AutismKB 2.0

Annotation Detail for HMOX2


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Basic Information Top
Gene Symbol:HMOX2 ( HO-2 )
Gene Full Name: heme oxygenase (decycling) 2
Band: 16p13.3
Quick LinksEntrez ID:3163; OMIM: 141251; Uniprot ID:HMOX2_HUMAN; ENSEMBL ID: ENSG00000103415; HGNC ID: 5014
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-5874heme degradation
Pathway IDPathway Name
hsa00860Porphyrin and chlorophyll metabolism
Pathway IDPathway Name
Metabolism of porphyrins
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of HMOX2 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of HMOX2 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of HMOX2 mRNAincreases expression 20458559
D001414 Bacitracin Bacitracin results in increased expression of HMOX2 mRNAincreases expression 18289764
D020122 tert-Butylhydroperoxide HMOX2 protein results in decreased susceptibility to tert-Butylhydroperoxidedecreases response to substance 15589375
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of HMOX2 mRNAincreases expression 16644059
D002259 Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of HMOX2 mRNAdecreases expression 16039398
D003520 Cyclophosphamide Cyclophosphamide results in decreased expression of HMOX2 mRNAdecreases expression 11906922
D003907 Dexamethasone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of HMOX2 mRNAaffects cotreatment|decreases expression 16054899
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of HMOX2 mRNAaffects cotreatment|decreases expression 18544905
D000431 Ethanol [Fish Oils co-treated with Ethanol] results in increased expression of HMOX2 mRNAaffects cotreatment|increases expression 17347304
D005395 Fish Oils [Fish Oils co-treated with Ethanol] results in increased expression of HMOX2 mRNAaffects cotreatment|increases expression 17347304
D006427 Hemin HMOX2 protein results in decreased susceptibility to Hemindecreases response to substance 15589375
D006861 Hydrogen Peroxide HMOX2 protein results in decreased susceptibility to Hydrogen Peroxidedecreases response to substance 15589375
D015056 1-Methyl-3-isobutylxanthine [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of HMOX2 mRNAaffects cotreatment|decreases expression 16054899
D007538 Isoniazid Isoniazid results in increased expression of HMOX2 mRNAincreases expression 12883083
C011890 kojic acid [Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of HMOX2 mRNAaffects cotreatment|decreases expression 18544905
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of HMOX2 mRNAincreases expression 12057914
D037742 Nanotubes, Carbon Nanotubes, Carbon results in decreased expression of HMOX2 mRNAdecreases expression 15585362
D037742 Nanotubes, Carbon Nanotubes, Carbon results in increased expression of HMOX2 mRNAincreases expression 17450800
C025589 ochratoxin A ochratoxin A results in decreased expression of HMOX2 mRNAdecreases expression 16251485
D010269 Paraquat Paraquat results in increased expression of HMOX2 mRNAincreases expression 17935786
C089730 rosiglitazone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of HMOX2 mRNAaffects cotreatment|decreases expression 16054899
D018038 Sodium Selenite Sodium Selenite results in increased expression of HMOX2 mRNAincreases expression 18175754
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of HMOX2 mRNAdecreases expression 16039398
D014212 Tretinoin [Tretinoin co-treated with zoledronic acid] results in increased expression of HMOX2 proteinaffects cotreatment|increases expression 20349282
C088658 zoledronic acid [Tretinoin co-treated with zoledronic acid] results in increased expression of HMOX2 proteinaffects cotreatment|increases expression 20349282
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 7.7718926900 17676605
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.7711752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 9.7718287403
MESH:D000138 Acidosis Ethanol 9.7711192467
MESH:D058186 Acute Kidney Injury zoledronic acid 4.2719715164
MESH:D055371 Acute Lung Injury Lipopolysaccharides 3.8411850527 18653653
MESH:D000210 Acute-Phase Reaction zoledronic acid 5.2720200999
MESH:D000230 Adenocarcinoma arsenic trioxide 2.2419825857 11798837
MESH:D000236 Adenoma Diethylnitrosamine 2.736695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.3518056438 19061943 16434500 17620307 17162532 19052882
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.3516835633
MESH:D000382 Agricultural Workers' Diseases Paraquat 3.5611874814
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.1115451040 15451039
MESH:D000505 Alopecia Tretinoin 3.4515955085
MESH:D000544 Alzheimer Disease rosiglitazone 2.8119621015
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7611748828
MESH:D000799 Angioedema Acetaminophen 3.6310982225
MESH:D000853 Anophthalmos Ethanol 4.6115513904
MESH:D001008 Anxiety Disorders Ethanol 3.8411141031
MESH:D001161 Arteriosclerosis Cyclophosphamide 4.3915014928
MESH:D001169 Arthritis, Experimental Dexamethasone 7.1017659584
MESH:D001169 Arthritis, Experimental Tretinoin 7.1016412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2216292516
