AutismKB 2.0

Annotation Detail for APAF1


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Basic Information Top
Gene Symbol:APAF1 ( APAF-1,CED4,DKFZp781B1145 )
Gene Full Name: apoptotic peptidase activating factor 1
Band: 12q23.1
Quick LinksEntrez ID:317; OMIM: 602233; Uniprot ID:APAF_HUMAN; ENSEMBL ID: ENSG00000120868; HGNC ID: 576
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05016Huntington's disease
hsa05010Alzheimer's disease
hsa05012Parkinson's disease
hsa04115p53 signaling pathway
hsa05222Small cell lung cancer
hsa04210Apoptosis
Pathway IDPathway Name
Apoptosis
Pathway IDPathway Name
200027E2F transcription factor network
200101Direct p53 effectors
Pathway IDPathway Name
P00029Huntington disease
P00006Apoptosis signaling pathway
P00059p53 pathway
Pathway IDPathway Name
500886Formation of apoptosome
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1907Depression
1911Intestinal disease
1934Cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of APAF1 mRNAaffects expression 21346803
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of APAF1 mRNAincreases expression 16788091
C010643 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Cholesterol analog results in increased expression of APAF1 mRNA]decreases reaction|increases expression 19477266
D000082 Acetaminophen Acetaminophen affects the expression of APAF1 mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in increased expression of APAF1 mRNAincreases expression 11752693
D000111 Acetylcysteine Acetylcysteine inhibits the reaction [Cholesterol analog results in increased expression of APAF1 mRNA]decreases reaction|increases expression 19477266
D000111 Acetylcysteine Acetylcysteine inhibits the reaction [tert-Butylhydroperoxide results in increased expression of APAF1 protein]decreases reaction|increases expression 15877105
D001151 Arsenic Arsenic results in increased expression of APAF1 mRNAincreases expression 19945496
D001152 Arsenicals Arsenicals analog results in increased expression of APAF1 mRNAincreases expression 16778962
C006632 arsenic trioxide arsenic trioxide results in increased expression of APAF1 mRNAincreases expression 19730151
D001554 Benzene Benzene results in increased expression of APAF1 proteinincreases expression 17171516
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of APAF1 mRNAdecreases expression 20064835
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of APAF1 proteinincreases expression 17419000
D020122 tert-Butylhydroperoxide Acetylcysteine inhibits the reaction [tert-Butylhydroperoxide results in increased expression of APAF1 protein]decreases reaction|increases expression 15877105
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of APAF1 proteinincreases expression 15877105
C105934 celecoxib celecoxib results in increased expression of APAF1 mRNAincreases expression 12960143
D002784 Cholesterol 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Cholesterol analog results in increased expression of APAF1 mRNA]decreases reaction|increases expression 19477266
D002784 Cholesterol Acetylcysteine inhibits the reaction [Cholesterol analog results in increased expression of APAF1 mRNA]decreases reaction|increases expression 19477266
D002784 Cholesterol Cholesterol analog results in increased expression of APAF1 mRNAincreases expression 19477266
D003474 Curcumin Curcumin results in increased expression of APAF1 proteinincreases expression 17277231
D003513 Cycloheximide Cycloheximide results in decreased expression of APAF1 mRNAdecreases expression 19684285
D003513 Cycloheximide [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in decreased expression of APAF1 mRNAaffects cotreatment|decreases expression 19684285
C014347 decitabine decitabine affects the expression of APAF1 mRNAaffects expression 17133271
C014347 decitabine decitabine results in increased expression of APAF1 mRNAincreases expression 15972851
C014347 decitabine TP53 protein affects the reaction [decitabine affects the expression of APAF1 mRNA]affects expression|affects reaction 17133271
D004041 Dietary Fats Dietary Fats results in decreased expression of APAF1 mRNAdecreases expression 18503570
C014476 diethyl maleate diethyl maleate results in increased expression of APAF1 mRNAincreases expression 11875189
D004052 Diethylnitrosamine AHR protein affects the reaction [Diethylnitrosamine affects the expression of APAF1 mRNA]affects expression|affects reaction 19996281
D004052 Diethylnitrosamine AHR protein inhibits the reaction [Diethylnitrosamine results in decreased expression of APAF1 mRNA]decreases expression|decreases reaction 19996281
D004052 Diethylnitrosamine Diethylnitrosamine affects the expression of APAF1 mRNAaffects expression 19996281
21159647
D019297 2,4-Dinitrophenol 2,4-Dinitrophenol results in increased expression of APAF1 mRNA alternative formincreases expression 17064354
D004317 Doxorubicin Doxorubicin results in increased expression of APAF1 mRNAincreases expression 15939500
16001973
D004317 Doxorubicin pluronic block copolymer p85 promotes the reaction [Doxorubicin results in increased expression of APAF1 mRNA]increases expression|increases reaction 15939500
D004610 Ellagic Acid Ellagic Acid results in decreased expression of APAF1 mRNAdecreases expression 12002526
C045651 epigallocatechin gallate epigallocatechin gallate results in increased expression of APAF1 proteinincreases expression 15657356
D005419 Flavonoids Flavonoids results in increased expression of APAF1 mRNAincreases expression 18035473
D005472 Fluorouracil Fluorouracil results in increased expression of APAF1 mRNAincreases expression 16557594
D005665 Furosemide Furosemide affects the expression of APAF1 mRNAaffects expression 17497460
D019833 Genistein Genistein results in increased expression of APAF1 mRNAincreases expression 15256057
C007845 gingerol gingerol results in increased expression of APAF1 mRNAincreases expression 19481070
C007845 gingerol gingerol results in increased expression of APAF1 proteinincreases expression 19481070
D007530 Isoflurane Isoflurane results in decreased expression of APAF1 mRNAdecreases expression 16978161
D008741 Methyl Methanesulfonate APAF1 protein affects the susceptibility to Methyl Methanesulfonateaffects response to substance 16019050
D008769 Methylnitronitrosoguanidine APAF1 protein affects the susceptibility to Methylnitronitrosoguanidineaffects response to substance 16019050
D009151 Mustard Gas Mustard Gas results in increased expression of APAF1 mRNAincreases expression 15674843
