AutismKB 2.0

Annotation Detail for HOXD3


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:HOXD3 ( HOX1D,HOX4,HOX4A,Hox-4.1,MGC10470 )
Gene Full Name: homeobox D3
Band: 2q31.1
Quick LinksEntrez ID:3232; OMIM: 142980; Uniprot ID:HXD3_HUMAN; ENSEMBL ID: ENSG00000128652; HGNC ID: 5137
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1770Melanoma
2051Leukemia
2150Duane retraction syndrome
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of HOXD3 mRNAdecreases expression 18648102
D000643 Ammonium Chloride Ammonium Chloride affects the expression of HOXD3 mRNAaffects expression 16483693
D002392 Catechin Catechin results in increased expression of HOXD3 mRNAincreases expression 15465739
C014347 decitabine decitabine results in decreased methylation of HOXD3 promoterdecreases methylation 19283074
C014347 decitabine decitabine results in increased expression of HOXD3 mRNAincreases expression 19283074
D005419 Flavonoids Flavonoids results in increased expression of HOXD3 mRNAincreases expression 15465739
D009151 Mustard Gas Mustard Gas results in increased expression of HOXD3 mRNAincreases expression 15674843
D010936 Plant Extracts Plant Extracts results in increased expression of HOXD3 mRNAincreases expression 15465739
C025299 polyphenols polyphenols results in increased expression of HOXD3 mRNAincreases expression 15465739
D018038 Sodium Selenite Sodium Selenite results in increased expression of HOXD3 mRNAincreases expression 18175754
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8418287403
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.863712494
MESH:D000544 Alzheimer Disease Plant Extracts 3.0516962711
MESH:D001169 Arthritis, Experimental Plant Extracts 4.0614686799
MESH:D001249 Asthma Mustard Gas 2.7610378619
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.3411289319 1440618
MESH:D001768 Blister Mustard Gas 5.4419167455
MESH:D002545 Brain Ischemia Plant Extracts 5.0116041641
MESH:D001943 Breast Neoplasms decitabine 2.5519208741 18320071
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.4415286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.2917687719 10378619
MESH:D002057 Burns, Chemical Plant Extracts 5.659625245
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 3.403581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Plant Extracts 3.4018834353
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.767296757
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.6419215824
MESH:D006332 Cardiomegaly Plant Extracts 3.9017645561
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.897505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.3019486331 9022650
MESH:D019457 Chromosome Breakage Sodium Selenite 5.0115894690
MESH:D003110 Colonic Neoplasms decitabine 4.1417616700
MESH:D003110 Colonic Neoplasms polyphenols 4.1416293270
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.062524372 8156756 11906362 12868966 14531868 18759878 8970840 11298694
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.713621924 2952479
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9616285004
MESH:D003928 Diabetic Nephropathies Plant Extracts 4.5919706694
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.686482804 18289764 11289319 18692083 18648102 6679447 1440618 7440962 9022650 9328219 9653073 16192314 8291058
MESH:D056486 Drug-Induced Liver Injury polyphenols 6.6819370779
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 6.6815131321
MESH:D004487 Edema Mustard Gas 8.069260866 11428647 11428631 11402378
MESH:D004487 Edema Plant Extracts 8.0612787963
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.4319294695
MESH:D004719 Endomyocardial Fibrosis Plant Extracts 6.0015268973
MESH:D004827 Epilepsy Plant Extracts 3.8219700373 19439326
MESH:D004890 Erythema Mustard Gas 5.449357497
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.153581430
MESH:D005234 Fatty Liver Plant Extracts 4.3015975614
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.346705139
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.267505956
MESH:D006258 Head and Neck Neoplasms decitabine 3.6219215824
MESH:D006333 Heart Failure Plant Extracts 3.9818097624
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.756705139
MESH:D006561 Herpes Simplex Plant Extracts 4.9110715843
MESH:D015658 HIV Infections Plant Extracts 3.7812878215
MESH:D019584 Hot Flashes Plant Extracts 5.0616566672 14716179 17454163
MESH:D020138 Hyperhomocysteinemia Catechin 10.5417292331
