AutismKB 2.0

Annotation Detail for ONECUT1


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Basic Information Top
Gene Symbol:ONECUT1 ( HNF-6,HNF6,HNF6A )
Gene Full Name: one cut homeobox 1
Band: 15q21.3
Quick LinksEntrez ID:3175; OMIM: 604164; Uniprot ID:HNF6_HUMAN; ENSEMBL ID: ENSG00000169856; HGNC ID: 8138
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04950Maturity onset diabetes of the young
Pathway IDPathway Name
Regulation of beta-cell development
Pathway IDPathway Name
200120FOXM1 transcription factor network
No data
Pathway IDPathway Name
500519Regulation of gene expression in early pancreatic precursor cells
500520Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
500518Regulation of beta-cell development
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of ONECUT1 mRNAaffects expression 17562736
C040534 alpha-hexachlorocyclohexane alpha-hexachlorocyclohexane affects the expression of ONECUT1 mRNAaffects expression 17785943
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ONECUT1 mRNAaffects expression 16483693
D001554 Benzene Benzene affects the expression of ONECUT1 mRNAaffects expression 15878777
D016572 Cyclosporine Cyclosporine results in decreased expression of ONECUT1 mRNAdecreases expression 20106945
D003907 Dexamethasone Dexamethasone results in increased expression of ONECUT1 mRNAincreases expression 12837037
D001556 Lindane Lindane results in decreased expression of ONECUT1 mRNAdecreases expression 17785943
C030957 methylmercury II methylmercury II results in increased expression of ONECUT1 mRNAincreases expression 17905399
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of ONECUT1 mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of ONECUT1 mRNAdecreases expression 19482888
19270015
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ONECUT1 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of ONECUT1 mRNAdecreases expression 18445702
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ONECUT1 mRNAdecreases expression 16054898
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.956195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.9515322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.7518287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.2718653653
MESH:D018248 Adenoma, Liver Cell Phenobarbital 18.4717620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 18.4716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 18.4716835633
MESH:D000382 Agricultural Workers' Diseases Lindane 4.5612661182
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D000741 Anemia, Aplastic Benzene 4.4814761424 11369114 17661222
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D001169 Arthritis, Experimental Dexamethasone 3.6217659584
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.2419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.2412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001855 Bone Marrow Diseases Benzene 5.4516183116
MESH:D001943 Breast Neoplasms Benzene 2.0511921183 17162533
MESH:D001943 Breast Neoplasms Lindane 2.0514688026
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0520435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.933084413
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 2.936705139 20007298 17173139 1701930 20935162
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4418670907 16120746 18850075
MESH:D002386 Cataract Acetaminophen 2.6610977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6212371664
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.434080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002779 Cholestasis Cyclosporine 8.1019486331
MESH:D002779 Cholestasis pirinixic acid 8.1019176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.158697196 15340226 16354765 15668235 12621046
MESH:D003110 Colonic Neoplasms Dexamethasone 2.5115824018
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1814669216 17141729
MESH:D019465 Craniofacial Abnormalities Benzene 3.9715643154
MESH:D019465 Craniofacial Abnormalities Dexamethasone 3.9717728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.9710048152 20055451 15322242
MESH:D003872 Dermatitis Benzene 4.9415902427
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.5812438553
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D003967 Diarrhea Dexamethasone 3.867237001
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.6817562736 16081117 19370779 14986274 15619225 15968718 19739265 16227642 11529661 19420014 11287661 12958197 12540782 18071297 12153990 11834606 14550746 12392966 19923254 17906064 16393943 16781746 18713872 17522070 10663392 16177239 12594235 12705907 10915739 19416960 11739529 11421492 11743745 10774834 2444490 16109766 19164858 14725611 16485898 11461765 19085960
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.6820420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D004421 Dystonia Phenobarbital 4.151851702
MESH:D004485 Eczema Dexamethasone 4.6212438553
MESH:D004487 Edema Dexamethasone 12.2719703484
MESH:D004487 Edema pirinixic acid 12.2712083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 12.2712711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1215322242 16714409 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.159294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.283659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.0911558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.9520417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.676401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.437750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.213659116
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver Cyclosporine 8.0319224547
MESH:D005234 Fatty Liver pirinixic acid 8.0319236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005355 Fibrosis Cyclosporine 9.0712168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.0720067830
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.418708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4011294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.6220558911
MESH:D006402 Hematologic Diseases Benzene 4.8016183116
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6215720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006529 Hepatomegaly Phenobarbital 15.4416109766
MESH:D006529 Hepatomegaly pirinixic acid 15.4419772884 18467677 19176532 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 15.4415340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 3.117520565
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2618606429 15340226 16354765 8697196 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.8116870215
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D006973 Hypertension Benzene 12.8017940673
MESH:D006973 Hypertension Cyclosporine 12.8010903974
MESH:D006973 Hypertension Dexamethasone 12.8017042910
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 12.8018670907 18850075
MESH:D007249 Inflammation Dexamethasone 5.3111099482 8960868
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.3112878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.7216306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6615604871
MESH:D007674 Kidney Diseases Acetaminophen 6.0512587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 6.058314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8512371664
MESH:D007938 Leukemia Benzene 3.4514694614 18335105 15935818 17119257
MESH:D007951 Leukemia, Myeloid Benzene 4.4617506065
MESH:D015470 Leukemia, Myeloid, Acute Benzene 2.7219478238
MESH:D008103 Liver Cirrhosis Phenobarbital 2.9621047994
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 3.5316718785
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5315474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5312878042
MESH:D008107 Liver Diseases Acetaminophen 6.8112969438 11587558 19460945 12587719 19014921 16610002 19784758 16611625
MESH:D008107 Liver Diseases Lindane 6.811715830
MESH:D008107 Liver Diseases Phenobarbital 6.8119363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3716871587 17185352
MESH:D008113 Liver Neoplasms Phenobarbital 7.6319812893 19482888 21047994 15975961 19073162 8742319
MESH:D008113 Liver Neoplasms pirinixic acid 7.6316377806 15890375 20007298
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.6316984957
MESH:D008114 Liver Neoplasms, Experimental Benzene 10.3912562636
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 10.3918308698 17172636 6150874 1399818 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.3912151625
MESH:D017563 Lung Diseases, Interstitial Benzene 5.0214698565
MESH:D008175 Lung Neoplasms Benzene 3.6112562636
MESH:D008175 Lung Neoplasms Dexamethasone 3.6111195469 15824018
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.6119555203 11884234
MESH:D008223 Lymphoma Benzene 3.8317584886 17119257
MESH:D015674 Mammary Neoplasms, Animal Benzene 4.6412562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 3.3911921183
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0116801185
MESH:D009101 Multiple Myeloma Benzene 7.9717119195
MESH:D009101 Multiple Myeloma Dexamethasone 7.9715744524 16118317 15867202
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.619809623
MESH:D009203 Myocardial Infarction pirinixic acid 2.1919151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0516411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.6717484760
MESH:D009369 Neoplasms Lindane 5.4712807735 16818664
MESH:D009369 Neoplasms pirinixic acid 5.4717405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4119348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3714600291
MESH:D009436 Neural Tube Defects Benzene 3.7615643154
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9918514411
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D009784 Occupational Diseases Benzene 4.3116737584 15576619 15913788 17119257 15727169 15935809 15612468 17178637 17479406
MESH:D010018 Osteomalacia Phenobarbital 4.5617016548
MESH:D010051 Ovarian Neoplasms Benzene 3.0012562636
MESH:D010146 Pain Acetaminophen 2.5016870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5316965848
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011230 Precancerous Conditions Cyclosporine 9.3912371664
MESH:D011230 Precancerous Conditions Phenobarbital 9.392563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.6221297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3811896295 11118676 11399792 11222880
MESH:D011471 Prostatic Neoplasms Lindane 4.1412661182 14688026
MESH:D019310 Pseudolymphoma Phenobarbital 4.7112752131
MESH:D011565 Psoriasis Cyclosporine 2.2716882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 4.1618379247 11700416
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012640 Seizures Lindane 6.6415475178 7539098 12842176
MESH:D012640 Seizures Phenobarbital 6.643137016 16876388 11442880 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 5.026407741
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1016192470
MESH:D013272 Stomach Diseases Dexamethasone 4.5115472012
MESH:D013274 Stomach Neoplasms Benzene 2.4212562636
MESH:D013276 Stomach Ulcer Dexamethasone 3.6215138204
MESH:D013953 Thymus Neoplasms Benzene 5.1510850423
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.161399818
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D014594 Uterine Neoplasms Benzene 4.4912562636
MESH:D014605 Uveitis Cyclosporine 12.511336536
MESH:D014605 Uveitis Dexamethasone 12.511336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
MESH:D014985 Xerophthalmia Cyclosporine 4.6617120751
Pathway ID Pathway Name
KEGG:04950 Maturity onset diabetes of the young
REACT:13698 Regulation of beta-cell development
REACT:13641 Regulation of Beta-Cell Development
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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