AutismKB 2.0

Annotation Detail for HMGA1


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Basic Information Top
Gene Symbol:HMGA1 ( HMG-R,HMGA1A,HMGIY,MGC12816,MGC4242,MGC4854 )
Gene Full Name: high mobility group AT-hook 1
Band: 6p21.31
Quick LinksEntrez ID:3159; OMIM: 600701; Uniprot ID:HMGA1_HUMAN; ENSEMBL ID: ENSG00000137309; HGNC ID: 5010
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
HIV Infection
Pathway IDPathway Name
200018IL4-mediated signaling events
200045Validated targets of C-MYC transcriptional activation
No data
No data
Related Diseases/Disorders Top
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Desease Name
height
DEVELOPMENTAL
Desease Name
Height
Desease Name
Lipoma
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C063002 2,3-dimethoxy-1,4-naphthoquinone 2,3-dimethoxy-1,4-naphthoquinone results in increased expression of HMGA1 mRNAincreases expression 17547211
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in increased expression of HMGA1 mRNAincreases expression 20713471
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of HMGA1 mRNAdecreases expression 18648102
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of HMGA1 mRNAdecreases expression 12419474
C075773 4-phenylbutyric acid 4-phenylbutyric acid results in decreased expression of HMGA1 mRNAdecreases expression 14583596
D000643 Ammonium Chloride Ammonium Chloride affects the expression of HMGA1 mRNAaffects expression 16483693
D000965 Antimony Antimony results in increased expression of HMGA1 mRNAincreases expression 17547211
D000966 Antimony Potassium Tartrate Antimony Potassium Tartrate results in increased expression of HMGA1 mRNAincreases expression 17547211
C006632 arsenic trioxide arsenic trioxide results in increased expression of HMGA1 mRNAincreases expression 17547211
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the expression of HMGA1 mRNAaffects expression 17331233
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of HMGA1 mRNAincreases expression 12839939
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of HMGA1 mRNAincreases expression 12839939
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of HMGA1 mRNAdecreases expression 12419474
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of HMGA1 mRNAincreases expression 15336504
D002857 Chromium Chromium results in increased expression of HMGA1 mRNAincreases expression 17547211
D004128 Dimethylnitrosamine Dimethylnitrosamine results in increased expression of HMGA1 mRNAincreases expression 17547211
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased expression of HMGA1 mRNAdecreases expression 12419474
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of HMGA1 mRNAincreases expression 20713471
D016685 Mitomycin HMGA1 protein affects the susceptibility to Mitomycinaffects response to substance 16217747
D011192 Potassium Dichromate Potassium Dichromate results in increased expression of HMGA1 mRNAincreases expression 17547211
D011374 Progesterone Progesterone results in decreased expression of HMGA1 mRNAdecreases expression 17404688
D019772 Topotecan HMGA1 protein affects the susceptibility to Topotecanaffects response to substance 16217747
C496197 trans-10,cis-12-conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid results in increased expression of HMGA1 mRNAincreases expression 17951470
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.4718287403
MESH:D000230 Adenocarcinoma arsenic trioxide 4.6119825857 11798837
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 4.6116033868
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 11.043712494
MESH:D000236 Adenoma Dimethylnitrosamine 11.0419555203
MESH:D000236 Adenoma Methylcholanthrene 11.0410545420 6695378
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 4.0510965797
MESH:D050197 Atherosclerosis Methylcholanthrene 3.4011922910
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.9411289319 1440618
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 3.5916206674
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.2617868700
MESH:D001930 Brain Injuries Progesterone 4.1715665606 15380490 15845082
MESH:D001943 Breast Neoplasms 2,4-diaminotoluene 2.0911921183
MESH:D001943 Breast Neoplasms Chromium 2.0915986119
MESH:D001943 Breast Neoplasms Methylcholanthrene 2.0917474063
MESH:D001943 Breast Neoplasms Progesterone 2.0916175315 15562024 17614352
MESH:D001991 Bronchitis Antimony 6.058768112
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.2411589617
MESH:D002277 Carcinoma Dimethylnitrosamine 8.5519555203
MESH:D002277 Carcinoma Methylcholanthrene 8.5510545420
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 2.987296757 3581430
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 2.9814691202 15553829 16217749 15073043 11135700
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.7919014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.637296757
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.0412490120
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 2.9316033868
MESH:D002311 Cardiomyopathy, Dilated Antimony 3.8910334427
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.4516936243
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.727505956
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 6.7216192471
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.0819486331 9022650
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.1012609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8810525206
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.0115213294
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 7.098156756 2524372 12868966 8970840 14531868 11298694 18759878 11906362
MESH:D017449 Dermatitis, Allergic Contact Potassium Dichromate 7.0916823706
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.413621924 2952479
MESH:D003929 Diabetic Neuropathies Progesterone 4.4117187935
MESH:D004283 Dog Diseases Antimony 5.5712019027
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 4.061440618 9022650 18692083 6679447 18289764 7440962 9328219 6482804 9653073 16192314 18648102 11289319 8291058
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 4.068172417
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.6917692515
MESH:D004715 Endometriosis Progesterone 3.6916134523
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.203581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 7.2012903497
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 7.2017016578
MESH:D005234 Fatty Liver arsenic trioxide 3.2115073043
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.946705139
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.8514633661 10962813
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.1816904648