18955075
D037742 Nanotubes, Carbon Nanotubes, Carbon results in increased expression of APAF1 mRNAincreases expression 15585362
D017239 Paclitaxel Paclitaxel results in increased expression of APAF1 proteinincreases expression 14749477
D010269 Paraquat Paraquat results in decreased expression of APAF1 mRNAdecreases expression 17064354
D010269 Paraquat Paraquat results in increased expression of APAF1 mRNA alternative formincreases expression 17064354
D010424 Pentobarbital Pentobarbital results in decreased expression of APAF1 mRNAdecreases expression 16978161
C058305 phenethyl isothiocyanate phenethyl isothiocyanate results in increased expression of APAF1 proteinincreases expression 16054126
C006253 pirinixic acid pirinixic acid results in decreased expression of APAF1 mRNAdecreases expression 17426115
C422648 pluronic block copolymer p85 pluronic block copolymer p85 promotes the reaction [Doxorubicin results in increased expression of APAF1 mRNA]increases expression|increases reaction 15939500
C009131 pyrimidin-2-one beta-ribofuranoside pyrimidin-2-one beta-ribofuranoside affects the expression of APAF1 mRNAaffects expression 17133271
D011794 Quercetin Quercetin results in decreased expression of APAF1 mRNAdecreases expression 15309432
C059514 resveratrol resveratrol results in decreased expression of APAF1 mRNAdecreases expression 12002526
C059514 resveratrol resveratrol results in decreased expression of APAF1 proteindecreases expression 14749477
C059514 resveratrol resveratrol results in increased expression of APAF1 mRNAincreases expression 12569576
D012402 Rotenone Rotenone results in increased expression of APAF1 mRNA alternative formincreases expression 17064354
C039961 S-(1,2-dichlorovinyl)cysteine S-(1,2-dichlorovinyl)cysteine results in increased expression of APAF1 proteinincreases expression 15967204
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in decreased expression of APAF1 mRNAaffects cotreatment|decreases expression 19684285
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of APAF1 mRNAdecreases expression 19684285
C026995 thallium acetate thallium acetate results in increased expression of APAF1 proteinincreases expression 15965099
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.3714514962 11752688 15322242
MESH:D058186 Acute Kidney Injury resveratrol 3.4216538975
MESH:D055371 Acute Lung Injury pirinixic acid 2.6718653653
MESH:D000230 Adenocarcinoma arsenic trioxide 11.9619825857 11798837
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 11.9620127859 20464547
MESH:D000230 Adenocarcinoma Doxorubicin 11.9617418594
MESH:D000230 Adenocarcinoma Fluorouracil 11.9617638652
MESH:D000230 Adenocarcinoma Genistein 11.9611473722
MESH:D000236 Adenoma Benzo(a)pyrene 9.486695378
MESH:D000236 Adenoma Diethylnitrosamine 9.4810737359 6695378
MESH:D000236 Adenoma resveratrol 9.4815688382
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 14.4619061943 16434500 19052882 18056438 17620307 17162532
MESH:D018248 Adenoma, Liver Cell pirinixic acid 14.4616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 14.4616835633
MESH:D011125 Adenomatous Polyposis Coli celecoxib 4.6619003578 16215675
MESH:D018246 Adrenocortical Adenoma Arsenic 4.7217306315
MESH:D000382 Agricultural Workers' Diseases Paraquat 3.2911874814
MESH:D000419 Albuminuria Doxorubicin 4.0821441931
MESH:D019973 Alcohol-Related Disorders Curcumin 4.5817887948
MESH:D000544 Alzheimer Disease Curcumin 4.0015590663
MESH:D000544 Alzheimer Disease resveratrol 4.0016162502 16183991
MESH:D000740 Anemia Fluorouracil 7.2816511603 15504547 17963324
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.2811748828
MESH:D000741 Anemia, Aplastic Benzene 3.9911369114 17661222 14761424
MESH:D000743 Anemia, Hemolytic Quercetin 3.8017084956
MESH:D000799 Angioedema Acetaminophen 3.3510982225
MESH:D001008 Anxiety Disorders Pentobarbital 4.3418313124 11141031
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.6019183758
MESH:D020261 Arsenic Poisoning Arsenic 2.7112569548 16835338 18414634 16251483
MESH:D001161 Arteriosclerosis Dietary Fats 3.4215238619
MESH:D001169 Arthritis, Experimental resveratrol 3.1917115116
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.6116807698
MESH:D001249 Asthma epigallocatechin gallate 4.7916516891
MESH:D001249 Asthma Mustard Gas 4.7910378619
MESH:D001260 Ataxia Telangiectasia Quercetin 4.4915336622
MESH:D050197 Atherosclerosis Arsenic 13.2512928151 19371607
MESH:D050197 Atherosclerosis Cholesterol 13.2516632123
MESH:D050197 Atherosclerosis Curcumin 13.2518704882
MESH:D050197 Atherosclerosis resveratrol 13.2516873680 17967414
MESH:D001321 Autistic Disorder Acetaminophen 1.4818445737
MESH:D001327 Autoimmune Diseases Curcumin 15.4319761891
MESH:D001327 Autoimmune Diseases epigallocatechin gallate 15.4319761891
MESH:D001327 Autoimmune Diseases Quercetin 15.4319761891
MESH:D001768 Blister Mustard Gas 4.6719167455
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 12.7616206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 12.7619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 12.7612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.2915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.4415746008
MESH:D001855 Bone Marrow Diseases Benzene 4.7316183116
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.2014601052
MESH:D001859 Bone Neoplasms Paclitaxel 4.1215867366
MESH:D002545 Brain Ischemia Curcumin 8.7116770732
MESH:D002545 Brain Ischemia resveratrol 8.7117600658
MESH:D001932 Brain Neoplasms Curcumin 7.5617596214
MESH:D001932 Brain Neoplasms Doxorubicin 7.5617150277
MESH:D001943 Breast Neoplasms Benzene 11.6711921183 17162533
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 11.6717474063 20146248
MESH:D001943 Breast Neoplasms Curcumin 11.6719250217 16243823 18593918 18462866
MESH:D001943 Breast Neoplasms decitabine 11.6718320071 19208741
MESH:D001943 Breast Neoplasms Dietary Fats 11.6720435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 11.6717474063
MESH:D001943 Breast Neoplasms Doxorubicin 11.6715993339 15939500 18382427 17426702 15994142 16264153 15668708 16935488 15692762 18695136 18234424 15634643 16826403 16322301 11325840 16595493 16115903 15136595 18628466 15567936 16096432 17983394 19526202 17369602
MESH:D001943 Breast Neoplasms Fluorouracil 11.6719217205 18357371 15136595 18608205 16557594 16595493 16110121
MESH:D001943 Breast Neoplasms Genistein 11.6717200150 16541309 16873071