MESH:D020138 Hyperhomocysteinemia Plant Extracts 10.5416484555
MESH:D006949 Hyperlipidemias Plant Extracts 4.6915268973 15975614
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2015034207
MESH:D007248 Infertility, Male decitabine 3.3317581917
MESH:D007249 Inflammation Flavonoids 12.9117296493
MESH:D007249 Inflammation Mustard Gas 12.9117524151 9260866 11428647 11428620 9357497 8975870 11428631 11402378 16001271
MESH:D007249 Inflammation Plant Extracts 12.9112787963 15997105 16366677 19332304
MESH:D007249 Inflammation polyphenols 12.9116366677
MESH:D007333 Insulin Resistance Sodium Selenite 3.4014714311
MESH:D007414 Intestinal Neoplasms Plant Extracts 4.8112584176 12628509 12351151
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.348074119 9022650
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.146582329
MESH:D007938 Leukemia decitabine 3.1619235587 18980019
MESH:D007951 Leukemia, Myeloid decitabine 4.2119117987 18454857 17236224
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.4118704418 18460780 19387464 19010910 18206229 17679729
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.7818055864
MESH:D008103 Liver Cirrhosis Plant Extracts 3.8417157831
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.319327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Plant Extracts 2.6815479170
MESH:D008107 Liver Diseases Plant Extracts 4.8117034775
MESH:D008107 Liver Diseases polyphenols 4.8116698588
MESH:D008113 Liver Neoplasms Plant Extracts 3.2119168119
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.653712494 598648 6587162 1399818
MESH:D008171 Lung Diseases Mustard Gas 3.5818702808 18161513
MESH:D008175 Lung Neoplasms Mustard Gas 2.983148597 8781369
MESH:D008175 Lung Neoplasms Plant Extracts 2.9820869020
MESH:D008223 Lymphoma decitabine 3.5619470736
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.2814737004
MESH:D008545 Melanoma decitabine 2.2717785578 16505122
MESH:D009101 Multiple Myeloma decitabine 3.4918172295
MESH:D009190 Myelodysplastic Syndromes decitabine 3.4919157545 19010910 16882708 18608210
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.543581430
MESH:D009369 Neoplasms decitabine 2.8017925555 19116145 19470736
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.046679447
MESH:D019954 Neurobehavioral Manifestations Plant Extracts 5.4417168769
MESH:D009503 Neutropenia Mustard Gas 4.197688884 16761898
MESH:D009765 Obesity Plant Extracts 3.1819056576 20132043
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.616482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.343988306
MESH:D010051 Ovarian Neoplasms decitabine 2.7019259094 19331143
MESH:D010190 Pancreatic Neoplasms decitabine 2.8319294695
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 10.347296757
MESH:D010212 Papilloma Plant Extracts 10.3415173996 16517061
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.796228378
MESH:D011041 Poisoning Mustard Gas 4.0215727166
MESH:D055728 Primary Myelofibrosis decitabine 4.9917616702
MESH:D011471 Prostatic Neoplasms marker/mechanism 19283074
MESH:D011471 Prostatic Neoplasms Plant Extracts 3.5814666653 17804756
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.5818760546
MESH:D011537 Pruritus Mustard Gas 4.3818058305
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9917720292 17894541 10334151 17266442 17620002
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.523692021
MESH:D012208 Rhabdomyosarcoma decitabine 4.6219155313
MESH:D012871 Skin Diseases Mustard Gas 2.7612880345 15451306 16961503
MESH:D012878 Skin Neoplasms Plant Extracts 3.5615173996 16517061
MESH:D013274 Stomach Neoplasms decitabine 2.1019037991
MESH:D013276 Stomach Ulcer Plant Extracts 4.1018193104 17135157 18237397 15255614 12787963
MESH:D013705 Temporomandibular Joint Disorders Plant Extracts 14.3617997062
MESH:D013705 Temporomandibular Joint Disorders polyphenols 14.3617997062
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.776582329 7505956 3712494 6587162 1399818
MESH:D013964 Thyroid Neoplasms decitabine 7.7717967635
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.408074119
MESH:D001749 Urinary Bladder Neoplasms decitabine 5.4017616700 19087683
MESH:D014604 Uveal Neoplasms decitabine 5.2317785578
MESH:D018487 Ventricular Dysfunction, Left Plant Extracts 5.0018097624
MESH:D020257 Ventricular Remodeling Plant Extracts 5.6018097624
MESH:D014947 Wounds and Injuries Plant Extracts 4.4219894650 20213670
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved