Annotation Detail for HPCA
Basic Information
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| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| D000643 |
Ammonium Chloride |
Ammonium Chloride affects the expression of HPCA mRNA | affects expression | 16483693
|
| C006632 |
arsenic trioxide |
arsenic trioxide results in decreased expression of HPCA mRNA | decreases expression | 20458559
|
| D002118 |
Calcium |
HPCA protein results in decreased susceptibility to Calcium | decreases response to substance | 12445469
|
| D002118 |
Calcium |
Calcium binds to HPCA protein | affects binding | 15607944
|
| D002118 |
Calcium |
Calcium promotes the reaction [NAIP protein binds to HPCA protein] | affects binding|increases reaction | 10899114
|
| D002118 |
Calcium |
HPCA protein results in decreased susceptibility to Calcium | decreases response to substance | 10899114
|
| D007608 |
Kainic Acid |
HPCA protein results in decreased susceptibility to Kainic Acid | decreases response to substance | 15607944
|
| C025299 |
polyphenols |
polyphenols results in decreased expression of HPCA mRNA | decreases expression | 16293270
|
| D019284 |
Thapsigargin |
HPCA protein results in decreased susceptibility to Thapsigargin | decreases response to substance | 15607944
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D000138 |
Acidosis |
|
Ammonium Chloride |
4.02 | 18287403 |
| MESH:D000230 |
Adenocarcinoma |
|
arsenic trioxide |
2.34 | 19825857 11798837 |
| MESH:D001778 |
Blood Coagulation Disorders |
|
arsenic trioxide |
4.00 | 16206674 |
| MESH:D002051 |
Burkitt Lymphoma |
|
arsenic trioxide |
4.68 | 11589617 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
arsenic trioxide |
1.97 | 15073043 14691202 15553829 16217749 11135700 |
| MESH:D002291 |
Carcinoma, Papillary |
|
arsenic trioxide |
5.40 | 19014326 |
| MESH:D018288 |
Carcinoma, Small Cell |
|
arsenic trioxide |
4.42 | 12490120 |
| MESH:D003110 |
Colonic Neoplasms |
|
polyphenols |
2.71 | 16293270 |
| MESH:D015179 |
Colorectal Neoplasms |
|
arsenic trioxide |
1.86 | 20501625 |
| MESH:D023903 |
Coronary Restenosis |
|
arsenic trioxide |
4.57 | 12609071 |
| MESH:D019465 |
Craniofacial Abnormalities |
|
arsenic trioxide |
1.89 | 10525206 |
| MESH:D016757 |
Death, Sudden, Cardiac |
|
arsenic trioxide |
4.45 | 15213294 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
polyphenols |
2.81 | 19370779 |
| MESH:D004938 |
Esophageal Neoplasms |
|
arsenic trioxide |
2.37 | 12903497 |
| MESH:D005234 |
Fatty Liver |
|
arsenic trioxide |
3.61 | 15073043 |
| MESH:D005706 |
Gallbladder Neoplasms |
|
arsenic trioxide |
4.64 | 16904648 |
| MESH:D007249 |
Inflammation |
|
polyphenols |
3.20 | 16366677 |
| MESH:D007683 |
Kidney Tubular Necrosis, Acute |
|
Calcium |
5.57 | 16316344 |
| MESH:D007938 |
Leukemia |
|
arsenic trioxide |
2.96 | 15070760 |
| MESH:D015459 |
Leukemia-Lymphoma, Adult T-Cell |
|
arsenic trioxide |
4.12 | 17077332 12560223 |
| MESH:D007948 |
Leukemia, Monocytic, Acute |
|
arsenic trioxide |
4.77 | 16972261 |
| MESH:D015464 |
Leukemia, Myelogenous, Chronic, BCR-ABL Positive |
|
arsenic trioxide |
3.66 | 14633726 |
| MESH:D007951 |
Leukemia, Myeloid |
|
arsenic trioxide |
4.09 | 19077051 |
| MESH:D015470 |
Leukemia, Myeloid, Acute |
|
arsenic trioxide |
2.18 | 16467208 16968895 19850784 17050201 20471514 |
| MESH:D015473 |
Leukemia, Promyelocytic, Acute |
|
arsenic trioxide |
3.41 | 17217047 16966277 15336539 19225113 12018890 15622746 17107899 15748426 16112521 16331271 19642359 17869043 19075265 11161223 16891316 16330433 12712474 12679006 16823087 11468182 9834237 19035177 17712046 15213294 17649720 |
| MESH:D015458 |
Leukemia, T-Cell |
|
arsenic trioxide |
4.73 | 16882451 |
| MESH:D008107 |
Liver Diseases |
|
polyphenols |
2.84 | 16698588 |
| MESH:D008113 |
Liver Neoplasms |
|
arsenic trioxide |
2.43 | 14682389 |
| MESH:D008114 |
Liver Neoplasms, Experimental |
|
arsenic trioxide |
2.91 | 20377131 |
| MESH:D008133 |
Long QT Syndrome |
|
arsenic trioxide |
3.59 | 15213294 |
| MESH:D008175 |
Lung Neoplasms |
|
arsenic trioxide |
1.87 | 11798837 19825857 |
| MESH:D009101 |
Multiple Myeloma |
|
arsenic trioxide |
3.32 | 11468182 19417148 19549372 15949261 14977855 |
| MESH:D009182 |
Mycosis Fungoides |
|
arsenic trioxide |
5.19 | 18349030 |
| MESH:D009190 |
Myelodysplastic Syndromes |
|
arsenic trioxide |
3.30 | 16105982 16882451 |
| MESH:D009361 |
Neoplasm Invasiveness |
|
arsenic trioxide |
4.34 | 16624393 |
| MESH:D009436 |
Neural Tube Defects |
|
arsenic trioxide |
3.31 | 10525206 |
| MESH:D010024 |
Osteoporosis |
|
Calcium |
3.96 | 17882678 |
| MESH:D010051 |
Ovarian Neoplasms |
|
arsenic trioxide |
2.48 | 19769630 16624393 12452020 |
| MESH:D010190 |
Pancreatic Neoplasms |
|
arsenic trioxide |
2.61 | 15580305 |
| MESH:D010235 |
Paraganglioma |
|
arsenic trioxide |
4.51 | 19927285 |
| MESH:D011471 |
Prostatic Neoplasms |
|
arsenic trioxide |
3.22 | 19131511 |
| MESH:D012512 |
Sarcoma, Ewing's |
|
arsenic trioxide |
4.34 | 16646077 |
| MESH:D012640 |
Seizures |
|
Kainic Acid |
4.57 | 17827730 1641125 10686065 16336964 15686955 14637104 18657176 19414003 19186208 |
| MESH:D012893 |
Sleep Disorders |
|
Kainic Acid |
6.16 | 19414003 |
| MESH:D013274 |
Stomach Neoplasms |
|
arsenic trioxide |
1.86 | 17007042 |
| MESH:D013705 |
Temporomandibular Joint Disorders |
|
polyphenols |
5.77 | 17997062 |
| MESH:D013964 |
Thyroid Neoplasms |
|
arsenic trioxide |
3.32 | 19014326 |
| MESH:D016171 |
Torsades de Pointes |
|
arsenic trioxide |
4.42 | 15213294 |
| MESH:D001749 |
Urinary Bladder Neoplasms |
|
arsenic trioxide |
2.58 | 11780464 20435036 12973940 12845720 |
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