MESH:D001943 Breast Neoplasms gingerol 11.6717683926
MESH:D001943 Breast Neoplasms Paclitaxel 11.6716115903 18223236 11325840 18234424 15136595 16273361 18323546 16244791
MESH:D001943 Breast Neoplasms Quercetin 11.6718628248
MESH:D001943 Breast Neoplasms resveratrol 11.6716393696 17651959 17534123
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 11.6720435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.6715286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.4817687719 10378619
MESH:D002051 Burkitt Lymphoma arsenic trioxide 3.8811589617
MESH:D002105 Cadmium Poisoning Quercetin 5.0516962696
MESH:D002276 Carcinoid Tumor Doxorubicin 10.7016051944
MESH:D002276 Carcinoid Tumor Fluorouracil 10.7016051944
MESH:D002277 Carcinoma Curcumin 11.7318593918
MESH:D002277 Carcinoma Fluorouracil 11.7317121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 11.7316835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.3015504454 17687452
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 23.7416705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 23.743084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 23.7417306315 16507464
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 23.7415553829 15073043 16217749 11135700 14691202
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 23.7418665156 17978847 10672840 18393292 20727157 16807293 19208518 16288022 20514400 19539802 19418558 20084675 16328049 17138121 18971187 19919837 16569478 17428255 16502159 19171122 10737359 19052882 16935385 19519916 20214788 3084413 18494052 18785209 11831363 19701751 16779866 17761372 20432363 16878318 18056438 17173139 18978308 20935162 18691550 18210153 16681979 18506893 17162532 17055752 16830150 3581430 20007298 19335982 20524982 18788625 20101231 19394651 19107877 19383236 20512989 16540662 19822196 21159647 16698587
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 23.7418059187 16023760 17876044 16234567
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 23.7416332177 17045692 18930000 17971768 16799960 17088986
MESH:D006528 Carcinoma, Hepatocellular Genistein 23.7416924424
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 23.7416313753
MESH:D006528 Carcinoma, Hepatocellular Quercetin 23.7419519916 12508355
MESH:D006528 Carcinoma, Hepatocellular resveratrol 23.7416227395 19321006
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.1116675471
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.7918414057
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.4817234771
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.3819014326
MESH:D002292 Carcinoma, Renal Cell marker/mechanism 17133271
MESH:D002292 Carcinoma, Renal Cell celecoxib 9.5416369983
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 9.5416201981 1485588
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 9.5418695887
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.6912490120
MESH:D002294 Carcinoma, Squamous Cell Acetylcysteine 23.1217015178
MESH:D002294 Carcinoma, Squamous Cell Arsenic 23.1218922899 17687452 15504454
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 23.1220419170
MESH:D002294 Carcinoma, Squamous Cell Curcumin 23.1218462866
MESH:D002294 Carcinoma, Squamous Cell decitabine 23.1219215824
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 23.126189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 23.1218986760 17066447 16757204 16280240
MESH:D002294 Carcinoma, Squamous Cell resveratrol 23.1216227395
MESH:D002295 Carcinoma, Transitional Cell marker/mechanism 17133271
MESH:D002295 Carcinoma, Transitional Cell Arsenic 3.6618640142
MESH:D006332 Cardiomegaly Quercetin 5.8519794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 5.8518670907 18850075 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.2017131338 17382496 17351982 17007740 16269455 16612575 16364871 17308081 16651473 15476868 18627295 16455267 17329180 16242529 15505089 17519947 16952015 17974986 16278810 17924179 15811867 16109756 16731534 17928571 15792986
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.7616243910 17334414
MESH:D002318 Cardiovascular Diseases Arsenic 10.2617938729 15738583 19152805
MESH:D002318 Cardiovascular Diseases Genistein 10.2616332659
MESH:D002318 Cardiovascular Diseases resveratrol 10.2615458977
MESH:D002340 Carotid Artery Diseases Arsenic 3.9016973168 18022660
MESH:D002386 Cataract Acetaminophen 2.2810977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 13.326135515
MESH:D002471 Cell Transformation, Neoplastic Acetylcysteine 13.3218226522
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 13.3217174075 2727394 7505956 21159647
MESH:D002471 Cell Transformation, Neoplastic Methylnitronitrosoguanidine 13.322727394
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 7.9619052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 7.9616835633
MESH:D002779 Cholestasis pirinixic acid 2.4619176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.8912621046 8697196 15340226 15668235 16354765
MESH:D003092 Colitis Curcumin 8.2218200517 16782535 16804969
MESH:D003092 Colitis resveratrol 8.2216474422
MESH:D003093 Colitis, Ulcerative phenethyl isothiocyanate 3.4720423518
MESH:D003103 Coloboma Curcumin 4.1118809619
MESH:D003110 Colonic Neoplasms celecoxib 15.5116004971
MESH:D003110 Colonic Neoplasms Curcumin 15.5116340194 19359593
MESH:D003110 Colonic Neoplasms decitabine 15.5117616700
MESH:D003110 Colonic Neoplasms Fluorouracil 15.5117018589 16340194 17287894 18772588 17169374 15001691 17172411 17725105 17016597 16510598
MESH:D003110 Colonic Neoplasms Genistein 15.5117182828
MESH:D003110 Colonic Neoplasms Quercetin 15.5117148506 19056647 11134977 16640504 15741050 17191121 19440933
MESH:D003110 Colonic Neoplasms resveratrol 15.5116338953
MESH:D015179 Colorectal Neoplasms arsenic trioxide 11.6420501625
MESH:D015179 Colorectal Neoplasms celecoxib 11.6418349538 11197048
MESH:D015179 Colorectal Neoplasms decitabine 11.6418981723
MESH:D015179 Colorectal Neoplasms Doxorubicin 11.6418802399 18259882
MESH:D015179 Colorectal Neoplasms Fluorouracil 11.6416524972 18448328 17695437 17094418 20501625 14970324 16391804 17255274 18802399 17401013 17454858 16331619 16282729 17594712 16303861 17016601 18509181 15148649 15289873 18288408 18383874 18949393
MESH:D015179 Colorectal Neoplasms Paclitaxel 11.6418802399
MESH:D015179 Colorectal Neoplasms Quercetin 11.6418852136 18095365
MESH:D015179 Colorectal Neoplasms resveratrol 11.6416550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.6514669216 17141729
