AutismKB 2.0

Annotation Detail for HNRNPH2


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Basic Information Top
Gene Symbol:HNRNPH2 ( FTP3,HNRPH',HNRPH2,hnRNPH' )
Gene Full Name: heterogeneous nuclear ribonucleoprotein H2 (H')
Band: Xq22.1
Quick LinksEntrez ID:3188; OMIM: 300610; Uniprot ID:HNRH2_HUMAN; ENSEMBL ID: ENSG00000126945; HGNC ID: 5042
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
mRNA Processing
Gene Expression
No data
No data
Pathway IDPathway Name
500866mRNA Splicing - Major Pathway
500655Processing of Capped Intron-Containing Pre-mRNA
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C006632 arsenic trioxide arsenic trioxide results in increased expression of HNRNPH2 mRNAincreases expression 20458559
D002104 Cadmium Cadmium results in decreased expression of HNRNPH2 mRNAdecreases expression 17547211
D019256 Cadmium Chloride Cadmium Chloride results in decreased expression of HNRNPH2 mRNAdecreases expression 17547211
D002857 Chromium Chromium results in decreased expression of HNRNPH2 mRNAdecreases expression 17547211
D003513 Cycloheximide Cycloheximide results in increased expression of HNRNPH2 mRNAincreases expression 19684285
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of HNRNPH2 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of HNRNPH2 mRNAincreases expression 17942748
C011890 kojic acid kojic acid results in increased expression of HNRNPH2 mRNAincreases expression 16595896
D015741 Metribolone Metribolone results in decreased expression of HNRNPH2 proteindecreases expression 17152098
D019800 Phenol Phenol results in decreased expression of HNRNPH2 mRNAdecreases expression 17547211
D011192 Potassium Dichromate Potassium Dichromate results in decreased expression of HNRNPH2 mRNAdecreases expression 17547211
D013629 Tamoxifen Tamoxifen results in increased expression of HNRNPH2 proteinincreases expression 17098229
D013629 Tamoxifen [Tretinoin co-treated with Tamoxifen] results in increased expression of HNRNPH2 proteinaffects cotreatment|increases expression 17098229
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of HNRNPH2 mRNAdecreases expression 19684285
D014212 Tretinoin [Tretinoin co-treated with Tamoxifen] results in increased expression of HNRNPH2 proteinaffects cotreatment|increases expression 17098229
D014212 Tretinoin Tretinoin results in increased expression of HNRNPH2 proteinincreases expression 17098229
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.6814745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9615322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0817505938
MESH:D000230 Adenocarcinoma arsenic trioxide 4.3519825857 11798837
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3514692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4916835633
MESH:D000505 Alopecia Tretinoin 3.6815955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.3715885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.3716412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2816292516
MESH:D001249 Asthma Tretinoin 2.3616456186
MESH:D050197 Atherosclerosis Cadmium 3.6915687053
MESH:D001471 Barrett Esophagus Tretinoin 4.5016935849
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 15.8316206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 15.8312125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 15.8316206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D001859 Bone Neoplasms Phenol 5.2910556009
MESH:D001913 Bowen's Disease Phenol 5.8919293009
MESH:D001943 Breast Neoplasms Chromium 2.0015986119
MESH:D001943 Breast Neoplasms Tamoxifen 2.0019189210 21152245 20135344 19059307 18351453 20065188 20544844 16818667 11161223 21138602 19142967 17242785 19115204 20005174 19189212 19200415 16202921 17440819 19084267 20390343 19221464 18425577 15565566 18821012 17893378 19288272 18815881 19289846 18855134 19487384 19155303 17049068 18629630 16273361 15668708 18997820 19011961 20859285 19103187 16873071 19410462 17261762 18984771 19244106 19066611
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0020435547
MESH:D001943 Breast Neoplasms Tretinoin 2.0016873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.7116813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.4211589617
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.6119066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.2916168501
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.6811135700 16217749 15073043 14691202 15553829
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.6816924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.681917145
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.0119014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.1912490120
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3116051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.6917572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4116120746 18670907 18850075
MESH:D002386 Cataract Tretinoin 3.1417460283
MESH:D002471 Cell Transformation, Neoplastic Cadmium 3.7417332340
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.7116129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2316835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9317110522 16919318 15861022 16105132 17333356 17681005 11677210
MESH:D002822 Choriocarcinoma Tretinoin 5.2916461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.8716354765 15340226 12621046 8697196 15668235
MESH:D002972 Cleft Palate Tretinoin 5.879407595
MESH:D003092 Colitis Tretinoin 3.8117035595
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1317141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.2812609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.8010525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8010048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.8014991402 10589399 8800419 16925845 9664655 17551590 9224671 9125849 9142499 9211117
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.1815213294
MESH:D003711 Demyelinating Diseases Tamoxifen 4.4719031437
MESH:D017449 Dermatitis, Allergic Contact Potassium Dichromate 4.4016823706
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.5519279558
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5520420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4612711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.4015322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 12.4018230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.2612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.2619031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.6119155303 16202921 20544844 17893378
MESH:D016889 Endometrial Neoplasms Tretinoin 7.6116569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.109294722 10568697
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3312903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.0411564622
MESH:D005124 Eye Abnormalities Tretinoin 9.0416938888 9664655
MESH:D005234 Fatty Liver arsenic trioxide 13.6015073043
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.6015345470
MESH:D005234 Fatty Liver Tamoxifen 13.6014986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2816709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.6414745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.3019069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.9720067830
MESH:D005355 Fibrosis Tretinoin 8.9717994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.3616904648
MESH:D005909 Glioblastoma Tretinoin 3.0517312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2416096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.2916084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6711294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 6.679664655 14991402
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0015340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1815340226 16354765 8697196 18606429 16959395
MESH:D006930 Hyperalgesia Tretinoin 3.2816870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.6716778211
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9318850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9116569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5417937319
MESH:D007249 Inflammation Tamoxifen 5.0219457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.0212200463 12878042
MESH:D007410 Intestinal Diseases Tretinoin 3.8717994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.2116580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.2115992940 17551590
MESH:D055623 Keratosis, Actinic Phenol 6.5819293009
MESH:D007674 Kidney Diseases Cadmium 15.0416322080 16962696 16226777
MESH:D007674 Kidney Diseases Cadmium Chloride 15.0416962696
MESH:D007674 Kidney Diseases Chromium 15.0417934191
MESH:D007674 Kidney Diseases Potassium Dichromate 15.0419665454
MESH:D007680 Kidney Neoplasms Tamoxifen 3.1118625569
MESH:D007938 Leukemia arsenic trioxide 6.4715070760
MESH:D007938 Leukemia Tretinoin 6.4717143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.8812560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.4216972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.4914633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 9.7519077051
MESH:D007951 Leukemia, Myeloid Tretinoin 9.7516482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.9316467208 17050201 19850784 16968895 20471514
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.9317596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.8117217047 19035177 11468182 17649720 17869043 12712474 19225113 17712046 16330433 19642359 12679006 9834237 16966277 16112521 11161223 16891316 15336539 15213294 15622746 16823087 15748426 17107899 16331271 19075265 12018890
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.8116891316 19029980 17361223 12679006 16788101 17217047 17294898 17506722 17649720 16766008 17107899 17368321 16823087 17301526 9834237 15748426 19075265 16331271 19035177 19225113 19642359 16935935 17339181 16140955 17712046
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.4516882451
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.369224671
MESH:D008064 Lipidoses Tamoxifen 3.2117567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.4918564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4912878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.4918397230 16248980
MESH:D008113 Liver Neoplasms arsenic trioxide 7.5714682389
MESH:D008113 Liver Neoplasms Tamoxifen 7.5716684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.5716984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 10.2020377131
MESH:D008114 Liver Neoplasms, Experimental kojic acid 10.2018544905
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.2012151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4115213294
MESH:D008175 Lung Neoplasms arsenic trioxide 3.4311798837 19825857
MESH:D008175 Lung Neoplasms Tamoxifen 3.4318625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4311884234 19555203
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.8819428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.6714580682 19196723 11731420 16827153 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.6819453300
MESH:D008527 Medulloblastoma Tretinoin 2.8117453147
MESH:D008545 Melanoma Tamoxifen 3.3319393235 12393984
MESH:D008545 Melanoma Tretinoin 3.3316752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.3015990972
MESH:D008591 Meningomyelocele Tretinoin 4.5316940565
MESH:D009101 Multiple Myeloma arsenic trioxide 3.1619417148 19549372 15949261 14977855 11468182
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.8118349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.5416105982 16882451
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.5417596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.0516624393
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5719393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5419410462
MESH:D009369 Neoplasms Tretinoin 2.4416594593 16946489
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.1319196722 19189210 19200415
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.8314600291
MESH:D009421 Nervous System Malformations Tretinoin 9.839125849
MESH:D009436 Neural Tube Defects arsenic trioxide 7.4710525206
MESH:D009436 Neural Tube Defects Tretinoin 7.479142499
MESH:D010051 Ovarian Neoplasms arsenic trioxide 4.9516624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms Tretinoin 4.9516936753
MESH:D010146 Pain Phenol 7.4717610455
MESH:D010146 Pain Tretinoin 7.4716870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.3815580305
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.3815976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7711578682
MESH:D010235 Paraganglioma arsenic trioxide 4.2519927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D010392 Pemphigus Phenol 6.5816522979 17163923
MESH:D016491 Peripheral Vascular Diseases Cadmium 5.5015687053
MESH:D010864 Pilonidal Sinus Phenol 6.5815622588 19655223
MESH:D011041 Poisoning Phenol 4.808825745
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3111118676 11399792 11222880 11896295
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.6519131511
MESH:D011471 Prostatic Neoplasms Cadmium 2.6517075824
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.6515067354
MESH:D011507 Proteinuria Tretinoin 3.6916636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.4315861022 16919318
MESH:D011625 Pterygium Tretinoin 4.9116723453
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.1916283617 16116481
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.0516646077
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.6816192470
MESH:D012878 Skin Neoplasms Tretinoin 5.6816467112
MESH:D013088 Spermatocele Ethinyl Estradiol 21.0816709447
MESH:D013088 Spermatocele Phenol 21.0818646496
MESH:D013088 Spermatocele Tamoxifen 21.0816709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.1519457130
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.4717007042
MESH:D013274 Stomach Neoplasms Tretinoin 2.4717261132
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.4219014326
MESH:D013964 Thyroid Neoplasms Tretinoin 7.4217045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 3.8616051514
MESH:D016171 Torsades de Pointes arsenic trioxide 4.0815213294
MESH:D014277 Trigeminal Neuralgia Phenol 6.5810223447 16527771
MESH:D014376 Tuberculosis Tretinoin 3.2716040207
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.2020435036 12973940 12845720 11780464
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.2016712894 8653321 17572228
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.7516129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3914692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.7416752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6214671159 15869587
MESH:D014820 Vitiligo Tretinoin 4.1516761959
MESH:D014860 Warts Phenol 6.2319122958
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
MESH:D009396 Wilms Tumor Tretinoin 4.0416287080
Pathway ID Pathway Name
REACT:71 Gene Expression
REACT:1675 mRNA Processing
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA162391316
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

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      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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