AutismKB 2.0

Annotation Detail for HNRNPK


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Basic Information Top
Gene Symbol:HNRNPK ( CSBP,FLJ41122,HNRPK,TUNP )
Gene Full Name: heterogeneous nuclear ribonucleoprotein K
Band: 9q21.32
Quick LinksEntrez ID:3190; OMIM: 600712; Uniprot ID:HNRPK_HUMAN; ENSEMBL ID: ENSG00000165119; HGNC ID: 5044
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03040Spliceosome
Pathway IDPathway Name
mRNA Processing
Gene Expression
No data
No data
Pathway IDPathway Name
500866mRNA Splicing - Major Pathway
500655Processing of Capped Intron-Containing Pre-mRNA
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1934Cancer
2257Hemolytic-Uremic syndrome
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of HNRNPK mRNAaffects expression 16483693
D000643 Ammonium Chloride Ammonium Chloride results in increased expression of HNRNPK mRNAincreases expression 12420312
C006632 arsenic trioxide arsenic trioxide results in decreased expression of HNRNPK proteindecreases expression 19747914
C006632 arsenic trioxide arsenic trioxide results in increased expression of HNRNPK proteinincreases expression 19364129
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of HNRNPK proteindecreases expression 20097212
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of HNRNPK mRNAincreases expression 20127859
C110772 benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [NSC606985 results in decreased expression of HNRNPK protein]decreases expression|decreases reaction 19747914
C072553 benzyloxycarbonylleucyl-leucyl-leucine aldehyde benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [NSC606985 results in decreased expression of HNRNPK protein]decreases expression|decreases reaction 19747914
C072553 benzyloxycarbonylleucyl-leucyl-leucine aldehyde benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [PRKCD protein results in increased ubiquitination of HNRNPK protein]increases reaction|increases ubiquitination 19747914
D003520 Cyclophosphamide Cyclophosphamide results in increased expression of HNRNPK proteinincreases expression 17475930
D004317 Doxorubicin Doxorubicin results in decreased expression of HNRNPK proteindecreases expression 19747914
C514334 NSC606985 benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [NSC606985 results in decreased expression of HNRNPK protein]decreases expression|decreases reaction 19747914
C514334 NSC606985 benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [NSC606985 results in decreased expression of HNRNPK protein]decreases expression|decreases reaction 19747914
C514334 NSC606985 NSC606985 results in decreased expression of HNRNPK proteindecreases expression 19747914
C514334 NSC606985 PRKCD protein affects the reaction [NSC606985 results in decreased expression of HNRNPK protein]affects reaction|decreases expression 19747914
C514334 NSC606985 PRKCD protein affects the reaction [NSC606985 results in increased cleavage of HNRNPK protein]affects reaction|increases cleavage 19747914
C514334 NSC606985 rottlerin inhibits the reaction [NSC606985 results in decreased expression of HNRNPK protein]decreases expression|decreases reaction 19747914
C085746 rottlerin rottlerin inhibits the reaction [NSC606985 results in decreased expression of HNRNPK protein]decreases expression|decreases reaction 19747914
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8418287403
MESH:D000230 Adenocarcinoma arsenic trioxide 7.3919825857 11798837
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.3920127859 20464547
MESH:D000230 Adenocarcinoma Doxorubicin 7.3917418594
MESH:D000236 Adenoma Benzo(a)pyrene 2.766695378
MESH:D000419 Albuminuria Doxorubicin 4.7821441931
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3319183758
MESH:D001161 Arteriosclerosis Cyclophosphamide 4.8615014928
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 3.8816206674
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 5.0214601052
MESH:D001932 Brain Neoplasms Doxorubicin 4.0017150277
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0220146248 17474063
MESH:D001943 Breast Neoplasms Cyclophosphamide 2.0212006526 18234424 15136595 11325840 18323546 17388661 17020986 15093573 16978400
MESH:D001943 Breast Neoplasms Doxorubicin 2.0215668708 19526202 15567936 18628466 11325840 16096432 15692762 16264153 17426702 15136595 16826403 18695136 16115903 15939500 16322301 18382427 16595493 16935488 18234424 17369602 15993339 15994142 15634643 17983394
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5511589617
MESH:D002276 Carcinoid Tumor Doxorubicin 5.1316051944
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.9215553829 16217749 11135700 14691202 15073043
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 4.9219701751
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 4.9216234567 16023760 18059187 17876044
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 5.1716152834
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.1919014326
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 7.1516201981
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 7.1516201981 1485588
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3112490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.8620419170
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 4.866189445
MESH:D009202 Cardiomyopathies Doxorubicin 3.6616651473 16278810 16731534 16242529 17351982 17974986 15476868 17382496 17308081 17924179 16269455 16109756 18627295 17007740 17329180 16612575 16364871 15811867 17131338 15792986 17519947 16952015 17928571 15505089 16455267
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 3.0017334414 16243910
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.6420501625
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.6418802399 18259882
MESH:D023903 Coronary Restenosis arsenic trioxide 4.4212609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D003556 Cystitis Cyclophosphamide 5.3018433785 10700343 12913760 11948286 18093676 18710439 18372110 18295254 10498854 12161096 15643279 12388444 16614059 18483878 15276878 16413132 16989017 16651033 17979934 17010015
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.3215213294
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 4.2410990075 11751995 15331540
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.2718772604
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 2.4917416283
MESH:D004362 Drug Toxicity Doxorubicin 3.8218602426
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.5817359293
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.4718037988
MESH:D004802 Eosinophilia Cyclophosphamide 4.4711006010
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.5912903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5916530937
MESH:D005234 Fatty Liver arsenic trioxide 3.4915073043
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.8719069698
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5016904648
MESH:D005909 Glioblastoma Doxorubicin 3.4717150277
MESH:D018316 Gliosarcoma Cyclophosphamide 5.8011389073
MESH:D006086 Graft vs Host Disease Cyclophosphamide 5.2916376943 11014644 15172196
