AutismKB 2.0

Annotation Detail for APBB1


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Basic Information Top
Gene Symbol:APBB1 ( FE65,MGC:9072,RIR )
Gene Full Name: amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
Band: 11p15.4
Quick LinksEntrez ID:322; OMIM: 602709; Uniprot ID:APBB1_HUMAN; ENSEMBL ID: ENSG00000166313; HGNC ID: 581
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05010Alzheimer's disease
No data
No data
Pathway IDPathway Name
P00003Alzheimer disease-amyloid secretase pathway
P00004Alzheimer disease-presenilin pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2046Polymyositis
Desease Name
Alzheimer's disease
NEUROLOGICAL
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of APBB1 mRNAaffects expression 16483693
D001151 Arsenic Arsenic affects the expression of APBB1 mRNAaffects expression 18414638
C006632 arsenic trioxide arsenic trioxide results in decreased expression of APBB1 mRNAdecreases expression 19128835
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of APBB1 mRNAdecreases expression 17484886
C044101 endotoxin, Escherichia coli endotoxin, Escherichia coli results in increased expression of APBB1 mRNAincreases expression 15919760
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of APBB1 mRNAincreases expression 15919760
D014501 Uranium Uranium affects the expression of APBB1 mRNAaffects expression 15672453
C005460 uranyl acetate uranyl acetate affects the expression of APBB1 mRNAaffects expression 15672453
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.9018287403
MESH:D055371 Acute Lung Injury Lipopolysaccharides 4.2918653653 11850527
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3311798837 19825857
MESH:D018246 Adrenocortical Adenoma Arsenic 5.5917306315
MESH:D020261 Arsenic Poisoning Arsenic 2.9218414634 16835338 16251483 12569548
MESH:D050197 Atherosclerosis Arsenic 3.3812928151 19371607
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 3.9116206674
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5911589617
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.0816011737 3786805 16124888 16050911 18705752 15700767 16097048 16227642 15721981 16192424 10355542 15673190
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.7117687452 15504454
MESH:D006528 Carcinoma, Hepatocellular Arsenic 4.8417306315 16507464
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.8415553829 14691202 15073043 11135700 16217749
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.8418788625
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.2519014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3512490120
MESH:D002294 Carcinoma, Squamous Cell Arsenic 2.7418922899 15504454 17687452
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.3018640142
MESH:D002318 Cardiovascular Diseases Arsenic 3.6117938729 15738583 19152805
MESH:D002340 Carotid Artery Diseases Arsenic 4.5218022660 16973168
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.4712609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.3615213294
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 2.0915027814 6884620 3732212 2869522 6623471 10092053 7179309 10915739 19336974 7440962 15998439 21278145 7120509 16177239 11566570 19085960 16227642 15968718 17522070 4309450 9327722 3786805
MESH:D019446 Endotoxemia endotoxin, Escherichia coli 12.2018509659 17637181
MESH:D019446 Endotoxemia Lipopolysaccharides 12.2015821434 15328337 17637181
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3612903497
MESH:D005234 Fatty Liver arsenic trioxide 8.6915073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.6912795759 17595544 15959796 16239168 61145 19224547 16045604 12631006
MESH:D005334 Fever endotoxin, Escherichia coli 10.5216997862
MESH:D005334 Fever Lipopolysaccharides 10.529205823 11852909
MESH:D005355 Fibrosis Carbon Tetrachloride 3.7618705752
MESH:D005534 Foot Diseases Arsenic 5.946392382
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5416904648
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.6116366002
MESH:D006505 Hepatitis Carbon Tetrachloride 3.8819110552 19900420
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8716899240
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.6817050553
MESH:D006973 Hypertension Arsenic 2.949931084 11953799 16076760
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3915338365
MESH:D006987 Hypesthesia Arsenic 5.9416093927
MESH:D007249 Inflammation Lipopolysaccharides 2.9817237260 17963957 9205823 17255318 12878042
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.8917255318
MESH:D007642 Keratosis Arsenic 5.3312749816 16930632
MESH:D007938 Leukemia arsenic trioxide 2.9315070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0412560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.6416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6014633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.0019077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1720471514 19850784 17050201 16467208 16968895
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 8.2817339181
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 8.2816966277 12712474 16891316 17712046 17649720 17107899 16823087 16330433 11161223 15748426 15622746 15336539 15213294 16331271 19225113 9834237 17869043 19035177 12018890 19642359 17217047 16112521 12679006 11468182 19075265
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.6316882451
MESH:D007970 Leukopenia Lipopolysaccharides 5.0315821434
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9216943688 17157831 16239168 17334410 21278145 11903743 16221502 11408273 17174718
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.7215650968 18251166 15931870 16136751 12389079 16192424 15893842 15996030 16015684 12546737 12666154 17869086 17565644 17761835 14512876 12632514 18054572 18339082 15925388 17631135 18317297 18412020 14716496 15123356 12445418 15338365 17823541 18187930 15370692 12649538 16116963 17481882 18006644 18277467 14620537 15730626 15052691 17708605 17922224 12586293 17698563 15818738 16638106 18472332 17976157 17557913 12609069 12632512 18395095 18376398 18166357 16248980 18418968 18395914 12667390 17805973 17525996 17714472 20821823 12741479 17640975 18210741 12445421 17766677 18420326 15673190 15876570 18472094 11481614 12898905 16027843 14748882 18156304 15362042 18429990 12958196 15959796 14716833 18263696 18481824 17900296 15057751 18705752 16097048 17721639 10355542 16033810 18279442 14724832 18205269 13678700 17944888 16011737
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 2.7212878042
MESH:D008107 Liver Diseases Arsenic 4.4111134558
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.4115720792 16246199 15830285 17285989 16964402
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4715123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.9216899240 14706259
MESH:D008113 Liver Neoplasms Arsenic 8.0016368122
MESH:D008113 Liver Neoplasms arsenic trioxide 8.0014682389
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 8.0019294768
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.4620377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.4615583823 12014681
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5315213294
MESH:D055370 Lung Injury Lipopolysaccharides 4.3121114838
MESH:D008175 Lung Neoplasms Arsenic 2.7117976673 19168569 17306315
MESH:D008175 Lung Neoplasms arsenic trioxide 2.7119825857 11798837
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2719549372 15949261 14977855 19417148 11468182
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.0518349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2616105982 16882451
MESH:D017202 Myocardial Ischemia Arsenic 4.1815371236
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2416624393
MESH:D009436 Neural Tube Defects Arsenic 7.9416620997
MESH:D009436 Neural Tube Defects arsenic trioxide 7.9410525206
MESH:D020078 Neurogenic Inflammation Arsenic 4.6417056641
MESH:D010051 Ovarian Neoplasms Arsenic 5.2317306315
MESH:D010051 Ovarian Neoplasms arsenic trioxide 5.2319769630 12452020 16624393
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5915580305
MESH:D010235 Paraganglioma arsenic trioxide 4.4219927285
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.4616093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.3316905509 6392382 15371236
MESH:D011014 Pneumonia Lipopolysaccharides 4.8912224865 11605937
MESH:D011471 Prostatic Neoplasms Arsenic 3.3616140617
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.3619131511
MESH:D011507 Proteinuria Arsenic 4.2621343184
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.8810835634
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2416646077
MESH:D012772 Shock, Septic endotoxin, Escherichia coli 5.9718063050
MESH:D012871 Skin Diseases Arsenic 2.8017548696 16759981 17938729 16702368 17453740 16353154 15952646 19834688 17050553 6392382 18709164
MESH:D012878 Skin Neoplasms Arsenic 3.1017029826 19538983 17976673 17050553 16251483 15504454
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.3915821434
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.2719014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.3015213294
MESH:D001749 Urinary Bladder Neoplasms Arsenic 5.5517306315 17976673 19322015 15987713 11144890 18640142 19429237
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.5520435036 12973940 11780464 12845720
MESH:D014652 Vascular Diseases Arsenic 5.0717056641
Pathway ID Pathway Name
KEGG:05010 Alzheimer's disease
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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