AutismKB 2.0

Annotation Detail for HNRNPF


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Basic Information Top
Gene Symbol:HNRNPF ( HNRPF,MGC110997,OK/SW-cl.23,mcs94-1 )
Gene Full Name: heterogeneous nuclear ribonucleoprotein F
Band: 10q11.21
Quick LinksEntrez ID:3185; OMIM: 601037; Uniprot ID:HNRPF_HUMAN; ENSEMBL ID: ENSG00000169813; HGNC ID: 5039
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
mRNA Processing
Gene Expression
No data
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Pathway IDPathway Name
500866mRNA Splicing - Major Pathway
500655Processing of Capped Intron-Containing Pre-mRNA
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1934Cancer
2053Colon cancer
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of HNRNPF mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of HNRNPF mRNAaffects expression 17562736
C109238 acyline acyline results in increased expression of HNRNPF mRNAincreases expression 17510436
D000643 Ammonium Chloride Ammonium Chloride affects the expression of HNRNPF mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of HNRNPF mRNAdecreases expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of HNRNPF mRNAincreases expression 20504355
D016572 Cyclosporine Cyclosporine results in decreased expression of HNRNPF mRNAdecreases expression 20106945
C014347 decitabine decitabine results in increased expression of HNRNPF mRNAincreases expression 17908484
D005472 Fluorouracil TP53 protein affects the reaction [Fluorouracil results in decreased expression of HNRNPF mRNA]affects reaction|decreases expression 15016801
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to HNRNPF protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone results in increased expression of HNRNPF proteinincreases expression 17152098
C006253 pirinixic acid pirinixic acid affects the expression of HNRNPF mRNAaffects expression 17950772
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.5320127859 20464547
MESH:D000230 Adenocarcinoma Fluorouracil 4.5317638652
MESH:D000236 Adenoma Benzo(a)pyrene 2.746695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7216434500
MESH:D000740 Anemia Fluorouracil 3.8716511603 17963324 15504547
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2919183758
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3219483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9520146248 17474063
MESH:D001943 Breast Neoplasms decitabine 1.9519208741 18320071
MESH:D001943 Breast Neoplasms Fluorouracil 1.9519217205 16110121 15136595 16557594 18357371 16595493 18608205
MESH:D002276 Carcinoid Tumor Fluorouracil 4.9316051944
MESH:D002277 Carcinoma Fluorouracil 3.7017121937
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.6816705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.683084413
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 4.6816332177 18930000 17045692 17088986 16799960 17971768
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0918695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.8320419170
MESH:D002294 Carcinoma, Squamous Cell decitabine 7.8319215824
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 7.8318986760 16757204 17066447 16280240
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6412371664
MESH:D002779 Cholestasis Cyclosporine 8.1819486331
MESH:D002779 Cholestasis pirinixic acid 8.1819176532
MESH:D003110 Colonic Neoplasms decitabine 3.9617616700
MESH:D003110 Colonic Neoplasms Fluorouracil 3.9616510598 17725105 15001691 17016597 17169374 16340194 17287894 17018589 17172411 18772588
MESH:D015179 Colorectal Neoplasms decitabine 2.6718981723
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.6715148649 15289873 17401013 16391804 16282729 17016601 17454858 18288408 18509181 17094418 16331619 17255274 16303861 18949393 16524972 17594712 18383874 14970324 17695437 18448328 20501625 18802399
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.2318551238
MESH:D007644 Darier Disease Fluorouracil 5.0316733453
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 3.8621346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.8611421492 10915739 12705907 17906064 12958197 18071297 19739265 11287661 16177239 11743745 17522070 16081117 19416960 19370779 19085960 15619225 15968718 2444490 11461765 11529661 14725611 19164858 16781746 10663392 11834606 12153990 16227642 12392966 16109766 12594235 14986274 10774834 19420014 11739529 17562736 16393943 14550746 12540782 19923254 18713872 16485898
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004487 Edema pirinixic acid 2.6512083418
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.3819294695
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.6216530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.6215173087 17638652 16337965 16785472 16481741
MESH:D005234 Fatty Liver Cyclosporine 8.1419224547
MESH:D005234 Fatty Liver pirinixic acid 8.1419236843 20131406
MESH:D005355 Fibrosis Cyclosporine 3.3612639820 12168785