MESH:D016510 Corneal Neovascularization Curcumin 4.4218497527
MESH:D003327 Coronary Disease resveratrol 3.4316507316
MESH:D023903 Coronary Restenosis arsenic trioxide 3.7212609071
MESH:D019465 Craniofacial Abnormalities marker/mechanism 9753321 9753320
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.4710525206
MESH:D019465 Craniofacial Abnormalities Benzene 3.4715643154
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.4715322242 20055451 10048152
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.5418551238
MESH:D003550 Cystic Fibrosis Acetylcysteine 3.9619747007
MESH:D007644 Darier Disease Fluorouracil 4.3016733453
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.6515213294
MESH:D003872 Dermatitis Benzene 4.2915902427
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.1818249437
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 7.2419496084
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 7.2416873680
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 12.0918403477
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 12.0920387270
MESH:D003924 Diabetes Mellitus, Type 2 epigallocatechin gallate 12.0916988119
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 12.0916647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 12.0917107852
MESH:D003928 Diabetic Nephropathies Curcumin 7.8818204486
MESH:D003928 Diabetic Nephropathies resveratrol 7.8816286809
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 13.0318551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 13.0317562736 14986274 19923254 11287661 16109766 12958197 19085960 10915739 15968718 14725611 19370779 16781746 12392966 17906064 12594235 17522070 16485898 11421492 16081117 16177239 2444490 18071297 19164858 11834606 16393943 16227642 15619225 12705907 19420014 12153990 10774834 12540782 10663392 11743745 11529661 11739529 19416960 11461765 18713872 19739265 14550746
MESH:D056486 Drug-Induced Liver Injury Acetylcysteine 13.0311287661
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 13.0319107877
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 13.0317416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 13.0320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.6019426721
MESH:D004362 Drug Toxicity Doxorubicin 6.9018602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 6.9011462148
MESH:D004381 Duodenal Ulcer Curcumin 3.5917351913
MESH:D050171 Dyslipidemias Dietary Fats 3.1018367378
MESH:D004417 Dyspnea Furosemide 4.4516935035
MESH:D004487 Edema Furosemide 17.0911834646
MESH:D004487 Edema Mustard Gas 17.099260866 11428647 11428631 11402378
MESH:D004487 Edema pirinixic acid 17.0912083418
MESH:D004487 Edema resveratrol 17.098985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 17.0911000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.4118230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 3.5717872969
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.6219294695
MESH:D004714 Endometrial Hyperplasia Genistein 4.1016402032
MESH:D016889 Endometrial Neoplasms Doxorubicin 6.5917359293
MESH:D016889 Endometrial Neoplasms Genistein 6.5911473722
MESH:D004715 Endometriosis celecoxib 7.9615652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.969294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.6618037988
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.3717923197
MESH:D004890 Erythema Mustard Gas 4.679357497
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.6216302075
MESH:D004938 Esophageal Neoplasms arsenic trioxide 9.1812903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 9.1816530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 9.1817638652 15173087 16481741 16337965 16785472
MESH:D004938 Esophageal Neoplasms Paclitaxel 9.1816481741
MESH:D005124 Eye Abnormalities marker/mechanism 9753320
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.6511564622
MESH:D005234 Fatty Liver arsenic trioxide 20.0615073043
MESH:D005234 Fatty Liver Curcumin 20.0619297423
MESH:D005234 Fatty Liver Dietary Fats 20.0617967931 18296743 19004024 19551842
MESH:D005234 Fatty Liver Diethylnitrosamine 20.0620387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 20.0619236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.9811858732
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.1019069698
MESH:D005355 Fibrosis Curcumin 17.3018705752
MESH:D005355 Fibrosis Dietary Fats 17.3018296743
MESH:D005355 Fibrosis Quercetin 17.3019474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 17.3020067830
MESH:D005534 Foot Diseases Arsenic 5.066392382
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.8016904648
MESH:D005756 Gastritis Acetaminophen 3.1816983495
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.2218462866
MESH:D005909 Glioblastoma Curcumin 14.3017596214
MESH:D005909 Glioblastoma Doxorubicin 14.3017150277
MESH:D005909 Glioblastoma Genistein 14.3016598420
MESH:D005909 Glioblastoma Quercetin 14.3019804834
MESH:D005910 Glioma Fluorouracil 5.4716145905
MESH:D005910 Glioma Quercetin 5.4717643826
MESH:D005911 Gliosis Paraquat 4.6711124998
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1010696789
MESH:D006258 Head and Neck Neoplasms Curcumin 15.7218829502 18462866
MESH:D006258 Head and Neck Neoplasms decitabine 15.7219215824
MESH:D006258 Head and Neck Neoplasms Doxorubicin 15.7215692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 15.7215162350 18337622 15102660
MESH:D034381 Hearing Loss Furosemide 4.4217868369
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 5.5420471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.5411294989 10048152
MESH:D006331 Heart Diseases Doxorubicin 3.1417888722 16879835 12587719 18006777 18674790 16495754 16330681 14766674 16707910 16244372 16144979 17875725 16244371
MESH:D006333 Heart Failure Doxorubicin 10.1317481944
MESH:D006333 Heart Failure Furosemide 10.1316011733 12660669 16845234
MESH:D006333 Heart Failure pirinixic acid 10.1320558911
MESH:D006394 Hemangiosarcoma Doxorubicin 3.4715692506
MESH:D006402 Hematologic Diseases Benzene 4.2016183116
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9011000095
MESH:D006529 Hepatomegaly pirinixic acid 6.6919176532 18467677 19772884 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 6.6912621046 15340226 16120746
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.5617701891
MESH:D006561 Herpes Simplex resveratrol 3.7016876885
MESH:D006689 Hodgkin Disease Doxorubicin 3.0117606976 18501091 15147373
