0615618244
MESH:D007674 Kidney Diseases Quercetin 9.0616962696
MESH:D007674 Kidney Diseases Vitamin E 9.0612488133
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 9.0616518626
MESH:D007676 Kidney Failure, Chronic Selenium 9.0616518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 10.8816705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 10.886582329
MESH:D007680 Kidney Neoplasms Estradiol 10.8815610895
MESH:D007889 Leiomyoma Raloxifene 4.2016973256
MESH:D007938 Leukemia decitabine 6.0218980019 19235587
MESH:D007938 Leukemia Quercetin 6.0217468513
MESH:D007951 Leukemia, Myeloid decitabine 3.7118454857 19117987 17236224
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.3218704418 17679729 18206229 18460780 19387464 19010910
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.1318055864
MESH:D008080 Liposarcoma Paclitaxel 4.5217353645
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 2.9915034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.2814659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 6.2812741479
MESH:D008106 Liver Cirrhosis, Experimental Taurine 6.2815931870 15893842
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.2812878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 6.2816169303
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 6.697678174
MESH:D008113 Liver Neoplasms Quercetin 6.6918980244
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 6.6916984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 12.442876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 12.446587162 598648 3712494 1399818
MESH:D008114 Liver Neoplasms, Experimental Quercetin 12.4419519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 12.4412151625
MESH:D008171 Lung Diseases Vitamin E 2.9616863852
MESH:D008175 Lung Neoplasms Quercetin 3.2216280456
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.2211884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 3.2211062179
MESH:D008223 Lymphoma decitabine 3.1919470736
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 3.8314749477
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.3316891317 11807958 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Selenium 5.3315318939
MESH:D020149 Manganese Poisoning Estradiol 4.1519453300
MESH:D008545 Melanoma decitabine 4.9816505122 17785578
MESH:D008545 Melanoma Paclitaxel 4.9812025231 16342250 12040289
MESH:D008545 Melanoma Vinblastine 4.9818176117 18505091 18332650 16432458 15577320 17761969 12374674 16248763 15577323 16809738
MESH:D008654 Mesothelioma Selenium 2.6615107826
MESH:D053842 Microsatellite Instability Methylnitronitrosoguanidine 5.5617671175
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.2215863610
MESH:D009101 Multiple Myeloma decitabine 10.9218172295
MESH:D009101 Multiple Myeloma Paclitaxel 10.9214749477
MESH:D009101 Multiple Myeloma Raloxifene 10.9216497877
MESH:D009190 Myelodysplastic Syndromes decitabine 3.2018608210 19010910 16882708 19157545
MESH:D009203 Myocardial Infarction Quercetin 2.8619595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7612213967
MESH:D015428 Myocardial Reperfusion Injury dong quai 13.1210815014
MESH:D015428 Myocardial Reperfusion Injury Estradiol 13.1216810080
MESH:D015428 Myocardial Reperfusion Injury Quercetin 13.1219207477
MESH:D009232 Myxoma Raloxifene 5.2216343187
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.547678174 18551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.503581430
MESH:D009362 Neoplasm Metastasis Paclitaxel 5.5015867366
MESH:D009369 Neoplasms decitabine 4.7919470736 19116145 17925555
MESH:D009369 Neoplasms Quercetin 4.7915185748
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4117289903
MESH:D009421 Nervous System Malformations Estradiol 8.4416427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.4414600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.706679447
MESH:D009447 Neuroblastoma Topotecan 3.6815176712
MESH:D020078 Neurogenic Inflammation Quercetin 4.0617929310
MESH:D009503 Neutropenia Vinblastine 4.2717378895
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 13.5316049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 13.534026338 6482804
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 13.5314694615
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.693988306
MESH:D010014 Osteolysis Paclitaxel 4.6515867366
MESH:D010024 Osteoporosis Alendronate 7.1217882678
MESH:D010024 Osteoporosis Raloxifene 7.1217882678 19059307 15775268
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 9.1919495926
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 9.1915758505 17823083 17893378 15579764
MESH:D010051 Ovarian Neoplasms CD 437 13.8417474084
MESH:D010051 Ovarian Neoplasms decitabine 13.8419331143 19259094
MESH:D010051 Ovarian Neoplasms Estradiol 13.8419401270
MESH:D010051 Ovarian Neoplasms Paclitaxel 13.8411161223
MESH:D010051 Ovarian Neoplasms Quercetin 13.8419005980
MESH:D010190 Pancreatic Neoplasms decitabine 5.1119294695
MESH:D010190 Pancreatic Neoplasms Quercetin 5.1116965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3911578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 8.267296757
MESH:D010212 Papilloma Hydrogen Peroxide 8.2612065085
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9212520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.146228378
MESH:D010954 Plasmacytoma Selenium 4.5615087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2518163543
MESH:D011230 Precancerous Conditions Quercetin 3.7119056647
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.8711222880 11118676 11399792 11896295
MESH:D055728 Primary Myelofibrosis decitabine 4.4117616702
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.5920887781
MESH:D011471 Prostatic Neoplasms Estradiol 1.9116740699
MESH:D011471 Prostatic Neoplasms Paclitaxel 1.9117172428 16356831 16729912 17136230
MESH:D011471 Prostatic Neoplasms Quercetin 1.9117292933 14715546
MESH:D011471 Prostatic Neoplasms Raloxifene 1.9115731164 16536755 16220300
MESH:D011471 Prostatic Neoplasms Vitamin E 1.9115084515
MESH:D011537 Pruritus Ethinyl Estradiol 2.9916919318 15861022
MESH:D011693 Purpura Raloxifene 5.2215770314
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5318990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.143692021
MESH:D012208 Rhabdomyosarcoma decitabine 4.1019155313
MESH:D012554 Schistosomiasis japonica Quercetin 5.2116862918
MESH:D012640 Seizures 2,6-dinitrotoluene 2.3318551238
MESH:D018805 Sepsis angelicae sinensis extract 10.0916424112
MESH:D018805 Sepsis dong quai 10.0916424112
MESH:D012772 Shock, Septic endotoxin, Escherichia coli 5.3118063050
MESH:D012871 Skin Diseases Vitamin E 2.3618709164
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 5.2112065085
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.2116192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.6116709447
MESH:D013274 Stomach Neoplasms decitabine 2.7019037991
MESH:D013274 Stomach Neoplasms Paclitaxel 2.7018396642 18506536
MESH:D020521 Stroke Raloxifene 7.8616837676
MESH:D020521 Stroke Vitamin E 7.8616517955
MESH:D024801 Tauopathies Paclitaxel 4.4916930453
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 11.2712697716
MESH:D013959 Thyroid Diseases Thyroxine 11.2719910387
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 6.433712494 6582329 1399818 7505956 6587162
MESH:D013964 Thyroid Neoplasms decitabine 6.4317967635
MESH:D013978 Tibial Fractures Estradiol 12.6119048282
MESH:D013978 Tibial Fractures Raloxifene 12.6119048282
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 18.1616049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 18.168074119
MESH:D001749 Urinary Bladder Neoplasms CD 437 18.1616720286
MESH:D001749 Urinary Bladder Neoplasms decitabine 18.1619087683 17616700
MESH:D001749 Urinary Bladder Neoplasms Quercetin 18.1616720314
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 18.1617572228
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 3.9910091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.9914692618
MESH:D014604 Uveal Neoplasms decitabine 4.5817785578
MESH:D014625 Vaginal Neoplasms Vinblastine 4.7315577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2612125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.8816837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2514671159 15869587
MESH:D014846 Vulvar Neoplasms Raloxifene 5.2216343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9215886252
Pathway ID Pathway Name
REACT:578 Apoptosis
KEGG:03410 Base excision repair
REACT:6900 Signaling in Immune system
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA188
    • No data
    Releated disease ID Related disease Name
    PA444065Epilepsy
    Releated drug ID Related drug Name
    PA452621antineoplastic agents
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB03131 - Beta-Mercaptoethanol
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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