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.6615692506
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7520471113
MESH:D006331 Heart Diseases Doxorubicin 3.6214766674 16144979 16244372 16707910 16495754 16330681 18006777 18674790 16879835 12587719 17875725 16244371 17888722
MESH:D006333 Heart Failure Doxorubicin 3.4617481944
MESH:D006394 Hemangiosarcoma Doxorubicin 4.1115692506
MESH:D006467 Hemophilia A Cyclophosphamide 5.5511918545
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.8514986274
MESH:D006689 Hodgkin Disease Cyclophosphamide 8.3217606976 16135485
MESH:D006689 Hodgkin Disease Doxorubicin 8.3215147373 17606976 18501091
MESH:D007154 Immune System Diseases Cyclophosphamide 5.6516076520
MESH:D007248 Infertility, Male Cyclophosphamide 3.7516517039 7193160
MESH:D007674 Kidney Diseases Doxorubicin 3.1615369732 15699352 16775033
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.3616707910
MESH:D007938 Leukemia arsenic trioxide 6.9115070760
MESH:D007938 Leukemia Cyclophosphamide 6.9110602166
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.4716085563
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.5717802794 18587576 18172266 17296974 17008537 17658394
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0017077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5916972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 9.1214633726
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 9.1210373061
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.9719077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1616467208 16968895 20471514 19850784 17050201
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3417649720 12018890 16823087 16331271 19075265 15748426 19642359 16966277 17712046 15336539 17107899 17869043 15213294 15622746 16891316 17217047 12712474 16330433 16112521 19225113 9834237 12679006 19035177 11161223 11468182
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5916882451
MESH:D007970 Leukopenia Cyclophosphamide 5.2510052129 11830472
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 2.1516439617 16595196
MESH:D008113 Liver Neoplasms arsenic trioxide 4.7814682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.7820195826 21137059
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.5420377131
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 6.5416842330 17085340
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5115213294
MESH:D008175 Lung Neoplasms arsenic trioxide 3.5911798837 19825857
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.5917053015 20464547 20064080 18816296 20135361 18569708 20869020 18520028 6695378
MESH:D008175 Lung Neoplasms Doxorubicin 3.5917418594 6189445
MESH:D008223 Lymphoma Cyclophosphamide 8.3612854902
MESH:D008223 Lymphoma Doxorubicin 8.3616098063
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 4.8216675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 9.5711911406
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 9.5717654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.8315621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 3.1515458769
MESH:D008545 Melanoma Doxorubicin 2.3116827129
MESH:D008546 Melanoma, Experimental Cyclophosphamide 5.0616388313
MESH:D008654 Mesothelioma Doxorubicin 3.1317638057
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.7015792986
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3516381670
MESH:D052016 Mucositis Doxorubicin 5.0817415656
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2519549372 19417148 11468182 14977855 15949261
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.9918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2516105982 16882451
MESH:D009203 Myocardial Infarction Doxorubicin 3.0219429709 15857846
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2016624393
MESH:D009362 Neoplasm Metastasis Doxorubicin 3.0218259882
MESH:D009369 Neoplasms Benzo(a)pyrene 5.5611141357
MESH:D009369 Neoplasms Cyclophosphamide 5.5618854779
MESH:D009401 Nephrosis Doxorubicin 5.0316636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.1816889571 15640375
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2410525206
MESH:D009447 Neuroblastoma Cyclophosphamide 7.538761367 16115947 15176712
MESH:D009447 Neuroblastoma Doxorubicin 7.5315555623
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 5.178761367 12837982
MESH:D009503 Neutropenia Cyclophosphamide 4.548291058
MESH:D009845 Oligospermia Cyclophosphamide 5.0016517039
MESH:D012516 Osteosarcoma Doxorubicin 4.2815930896
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4619769630 16624393 12452020
MESH:D010146 Pain Cyclophosphamide 3.7918093676 12161096
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.7715580305
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 5.7711332152
MESH:D010235 Paraganglioma arsenic trioxide 4.3819927285
MESH:D003557 Phyllodes Tumor Doxorubicin 5.4717983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.4717638057
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.9121297632
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.0919131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0917292933
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 2.0917136230
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.0918437689 16868541 15897917 15749863 16729912 16888761
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 3.3516636934
MESH:D051437 Renal Insufficiency Doxorubicin 4.4817922066
MESH:D012509 Sarcoma Doxorubicin 4.1815675481 16767912 17203757 15625365 18313854 17710206
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 11.0916646077
MESH:D012512 Sarcoma, Ewing's Doxorubicin 11.0916326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 5.0817846226
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 5.0416636934
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 6.0919755658 10029692
MESH:D012878 Skin Neoplasms Doxorubicin 6.0915692506
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.8317203757 16767912 15625365
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.8016517039
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.4117007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.4120155912 2093021
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 5.3412837982
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.8619014326
MESH:D013964 Thyroid Neoplasms Doxorubicin 7.8617909728 16010429
MESH:D016171 Torsades de Pointes arsenic trioxide 4.2415213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 12.5712973940 20435036 11780464 12845720
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 12.5717053015
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 12.5714692829
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 12.5717653716
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.4817678736 16364871 17334414 17638931
Pathway ID Pathway Name
REACT:71 Gene Expression
REACT:1675 mRNA Processing
KEGG:03040 Spliceosome
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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