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.5518606429 15340226 16959395 8697196 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.3216870215
MESH:D006934 Hypercalcemia Furosemide 4.6417652376
MESH:D053565 Hypercalciuria Furosemide 5.1617652376
MESH:D006937 Hypercholesterolemia Cholesterol 18.3116933029
MESH:D006937 Hypercholesterolemia Curcumin 18.3118704882
MESH:D006937 Hypercholesterolemia Dietary Fats 18.3121332399
MESH:D006937 Hypercholesterolemia resveratrol 18.3117188708
MESH:D006943 Hyperglycemia pirinixic acid 7.8420558911
MESH:D006943 Hyperglycemia Quercetin 7.8418262572 11834736
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.0317050553
MESH:D006949 Hyperlipidemias Dietary Fats 7.8021332399
MESH:D006949 Hyperlipidemias resveratrol 7.8016873680
MESH:D006962 Hyperparathyroidism, Secondary Furosemide 5.3815086907
MESH:D006973 Hypertension Arsenic 10.719931084 11953799 16076760
MESH:D006973 Hypertension Benzene 10.7117940673
MESH:D006973 Hypertension Quercetin 10.7118356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 10.7118850075 18670907
MESH:D046110 Hypertension, Pregnancy-Induced Furosemide 4.8116612254
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 3.8817488730
MESH:D006987 Hypesthesia Arsenic 5.0616093927
MESH:C537153 Hypomagnesemia primary Furosemide 5.1611041285
MESH:D007019 Hypoproteinemia Furosemide 5.3816096441
MESH:D007022 Hypotension Furosemide 8.3811041285
MESH:D007022 Hypotension Isoflurane 8.3812967683
MESH:D007024 Hypotension, Orthostatic Furosemide 4.9215811171
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.1717600658
MESH:D007248 Infertility, Male decitabine 5.9017581917
MESH:D007248 Infertility, Male Paraquat 5.904850670
MESH:D007249 Inflammation Curcumin 20.0816956363 18403477 17151092
MESH:D007249 Inflammation Dietary Fats 20.0820412841
MESH:D007249 Inflammation Diethylnitrosamine 20.0818785209
MESH:D007249 Inflammation Flavonoids 20.0817296493
MESH:D007249 Inflammation Mustard Gas 20.0817524151 11428620 8975870 9260866 11402378 11428631 9357497 11428647 16001271
MESH:D007249 Inflammation resveratrol 20.0816366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 20.0812200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.0018596194 18200517
MESH:D007251 Influenza, Human Quercetin 9.5416624496
MESH:D007251 Influenza, Human resveratrol 9.5416624496
MESH:D007333 Insulin Resistance Dietary Fats 6.1611836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 6.1616306350
MESH:D007414 Intestinal Neoplasms Curcumin 3.8010783313
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 2.9016580747
MESH:D007627 Keloid Quercetin 4.4817086741
MESH:D007642 Keratosis Arsenic 4.5012749816 16930632
MESH:D007674 Kidney Diseases Acetaminophen 12.0915629191 12587719
MESH:D007674 Kidney Diseases Doxorubicin 12.0915699352 15369732 16775033
MESH:D007674 Kidney Diseases Furosemide 12.0911041285
MESH:D007674 Kidney Diseases Quercetin 12.0916962696
MESH:D007676 Kidney Failure, Chronic Doxorubicin 3.7216707910
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 6.1816705839
MESH:D007680 Kidney Neoplasms Fluorouracil 6.1816985049
MESH:D007859 Learning Disorders Cholesterol 4.6217134702
MESH:D007889 Leiomyoma Curcumin 4.1218555241
MESH:D007896 Leishmaniasis Arsenicals 5.5015220340
MESH:D007938 Leukemia arsenic trioxide 21.2515070760
MESH:D007938 Leukemia Benzene 21.2517119257 15935818 18335105 14694614
MESH:D007938 Leukemia Curcumin 21.2518462866
MESH:D007938 Leukemia decitabine 21.2518980019 19235587
MESH:D007938 Leukemia Genistein 21.2517468513 18980019
MESH:D007938 Leukemia Quercetin 21.2517468513
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.6616085563
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 8.3212560223 17077332
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 8.3216106398
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 3.8216972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Arsenicals 8.0315748426
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 8.0314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 13.5619077051
MESH:D007951 Leukemia, Myeloid Benzene 13.5617506065
MESH:D007951 Leukemia, Myeloid decitabine 13.5617236224 18454857 19117987
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 5.5716467208 16968895 20471514 19850784 17050201
MESH:D015470 Leukemia, Myeloid, Acute Benzene 5.5719478238
MESH:D015470 Leukemia, Myeloid, Acute decitabine 5.5719387464 18460780 18704418 19010910 18206229 17679729
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 4.9618055864
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 10.9317339181
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 10.9317107899 16331271 16112521 9834237 19075265 15622746 11468182 17869043 17649720 17712046 19035177 12712474 19642359 15336539 16823087 12018890 16891316 15748426 11161223 16330433 12679006 17217047 15213294 16966277 19225113
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 10.9316087638
MESH:D015458 Leukemia, T-Cell arsenic trioxide 10.1716882451
MESH:D015458 Leukemia, T-Cell Curcumin 10.1716106398
MESH:D008080 Liposarcoma Paclitaxel 4.3717353645
MESH:D008103 Liver Cirrhosis Dietary Fats 5.6918296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 5.6920032147 18407596 18665156 19638242 18522880
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 9.7217355460 18705752 18006644
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 9.7216439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental epigallocatechin gallate 9.7217481882
MESH:D008106 Liver Cirrhosis, Experimental Genistein 9.7217823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 9.7215474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 9.7212741479
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 9.7212878042
MESH:D008107 Liver Diseases Acetaminophen 8.1516610002 12587719 19014921 11587558 19784758 16611625 12969438 19460945
MESH:D008107 Liver Diseases Arsenic 8.1511134558
MESH:D008107 Liver Diseases Curcumin 8.1516956363
MESH:D008107 Liver Diseases Diethylnitrosamine 8.1517034775
MESH:D017114 Liver Failure, Acute Acetaminophen 2.8116871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 29.847678174
MESH:D008113 Liver Neoplasms Arsenic 29.8416368122
MESH:D008113 Liver Neoplasms arsenic trioxide 29.8414682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 29.8421137059 20195826
