AutismKB 2.0

Annotation Detail for APBB2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:APBB2 ( DKFZp434E033,FE65L,FE65L1,MGC35575 )
Gene Full Name: amyloid beta (A4) precursor protein-binding, family B, member 2
Band: 4p14-p13
Quick LinksEntrez ID:323; OMIM: 602710; Uniprot ID:APBB2_HUMAN; ENSEMBL ID: ENSG00000163697; HGNC ID: 582
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
No data
No data
Pathway IDPathway Name
P00004Alzheimer disease-presenilin pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1740Alzheimer's disease
No data
No data
Desease Name
Alzheimer disease, late-onset
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of APBB2 mRNAincreases expression 19933214
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of APBB2 mRNAdecreases expression 20064835
20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of APBB2 mRNAdecreases expression 20382639
19150397
C006780 bisphenol A bisphenol A affects the expression of APBB2 mRNAaffects expression 20170705
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of APBB2 mRNAaffects expression 17484886
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of APBB2 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of APBB2 mRNAaffects cotreatment|increases expression 17942748
D005472 Fluorouracil APBB2 protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of APBB2 mRNAincreases expression 20106945
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of APBB2 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of APBB2 mRNAincreases expression 19933214
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of APBB2 mRNAincreases expression 18796159
D014810 Vitamin E Vitamin E results in decreased expression of APBB2 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1314514962 15322242 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2617505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.3120127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.3114692618
MESH:D000230 Adenocarcinoma Fluorouracil 7.3117638652
MESH:D000236 Adenoma Benzo(a)pyrene 2.766695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6616835633
MESH:D000544 Alzheimer Disease marker/mechanism
MESH:D000740 Anemia Fluorouracil 9.3315504547 16511603 17963324
MESH:D000740 Anemia Tetrachlorodibenzodioxin 9.3311748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3319183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7815885639
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D001862 Bone Resorption bisphenol A 4.0711985600
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9720146248 17474063
MESH:D001943 Breast Neoplasms bisphenol A 1.9717123778
MESH:D001943 Breast Neoplasms Fluorouracil 1.9718357371 15136595 16110121 18608205 16595493 16557594 19217205
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9720435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 10.8118705752 16192424 16097048 16050911 10355542 15721981 16124888 16227642 16011737 15673190 3786805 15700767
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 10.8116050911
MESH:D002276 Carcinoid Tumor Fluorouracil 4.9916051944
MESH:D002277 Carcinoma Fluorouracil 8.7417121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.7416835633
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.1918788625
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 3.1916332177 17088986 17045692 17971768 16799960 18930000
MESH:D002278 Carcinoma in Situ bisphenol A 5.2717123778
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.1018695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.8120419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.8116757204 17066447 18986760 16280240
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4718850075 18670907 16120746
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.8620889678
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0217110522 17681005 17333356 16919318 11677210 16105132 15861022
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1815340226 12621046 8697196 15668235 16354765
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2617287894 16340194 17016597 17169374 17018589 16510598 18772588 17725105 17172411 15001691
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0017401013 18949393 20501625 18288408 18509181 18448328 17454858 16391804 16524972 17016601 17255274 15289873 16331619 17594712 16303861 17695437 17094418 16282729 15148649 18802399 18383874 14970324
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5315322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.5319769572
MESH:D007644 Darier Disease Fluorouracil 5.0816733453
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.8916177239 10092053 19336974 21278145 11566570 3732212 6623471 15027814 3786805 7179309 7440962 6884620 15998439 10915739 7120509 2869522 19085960 9327722 15968718 16227642 17522070 4309450
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:C538011 Eales disease Vitamin E 5.029068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2218230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.4212538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.219294722 10568697
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.5020426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.5016530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 7.5016337965 16481741 17638652 15173087 16785472
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.3916239168 61145 17595544 19224547 15959796 16045604 12631006 12795759
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.3915345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005355 Fibrosis Carbon Tetrachloride 9.4718705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.4720067830
MESH:D005910 Glioma Fluorouracil 2.9416145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.5218337622 15162350 15102660
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 11.6820471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.6811294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 11.6816080930
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.8319900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1512621046 15340226 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7616490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.2914716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3616959395 8697196 16354765 15340226 18606429
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8216899240
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9718670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3515338365
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0716945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6217937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9512200463 12878042
MESH:D007251 Influenza, Human Vitamin E 4.5316624496
MESH:D007333 Insulin Resistance bisphenol A 3.4116393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007674 Kidney Diseases Vitamin E 2.9112488133
MESH:D007680 Kidney Neoplasms Fluorouracil 3.4816985049
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9111408273 11903743 17174718 16239168 17334410 16943688 21278145 17157831 16221502
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5712389079 12741479 17823541 18210741 14620537 18429990 18277467 16248980 16015684 18376398 17900296 12546737 17708605 15996030 16097048 12586293 17869086 15673190 15052691 17721639 18472094 18412020 15370692 12898905 18472332 10355542 17698563 18279442 14716833 16027843 15959796 17714472 12649538 17557913 17922224 18395914 14748882 12632514 12609069 15730626 16033810 18205269 18395095 17805973 14512876 15338365 17481882 15123356 18251166 17640975 17761835 11481614 15925388 15362042 16136751 18418968 18263696 18481824 14716496 18339082 18420326 12445421 16638106 18156304 18006644 18187930 12666154 18166357 17976157 16116963 18054572 18705752 15931870 15057751 12445418 15876570 15818738 17525996 18317297 17944888 16192424 12632512 17631135 17565644 12958196 16011737 15650968 12667390 15893842 14724832 13678700 17766677 20821823
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5712878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.5716169303
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1215720792 17285989 16246199 16964402 15830285
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4215123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.8814706259 16899240
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.2721137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 11.2719294768
MESH:D008113 Liver Neoplasms Fluorouracil 11.2716603448 17045692 15113037 18383874
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.2716984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.1612014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.1612151625
MESH:D008171 Lung Diseases Vitamin E 3.3116863852
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 5.0018816296 20064080 20464547 20869020 18520028 18569708 17053015 6695378 20135361
MESH:D008175 Lung Neoplasms Fluorouracil 5.0015246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 5.0019555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 5.0011062179
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.0815086387
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 9.0616381670
MESH:D009062 Mouth Neoplasms Fluorouracil 9.0616757204 18986760
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D009369 Neoplasms Benzo(a)pyrene 5.3711141357
MESH:D009369 Neoplasms Fluorouracil 5.3716928823 18600527 18239605
MESH:D009421 Nervous System Malformations bisphenol A 10.3911399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.3914600291
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5716436463
MESH:D010049 Ovarian Diseases bisphenol A 5.2711985600
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7216929163 15113037 19003803 16500647
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9111578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 10.4810548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.4811896295 11222880 11118676 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.4120887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0617292933
MESH:D011471 Prostatic Neoplasms bisphenol A 2.0616740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.0619082440 18626508
MESH:D011471 Prostatic Neoplasms Vitamin E 2.0615084515
MESH:D011537 Pruritus Ethinyl Estradiol 3.6016919318 15861022
MESH:D011629 Puberty, Precocious bisphenol A 5.0710548101
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1918722050 15538739 16160472 18286688
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012871 Skin Diseases Vitamin E 2.4818709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.7610029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7616192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2616709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.462093021 20155912
MESH:D013274 Stomach Neoplasms Fluorouracil 2.4618567086 17522103 17172411 16424979 19015929 17498489 19084572 16951190 15786421 18396642
MESH:D020521 Stroke Vitamin E 3.6816517955
MESH:D019966 Substance-Related Disorders bisphenol A 4.2716684133 16045194
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D014062 Tongue Neoplasms Fluorouracil 4.1816280240
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2417053015
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.0716803524
MESH:D014591 Uterine Diseases bisphenol A 5.3314652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5414692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7515869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24874
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved