AutismKB 2.0

Annotation Detail for ACACB


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Basic Information Top
Gene Symbol:ACACB ( ACC2,ACCB,HACC275 )
Gene Full Name: acetyl-CoA carboxylase beta
Band: 12q24.11
Quick LinksEntrez ID:32; OMIM: 601557; Uniprot ID:ACACB_HUMAN; ENSEMBL ID: ENSG00000076555; HGNC ID: 85
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY0-1264biotin-carboxyl carrier protein assembly
Pathway IDPathway Name
hsa04920Adipocytokine signaling pathway
hsa04910Insulin signaling pathway
hsa00640Propanoate metabolism
hsa01100Metabolic pathways
hsa00061Fatty acid biosynthesis
hsa00620Pyruvate metabolism
Pathway IDPathway Name
Activated AMPK stimulates fatty-acid oxidation in muscle
Metabolism of lipids and lipoproteins
Integration of energy metabolism
No data
No data
Pathway IDPathway Name
500602Import of palmitoyl-CoA into the mitochondrial matrix
500601Activated AMPK stimulates fatty-acid oxidation in muscle
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of ACACB mRNAdecreases expression 18648102
C438505 6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one 6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one results in increased phosphorylation of ACACB proteinincreases phosphorylation 16873680
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of ACACB proteinaffects expression 20106945
C031143 AICA ribonucleotide AICA ribonucleotide results in increased phosphorylation of ACACB proteinincreases phosphorylation 16873680
D013196 Dihydrotestosterone Dihydrotestosterone results in decreased phosphorylation of ACACB proteindecreases phosphorylation 16990341
D000638 Amiodarone Amiodarone results in increased expression of ACACB mRNAincreases expression 19224547
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ACACB mRNAaffects expression 16483693
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ACACB mRNAaffects cotreatment|increases expression 18164116
D001629 Bezafibrate Bezafibrate results in increased expression of ACACB mRNAincreases expression 17118139
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of ACACB mRNAdecreases expression 19224547
D016572 Cyclosporine Cyclosporine results in decreased expression of ACACB mRNAdecreases expression 20106945
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ACACB mRNAaffects cotreatment|increases expression 18164116
D011345 Fenofibrate Fenofibrate results in increased expression of ACACB mRNAincreases expression 17118139
D005632 Fructose Fructose results in decreased expression of ACACB mRNAdecreases expression 18063403
D005632 Fructose Fructose results in increased expression of ACACB mRNAincreases expression 19053045
D008687 Metformin Metformin results in increased phosphorylation of ACACB proteinincreases phosphorylation 16873680
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of ACACB mRNAincreases expression 17681415
C006253 pirinixic acid pirinixic acid results in increased expression of ACACB mRNAincreases expression 17118139
18301758
17426115
C418563 tenofovir disoproxil tenofovir disoproxil affects the expression of ACACB mRNAaffects expression 20032539
D014415 Tunicamycin Tunicamycin results in decreased expression of ACACB mRNAdecreases expression 17127020
D015215 Zidovudine Zidovudine affects the expression of ACACB mRNAaffects expression 20032539
D015032 Zinc Zinc results in increased expression of ACACB mRNAincreases expression 17074742
D019287 Zinc Sulfate Zinc Sulfate results in increased expression of ACACB mRNAincreases expression 17074742
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 10.1818287403
MESH:D000138 Acidosis Zinc Sulfate 10.187265320
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.699612607
MESH:D000169 Acrodermatitis Zinc 5.2717190629 16889938 17202136
MESH:D055371 Acute Lung Injury pirinixic acid 2.9918653653
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 10.783712494
MESH:D000236 Adenoma beta-Naphthoflavone 10.7819389873
MESH:D000236 Adenoma Diethylnitrosamine 10.7810737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.6616434500 19052882 18056438 19061943 17162532 17620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.6616434500
MESH:D000544 Alzheimer Disease Zinc 2.7316410023 16580781 17119284 16325427
MESH:D000755 Anemia, Sickle Cell Zinc 4.7716916123
MESH:D000860 Anoxia Zinc Sulfate 4.897265320
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.6920041841 18057881 18218290
MESH:D001249 Asthma Zinc 2.9217085522
MESH:D001281 Atrial Fibrillation Amiodarone 3.8018651412 19698954
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.8911289319 1440618
MESH:D001778 Blood Coagulation Disorders Amiodarone 8.6819483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.6819483382
MESH:D001930 Brain Injuries Zinc 4.5617109824
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2617474063
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.6516192424 16227642 15721981 18705752 3786805 15673190 16050911 16011737 15700767 16097048 16124888 10355542
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.407296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.4012619106 21507988 12907637
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.4018788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.4020007298 20727157 18785209 18210153 19394651 16569478 11831363 16878318 20935162 19052882 19822196 3084413 16830150 16935385 19701751 20214788 19335982 20514400 21159647 16502159 17978847 18788625 17138121 16328049 17428255 17761372 18506893 18393292 19171122 18494052 16807293 17162532 20084675 19418558 17173139 18691550 19539802 10737359 16288022 19208518 16540662 10672840 16779866 18056438 19519916 18971187 3581430 20432363 20524982 18665156 19919837 20512989 16681979 17055752 18978308 16698587 19383236 19107877 20101231
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.617296757
MESH:D002294 Carcinoma, Squamous Cell Zinc 2.8616543248
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.8519225199 15710769
MESH:D002318 Cardiovascular Diseases Zinc 3.5716936243
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.9518974383
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 10.637505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.6312371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 10.632727394 7505956 17174075 21159647
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.5719052882
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 12.8219486331 9022650
MESH:D002779 Cholestasis Cyclosporine 12.8219486331
MESH:D002779 Cholestasis pirinixic acid 12.8219176532
MESH:D003327 Coronary Disease Fructose 4.3918504504
MESH:D019465 Craniofacial Abnormalities Zinc 2.4219302082
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.6818759878 11906362 12868966 8970840 2524372 11298694 8156756 14531868
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3718249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.373621924 2952479
MESH:D003920 Diabetes Mellitus Metformin 9.5817446233
MESH:D003920 Diabetes Mellitus Zinc 9.5816479319
MESH:D003921 Diabetes Mellitus, Experimental Fructose 4.3818603373
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 7.3520387270
MESH:D003924 Diabetes Mellitus, Type 2 Fructose 7.3518603373
MESH:D003924 Diabetes Mellitus, Type 2 Metformin 7.3521186350
MESH:D003925 Diabetic Angiopathies Metformin 5.8916385087
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 8.681440618 18648102 6679447 6482804 7440962 9022650 9328219 9653073 16192314 11289319 18289764 8291058 18692083
MESH:D056486 Drug-Induced Liver Injury Amiodarone 8.6818218290 15265979
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 8.686623471 4309450 7120509 7179309 19336974 21278145 3786805 10092053 15998439 6884620 3732212 15027814 9327722 2869522 17522070 10915739 15968718 16227642 7440962 19085960 11566570 16177239
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 8.6819107877
MESH:D004362 Drug Toxicity Zidovudine 3.9115040536
MESH:D050171 Dyslipidemias Fenofibrate 4.3316707586
MESH:D004487 Edema perfluorooctanoic acid 6.5917259670 12083418
MESH:D004487 Edema pirinixic acid 6.5912083418
MESH:D016889 Endometrial Neoplasms Fenofibrate 4.0016569247
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9916302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.563581430
MESH:D004938 Esophageal Neoplasms Zinc 4.5616543248
MESH:D005234 Fatty Liver Amiodarone 35.1514986274
MESH:D005234 Fatty Liver Carbon Tetrachloride 35.1515959796 19224547 16045604 12631006 16239168 12795759 17595544 61145
MESH:D005234 Fatty Liver Cyclosporine 35.1519224547
MESH:D005234 Fatty Liver Diethylnitrosamine 35.1520387270 21071580
MESH:D005234 Fatty Liver Fructose 35.1518395287 19196556 18641190
MESH:D005234 Fatty Liver pirinixic acid 35.1519236843 20131406
MESH:D005234 Fatty Liver Zidovudine 35.1518299183
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.896705139
MESH:D005355 Fibrosis Carbon Tetrachloride 14.1918705752
MESH:D005355 Fibrosis Cyclosporine 14.1912639820 12168785
MESH:D005355 Fibrosis Fructose 14.1918504504
MESH:D005756 Gastritis Zinc 4.6717241300
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.098708960
MESH:D018149 Glucose Intolerance Fructose 5.2019165636
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.917505956
MESH:D006130 Growth Disorders Zinc 3.8817217573
MESH:D006333 Heart Failure pirinixic acid 6.8820558911
MESH:D006333 Heart Failure Zinc 6.8817162251
MESH:D006335 Heart Injuries Zinc 5.6417074742
MESH:D016481 Helicobacter Infections Zinc 4.4117241300
MESH:D006402 Hematologic Diseases Zidovudine 4.5912579204
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2915720958
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 8.806705139
MESH:D006505 Hepatitis Carbon Tetrachloride 8.8019900420 19110552
MESH:D006527 Hepatolenticular Degeneration Zinc 10.8817276780
MESH:D006527 Hepatolenticular Degeneration Zinc Sulfate 10.8817063115
MESH:D006529 Hepatomegaly Amiodarone 13.8315265979
MESH:D006529 Hepatomegaly perfluorooctanoic acid 13.833609246
MESH:D006529 Hepatomegaly pirinixic acid 13.8319176532 16221962 19772884 18467677
MESH:D015658 HIV Infections tenofovir disoproxil 7.4220032539
MESH:D015658 HIV Infections Zidovudine 7.4220032539 11363243 11698656 17358032 11141242
MESH:D006930 Hyperalgesia perfluorooctanoic acid 3.7512083418
MESH:D017588 Hyperandrogenism Metformin 5.8617062894 15356085
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.4016899240
MESH:D006937 Hypercholesterolemia Amiodarone 3.759751232 8137927
MESH:D006943 Hyperglycemia pirinixic acid 3.0720558911
MESH:D006946 Hyperinsulinism Fructose 4.7818563319 14757778 15752949 19008412 18360027
MESH:D006949 Hyperlipidemias Fructose 4.6315752949
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.8115034207
MESH:D006973 Hypertension Cyclosporine 5.4110903974
MESH:D006973 Hypertension Fructose 5.4116843071 19008412 14633139 14568997 14573337
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9615338365
MESH:D015228 Hypertriglyceridemia Fructose 4.9619342510 19799862
MESH:D007022 Hypotension Zinc Sulfate 4.357265320
MESH:D007037 Hypothyroidism Amiodarone 4.3818020914 17991464
MESH:D007249 Inflammation Diethylnitrosamine 5.1218785209
MESH:D007249 Inflammation perfluorooctanoic acid 5.1212083418
MESH:D007333 Insulin Resistance Fructose 12.2018563319 14757778 19008412 19342510 14633139 17133782 14573337 18981581 19586609 19799862 18057795
MESH:D007333 Insulin Resistance Metformin 12.2017062894
MESH:D007333 Insulin Resistance pirinixic acid 12.2016306350
MESH:D007511 Ischemia Zinc 4.5016584753
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.898074119 9022650
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3115604871
MESH:D007674 Kidney Diseases Cyclosporine 5.968314463 10903974 18776723
MESH:D007674 Kidney Diseases Zinc 5.9616960431
MESH:D007676 Kidney Failure, Chronic Zinc 4.3016518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 11.856582329
MESH:D007680 Kidney Neoplasms Cyclosporine 11.8512371664
MESH:D007680 Kidney Neoplasms Zidovudine 11.8512579204
MESH:D016773 Leishmaniasis, Cutaneous Zinc Sulfate 4.1515237267
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.2920370541
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 5.108812269
MESH:D008064 Lipidoses Amiodarone 3.4215342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.3717157831 21278145 16221502 17334410 17174718 11408273 11903743 16239168 16943688
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.3720032147 18407596 19638242 18665156 18522880
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.1115034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5118279442 18317297 16027843 15931870 18210741 17922224 16192424 15959796 17805973 12609069 17766677 17944888 12445421 16116963 18156304 18472332 17708605 14724832 15338365 18277467 12632512 17481882 15673190 12649538 18339082 12586293 15362042 16638106 13678700 15052691 15730626 16097048 15123356 14716833 17631135 20821823 18429990 18705752 17761835 17565644 18187930 18420326 17721639 17900296 17640975 17976157 12667390 11481614 17525996 16011737 12632514 18472094 18205269 18166357 10355542 15996030 15876570 12958196 16248980 15893842 18418968 15650968 15925388 15057751 14620537 12741479 18006644 14748882 17557913 16033810 18395914 17869086 12898905 18481824 18054572 16136751 16015684 18395095 12445418 18263696 18251166 18376398 17714472 12546737 14716496 15818738 18412020 14512876 15370692 12666154 17823541 12389079 17698563
MESH:D008106 Liver Cirrhosis, Experimental Fenofibrate 3.5115474484
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5115474484
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.9615830285 17285989 15720792 16964402 16246199
MESH:D008107 Liver Diseases Diethylnitrosamine 3.9617034775
MESH:D017093 Liver Failure Carbon Tetrachloride 4.0315123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.5714706259 16899240
MESH:D008113 Liver Neoplasms Aflatoxin B1 21.1615890375 9163691 2125692 18177683
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 21.1619389873 21295105
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 21.1619294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 21.1619090486 18754104 15885732 18644402 19254457 19294768 20501860 19812893 20118626 20452335 2422723 18977376 15175105 19073162 19850985 19833225 21071580 20137499 20434301 19256749 2862719 20492335 19642983 20405173 20101389 19499222 21167192 21278145 18978307 19427195 19551842 19638242 18648771 10737359 19996281 16942905 19426721 19255062 21047994 19690152 12112319 9163691 20583210 12771043
MESH:D008113 Liver Neoplasms Fenofibrate 21.1618978307
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 21.1618709148 14757943
MESH:D008113 Liver Neoplasms pirinixic acid 21.1615890375 20007298 16377806
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 22.331399818 3712494 6587162 598648
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 22.338603461
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 22.3318164116
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 22.3312014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 22.3317942915 19539802 19519916 18775883 19126423 18544905 18093689 16267830 18282651 18079962 18253720 19009564 18164116 19004024 3124819 21159647 9362446 17854601 16842330 18308698 17174075 2563599
MESH:D008114 Liver Neoplasms, Experimental Fenofibrate 22.3318253720 18775883
MESH:D008133 Long QT Syndrome Amiodarone 3.4815350150 11989578 17391786
MESH:D008171 Lung Diseases Amiodarone 3.2912587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.3518516814
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.4714755239
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.4721163286 20970405 6695378 20512841
MESH:D008175 Lung Neoplasms Zidovudine 3.4718800350
MESH:D008325 Mammary Neoplasms, Experimental Zinc 3.2112773700
MESH:D024821 Metabolic Syndrome X Fructose 4.7117261469 19165636 17098227 18497449 16815490
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6616801185
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.7117358032
MESH:D009135 Muscular Diseases Bezafibrate 10.3016239165
MESH:D009135 Muscular Diseases pirinixic acid 10.3016239165
MESH:D009181 Mycoses Amiodarone 4.7712754197 17974566
MESH:D009203 Myocardial Infarction pirinixic acid 2.0919151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8416411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.533581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.533581430 9029167
MESH:D009369 Neoplasms pirinixic acid 1.8917405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1719348381 18481113
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.836679447
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.2320387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9920387270
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 4.829802331
MESH:D009765 Obesity Fructose 4.7417707055 18585860
MESH:D009765 Obesity pirinixic acid 4.7420558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.304026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.893988306
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.3816540662
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.357296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.346228378
MESH:D011085 Polycystic Ovary Syndrome Metformin 5.4215356085 17062894
MESH:D011230 Precancerous Conditions Cyclosporine 8.5712371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.572563599
MESH:D011225 Pre-Eclampsia Zinc 4.0717114810
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 4.2717132714
MESH:D011471 Prostatic Neoplasms Zinc 3.8616606632 12429649 16700911 16517595
MESH:D011565 Psoriasis Cyclosporine 2.1816882103
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.8011597910 12832656 12490602
MESH:D015427 Reperfusion Injury pirinixic acid 2.3219058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 8.683692021
MESH:D012162 Retinal Degeneration Zinc 8.6816584753
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.9518724381
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.6418456281
MESH:D013274 Stomach Neoplasms Zidovudine 2.6417696246
MESH:D013276 Stomach Ulcer Amiodarone 3.2018087811
MESH:D013610 Tachycardia Amiodarone 4.1611238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.0619225199
MESH:D013959 Thyroid Diseases Amiodarone 4.6319731979
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 6.797505956 1399818 6587162 6582329 3712494
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 6.797505956
MESH:D013971 Thyrotoxicosis Amiodarone 4.7318020914 19584973
MESH:D014062 Tongue Neoplasms Zinc 4.2816543248
MESH:D016171 Torsades de Pointes Amiodarone 4.0617467628 11989578
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.238074119
MESH:D014605 Uveitis Cyclosporine 3.851336536
MESH:D014625 Vaginal Neoplasms Zidovudine 4.6312579204
MESH:D014985 Xerophthalmia Cyclosporine 4.3117120751
Pathway ID Pathway Name
REACT:11163 Activated AMPK stimulates fatty-acid oxidation in muscle
KEGG:04920 Adipocytokine signaling pathway
KEGG:00061 Fatty acid biosynthesis
KEGG:04910 Insulin signaling pathway
REACT:1505 Integration of energy metabolism
KEGG:01100 Metabolic pathways
REACT:22258 Metabolism of lipids and lipoproteins
KEGG:00640 Propanoate metabolism
KEGG:00620 Pyruvate metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24422
    • No data
    Releated disease ID Related disease Name
    PA444516Hypercholesterolemia
    Releated drug ID Related drug Name
    PA133950441hmg coa reductase inhibitors
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00121 - Biotin Dietary supplement;Micronutrient;Vitamins (Vitamin B Complex);Vitamin B Complex
    DB00173 - Adenine Dietary supplement;Micronutrient
    DB02859 - Soraphen A
    DB03781 - 2-[4-(2,4-Dichlorophenoxy)Phenoxy]Propanoic Acid
    DB07870 - (2S)-2-(4-{[3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDIN-2-YL]OXY}PHENOXY)PROPANOIC ACID
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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