MESH:D001249 Asthma Tretinoin 2.2816456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001471 Barrett Esophagus Tretinoin 4.2016935849
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 14.2416206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.2412125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 14.2416206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5815340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6315746008
MESH:D001859 Bone Neoplasms zoledronic acid 4.7619442620 16778634 16121404 15867366 11697798 17312309
MESH:D001862 Bone Resorption zoledronic acid 4.518053405 15845617 16769263 11869084 18496637 18404659
MESH:D001943 Breast Neoplasms Cyclophosphamide 2.8717020986 11325840 15136595 18234424 16978400 17388661 18323546 12006526 15093573
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.8717474063
MESH:D001943 Breast Neoplasms ochratoxin A 2.8711921183
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.8720435547
MESH:D001943 Breast Neoplasms Tretinoin 2.8716873071 16443354 16166294
MESH:D001943 Breast Neoplasms zoledronic acid 2.8716096432 18695136
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.3816813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.1311589617
MESH:D002056 Burns Ethanol 4.4416374292
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.5716124888 3786805 16227642 16050911 15721981 16192424 15700767 16097048 15673190 16011737 18705752 10355542
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6316835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9516168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.553084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 13.5514691202 16217749 15073043 11135700 15553829
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 13.5518788625
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 13.5519701751
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 13.5519052882 19383236 19539802 20512989 16569478 18691550 18210153 19107877 20727157 21159647 19701751 16779866 20214788 20084675 16935385 20432363 18788625 18494052 20514400 19519916 10672840 17162532 3084413 18978308 19919837 20007298 16878318 16681979 19208518 19394651 18393292 20101231 16328049 10737359 16502159 18056438 17978847 18971187 17138121 19418558 17173139 16830150 18506893 3581430 16288022 19335982 19171122 11831363 17761372 16698587 17055752 17428255 16540662 16807293 18665156 18785209 19822196 20935162 20524982
MESH:D006528 Carcinoma, Hepatocellular Ethanol 13.5518788625 15763234 15289165
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 13.551917145
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 4.6816152834
MESH:D002289 Carcinoma, Non-Small-Cell Lung zoledronic acid 3.4719233551
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.6619014326
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 6.7916201981
MESH:D002292 Carcinoma, Renal Cell zoledronic acid 6.7918507039
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.9312490120
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.2316051514 16096774
MESH:D006332 Cardiomegaly Ethanol 6.4619332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.4618850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.3716936243
MESH:D002386 Cataract Acetaminophen 6.8210977129
MESH:D002386 Cataract Tretinoin 6.8217460283
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 2.7217174075 2727394 7505956 21159647
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.3816129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.7419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.7416835633
MESH:D002822 Choriocarcinoma Tretinoin 4.9516461808
MESH:D019457 Chromosome Breakage Sodium Selenite 4.5415894690
MESH:D002971 Cleft Lip Ethanol 3.4815513904
MESH:D002972 Cleft Palate Ethanol 9.3315513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 9.3312621046 15340226 16354765 8697196 15668235
MESH:D002972 Cleft Palate Tretinoin 9.339407595
MESH:D003092 Colitis Tretinoin 3.5017035595
MESH:D003110 Colonic Neoplasms Dexamethasone 2.4615824018
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8817141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 3.9812609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 9.1710525206
MESH:D019465 Craniofacial Abnormalities Dexamethasone 9.1717728286
MESH:D019465 Craniofacial Abnormalities Ethanol 9.1711198716 15451039 15513904 19302082 11873399 15451040 10194807
MESH:D019465 Craniofacial Abnormalities ochratoxin A 9.1720036863
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 9.1715322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 9.179142499 17551590 9211117 10589399 9664655 16925845 9224671 8800419 9125849 14991402
MESH:D003556 Cystitis Cyclophosphamide 4.7718710439 18433785 10700343 18372110 18295254 10498854 11948286 12388444 17979934 15276878 16651033 16413132 17010015 18093676 16989017 16614059 18483878 12913760 12161096 15643279
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.9015213294
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.2112438553
MESH:D003920 Diabetes Mellitus rosiglitazone 8.8417446233