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.957505956
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.436705139
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.8515034207
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.3115869954
MESH:D007249 Inflammation Progesterone 2.5615869954
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.949022650 8074119
MESH:D007674 Kidney Diseases Chromium 6.8917934191
MESH:D007674 Kidney Diseases Potassium Dichromate 6.8919665454
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 4.1916518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 2.896582329
MESH:D007890 Leiomyosarcoma marker/mechanism 18645019
MESH:D007896 Leishmaniasis Antimony 4.7321182181 15220340 10953559 12019027 21063981
MESH:D016773 Leishmaniasis, Cutaneous Antimony 4.598889330 19141829 11475954
MESH:D007897 Leishmaniasis, Mucocutaneous Antimony 5.4010651420 10881086 9643325 11370249 7854095
MESH:D007898 Leishmaniasis, Visceral Antimony 8.517875148 11105143 20495762 8142506 1899875 7854095 7554475
MESH:D007898 Leishmaniasis, Visceral Antimony Potassium Tartrate 8.5112707265
MESH:D007938 Leukemia arsenic trioxide 2.7915070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.7112560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.2216972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.3614633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.6819077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1216467208 16968895 17050201 20471514 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Antimony Potassium Tartrate 7.949834237
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.9416331271 16823087 16966277 17107899 15748426 12712474 17869043 19035177 12679006 16891316 12018890 16112521 19225113 15213294 17217047 19075265 16330433 11468182 11161223 17712046 15336539 19642359 15622746 17649720 9834237
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.2716882451
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.149327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 2.4615099470 16009107 16042886 16627068 18371158 17203207 18237412 15504291 15138612 14568256 15067225 14726149 15298665 17724770 15842777 16570917 16544323 18239293 15479170 15798949 17465448 16169303 18210741 15571005 15733078 15161499 12918455 15383259 17719030 18567088 16270385 18637143 15339415 15744066 15366600 15723089 14659978 17201889 17196135 16603200 17640959 15591649 12925901 15369754 17881167 15577212 17432682 18629640 18672772 15086199 15081153 14643895 15492853 15793283 15942678 17534399 15763062 17198567 18364076 18095165 17666798 15864749 17348192 14709902 17036385
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 4.3317457977
MESH:D008113 Liver Neoplasms arsenic trioxide 7.5214682389
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 7.523113478 15890375
MESH:D008113 Liver Neoplasms Mitomycin 7.5215113037
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 13.743712494 598648 1399818 6587162
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 13.7420377131
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 13.7415603536 1848544 6150874
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 13.74598648 1399818
MESH:D008133 Long QT Syndrome arsenic trioxide 3.2815213294
MESH:D055370 Lung Injury Asbestos, Crocidolite 3.9417365036
MESH:D008175 Lung Neoplasms arsenic trioxide 3.5819825857 11798837
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 3.5819555203 16061637 11884234
MESH:D008175 Lung Neoplasms Methylcholanthrene 3.5816337739 21163286 9230183 10545420 15390079 11893704 1399818 20512841 7750092 6695378 16271038 17909032 20970405
MESH:D008325 Mammary Neoplasms, Experimental 2,4-diaminotoluene 6.2411921183
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.2411408345 17203775
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.1518303189 16966607 16166281
MESH:D009101 Multiple Myeloma arsenic trioxide 3.0414977855 19417148 15949261 11468182 19549372
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.5918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.0916105982 16882451
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.8716624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.433581430
MESH:D009369 Neoplasms 4-phenylbutyric acid 3.6719116145
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.066679447
MESH:D009436 Neural Tube Defects arsenic trioxide 7.0610525206
MESH:D009447 Neuroblastoma Topotecan 3.8015176712
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.346482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.943988306
MESH:D010051 Ovarian Neoplasms arsenic trioxide 4.8516624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms Progesterone 4.8516525653 17393432
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.5515580305
MESH:D010190 Pancreatic Neoplasms Mitomycin 5.5515113037
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 9.037296757
MESH:D010212 Papilloma Hydrogen Peroxide 9.0312065085
MESH:D010235 Paraganglioma arsenic trioxide 4.0819927285
MESH:D010409 Penile Diseases Antimony 5.649643325
MESH:D010493 Pericarditis Antimony 6.0320465667
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 12.726228378
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 12.7211550810
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.8110923243
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.3019131511
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.0017975199 17365031 17322281 15814490
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.313692021
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8318045962
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.8716646077
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 5.8312065085
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 5.838532709
MESH:D013119 Spinal Cord Injuries Progesterone 4.1916503802 15862959
MESH:D013158 Splenic Diseases Dimethylnitrosamine 5.1912587719
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.6817007042
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 2.6816033868
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 6.936587162 6582329 1399818 3712494 7505956
MESH:D013964 Thyroid Neoplasms arsenic trioxide 6.9319014326
MESH:D016171 Torsades de Pointes arsenic trioxide 3.8815213294
MESH:D014352 Trypanosomiasis Antimony 5.8515220340
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 4.968074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 4.9612973940 20435036 11780464 12845720
MESH:D014594 Uterine Neoplasms marker/mechanism 18645019
Pathway ID Pathway Name
REACT:6185 HIV Infection
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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