MESH:D008113 Liver Neoplasms Diethylnitrosamine 29.842862719 19073162 15175105 19255062 18648771 15885732 18977376 19427195 20101389 20501860 19294768 16942905 19642983 20434301 21071580 19996281 19090486 20583210 19551842 21167192 2422723 19850985 19254457 20118626 12771043 18978307 19690152 21047994 12112319 19833225 19638242 10737359 18754104 19256749 19812893 18644402 20137499 19426721 21278145 20405173 20492335 9163691 19499222 20452335
MESH:D008113 Liver Neoplasms Fluorouracil 29.8418383874 15113037 16603448 17045692
MESH:D008113 Liver Neoplasms pirinixic acid 29.8415890375 20007298 16377806
MESH:D008113 Liver Neoplasms Quercetin 29.8418980244
MESH:D008113 Liver Neoplasms resveratrol 29.8419321006 19073162 20405173 19812893
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 29.8416984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 23.436135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 23.4320377131
MESH:D008114 Liver Neoplasms, Experimental Benzene 23.4312562636
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 23.439362446 18164116 19519916 18253720 2563599 19004024 19539802 16842330 18544905 17854601 3124819 19126423 19009564 17174075 18093689 21159647 16267830 18308698 17942915 18282651 18079962 18775883
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 23.4316842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Quercetin 23.4319519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 23.4312151625
MESH:D008133 Long QT Syndrome arsenic trioxide 2.9815213294
MESH:D008171 Lung Diseases Acetylcysteine 6.7512815614
MESH:D008171 Lung Diseases Mustard Gas 6.7518702808 18161513
MESH:D017563 Lung Diseases, Interstitial Benzene 4.3114698565
MESH:D008175 Lung Neoplasms Arsenic 18.6819168569 17976673 17306315
MESH:D008175 Lung Neoplasms arsenic trioxide 18.6811798837 19825857
MESH:D008175 Lung Neoplasms Benzene 18.6812562636
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 18.686695378 18569708 18816296 18520028 20064080 17053015 20135361 20464547 20869020
MESH:D008175 Lung Neoplasms Curcumin 18.6819359593 16243823 18462866
MESH:D008175 Lung Neoplasms Diethylnitrosamine 18.6821163286 6695378 20512841 20970405
MESH:D008175 Lung Neoplasms Doxorubicin 18.6817418594 6189445
MESH:D008175 Lung Neoplasms Fluorouracil 18.6815246190
MESH:D008175 Lung Neoplasms Mustard Gas 18.688781369 3148597
MESH:D008175 Lung Neoplasms Quercetin 18.6816280456
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 18.6811884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.3015086387
MESH:D008223 Lymphoma Benzene 15.0217584886 17119257
MESH:D008223 Lymphoma Curcumin 15.0218462866
MESH:D008223 Lymphoma decitabine 15.0219470736
MESH:D008223 Lymphoma Doxorubicin 15.0216098063
MESH:D016393 Lymphoma, B-Cell resveratrol 3.8517088997
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 12.3317654614
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 12.3314749477
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 12.3314749477
MESH:D016399 Lymphoma, T-Cell Curcumin 9.9816173963
MESH:D016399 Lymphoma, T-Cell Doxorubicin 9.9815621674
MESH:D015674 Mammary Neoplasms, Animal Benzene 8.6412562636
MESH:D015674 Mammary Neoplasms, Animal resveratrol 8.6415688416
MESH:D008325 Mammary Neoplasms, Experimental Benzene 15.4411921183
MESH:D008325 Mammary Neoplasms, Experimental celecoxib 15.4419196722 12104042
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 15.4415458769
MESH:D008325 Mammary Neoplasms, Experimental Genistein 15.4412929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 15.448985016 11606380
MESH:D008545 Melanoma 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid 16.5217992120
MESH:D008545 Melanoma Curcumin 16.5218462866 17885582
MESH:D008545 Melanoma decitabine 16.5217785578 16505122
MESH:D008545 Melanoma Doxorubicin 16.5216827129
MESH:D008545 Melanoma epigallocatechin gallate 16.5217992120 11746506
MESH:D008545 Melanoma Paclitaxel 16.5212040289 16342250 12025231
MESH:D008545 Melanoma pyrimidin-2-one beta-ribofuranoside 16.5216505122
MESH:D008545 Melanoma resveratrol 16.5217992120
MESH:D008546 Melanoma, Experimental Acetaminophen 3.0919513568
MESH:D008569 Memory Disorders Curcumin 3.6917263510
MESH:D008654 Mesothelioma Doxorubicin 2.8517638057
MESH:D008659 Metabolic Diseases resveratrol 3.9417112576
MESH:D053842 Microsatellite Instability Methylnitronitrosoguanidine 5.4017671175
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.0615792986
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 7.2816381670
MESH:D009062 Mouth Neoplasms Fluorouracil 7.2816757204 18986760
MESH:D052016 Mucositis Doxorubicin 4.3017415656
MESH:D009101 Multiple Myeloma arsenic trioxide 28.6319549372 14977855 11468182 15949261 19417148
MESH:D009101 Multiple Myeloma Benzene 28.6317119195
MESH:D009101 Multiple Myeloma celecoxib 28.6316123214
MESH:D009101 Multiple Myeloma Curcumin 28.6319372569
MESH:D009101 Multiple Myeloma decitabine 28.6318172295
MESH:D009101 Multiple Myeloma Paclitaxel 28.6314749477
MESH:D009101 Multiple Myeloma resveratrol 28.6316267019 17935668 17164350 14749477 17049120 16490592
MESH:D009134 Muscular Atrophy, Spinal Curcumin 18.3317962980
MESH:D009134 Muscular Atrophy, Spinal epigallocatechin gallate 18.3317962980
MESH:D009134 Muscular Atrophy, Spinal resveratrol 18.3317962980
MESH:D009135 Muscular Diseases pirinixic acid 3.0316239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.1718349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 6.5216882451 16105982
MESH:D009190 Myelodysplastic Syndromes decitabine 6.5219157545 16882708 19010910 18608210
MESH:D009203 Myocardial Infarction Doxorubicin 15.5119429709 15857846
MESH:D009203 Myocardial Infarction Genistein 15.5117141266
MESH:D009203 Myocardial Infarction pirinixic acid 15.5119151258
MESH:D009203 Myocardial Infarction Quercetin 15.5119595682
MESH:D009203 Myocardial Infarction resveratrol 15.5116317513 17125593 16456233 16525036 17015251 17188708
MESH:D017202 Myocardial Ischemia Arsenic 13.0615371236
MESH:D017202 Myocardial Ischemia resveratrol 13.0617125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 13.0612213967
MESH:D015428 Myocardial Reperfusion Injury Genistein 12.0617141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 12.0616411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 12.0619207477
MESH:D009205 Myocarditis resveratrol 4.2717322642
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.387678174 18551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 8.7916624393
MESH:D009361 Neoplasm Invasiveness Curcumin 8.7918495463