MESH:D003920 Diabetes Mellitus Sodium Selenite 8.8416285004
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 3.9011751995 15331540 10990075
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.1618772604
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.8520387270
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 6.8512642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.8517107852
MESH:D003967 Diarrhea Dexamethasone 3.507237001
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 17.7119923254 15619225 11739529 12392966 10774834 19420014 19164858 17522070 14550746 12958197 2444490 16081117 12153990 19739265 12594235 19416960 16393943 16109766 12540782 16227642 17562736 18071297 11529661 19085960 19370779 12705907 11743745 11834606 16485898 11287661 18713872 17906064 10663392 16177239 16781746 10915739 14725611 11461765 15968718 11421492 14986274
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 17.717120509 10915739 6884620 15968718 6623471 21278145 15998439 16177239 19336974 17522070 3786805 9327722 7179309 2869522 3732212 16227642 15027814 4309450 10092053 11566570 7440962 19085960
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 17.7119107877
MESH:D056486 Drug-Induced Liver Injury Ethanol 17.7111566570
MESH:D056486 Drug-Induced Liver Injury Isoniazid 17.7117950035 16770646 14986274
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 17.7115131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 17.7120420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8919426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6111462148
MESH:D004485 Eczema Dexamethasone 4.2612438553
MESH:D004487 Edema Dexamethasone 10.5119703484
MESH:D004487 Edema rosiglitazone 10.5112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.5112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.2315322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 11.2318230668
MESH:D016889 Endometrial Neoplasms Tretinoin 2.9716569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8410568697 9294722
MESH:D019446 Endotoxemia Lipopolysaccharides 4.1915821434 17637181 15328337
MESH:D004802 Eosinophilia Cyclophosphamide 4.0111006010
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9016302075
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.5312903497
MESH:D004938 Esophageal Neoplasms Ethanol 4.5316704527
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.3211564622
MESH:D005124 Eye Abnormalities Tretinoin 8.3216938888 9664655
MESH:D005234 Fatty Liver arsenic trioxide 28.2715073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 28.2715959796 16239168 12631006 17595544 12795759 16045604 61145 19224547
MESH:D005234 Fatty Liver Diethylnitrosamine 28.2721071580 20387270
MESH:D005234 Fatty Liver Ethanol 28.2719236843 18620774 16409862
MESH:D005234 Fatty Liver Fish Oils 28.2718620774
MESH:D005234 Fatty Liver rosiglitazone 28.2719196556
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.4517920746
MESH:D005264 Femoral Fractures zoledronic acid 5.6216234978
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.0915513904 16946407 10194807 15451040
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2511858732
MESH:D005334 Fever Lipopolysaccharides 3.8311852909 9205823
MESH:D005355 Fibrosis Carbon Tetrachloride 13.5618705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.5620067830
MESH:D005355 Fibrosis Tretinoin 13.5617994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.0616904648
MESH:D005756 Gastritis Acetaminophen 10.4216983495
MESH:D005756 Gastritis Ethanol 10.4215046732
MESH:D005909 Glioblastoma Tretinoin 2.8717312396
MESH:D018316 Gliosarcoma Cyclophosphamide 5.3011389073
MESH:D005911 Gliosis Paraquat 4.9511124998
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3810696789
MESH:D006086 Graft vs Host Disease Cyclophosphamide 4.8316376943 15172196 11014644
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.0516096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9516084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.1710048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 6.179664655 14991402
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.2016366002
MESH:D006467 Hemophilia A Cyclophosphamide 5.0811918545
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1511000095
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.3214986274
MESH:D006505 Hepatitis Carbon Tetrachloride 3.3919900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.6916120746 15340226 12621046
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 3.007520565
MESH:D006689 Hodgkin Disease Cyclophosphamide 3.6117606976 16135485
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8316959395 15340226 18606429 8697196 16354765
MESH:D006930 Hyperalgesia Acetaminophen 22.7516870215
MESH:D006930 Hyperalgesia Ethanol 22.7518783367
MESH:D006930 Hyperalgesia rosiglitazone 22.7512083418
MESH:D006930 Hyperalgesia Tretinoin 22.7516870215
MESH:D006930 Hyperalgesia zoledronic acid 22.7516769263
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3216899240
MESH:D006934 Hypercalcemia zoledronic acid 4.8619622757 18089816
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3616778211
MESH:D006949 Hyperlipidemias Fish Oils 4.5615752949
MESH:D006968 Hypersensitivity, Delayed Fish Oils 5.2911484837
MESH:D006973 Hypertension Dexamethasone 4.9917042910
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.9918850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8815338365
MESH:D006996 Hypocalcemia zoledronic acid 5.9812669777
MESH:D007077 Ileal Diseases 1-Methyl-3-isobutylxanthine 5.2318306037
MESH:D007154 Immune System Diseases Cyclophosphamide 5.1216076520
MESH:D007248 Infertility, Male Cyclophosphamide 6.707193160 16517039
MESH:D007248 Infertility, Male Paraquat 6.704850670
MESH:D007249 Inflammation Dexamethasone 14.7311099482 8960868
MESH:D007249 Inflammation Diethylnitrosamine 14.7318785209
MESH:D007249 Inflammation Lipopolysaccharides 14.7317237260 17963957 12878042 9205823 17255318
MESH:D007249 Inflammation rosiglitazone 14.7312083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 14.7312878042 12200463
MESH:D007333 Insulin Resistance rosiglitazone 7.2916306350
MESH:D007333 Insulin Resistance Sodium Selenite 7.2914714311
MESH:D007410 Intestinal Diseases Tretinoin 3.5617994277
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.4317255318
MESH:D007569 Jaw Abnormalities Ethanol 16.0815513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 16.0816580747
MESH:D007569 Jaw Abnormalities Tretinoin 16.0815992940 17551590
MESH:D007579 Jejunal Diseases 1-Methyl-3-isobutylxanthine 5.2318306037
MESH:D007674 Kidney Diseases Acetaminophen 9.7612587719 15629191
MESH:D007674 Kidney Diseases Bacitracin 9.7618289764
MESH:D007674 Kidney Diseases ochratoxin A 9.7611409539
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 4.0816518626
MESH:D007680 Kidney Neoplasms ochratoxin A 4.3316251485
MESH:D007859 Learning Disorders Ethanol 4.0015451040
MESH:D007938 Leukemia arsenic trioxide 9.9615070760
MESH:D007938 Leukemia Cyclophosphamide 9.9610602166
MESH:D007938 Leukemia Tretinoin 9.9617143497
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.4117802794 18172266 17296974 18587576 17008537 17658394
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 9.3417077332 12560223
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell zoledronic acid 9.3418089816
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.1016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 8.1114633726
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 8.1110373061
MESH:D007951 Leukemia, Myeloid arsenic trioxide 8.8419077051
MESH:D007951 Leukemia, Myeloid Tretinoin 8.8416482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.7516968895 17050201 16467208 19850784 20471514
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.7517596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.1812018890 19075265 15748426 15213294 15622746 17649720 12679006 19642359 19225113 19035177 16966277 16823087 15336539 9834237 17217047 11468182 17869043 17712046 16331271 16891316 11161223 12712474 16330433 16112521 17107899
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.1817712046 16935935 19642359 19029980 16823087 17368321 9834237 17506722 17339181 17301526 17294898 16140955 16891316 12679006 19035177 16766008 19225113 15748426 16788101 16331271 17361223 17217047 17107899 17649720 19075265
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.1516882451
MESH:D007970 Leukopenia Cyclophosphamide 11.0611830472 10052129
MESH:D007970 Leukopenia Lipopolysaccharides 11.0615821434
MESH:D017880 Limb Deformities, Congenital Ethanol 7.8217676605
MESH:D017880 Limb Deformities, Congenital Tretinoin 7.829224671
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.4211903743 11408273 17157831 16943688 21278145 16221502 17174718 17334410 16239168
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 10.4220032147 18407596 18665156 19638242 18522880
MESH:D008103 Liver Cirrhosis Ethanol 10.4215289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.8918295389
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 10.5114748882 17557913 15730626 18279442 17805973 18263696 18472332 17565644 15338365 12586293 12632514 18429990 17714472 12445421 17823541 12667390 18412020 15893842 12445418 17640975 16015684 18339082 14716496 15996030 17708605 18205269 18210741 12958196 12898905 16116963 15673190 13678700 18277467 18395095 18376398 18166357 12666154 18187930 12546737 16033810 18395914 16011737 16248980 12632512 18251166 15876570 18054572 16192424 17761835 16097048 15818738 17900296 17698563 17721639 16136751 15650968 14620537 10355542 12389079 17525996 17922224 14716833 18006644 17766677 17869086 11481614 15370692 12609069 16638106 18317297 17481882 15362042 15925388 18420326 15052691 18481824 18472094 18705752 12649538 18418968 14512876 15057751 15931870 14724832 17631135 17944888 15123356 16027843 18156304 17976157 20821823 15959796 12741479
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 10.5116718785
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 10.5118166357
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 10.5112878042
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 10.5115980055 17347453
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 10.5112878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 10.5116248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 8.9916610002 19460945 16611625 12969438 12587719 19784758 11587558 19014921
MESH:D008107 Liver Diseases Carbon Tetrachloride 8.9917285989 16964402 15720792 15830285 16246199
MESH:D008107 Liver Diseases Diethylnitrosamine 8.9917034775
MESH:D008107 Liver Diseases Hemin 8.9917173083
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.4417207112 17347304
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9615123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.8016871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.8014706259 16899240
MESH:D008113 Liver Neoplasms arsenic trioxide 10.0314682389
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 10.0319294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 10.032862719 18648771 19551842 19426721 21047994 18977376 16942905 19294768 19996281 19690152 19255062 18644402 21167192 15175105 21071580 19254457 19090486 20101389 20501860 18754104 20492335 19638242 19073162 12112319 2422723 19499222 18978307 21278145 20118626 20137499 19833225 19812893 15885732 20452335 20583210 19427195 19256749 12771043 9163691 19642983 20405173 10737359 19850985 20434301
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.0316984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 17.2720377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 17.2712014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 17.2717854601 18775883 17942915 19009564 3124819 16267830 16842330 19539802 19004024 18544905 18308698 18079962 18282651 18253720 21159647 18164116 9362446 17174075 19126423 18093689 2563599 19519916
MESH:D008114 Liver Neoplasms, Experimental kojic acid 17.2718544905
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 17.2712151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.1915213294
MESH:D055370 Lung Injury Lipopolysaccharides 3.8021114838
MESH:D008175 Lung Neoplasms arsenic trioxide 4.6511798837 19825857
MESH:D008175 Lung Neoplasms Dexamethasone 4.6515824018 11195469
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.6521163286 20970405 6695378 20512841
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.6519555203 11884234
MESH:D008223 Lymphoma Cyclophosphamide 3.6912854902
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 9.7316675587
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 9.7314737004
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 4.0011911406
MESH:D008325 Mammary Neoplasms, Experimental ochratoxin A 9.6211921183
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 9.6216827153
MESH:D008325 Mammary Neoplasms, Experimental zoledronic acid 9.6217312309
MESH:D008527 Medulloblastoma Tretinoin 2.7017453147
MESH:D008545 Melanoma Tretinoin 1.9216752155
MESH:D008546 Melanoma, Experimental Acetaminophen 10.1419513568
MESH:D008546 Melanoma, Experimental Cyclophosphamide 10.1416388313
MESH:D008569 Memory Disorders Ethanol 3.9915451040 18411066
MESH:D008591 Meningomyelocele Tretinoin 4.2216940565
MESH:D008654 Mesothelioma zoledronic acid 3.6716675582
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.2017261469
MESH:D008850 Microphthalmos ochratoxin A 5.5920036863
MESH:D009101 Multiple Myeloma arsenic trioxide 11.4319417148 15949261 19549372 14977855 11468182
MESH:D009101 Multiple Myeloma Dexamethasone 11.4315867202 16118317 15744524
MESH:D009101 Multiple Myeloma zoledronic acid 11.4318089719 19621390 16996129
MESH:D009164 Mycobacterium Infections Isoniazid 5.7618474467
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.4618349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 11.6816882451 16105982
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 11.689809623
MESH:D009190 Myelodysplastic Syndromes Tretinoin 11.6817596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8512213967
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.7616624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.853581430 9029167
MESH:D009362 Neoplasm Metastasis zoledronic acid 5.8519139120 15867366 17312309
MESH:D009369 Neoplasms Cyclophosphamide 5.0018854779
MESH:D009369 Neoplasms Tretinoin 5.0016594593 16946489
MESH:D009410 Nerve Degeneration Paraquat 3.5616893418
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.8414600291
MESH:D009421 Nervous System Malformations Tretinoin 8.849125849
MESH:D009436 Neural Tube Defects arsenic trioxide 11.5510525206
MESH:D009436 Neural Tube Defects ochratoxin A 11.5520036863
MESH:D009436 Neural Tube Defects Tretinoin 11.559142499
MESH:D009447 Neuroblastoma Cyclophosphamide 3.538761367 16115947 15176712
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.6218514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.6220387270
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 4.6812837982 8761367
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9020387270
MESH:D009503 Neutropenia Cyclophosphamide 4.138291058
MESH:D009845 Oligospermia Cyclophosphamide 4.5016517039
MESH:D010014 Osteolysis zoledronic acid 5.1615867366
MESH:D010024 Osteoporosis zoledronic acid 3.9117882678
MESH:D010051 Ovarian Neoplasms arsenic trioxide 4.6519769630 16624393 12452020
MESH:D010051 Ovarian Neoplasms Tretinoin 4.6516936753
MESH:D010146 Pain Acetaminophen 14.7716870215
MESH:D010146 Pain Cyclophosphamide 14.7712161096 18093676
MESH:D010146 Pain Tretinoin 14.7716870215
MESH:D010146 Pain zoledronic acid 14.7716475674
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 15.5215580305
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 15.5211332152
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 15.5216540662
MESH:D010190 Pancreatic Neoplasms Ethanol 15.5212384795
MESH:D010190 Pancreatic Neoplasms Tretinoin 15.5215976015
MESH:D010212 Papilloma Hydrogen Peroxide 3.8812065085
MESH:D010235 Paraganglioma arsenic trioxide 3.9719927285
MESH:D010300 Parkinson Disease Paraquat 2.7412911755 16510128 15451049 15824117 11445065 11181820 16140633 11124998
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.2216190885
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0412520081
MESH:D011014 Pneumonia Lipopolysaccharides 10.4211605937 12224865
MESH:D011014 Pneumonia Paraquat 10.4212504350
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3618163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.382563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 7.4321297632
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 7.4321297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.9811896295 11399792 11222880 11118676
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.2019131511
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 2.2017136230
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.2018760546
MESH:D011471 Prostatic Neoplasms zoledronic acid 2.2012438248 19103299
MESH:D011507 Proteinuria Tretinoin 3.4116636307
MESH:D011625 Pterygium Tretinoin 4.5816723453
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 5.7316636934
MESH:D011658 Pulmonary Fibrosis Paraquat 5.7317997886 16324872
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 8.6118379247 11700416
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 8.6111700416
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.5910835634
MESH:D012135 Respiratory Sounds Paraquat 3.8511874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6418990726
MESH:D012162 Retinal Degeneration Paraquat 3.7116458197
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.9016283617 16116481
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 9.8616646077
MESH:D012512 Sarcoma, Ewing's zoledronic acid 9.8616121404
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.6316636934
MESH:D012640 Seizures Ethanol 6.409754883
MESH:D012640 Seizures Isoniazid 6.4016107249
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 12.7712065085
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 12.778532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.7716192470
MESH:D012878 Skin Neoplasms Tretinoin 12.7716467112
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.3016517039
MESH:D013272 Stomach Diseases Dexamethasone 4.1115472012
MESH:D013274 Stomach Neoplasms arsenic trioxide 4.5617007042
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.5618456281
MESH:D013274 Stomach Neoplasms Ethanol 4.5618456281
MESH:D013274 Stomach Neoplasms Tretinoin 4.5617261132
MESH:D013276 Stomach Ulcer Dexamethasone 6.9315138204
MESH:D013276 Stomach Ulcer Ethanol 6.939562338 17918041 17189318 11906479 9211565 16755016
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.079754883
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 4.8512837982
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.9815821434
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6912697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 11.0619014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 11.067505956
MESH:D013964 Thyroid Neoplasms Tretinoin 11.0616026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.6016051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.7515213294
MESH:D014376 Tuberculosis Isoniazid 8.1615236969 16770646 17950035 15673755 18397238 17720495
MESH:D014376 Tuberculosis Tretinoin 8.1616040207
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.1220435036 12845720 11780464 12973940
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 5.1214692829
MESH:D014581 Urticaria Acetaminophen 2.7810982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.4916129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.4016752155
MESH:D014605 Uveitis Dexamethasone 4.601336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3812125929
MESH:D014820 Vitiligo Tretinoin 3.8516761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0415886252
MESH:D009396 Wilms Tumor Tretinoin 3.7916287080
Pathway ID Pathway Name
REACT:9431 Metabolism of porphyrins
KEGG:04978 Mineral absorption
KEGG:00860 Porphyrin and chlorophyll metabolism
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00157 - NADH Dietary supplement;Micronutrient
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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