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D005910 Glioma Fluorouracil 2.9316145905
MESH:D006258 Head and Neck Neoplasms decitabine 8.2819215824
MESH:D006258 Head and Neck Neoplasms Fluorouracil 8.2815162350 18337622 15102660
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7420471113
MESH:D006333 Heart Failure pirinixic acid 2.6320558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006529 Hepatomegaly pirinixic acid 3.2116221962 18467677 19176532 19772884
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D006973 Hypertension Cyclosporine 2.1510903974
MESH:D007248 Infertility, Male decitabine 3.3117581917
MESH:D007333 Insulin Resistance pirinixic acid 2.7416306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007674 Kidney Diseases Acetaminophen 6.1012587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 6.1018776723 10903974 8314463
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.2716705839
MESH:D007680 Kidney Neoplasms Cyclosporine 13.2712371664
MESH:D007680 Kidney Neoplasms Fluorouracil 13.2716985049
MESH:D007938 Leukemia decitabine 3.1519235587 18980019
MESH:D007951 Leukemia, Myeloid decitabine 4.1719117987 18454857 17236224
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.4019387464 17679729 18704418 18460780 18206229 19010910
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.7318055864
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3415474484
MESH:D008107 Liver Diseases Acetaminophen 1.6612587719 12969438 11587558 19460945 16610002 19014921 16611625 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4016871587 17185352
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.7520195826 21137059
MESH:D008113 Liver Neoplasms Fluorouracil 7.7516603448 18383874 17045692 15113037
MESH:D008113 Liver Neoplasms pirinixic acid 7.7520007298 16377806 15890375
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.516695378 18816296 20869020 20464547 17053015 18569708 18520028 20064080 20135361
MESH:D008175 Lung Neoplasms Fluorouracil 2.5115246190
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.0315086387
MESH:D008223 Lymphoma decitabine 3.5419470736
MESH:D008545 Melanoma decitabine 2.2616505122 17785578
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.9716381670
MESH:D009062 Mouth Neoplasms Fluorouracil 8.9716757204 18986760
MESH:D009101 Multiple Myeloma decitabine 3.4618172295
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009190 Myelodysplastic Syndromes decitabine 3.4719010910 16882708 19157545 18608210
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0816411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.0918551238
MESH:D009369 Neoplasms Benzo(a)pyrene 12.5211141357
MESH:D009369 Neoplasms decitabine 12.5219470736 19116145 17925555
MESH:D009369 Neoplasms Fluorouracil 12.5218239605 18600527 16928823
MESH:D009369 Neoplasms pirinixic acid 12.5217405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4419348381 18481113
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5516436463
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.5916049721 12819281
MESH:D010051 Ovarian Neoplasms decitabine 2.6919259094 19331143
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D010190 Pancreatic Neoplasms decitabine 5.6319294695
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.6316500647 16929163 19003803 15113037
MESH:D011230 Precancerous Conditions Cyclosporine 3.3712371664
MESH:D055728 Primary Myelofibrosis decitabine 4.9417616702
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1917292933
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.1918626508 19082440
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1616160472 15538739 18286688 18722050
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D012208 Rhabdomyosarcoma decitabine 4.5919155313
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6418551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4419755658 10029692
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.482093021 20155912
MESH:D013274 Stomach Neoplasms decitabine 3.4819037991
MESH:D013274 Stomach Neoplasms Fluorouracil 3.4818396642 17498489 16424979 18567086 17522103 17172411 19015929 19084572 16951190 15786421
MESH:D013964 Thyroid Neoplasms decitabine 3.4617967635
MESH:D014062 Tongue Neoplasms Fluorouracil 4.1516280240
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.6716049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.6717053015
MESH:D001749 Urinary Bladder Neoplasms decitabine 8.6717616700 19087683
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.5510091137
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.0416803524
MESH:D014604 Uveal Neoplasms decitabine 5.1817785578
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
Pathway ID Pathway Name
REACT:71 Gene Expression
REACT:1675 mRNA Processing
Pharmacogenomics Knowledge Base Top
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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