MESH:D009362 Neoplasm Metastasis Acetylcysteine 11.8814720322
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 11.889029167 3581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 11.8818259882
MESH:D009362 Neoplasm Metastasis Paclitaxel 11.8815867366
MESH:D009369 Neoplasms Benzo(a)pyrene 12.9611141357
MESH:D009369 Neoplasms decitabine 12.9617925555 19116145 19470736
MESH:D009369 Neoplasms Fluorouracil 12.9618600527 16928823 18239605
MESH:D009369 Neoplasms pirinixic acid 12.9617405874
MESH:D009369 Neoplasms Quercetin 12.9615185748
MESH:D009374 Neoplasms, Experimental resveratrol 3.538985016
MESH:D009376 Neoplasms, Hormone-Dependent celecoxib 9.7219196722
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 9.7212497104
MESH:D009397 Nephrocalcinosis Furosemide 5.3815086907
MESH:D009401 Nephrosis Doxorubicin 4.2916636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.5915640375 16889571
MESH:D009410 Nerve Degeneration Paraquat 7.3916893418
MESH:D009410 Nerve Degeneration Rotenone 7.3918619942 15790535 17356569
MESH:D009421 Nervous System Malformations Genistein 8.0716427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.0714600291
MESH:D009423 Nervous System Neoplasms Curcumin 5.1318462866
MESH:D009436 Neural Tube Defects Acetylcysteine 14.7319446573
MESH:D009436 Neural Tube Defects Arsenic 14.7316620997
MESH:D009436 Neural Tube Defects arsenic trioxide 14.7310525206
MESH:D009436 Neural Tube Defects Benzene 14.7315643154
MESH:D009447 Neuroblastoma Doxorubicin 3.0015555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 11.7518514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 11.7520387270
MESH:D019636 Neurodegenerative Diseases resveratrol 11.7517652729
MESH:D020078 Neurogenic Inflammation Arsenic 15.2217056641
MESH:D020078 Neurogenic Inflammation Quercetin 15.2217929310
MESH:D020078 Neurogenic Inflammation resveratrol 15.2217929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.6220387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.1016436463
MESH:D009503 Neutropenia Mustard Gas 3.537688884 16761898
MESH:D052556 Niemann-Pick Disease, Type C Cholesterol 5.2320557099 9802331
MESH:D053206 Nocturnal Enuresis Furosemide 5.3817945291
MESH:D009765 Obesity Curcumin 6.5819297423
MESH:D009765 Obesity Dietary Fats 6.5821332399 20518802 19632207 20132043 17217161 11836018 18674790 18457598 16723640
MESH:D009765 Obesity pirinixic acid 6.5820558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 7.7616049721
MESH:D009784 Occupational Diseases Benzene 7.7616737584 15612468 15913788 15727169 15935809 17479406 15576619 17119257 17178637
MESH:D010014 Osteolysis Paclitaxel 4.4915867366
MESH:D010024 Osteoporosis Curcumin 6.3218719352
MESH:D010024 Osteoporosis Genistein 6.3219401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 14.3016169203
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 14.3019495926
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 14.3017513867
MESH:D012516 Osteosarcoma Doxorubicin 3.7215930896
MESH:D010051 Ovarian Neoplasms Arsenic 24.0117306315
MESH:D010051 Ovarian Neoplasms arsenic trioxide 24.0116624393 12452020 19769630
MESH:D010051 Ovarian Neoplasms Benzene 24.0112562636
MESH:D010051 Ovarian Neoplasms Curcumin 24.0118462866 19020741
MESH:D010051 Ovarian Neoplasms decitabine 24.0119331143 19259094
MESH:D010051 Ovarian Neoplasms Genistein 24.0119005980
MESH:D010051 Ovarian Neoplasms Paclitaxel 24.0111161223
MESH:D010051 Ovarian Neoplasms Quercetin 24.0119005980
MESH:D010146 Pain Acetaminophen 2.0116870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 17.9215580305
MESH:D010190 Pancreatic Neoplasms Curcumin 17.9217440100 19196508 19401701
MESH:D010190 Pancreatic Neoplasms decitabine 17.9219294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 17.9216540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 17.9219003803 16929163 16500647 15113037
MESH:D010190 Pancreatic Neoplasms Quercetin 17.9216965848
MESH:D010235 Paraganglioma arsenic trioxide 3.7119927285
MESH:D010300 Parkinson Disease Paraquat 4.9011181820 12911755 16510128 11445065 11124998 15451049 16140633 15824117
MESH:D010300 Parkinson Disease Rotenone 4.9016412576 15451049 18619942 16140633 19232380 19114014 11535288 18191903 11445065
MESH:D010302 Parkinson Disease, Secondary Paraquat 3.9616190885
MESH:D020734 Parkinsonian Disorders Rotenone 3.6615927086 15795934 15574749 18197244
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.7512520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 3.7216093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.5016905509 15371236 6392382
MESH:D010538 Peritonitis Isoflurane 4.7517414419
MESH:D003557 Phyllodes Tumor Doxorubicin 4.6617983394
MESH:D010997 Pleural Neoplasms Doxorubicin 4.6617638057
MESH:D011014 Pneumonia Paraquat 3.9712504350
MESH:D011041 Poisoning Mustard Gas 3.3515727166
MESH:D011141 Polyuria Furosemide 5.1617945291
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.1018163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 7.862563599
MESH:D011230 Precancerous Conditions Quercetin 7.8619056647
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 7.9816679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 7.9811399792 11896295 11222880 11118676
MESH:D055728 Primary Myelofibrosis decitabine 4.2517616702
MESH:D011471 Prostatic Neoplasms Arsenic 3.9116140617
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.9119131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.9117292933
MESH:D011471 Prostatic Neoplasms celecoxib 3.9115570007 17908994
MESH:D011471 Prostatic Neoplasms Curcumin 3.9111398177 18156803 15129424 18226269 10851300 18769126 12497104
MESH:D011471 Prostatic Neoplasms Doxorubicin 3.9115897917 16729912 16868541 18437689 15749863 16888761
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.9118626508 19082440
MESH:D011471 Prostatic Neoplasms Genistein 3.9115256057 16925846 15378649
MESH:D011471 Prostatic Neoplasms Paclitaxel 3.9116729912 17172428 17136230 16356831
MESH:D011471 Prostatic Neoplasms Quercetin 3.9117292933 14715546
MESH:D011471 Prostatic Neoplasms resveratrol 3.9115767336 17636462 16731767 17804756 17718901 17675339
MESH:D011507 Proteinuria Arsenic 3.5621343184
MESH:D011537 Pruritus Mustard Gas 3.6118058305
MESH:D011656 Pulmonary Emphysema Curcumin 4.1019168576
MESH:D011658 Pulmonary Fibrosis Mustard Gas 5.1717894541 17720292 10334151 17620002 17266442
MESH:D011658 Pulmonary Fibrosis Paraquat 5.1717997886 16324872
MESH:D012004 Rectal Neoplasms Fluorouracil 3.6015538739 18722050 18286688 16160472
MESH:D012021 Reflex, Abnormal Pentobarbital 5.5310930210
MESH:D051437 Renal Insufficiency Doxorubicin 3.7517922066
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.0916325855
MESH:D015427 Reperfusion Injury Furosemide 9.5616526316
MESH:D015427 Reperfusion Injury pirinixic acid 9.5619058328
MESH:D015427 Reperfusion Injury resveratrol 9.5616317513 17520802 17058453 16314181 15827377
MESH:D012128 Respiratory Distress Syndrome, Adult Acetylcysteine 17.9912210543
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 17.9918379247 10666014
MESH:D012128 Respiratory Distress Syndrome, Adult Furosemide 17.9912394941 16096441 15912074
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 17.9911700416
MESH:D012135 Respiratory Sounds Paraquat 3.5811874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.3718990726
MESH:D012162 Retinal Degeneration Paraquat 3.5016458197
MESH:D012208 Rhabdomyosarcoma decitabine 3.9519155313
MESH:D012509 Sarcoma Curcumin 8.1618462866
MESH:D012509 Sarcoma Doxorubicin 8.1615625365 17203757 15675481 16767912 18313854 17710206
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 8.7416646077
MESH:D012512 Sarcoma, Ewing's Doxorubicin 8.7416326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.3017846226
MESH:D012554 Schistosomiasis japonica Quercetin 5.0516862918
MESH:D012640 Seizures 2,6-dinitrotoluene 5.2618551238
MESH:D012640 Seizures Pentobarbital 5.269754883 10087439
MESH:D018805 Sepsis Curcumin 8.4918389075
MESH:D018805 Sepsis Isoflurane 8.4917414419
MESH:D012868 Skin Abnormalities marker/mechanism 9753320
MESH:D012871 Skin Diseases Arsenic 4.6417453740 17548696 17938729 18709164 16759981 16353154 16702368 17050553 19834688 15952646 6392382
MESH:D012871 Skin Diseases Mustard Gas 4.6412880345 16961503 15451306
MESH:D012878 Skin Neoplasms Arsenic 23.3917029826 15504454 17050553 17976673 16251483 19538983
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 23.3919755658 10029692
MESH:D012878 Skin Neoplasms Doxorubicin 23.3915692506
MESH:D012878 Skin Neoplasms gingerol 23.3919481070
MESH:D012878 Skin Neoplasms resveratrol 23.3915837718 8985016
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 23.398532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 23.3916192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.0915625365 16767912 17203757
MESH:D013274 Stomach Neoplasms arsenic trioxide 13.6917007042
MESH:D013274 Stomach Neoplasms Benzene 13.6912562636
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 13.692093021 20155912
MESH:D013274 Stomach Neoplasms celecoxib 13.6915609394
MESH:D013274 Stomach Neoplasms decitabine 13.6919037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 13.6918456281
MESH:D013274 Stomach Neoplasms Fluorouracil 13.6919015929 18396642 17498489 16424979 18567086 17172411 19084572 15786421 16951190 17522103
MESH:D013274 Stomach Neoplasms Furosemide 13.6917052386
MESH:D013274 Stomach Neoplasms Paclitaxel 13.6918396642 18506536
MESH:D013276 Stomach Ulcer Acetylcysteine 6.3017918041
MESH:D013276 Stomach Ulcer Curcumin 6.3016631530 19188055
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.0516321402
MESH:D013375 Substance Withdrawal Syndrome Pentobarbital 4.559754883 11529278
MESH:D024801 Tauopathies Paclitaxel 4.3316930453
MESH:D013733 Testicular Diseases phenethyl isothiocyanate 4.4615864552
MESH:D013953 Thymus Neoplasms Benzene 4.4710850423
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.4112697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 14.0719014326
MESH:D013964 Thyroid Neoplasms decitabine 14.0717967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 14.077505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 14.0717909728 16010429
MESH:D014062 Tongue Neoplasms Fluorouracil 8.5816280240
MESH:D014062 Tongue Neoplasms resveratrol 8.5816227395
MESH:D016171 Torsades de Pointes arsenic trioxide 3.4815213294
MESH:D014352 Trypanosomiasis Arsenicals 6.5315220340
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 28.8216049721
MESH:D001749 Urinary Bladder Neoplasms Arsenic 28.8219322015 18640142 17306315 19429237 11144890 17976673 15987713
MESH:D001749 Urinary Bladder Neoplasms Arsenicals 28.8212846360
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 28.8212973940 11780464 12845720 20435036
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 28.8217053015
MESH:D001749 Urinary Bladder Neoplasms Curcumin 28.8218593936
MESH:D001749 Urinary Bladder Neoplasms decitabine 28.8219087683 17616700
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 28.8217653716
MESH:D001749 Urinary Bladder Neoplasms Quercetin 28.8216720314
MESH:D014565 Urogenital Neoplasms Curcumin 4.7818462866
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 3.8310091137
MESH:D014581 Urticaria Acetaminophen 2.5310982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 8.2016803524
MESH:D002583 Uterine Cervical Neoplasms resveratrol 8.2017473185
MESH:D014594 Uterine Neoplasms Benzene 13.6812562636
MESH:D014594 Uterine Neoplasms celecoxib 13.6818645019
MESH:D014594 Uterine Neoplasms resveratrol 13.6817044934
MESH:D014604 Uveal Neoplasms decitabine 4.4217785578
MESH:D014652 Vascular Diseases Arsenic 4.2517056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1012125929
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 8.7617334414 16364871 17678736 17638931
MESH:D018487 Ventricular Dysfunction, Left resveratrol 8.7617488730
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.7515886252
MESH:D015430 Weight Gain Dietary Fats 3.3316723640
Pathway ID Pathway Name
KEGG:05010 Alzheimer's disease
KEGG:05014 Amyotrophic lateral sclerosis (ALS)
KEGG:04210 Apoptosis
REACT:578 Apoptosis
KEGG:05016 Huntington's disease
KEGG:04115 p53 signaling pathway
KEGG:05012 Parkinson's disease
KEGG:05222 Small cell lung cancer
KEGG:05152 Tuberculosis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24868
    • No data
    Releated disease ID Related disease Name
    PA446661Carcinoma, Small Cell
    PA444818Lung Neoplasms
    PA443622Carcinoma, Non-Small-Cell Lung
    Releated drug ID Related drug Name
    PA131301952gefitinib
    PA449780glutathione
    PA449014cisplatin
    PA449383docetaxel
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00171 - Adenosine triphosphate Dietary supplement;Micronutrient
    DB03131 - Beta-Mercaptoethanol
    DB03431 - Adenosine-5'-Diphosphate
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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